Citations for
1ITGB1, MARVELD1, PTK2
MARVELD1 depletion leads to dysfunction of motor and cognition via regulating glia-dependent neuronal migration during brain development
Liu W, Han F, Qu S, Yao Y, Zhao J, Akhtar ML, Ci Y, Zhang H, Li H, Zhao Y, Yue L, Zhang Y, Wang C, Li Y.
Cell Death Dis. Sep 24;9(10):999. doi: 10.1038/s41419-018-1027-6. 2018
2CA8, MMP9, PTK2
Oncogenic roles of carbonic anhydrase 8 in human osteosarcoma cells.
Wang TK, Lin YM, Lo CM, Tang CH, Teng CL, Chao WT, Wu MH, Liu CS, Hsieh M.
Tumour Biol 37(6):7989-8005. doi: 10.1007/s13277-015-4661-y. Epub 2015 Dec 28. 2016
3MMP14, PTK2, TGFB1I1
Hic-5 mediates the initiation of endothelial sprouting by regulating a key surface metalloproteinase.
Dave JM, Abbey CA, Duran CL, Seo H, Johnson GA, Bayless KJ.
J Cell Sci 129(4):743-56. doi: 10.1242/jcs.170571. Epub 2016 Jan 14. 2016
4PTK2, PTK2B, PYCARD
Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis.
Chung IC, OuYang CN, Yuan SN, Li HP, Chen JT, Shieh HR, Chen YJ, Ojcius DM, Chu CL, Yu JS, Chang YS, Chen LC.
Sci Rep 6:36214. doi: 10.1038/srep36214. 2016
5PTK2, PXN, RACGAP1, RHOA
RacGAP1-driven focal adhesion formation promotes melanoma transendothelial migration through mediating adherens junction disassembly.
Zhang P, Bai H, Fu C, Chen F, Zeng P, Wu C, Ye Q, Dong C, Song Y, Song E.
Biochem Biophys Res Commun 459(1):1-9. doi: 10.1016/j.bbrc.2014.11.088. 2015
6MMP2, PTK2, SERPINB1
Serine protease inhibitor (SERPIN) B1 suppresses cell migration and invasion in glioma cells.
Huasong G, Zongmei D, Jianfeng H, Xiaojun Q, Jun G, Sun G, Donglin W, Jianhong Z.
Brain Res 1600:59-69. doi: 10.1016/j.brainres.2014.06.017. Epub 2014 Jun 23. 2015
7AGAP2, PTK2, RACK1
RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK.
Dwane S, Durack E, O'Connor R, Kiely PA.
Cell Signal 26(1):9-18. doi: 10.1016/j.cellsig.2013.08.036. Epub 2013 Sep 19. 2014
8GRB2, PTK2, PTPRA
Grb2 promotes integrin-induced focal adhesion kinase (FAK) autophosphorylation and directs the phosphorylation of protein tyrosine phosphatase α by the Src-FAK kinase complex.
Cheng SY, Sun G, Schlaepfer DD, Pallen CJ.
Mol Cell Biol 34(3):348-61. doi: 10.1128/MCB.00825-13. 2014
9PTK2, TRIM72, UBE2H
Mitsugumin 53 (MG53) ligase ubiquitinates focal adhesion kinase during skeletal myogenesis.
Nguyen N, Yi JS, Park H, Lee JS, Ko YG.
J Biol Chem 289(6):3209-16. doi: 10.1074/jbc.M113.525154. 2014
10ARHGEF28, PTK2
RhoGEFs in cell motility: novel links between Rgnef and focal adhesion kinase.
Miller NL, Kleinschmidt EG, Schlaepfer DD.
Curr Mol Med 14(2):221-34. Review. 2014
11PTK2, THOC2
A de novo X;8 translocation creates a PTK2-THOC2 gene fusion with THOC2 expression knockdown in a patient with psychomotor retardation and congenital cerebellar hypoplasia.
