| 1 | PTK2, TARDBP
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| PTK2/FAK regulates UPS impairment via SQSTM1/p62 phosphorylation in TARDBP/TDP-43 proteinopathies
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| Lee S, Jeon YM, Cha SJ, Kim S, Kwon Y, Jo M, Jang YN, Lee S, Kim J, Kim SR, Lee KJ, Lee SB, Kim K, Kim HJ.
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| Autophagy. Aug;16(8):1396-1412. doi: 10.1080/15548627.2019.1686729. Epub 2019 Nov 5. 2020
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| 2 | ITGB1, MARVELD1, PTK2
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| MARVELD1 depletion leads to dysfunction of motor and cognition via regulating glia-dependent neuronal migration during brain development
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| Liu W, Han F, Qu S, Yao Y, Zhao J, Akhtar ML, Ci Y, Zhang H, Li H, Zhao Y, Yue L, Zhang Y, Wang C, Li Y.
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| Cell Death Dis. Sep 24;9(10):999. doi: 10.1038/s41419-018-1027-6. 2018
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| 3 | CA8, MMP9, PTK2
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| Oncogenic roles of carbonic anhydrase 8 in human osteosarcoma cells.
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| Wang TK, Lin YM, Lo CM, Tang CH, Teng CL, Chao WT, Wu MH, Liu CS, Hsieh M.
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| Tumour Biol 37(6):7989-8005. doi: 10.1007/s13277-015-4661-y. Epub 2015 Dec 28.
2016
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| 4 | MMP14, PTK2, TGFB1I1
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| Hic-5 mediates the initiation of endothelial sprouting by regulating a key surface metalloproteinase.
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| Dave JM, Abbey CA, Duran CL, Seo H, Johnson GA, Bayless KJ.
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| J Cell Sci 129(4):743-56. doi: 10.1242/jcs.170571. Epub 2016 Jan 14.
2016
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| 5 | PTK2, PTK2B, PYCARD
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| Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis.
|
| Chung IC, OuYang CN, Yuan SN, Li HP, Chen JT, Shieh HR, Chen YJ, Ojcius DM, Chu CL, Yu JS, Chang YS, Chen LC.
|
| Sci Rep 6:36214. doi: 10.1038/srep36214.
2016
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| 6 | PTK2, PXN, RACGAP1, RHOA
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| RacGAP1-driven focal adhesion formation promotes melanoma transendothelial migration through mediating adherens junction disassembly.
|
| Zhang P, Bai H, Fu C, Chen F, Zeng P, Wu C, Ye Q, Dong C, Song Y, Song E.
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| Biochem Biophys Res Commun 459(1):1-9. doi: 10.1016/j.bbrc.2014.11.088.
2015
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| 7 | MMP2, PTK2, SERPINB1
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| Serine protease inhibitor (SERPIN) B1 suppresses cell migration and invasion in glioma cells.
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| Huasong G, Zongmei D, Jianfeng H, Xiaojun Q, Jun G, Sun G, Donglin W, Jianhong Z.
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| Brain Res 1600:59-69. doi: 10.1016/j.brainres.2014.06.017. Epub 2014 Jun 23.
2015
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| 8 | AGAP2, PTK2, RACK1
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| RACK1 promotes neurite outgrowth by scaffolding AGAP2 to FAK.
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| Dwane S, Durack E, O'Connor R, Kiely PA.
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| Cell Signal 26(1):9-18. doi: 10.1016/j.cellsig.2013.08.036. Epub 2013 Sep 19. 2014
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| 9 | GRB2, PTK2, PTPRA
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| Grb2 promotes integrin-induced focal adhesion kinase (FAK) autophosphorylation and directs the phosphorylation of protein tyrosine phosphatase α by the Src-FAK kinase complex.
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| Cheng SY, Sun G, Schlaepfer DD, Pallen CJ.
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| Mol Cell Biol 34(3):348-61. doi: 10.1128/MCB.00825-13.