Di Gregorio E, Bianchi FT, Schiavi A, Chiotto AM, Rolando M, Verdun di Cantogno L, Grosso E, Cavalieri S, Calcia A, Lacerenza D, Zuffardi O, Retta SF, Stevanin G, Marelli C, Durr A, Forlani S, Chelly J, Montarolo F, Tempia F, Beggs HE, Reed R, Squadrone S, Abete MC, Brussino A, Ventura N, Di Cunto F, Brusco A.
J Med Genet 50(8):543-51. doi: 10.1136/jmedgenet-2013-101542. Epub 2013 Jun 7. 2013
12PTK2
Distinct FAK activities determine progenitor and mammary stem cell characteristics.
Luo M, Zhao X, Chen S, Liu S, Wicha MS, Guan JL.
Cancer Res 73(17):5591-602. doi: 10.1158/0008-5472.CAN-13-1351. Epub 2013 Jul 5. 2013
13PTK2
Influence of focal adhesion kinase on the mechanical behavior of cell populations.
Lange J, Auernheimer V, Strissel PL, Goldmann WH.
Biochem Biophys Res Commun 436(2):246-51. doi: 10.1016/j.bbrc.2013.05.084. Epub 2013 May 30. 2013
14PTK2, STK11
LKB1 represses focal adhesion kinase (FAK) signaling via a FAK-LKB1 complex to regulate FAK site maturation and directional persistence.
Kline ER, Shupe J, Gilbert-Ross M, Zhou W, Marcus AI.
J Biol Chem 288(24):17663-74. doi: 10.1074/jbc.M112.444620. Epub 2013 May 1. 2013
15PTK2
Focal adhesion kinase regulates intestinal epithelial barrier function via redistribution of tight junction.
Ma Y, Semba S, Khan RI, Bochimoto H, Watanabe T, Fujiya M, Kohgo Y, Liu Y, Taniguchi T.
Biochim Biophys Acta 1832(1):151-9. doi: 10.1016/j.bbadis.2012.10.006. Epub 2012 Oct 12. 2013
16PTK2, PTK6
Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT.
Zheng Y, Gierut J, Wang Z, Miao J, Asara JM, Tyner AL.
Oncogene 32(36):4304-12. doi: 10.1038/onc.2012.427. Epub 2012 Oct 1. 2013
17BMP4, PTK2
The role of focal adhesion kinase in BMP4 induction of mesenchymal stem cell adipogenesis.
Lee JS, Ha L, Kwon IK, Lim JY.
Biochem Biophys Res Commun 435(4):696-701. doi: 10.1016/j.bbrc.2013.05.045. Epub 2013 May 20. 2013
18ETV4, PTK2
Requirement of PEA3 for transcriptional activation of FAK gene in tumor metastasis.
Li S, Huang X, Zhang D, Huang Q, Pei G, Wang L, Jiang W, Hu Q, Tan R, Hua ZC.
PLoS One 8(11):e79336. doi: 10.1371/journal.pone.0079336. eCollection 2013. 2013
19LCK, PTK2
Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor.
Chapman NM, Connolly SF, Reinl EL, Houtman JC.
J Immunol 191(12):6208-21. doi: 10.4049/jimmunol.1301587. Epub 2013 Nov 13. 2013
20ARHGEF28, PTK2
A non-canonical role for Rgnef in promoting integrin-stimulated focal adhesion kinase activation.
Miller NL, Lawson C, Kleinschmidt EG, Tancioni I, Uryu S, Schlaepfer DD.
J Cell Sci 126(Pt 21):5074-85. doi: 10.1242/jcs.135509. Epub 2013 Sep 4. 2013
21PTK2, PTK2B
Regulation of osteoclast structure and function by FAK family kinases.
Ray BJ, Thomas K, Huang CS, Gutknecht MF, Botchwey EA, Bouton AH.
J Leukoc Biol 92(5):1021-8. doi: 10.1189/jlb.0512259. Epub 2012 Aug 31. 2012
22CDC42, PTK2
Focal adhesion kinase modulates Cdc42 activity downstream of positive and negative axon guidance cues.
Myers JP, Robles E, Ducharme-Smith A, Gomez TM.
J Cell Sci 125(Pt 12):2918-29. doi: 10.1242/jcs.100107. Epub 2012 Mar 5. 2012
23ADAM15, PTK2
ADAM15 protein amplifies focal adhesion kinase phosphorylation under genotoxic stress conditions.
Fried D, Böhm BB, Krause K, Burkhardt H.
J Biol Chem 287(25):21214-23. doi: 10.1074/jbc.M112.347120. Epub 2012 Apr 27. 2012
24PTK2, PTK2B, XIAP
XIAP reverses various functional activities of FRNK in endothelial cells.
Ahn S, Kim HJ, Chi SG, Park H.
Biochem Biophys Res Commun 419(2):419-24. doi: 10.1016/j.bbrc.2012.02.037. Epub 2012 Feb 14. 2012
25PTK2
Focal adhesion kinase regulates actin nucleation and neuronal filopodia formation during axonal growth.
Chacón MR, Navarro AI, Cuesto G, del Pino I, Scott R, Morales M, Rico B.
Development 139(17):3200-10. doi: 10.1242/dev.080564. 2012
26PTK2, TLN1
FAK promotes recruitment of talin to nascent adhesions to control cell motility.
Lawson C, Lim ST, Uryu S, Chen XL, Calderwood DA, Schlaepfer DD.
J Cell Biol 196(2):223-32. doi: 10.1083/jcb.201108078. Erratum in: J Cell Biol. 2012 Feb 6;196(3):387. 2012
27GRPR, PTK2
FAK is a critical regulator of neuroblastoma liver metastasis.
Lee S, Qiao J, Paul P, O'Connor KL, Evers MB, Chung DH.
Oncotarget 3(12):1576-87. 2012
28CTTN, PTK2
Cortactin tyrosine phosphorylation promotes its deacetylation and inhibits cell spreading.
Meiler E, Nieto-Pelegrín E, Martinez-Quiles N.
PLoS One 7(3):e33662. doi: 10.1371/journal.pone.0033662. Epub 2012 Mar 30. 2012
29PTK2, UCHL1
Ubiquitin C-terminal hydrolase-L1 interacts with adhesion complexes and promotes cell migration, survival, and anchorage independent growth.
Frisan T, Coppotelli G, Dryselius R, Masucci MG.
FASEB J 26(12):5060-70. doi: 10.1096/fj.12-211946. Epub 2012 Aug 29. 2012
30NANOG, PTK2
Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated.
Ho B, Olson G, Figel S, Gelman I, Cance WG, Golubovskaya VM.
J Biol Chem 287(22):18656-73. doi: 10.1074/jbc.M111.322883. Epub 2012 Apr 5. 2012
31GATA4, PTK2, VCAM1
Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression.
Lim ST, Miller NL, Chen XL, Tancioni I, Walsh CT, Lawson C, Uryu S, Weis SM, Cheresh DA, Schlaepfer DD.
J Cell Biol 197(7):907-19. doi: 10.1083/jcb.201109067. 2012
32PTK2, SNAI1
Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells.
Li XY, Zhou X, Rowe RG, Hu Y, Schlaepfer DD, Ilić D, Dressler G, Park A, Guan JL, Weiss SJ.
J Cell Biol 195(5):729-38. Epub 2011 Nov 21. 2011
33PTK2
FAK is required for the assembly of podosome rosettes.
Pan YR, Chen CL, Chen HC.
J Cell Biol 195(1):113-29. 2011
34DLC1, PTK2
Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK).
Li G, Du X, Vass WC, Papageorge AG, Lowy DR, Qian X.
Proc Natl Acad Sci U S A 108(41):17129-34. Epub 2011 Oct 3. 2011
35IQGAP1, ITGB1BP2, PTK2, RAF1
ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1.
Sbroggiò M, Bertero A, Velasco S, Fusella F, De Blasio E, Bahou WF, Silengo L, Turco E, Brancaccio M, Tarone G.
J Cell Sci 124(Pt 20):3515-24. doi: 10.1242/jcs.091140. 2011
36ABCB1, OCLN, PTK2, TJP1
P-glycoprotein regulates blood-testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK).
Su L, Mruk DD, Lui WY, Lee WM, Cheng CY.