2014
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| 10 | PTK2, TRIM72, UBE2H
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| Mitsugumin 53 (MG53) ligase ubiquitinates focal adhesion kinase during skeletal myogenesis.
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| Nguyen N, Yi JS, Park H, Lee JS, Ko YG.
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| J Biol Chem 289(6):3209-16. doi: 10.1074/jbc.M113.525154.
2014
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| 11 | ARHGEF28, PTK2
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| RhoGEFs in cell motility: novel links between Rgnef and focal adhesion kinase.
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| Miller NL, Kleinschmidt EG, Schlaepfer DD.
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| Curr Mol Med 14(2):221-34. Review.
2014
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| 12 | PTK2, THOC2
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| A de novo X;8 translocation creates a PTK2-THOC2 gene fusion with THOC2 expression knockdown in a patient with psychomotor retardation and congenital cerebellar hypoplasia.
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| Di Gregorio E, Bianchi FT, Schiavi A, Chiotto AM, Rolando M, Verdun di Cantogno L, Grosso E, Cavalieri S, Calcia A, Lacerenza D, Zuffardi O, Retta SF, Stevanin G, Marelli C, Durr A, Forlani S, Chelly J, Montarolo F, Tempia F, Beggs HE, Reed R, Squadrone S, Abete MC, Brussino A, Ventura N, Di Cunto F, Brusco A.
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| J Med Genet 50(8):543-51. doi: 10.1136/jmedgenet-2013-101542. Epub 2013 Jun 7.
2013
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| 13 | PTK2
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| Distinct FAK activities determine progenitor and mammary stem cell characteristics.
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| Luo M, Zhao X, Chen S, Liu S, Wicha MS, Guan JL.
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| Cancer Res 73(17):5591-602. doi: 10.1158/0008-5472.CAN-13-1351. Epub 2013 Jul 5.
2013
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| 14 | PTK2
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| Influence of focal adhesion kinase on the mechanical behavior of cell populations.
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| Lange J, Auernheimer V, Strissel PL, Goldmann WH.
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| Biochem Biophys Res Commun 436(2):246-51. doi: 10.1016/j.bbrc.2013.05.084. Epub 2013 May 30.
2013
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| 15 | PTK2, STK11
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| LKB1 represses focal adhesion kinase (FAK) signaling via a FAK-LKB1 complex to regulate FAK site maturation and directional persistence.
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| Kline ER, Shupe J, Gilbert-Ross M, Zhou W, Marcus AI.
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| J Biol Chem 288(24):17663-74. doi: 10.1074/jbc.M112.444620. Epub 2013 May 1.
2013
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| 16 | PTK2
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| Focal adhesion kinase regulates intestinal epithelial barrier function via redistribution of tight junction.
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| Ma Y, Semba S, Khan RI, Bochimoto H, Watanabe T, Fujiya M, Kohgo Y, Liu Y, Taniguchi T.
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| Biochim Biophys Acta 1832(1):151-9. doi: 10.1016/j.bbadis.2012.10.006. Epub 2012 Oct 12.
2013
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| 17 | PTK2, PTK6
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| Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT.
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| Zheng Y, Gierut J, Wang Z, Miao J, Asara JM, Tyner AL.
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| Oncogene 32(36):4304-12. doi: 10.1038/onc.2012.427. Epub 2012 Oct 1.
2013
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| 18 | BMP4, PTK2
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| The role of focal adhesion kinase in BMP4 induction of mesenchymal stem cell adipogenesis.
|
| Lee JS, Ha L, Kwon IK, Lim JY.
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| Biochem Biophys Res Commun 435(4):696-701. doi: 10.1016/j.bbrc.2013.05.045. Epub 2013 May 20.
2013
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| 19 | ETV4, PTK2
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| Requirement of PEA3 for transcriptional activation of FAK gene in tumor metastasis.
|
| Li S, Huang X, Zhang D, Huang Q, Pei G, Wang L, Jiang W, Hu Q, Tan R, Hua ZC.
|
| PLoS One 8(11):e79336. doi: 10.1371/journal.pone.0079336. eCollection 2013.