Proc Natl Acad Sci U S A 108(49):19623-8. doi: 10.1073/pnas.1111414108. Epub 2011 Nov 21. 2011
37GJB2, PTK2
Focal adhesion kinase modulates radial glia-dependent neuronal migration through connexin-26.
Valiente M, Ciceri G, Rico B, Marín O.
J Neurosci 31(32):11678-91. doi: 10.1523/JNEUROSCI.2678-11.2011. 2011
38PTK2, ZG16B
PAUF promotes adhesiveness of pancreatic cancer cells by modulating focal adhesion kinase.
Lee YS, Kim SJ, Min HJ, Jo JY, Park EH, Koh SS.
Exp Mol Med 43(5):291-7. doi: 10.3858/emm.2011.43.5.030. 2011
39CADM1, PTK2
SynCAM 1 participates in axo-dendritic contact assembly and shapes neuronal growth cones.
Stagi M, Fogel AI, Biederer T.
Proc Natl Acad Sci U S A 107(16):7568-73. Epub 2010 Apr 5. 2010
40PTK2, XIAP
XIAP is essential for shear stress-enhanced Tyr-576 phosphorylation of FAK.
Ahn S, Park H.
Biochem Biophys Res Commun 399(2):256-61. Epub 2010 Jul 22.PMID: 20655298 2010
41PTK2
The FERM domain: organizing the structure and function of FAK.
Frame MC, Patel H, Serrels B, Lietha D, Eck MJ.
Nat Rev Mol Cell Biol 11(11):802-14. Review. 2010
42PTK2, PTK2B
The influence of Pyk2 on the mechanical properties in fibroblasts.
Klemm AH, Kienle S, Rheinlaender J, Schäffer TE, Goldmann WH.
Biochem Biophys Res Commun 393(4):694-7. Epub 2010 Feb 17. 2010
43MAPK7, PTK2
A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling.
Sawhney RS, Liu W, Brattain MG.
J Cell Physiol 219(1):152-61. 2009
44IGF1R, PTK2
Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor.
Andersson S, D'Arcy P, Larsson O, Sehat B.
Biochem Biophys Res Commun 387(1):36-41. Epub 2009 Jun 21. 2009
45NR1H4, PTK2
FXR promotes endothelial cell motility through coordinated regulation of FAK and MMP-9.
Das A, Yaqoob U, Mehta D, Shah VH.
Arterioscler Thromb Vasc Biol 29(4):562-70. Epub 2009 Jan 15. 2009
46PTK2, PTPN11
SHP-2 regulates myogenesis by coupling to FAK signaling pathway.
de Oliveira MV, Marin TM, Clemente CF, Costa AP, Judice CC, Franchini KG.
FEBS Lett 583(18):2975-81. Epub 2009 Aug 19.PMID: 19698715 2009
47IGF1R, PTK2
Targeting of the protein interaction site between FAK and IGF-1R.
Zheng D, Kurenova E, Ucar D, Golubovskaya V, Magis A, Ostrov D, Cance WG, Hochwald SN.
Biochem Biophys Res Commun 388(2):301-5. Epub 2009 Aug 5.PMID: 19664602 2009
48ARHGAP35, PTK2, RASA1
A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells.
Tomar A, Lim ST, Lim Y, Schlaepfer DD.
J Cell Sci 122(Pt 11):1852-62. Epub 2009 May 12. Erratum in: J Cell Sci. 2009 Aug 15;122(Pt 16):3005. PMID: 1943580 2009
49EMP2, PTK2
Functional consequences of interactions between FAK and epithelial membrane protein 2 (EMP2).
Morales SA, Mareninov S, Coulam P, Wadehra M, Goodglick L, Braun J, Gordon LK.
Invest Ophthalmol Vis Sci. 50(10):4949-56. 2009
50GNB1, PTK2
The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin.
Knezevic N, Tauseef M, Thennes T, Mehta D.
J Exp Med 206(12):2761-77. Epub 2009 Nov 16. 2009
51PTK2, PTK2B
B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading.
Tse KW, Dang-Lawson M, Lee RL, Vong D, Bulic A, Buckbinder L, Gold MR.
J Biol Chem 284(34):22865-77. doi: 10.1074/jbc.M109.013169. Epub 2009 Jun 26. 2009
52ARHGAP21, PTK2
ARHGAP21 modulates FAK activity and impairs glioblastoma cell migration.
Bigarella CL, Borges L, Costa FF, Saad ST.
Biochim Biophys Acta 1793(5):806-16. doi: 10.1016/j.bbamcr.2009.02.010. Epub 2009 Mar 4. 2009
53AGAP2, PTK2
Arf GTPase-activating protein AGAP2 regulates focal adhesion kinase activity and focal adhesion remodeling.
Zhu Y, Wu Y, Kim JI, Wang Z, Daaka Y, Nie Z.
J Biol Chem 284(20):13489-96. doi: 10.1074/jbc.M900469200. Epub 2009 Mar 24. 2009
54PTK2, CTGF
Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2.
Pala D, Kapoor M, Woods A, Kennedy L, Liu S, Chen S, Bursell L, Lyons KM, Carter DE, Beier F, Leask A.
J Biol Chem 283(14):9239-47. Epub 2008 Feb 13. 2008
55PTK2
FAK nuclear export signal sequences.
Ossovskaya V, Lim ST, Ota N, Schlaepfer DD, Ilic D.
FEBS Lett 582(16):2402-6. Epub 2008 Jun 10. 2008
56ARHGAP21, PRKCZ, PTK2
ARHGAP21 associates with FAK and PKCzeta and is redistributed after cardiac pressure overload.
Borges L, Bigarella CL, Baratti MO, Crosara-Alberto DP, Joazeiro PP, Franchini KG, Costa FF, Saad ST.
Biochem Biophys Res Commun 374(4):641-6. Epub 2008 Jul 26. 2008
57PTK2
Biphasic function of focal adhesion kinase in endothelial tube formation induced by fibril-forming collagens.
Nakamura J, Shigematsu S, Yamauchi K, Takeda T, Yamazaki M, Kakizawa T, Hashizume K.
Biochem Biophys Res Commun 374(4):699-703. Epub 2008 Aug 3. 2008
58KLF8, PTK2, SP1
Activation of KLF8 transcription by focal adhesion kinase in human ovarian epithelial and cancer cells.
Wang X, Urvalek AM, Liu J, Zhao J.
J Biol Chem 283(20):13934-42. Epub 2008 Mar 19. 2008
59ELK1, PTK2
Elk-1 associates with FAK, regulates the expression of FAK and MAP kinases as well as apoptosis in HK-2 cells.
Mamali I, Kotsantis P, Lampropoulou M, Marmaras VJ.
J Cell Physiol 216(1):198-206. 2008
60PTK2
Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocytes focal adhesion kinase (FAK) conditional knockout mice.
Peng, X., Wu, X., Druso, J. E., Wei, H., Park, A. Y.-J., Kraus, M. S., Alcaraz, A., Chen, J., Chien, S., Cerione, R. A., Guan, J.-L.
Proc. Nat. Acad. Sci. 105, 6638-6643 2008
61CD4, PTK2
Structural basis for the interaction between focal adhesion kinase and CD4.
Garron ML, Arthos J, Guichou JF, McNally J, Cicala C, Arold ST.
J Mol Biol 375(5):1320-8. Epub 2007 Nov 22.PMID: 18078954 2008
62ARHGEF11, PTK2, ROCK2
FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts.
Iwanicki MP, Vomastek T, Tilghman RW, Martin KH, Banerjee J, Wedegaertner PB, Parsons JT.
J Cell Sci 121(Pt 6):895-905. Epub 2008 Feb 26.PMID: 18303050 2008
63AKT1,PTK2
Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts.
Horowitz JC, Rogers DS, Sharma V, Vittal R, White ES, Cui Z, Thannickal VJ.
Cell Signal 19(4):761-71. Epub 2006 Nov 17. 2007
64EPS8,PTK2
Eps8 facilitates cellular growth and motility of colon cancer cells by increasing the expression and activity of focal adhesion kinase.
Maa MC, Lee JC, Chen YJ, Chen YJ, Lee YC, Wang ST, Huang CC, Chow NH, Leu TH.