2013
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| 20 | LCK, PTK2
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| Focal adhesion kinase negatively regulates Lck function downstream of the T cell antigen receptor.
|
| Chapman NM, Connolly SF, Reinl EL, Houtman JC.
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| J Immunol 191(12):6208-21. doi: 10.4049/jimmunol.1301587. Epub 2013 Nov 13.
2013
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| 21 | ARHGEF28, PTK2
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| A non-canonical role for Rgnef in promoting integrin-stimulated focal adhesion kinase activation.
|
| Miller NL, Lawson C, Kleinschmidt EG, Tancioni I, Uryu S, Schlaepfer DD.
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| J Cell Sci 126(Pt 21):5074-85. doi: 10.1242/jcs.135509. Epub 2013 Sep 4.
2013
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| 22 | PTK2, PTK2B
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| Regulation of osteoclast structure and function by FAK family kinases.
|
| Ray BJ, Thomas K, Huang CS, Gutknecht MF, Botchwey EA, Bouton AH.
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| J Leukoc Biol 92(5):1021-8. doi: 10.1189/jlb.0512259. Epub 2012 Aug 31.
2012
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| 23 | CDC42, PTK2
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| Focal adhesion kinase modulates Cdc42 activity downstream of positive and negative axon guidance cues.
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| Myers JP, Robles E, Ducharme-Smith A, Gomez TM.
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| J Cell Sci 125(Pt 12):2918-29. doi: 10.1242/jcs.100107. Epub 2012 Mar 5.
2012
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| 24 | ADAM15, PTK2
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| ADAM15 protein amplifies focal adhesion kinase phosphorylation under genotoxic stress conditions.
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| Fried D, Böhm BB, Krause K, Burkhardt H.
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| J Biol Chem 287(25):21214-23. doi: 10.1074/jbc.M112.347120. Epub 2012 Apr 27.
2012
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| 25 | PTK2, PTK2B, XIAP
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| XIAP reverses various functional activities of FRNK in endothelial cells.
|
| Ahn S, Kim HJ, Chi SG, Park H.
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| Biochem Biophys Res Commun 419(2):419-24. doi: 10.1016/j.bbrc.2012.02.037. Epub 2012 Feb 14.
2012
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| 26 | PTK2
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| Focal adhesion kinase regulates actin nucleation and neuronal filopodia formation during axonal growth.
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| Chacón MR, Navarro AI, Cuesto G, del Pino I, Scott R, Morales M, Rico B.
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| Development 139(17):3200-10. doi: 10.1242/dev.080564.
2012
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| 27 | PTK2, TLN1
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| FAK promotes recruitment of talin to nascent adhesions to control cell motility.
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| Lawson C, Lim ST, Uryu S, Chen XL, Calderwood DA, Schlaepfer DD.
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| J Cell Biol 196(2):223-32. doi: 10.1083/jcb.201108078. Erratum in: J Cell Biol. 2012 Feb 6;196(3):387.
2012
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| 28 | GRPR, PTK2
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| FAK is a critical regulator of neuroblastoma liver metastasis.
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| Lee S, Qiao J, Paul P, O'Connor KL, Evers MB, Chung DH.
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| Oncotarget 3(12):1576-87.
2012
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| 29 | CTTN, PTK2
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| Cortactin tyrosine phosphorylation promotes its deacetylation and inhibits cell spreading.
|
| Meiler E, Nieto-Pelegrín E, Martinez-Quiles N.
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| PLoS One 7(3):e33662. doi: 10.1371/journal.pone.0033662. Epub 2012 Mar 30.
2012
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| 30 | PTK2, UCHL1
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| Ubiquitin C-terminal hydrolase-L1 interacts with adhesion complexes and promotes cell migration, survival, and anchorage independent growth.
|
| Frisan T, Coppotelli G, Dryselius R, Masucci MG.