J Biol Chem 282(27):19399-409. Epub 2007 May 12. 2007
65KLF8, PTK2
KLF8 transcription factor participates in oncogenic transformation.
Wang X, Zhao J.
Oncogene 26(3):456-61. Epub 2006 Jul 10. 2007
66PTK2, TSC2
Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth.
Gan B, Yoo Y, Guan JL.
J Biol Chem. 281(49):37321-9. 2006
67PTK2
EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation.
Moeller ML, Shi Y, Reichardt LF, Ethell IM.
J Biol Chem. 281(3):1587-98. 2006
68PTK2
Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells.
Garces CA, Kurenova EV, Golubovskaya VM, Cance WG.
Cancer Res. 66(3):1446-54. 2006
69PTK2
Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice.
Peng, X., Kraus, M. S., Wei, H., Shen, T.-L., Pariaut, R., Alcaraz, A., Ji, G., Cheng, L., Yang, Q., Kotlikoff, M. I., Chen, J., Chien, K., Gu, H., Guan, J.-L.
J. Clin. Invest. 116, 217-227 2006
70PTK2
JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: JNK links FAK and p53.
Tafolla E, Wang S, Wong B, Leong J, Kapila YL.
J Biol Chem 280(20):19992-9. Epub 2005 Mar 18. 2005
71ASAP1, DLGAP3, PTK2
FAK and PYK2 interact with SAP90/PSD-95-Associated Protein-3.
Bongiorno-Borbone L, Kadare G, Benfenati F, Girault JA.
Biochem Biophys Res Commun 337(2):641-6. Epub 2005 Sep 26. 2005
72MAPK8IP3,PTK2
JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration.
Takino T, Nakada M, Miyamori H, Watanabe Y, Sato T, Gantulga D, Yoshioka K, Yamada KM, Sato H.
J Biol Chem 280(45):37772-81. Epub 2005 Sep 2. 2005
73PTK2
Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase.
Ezratty EJ, Partridge MA, Gundersen GG.
Nat Cell Biol. 7(6):581-90. 2005
74PTK2
Direct interaction of the N-terminal domain of focal adhesion kinase with the N-terminal transactivation domain of p53.
Golubovskaya VM, Finch R, Cance WG.
J Biol Chem. 280(26):25008-21. 2005
75PTK2
Direct phosphorylation of proliferative and survival pathway proteins by RET.
Panta GR, Du L, Nwariaku FE, Kim LT.
Surgery. 138(2):269-74. 2005
76GIT2, PTK2, SRC
Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness.
Brown MC, Cary LA, Jamieson JS, Cooper JA, Turner CE.
Mol Biol Cell 16(9):4316-28. 2005
77PTK2
Cloning and characterization of the promoter region of human focal adhesion kinase gene: nuclear factor kappa B and p53 binding sites.
Golubovskaya V, Kaur A, Cance W.
Biochim Biophys Acta 1678(2-3):111-25. 2004
78PTK2
HIV-1 Tat-mediated effects on focal adhesion assembly and permeability in brain microvascular endothelial cells.
Avraham HK, Jiang S, Lee TH, Prakash O, Avraham S.
J Immunol. 173(10):6228-33. 2004
79PTK2, RIPK1
Focal adhesion kinase suppresses apoptosis by binding to the death domain of receptor-interacting protein.
Kurenova E, Xu LH, Yang X, Baldwin AS Jr, Craven RJ, Hanks SK, Liu ZG, Cance WG.
Mol Cell Biol. 24(10):4361-71. 2004
80PTK2
Focal adhesion kinase in netrin-1 signaling.
Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, Xiong WC.
Nat Neurosci. 7(11):1204-12 2004
81PTK2
Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression
McLean, G. W., Komiyama, N. H., Serrels, B., Asano, H., Reynolds, L., Conti, F., Hodivala-Dilke, K., Metzger, D., Chambon, P., Grant, S. G. N., Frame, M. C.
Genes Dev. 18, 2998-3003 2004
82EIF3H,PTK2
PTK2 and EIF3S3 genes may be amplification targets at 8q23-q24 and are associated with large hepatocellular carcinomas.