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| FASEB J 26(12):5060-70. doi: 10.1096/fj.12-211946. Epub 2012 Aug 29.
2012
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| 31 | NANOG, PTK2
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| Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated.
|
| Ho B, Olson G, Figel S, Gelman I, Cance WG, Golubovskaya VM.
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| J Biol Chem 287(22):18656-73. doi: 10.1074/jbc.M111.322883. Epub 2012 Apr 5.
2012
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| 32 | GATA4, PTK2, VCAM1
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| Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression.
|
| Lim ST, Miller NL, Chen XL, Tancioni I, Walsh CT, Lawson C, Uryu S, Weis SM, Cheresh DA, Schlaepfer DD.
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| J Cell Biol 197(7):907-19. doi: 10.1083/jcb.201109067.
2012
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| 33 | PTK2, TM4SF5
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| Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells
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| Jung O, Choi S, Jang SB, Lee SA, Lim ST, Choi YJ, Kim HJ, Kim DH, Kwak TK, Kim H, Kang M, Lee MS, Park SY, Ryu J, Jeong D, Cheong HK, Kim HJ, Park KH, Lee BJ, Schlaepfer DD, Lee JW.
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| J Cell Sci. Dec 15;125(Pt 24):5960-73. doi: 10.1242/jcs.100586. Epub 2012 Oct 17. 2012
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| 34 | PTK2, SNAI1
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| Snail1 controls epithelial-mesenchymal lineage commitment in focal adhesion kinase-null embryonic cells.
|
| Li XY, Zhou X, Rowe RG, Hu Y, Schlaepfer DD, Ilić D, Dressler G, Park A, Guan JL, Weiss SJ.
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| J Cell Biol 195(5):729-38. Epub 2011 Nov 21.
2011
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| 35 | PTK2
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| FAK is required for the assembly of podosome rosettes.
|
| Pan YR, Chen CL, Chen HC.
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| J Cell Biol 195(1):113-29.
2011
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| 36 | DLC1, PTK2
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| Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK).
|
| Li G, Du X, Vass WC, Papageorge AG, Lowy DR, Qian X.
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| Proc Natl Acad Sci U S A 108(41):17129-34. Epub 2011 Oct 3.
2011
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| 37 | IQGAP1, ITGB1BP2, PTK2, RAF1
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| ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1.
|
| Sbroggiò M, Bertero A, Velasco S, Fusella F, De Blasio E, Bahou WF, Silengo L, Turco E, Brancaccio M, Tarone G.
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| J Cell Sci 124(Pt 20):3515-24. doi: 10.1242/jcs.091140.
2011
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| 38 | ABCB1, OCLN, PTK2, TJP1
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| P-glycoprotein regulates blood-testis barrier dynamics via its effects on the occludin/zonula occludens 1 (ZO-1) protein complex mediated by focal adhesion kinase (FAK).
|
| Su L, Mruk DD, Lui WY, Lee WM, Cheng CY.
|
| Proc Natl Acad Sci U S A 108(49):19623-8. doi: 10.1073/pnas.1111414108. Epub 2011 Nov 21.
2011
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| 39 | GJB2, PTK2
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| Focal adhesion kinase modulates radial glia-dependent neuronal migration through connexin-26.
|
| Valiente M, Ciceri G, Rico B, Marín O.
|
| J Neurosci 31(32):11678-91. doi: 10.1523/JNEUROSCI.2678-11.2011.
2011
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| 40 | PTK2, ZG16B
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| PAUF promotes adhesiveness of pancreatic cancer cells by modulating focal adhesion kinase.
|
| Lee YS, Kim SJ, Min HJ, Jo JY, Park EH, Koh SS.
|
| Exp Mol Med 43(5):291-7. doi: 10.3858/emm.2011.43.5.030.
2011
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| 41 | CADM1, PTK2
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| SynCAM 1 participates in axo-dendritic contact assembly and shapes neuronal growth cones.
|
| Stagi M, Fogel AI, Biederer T.