Okamoto H, Yasui K, Zhao C, Arii S, Inazawa J.
Hepatology 38(5):1242-9. 2003
83PTK2
Specific interactions of neuronal focal adhesion kinase isoforms with Src kinases and amphiphysin.
Messina S, Onofri F, Bongiorno-Borbone L, Giovedì S, Valtorta F, Girault JA, Benfenati F.
J Neurochem. 84(2):253-65. 2003
84PTK2
Calcium-and integrin-binding protein regulates focal adhesion kinase activity during platelet spreading on immobilized fibrinogen.
Naik MU, Naik UP.
Blood. 102(10):3629-36. 2003
85PTK2
Site-specific phosphorylation of platelet focal adhesion kinase by low-density lipoprotein.
Relou IA, Bax LA, van Rijn HJ, Akkerman JW.
Biochem J. 369(Pt 2):407-16. 2003
86PTK2
Focal adhesion kinase pp125FAK interacts with the large conductance calcium-activated hSlo potassium channel in human osteoblasts: potential role in mechanotransduction.
Rezzonico R, Cayatte C, Bourget-Ponzio I, Romey G, Belhacene N, Loubat A, Rocchi S, Van Obberghen E, Girault JA, Rossi B, Schmid-Antomarchi H.
J. Bone Miner. Res. 18(10):1863-71. 2003
87PTK2
PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation.
Kadaré G, Toutant M, Formstecher E, Corvol JC, Carnaud M, Boutterin MC, Girault JA.
J Biol Chem. 278(48):47434-40 2003
88PTK2
Signaling between focal adhesion kinase and trio.
Medley QG, Buchbinder EG, Tachibana K, Ngo H, Serra-Pagès C, Streuli M.
J Biol Chem. 278(15):13265-70. 2003
89PTK2
The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly.
Liu Y, Loijens JC, Martin KH, Karginov AV, Parsons JT.
Mol Biol Cell. 13(6):2147-56. 2002
90PTK2
A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated.
Takino T, Yoshioka K, Miyamori H, Yamada KM, Sato H.
Oncogene. 21(42):6488-97. 2002
91PTK2
Nck-2 interacts with focal adhesion kinase and modulates cell motility.
Goicoechea SM, Tu Y, Hua Y, Chen K, Shen TL, Guan JL, Wu C.
Int J Biochem Cell Biol. 34(7):791-805. 2002
92PTK2
Focal adhesion kinase is involved in mechanosensing during fibroblast migration.
Wang HB, Dembo M, Hanks SK, Wang Y.
Proc Natl Acad Sci U S A 98(20):11295-300. 2001
93PTK2
Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase.
Nishiya N, Tachibana K, Shibanuma M, Mashimo JI, Nose K.
Mol Cell Biol. 21(16):5332-45. 2001
94PTK2
Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain.
Chen R, Kim O, Li M, Xiong X, Guan JL, Kung HJ, Chen H, Shimizu Y, Qiu Y.
Nat Cell Biol. 3(5):439-44. 2001
95PTK2
Ezrin interacts with focal adhesion kinase and induces its activation independently of cell-matrix adhesion.
Poullet P, Gautreau A, Kadaré G, Girault JA, Louvard D, Arpin M.
J Biol Chem. 276(40):37686-91. 2001
96PTK2
Cell-cycle-dependent association of protein phosphatase 1 and focal adhesion kinase.
Fresu M, Bianchi M, Parsons JT, Villa-Moruzzi E.
Biochem J. 358(Pt 2):407-14. 2001
97PTK2
FAK integrates growth-factor and integrin signals to promote cell migration.
Sieg DJ, Hauck CR, Ilic D, Klingbeil CK, Schaefer E, Damsky CH, Schlaepfer DD.
Nat Cell Biol. 2(5):249-56. 2000
98PTK2
Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation.
Miao H, Burnett E, Kinch M, Simon E, Wang B.
Nat Cell Biol. 2(2):62-9. 2000
99PLCG1, PTK2
Focal adhesion kinase promotes phospholipase C-gamma1 activity.
Zhang X, et al.
Proc Natl Acad Sci U S A 96(16):9021-6. 1999
100PTK2
Association of focal adhesion kinase with Grb7 and its role in cell migration.
Han DC, Guan JL.
J Biol Chem. 274(34):24425-30. 1999
101PTK2
PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway.
Tamura M, Gu J, Danen EH, Takino T, Miyamoto S, Yamada KM.
J Biol Chem. 274(29):20693-703. 1999
102PTK2, SORBS1
A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions.
Ribon V, Herrera R, Kay BK, Saltiel AR.
J Biol Chem. 273(7):4073-80. 1998
103PTK2
Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase.
Fujita H, Kamiguchi K, Cho D, Shibanuma M, Morimoto C, Tachibana K.
J Biol Chem. 273(41):26516-21. 1998
104PTK2
Dot far-western blot analysis of relative binding affinities of the Src homology 3 domains of Efs and its related proteins.
Ohba T, Ishino M, Aoto H, Sasaki T.
Anal Biochem. 262(2):185-92. 1998
105PTK2
Insulin receptor substrate-1 as a signaling molecule for focal adhesion kinase pp125(FAK) and pp60(src).
Lebrun P, Mothe-Satney I, Delahaye L, Van Obberghen E, Baron V.
J Biol Chem. 273(48):32244-53. 1998
106JAK2, PTK2
Growth hormone stimulates the tyrosine phosphorylation and association of p125 focal adhesion kinase (FAK) with JAK2. Fak is not required for stat-mediated transcription.
Zhu T, Goh EL, Lobie PE.
J Biol Chem. 273(17):10682-9. 1998
107PTK2
Relocation of Syk protein-tyrosine kinase to the actin filament network and subsequent association with Fak.
Sada K, Minami Y, Yamamura H.
Eur J Biochem. 248(3):827-33. 1997
108PTK2
T cell receptor engagement induces tyrosine phosphorylation of FAK and Pyk2 and their association with Lck.
Berg NN, Ostergaard HL.
J Immunol. 159(4):1753-7. 1997
109ARHGAP26, PTK2
An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinase.
Hildebrand JD, Taylor JM, Parsons JT.
Mol Cell Biol 16(6):3169-78. 1996
110NEDD9, PTK2
Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae.
Law SF, Estojak J, Wang B, Mysliwiec T, Kruh G, Golemis EA.
Mol Cell Biol 16(7):3327-37. 1996
111PTK2
Mapping of the focal adhesion kinase (Fadk) gene to mouse chromosome 15 and human chromosome 8.
Fiedorek FT, et al.
Mamm Genome 6 : 123-126. 1995
112PTK2
Interaction of focal adhesion kinase with cytoskeletal protein talin
Chen HC, Appeddu PA, Parsons JT, Hildebrand JD, Schaller MD, Guan JL.
J Biol Chem. 270(28):16995-9. 1995
113PTK2
Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas.
Polte TR, Hanks SK.
Proc Natl Acad Sci U S A. 92(23):10678-82. 1995
114PTK2
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice.
Ilic, D., Furuta, Y., Kanazawa, S., Takeda, N., Sobue, K., Nakatsuji, N., Nomura, S., Fujimoto, J., Okada, M., Yamamoto, T., Aizawa, S.
Nature. 377, 539-544 1995
115PTK2
Focal adhesion kinase-related fakB is regulated by the integrin LFA-1 and interacts with the SH3 domain of phospholipase C gamma 1.
Kanner SB.
Cell Immunol. 171(1):164-9. 1995
116PTK2
Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK.
Whitney GS, et al.
DNA Cell Biol 12 : 823-830. 1993
117CCZ1, PTK2
Expression of an N-terminally truncated form of human focal adhesion kinase in brain.
Andre E, Becker-Andre M.
Biochem Biophys Res Commun 190(1):140-7. 1993
118PTK2, TENM4
Teneurin-4 promotes cellular protrusion formation and neurite outgrowth through focal adhesion kinase signaling.
Suzuki N, Numakawa T, Chou J, de Vega S, Mizuniwa C, Sekimoto K, Adachi N, Kunugi H, Arikawa-Hirasawa E, Yamada Y, Akazawa C.