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| Proc Natl Acad Sci U S A 107(16):7568-73. Epub 2010 Apr 5. 2010
|
| 42 | PTK2, XIAP
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| XIAP is essential for shear stress-enhanced Tyr-576 phosphorylation of FAK.
|
| Ahn S, Park H.
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| Biochem Biophys Res Commun 399(2):256-61. Epub 2010 Jul 22.PMID: 20655298 2010
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| 43 | PTK2
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| The FERM domain: organizing the structure and function of FAK.
|
| Frame MC, Patel H, Serrels B, Lietha D, Eck MJ.
|
| Nat Rev Mol Cell Biol 11(11):802-14. Review. 2010
|
| 44 | PTK2, PTK2B
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| The influence of Pyk2 on the mechanical properties in fibroblasts.
|
| Klemm AH, Kienle S, Rheinlaender J, Schäffer TE, Goldmann WH.
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| Biochem Biophys Res Commun 393(4):694-7. Epub 2010 Feb 17.
2010
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| 45 | MAPK7, PTK2
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| A novel role of ERK5 in integrin-mediated cell adhesion and motility in cancer cells via Fak signaling.
|
| Sawhney RS, Liu W, Brattain MG.
|
| J Cell Physiol 219(1):152-61.
2009
|
| 46 | IGF1R, PTK2
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| Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor.
|
| Andersson S, D'Arcy P, Larsson O, Sehat B.
|
| Biochem Biophys Res Commun 387(1):36-41. Epub 2009 Jun 21.
2009
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| 47 | NR1H4, PTK2
|
| FXR promotes endothelial cell motility through coordinated regulation of FAK and MMP-9.
|
| Das A, Yaqoob U, Mehta D, Shah VH.
|
| Arterioscler Thromb Vasc Biol 29(4):562-70. Epub 2009 Jan 15.
2009
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| 48 | PTK2, PTPN11
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| SHP-2 regulates myogenesis by coupling to FAK signaling pathway.
|
| de Oliveira MV, Marin TM, Clemente CF, Costa AP, Judice CC, Franchini KG.
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| FEBS Lett 583(18):2975-81. Epub 2009 Aug 19.PMID: 19698715 2009
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| 49 | IGF1R, PTK2
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| Targeting of the protein interaction site between FAK and IGF-1R.
|
| Zheng D, Kurenova E, Ucar D, Golubovskaya V, Magis A, Ostrov D, Cance WG, Hochwald SN.
|
| Biochem Biophys Res Commun 388(2):301-5. Epub 2009 Aug 5.PMID: 19664602 2009
|
| 50 | ARHGAP35, PTK2, RASA1
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| A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells.
|
| Tomar A, Lim ST, Lim Y, Schlaepfer DD.
|
| J Cell Sci 122(Pt 11):1852-62. Epub 2009 May 12. Erratum in: J Cell Sci. 2009 Aug 15;122(Pt 16):3005. PMID: 1943580 2009
|
| 51 | EMP2, PTK2
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| Functional consequences of interactions between FAK and epithelial membrane protein 2 (EMP2).
|
| Morales SA, Mareninov S, Coulam P, Wadehra M, Goodglick L, Braun J, Gordon LK.
|
| Invest Ophthalmol Vis Sci. 50(10):4949-56. 2009
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| 52 | GNB1, PTK2
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| The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin.
|
| Knezevic N, Tauseef M, Thennes T, Mehta D.
|
| J Exp Med 206(12):2761-77. Epub 2009 Nov 16.
2009
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| 53 | PTK2, PTK2B
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| B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading.
|
| Tse KW, Dang-Lawson M, Lee RL, Vong D, Bulic A, Buckbinder L, Gold MR.
|
| J Biol Chem 284(34):22865-77. doi: 10.1074/jbc.M109.013169. Epub 2009 Jun 26.
2009
|
| 54 | ARHGAP21, PTK2
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| ARHGAP21 modulates FAK activity and impairs glioblastoma cell migration.
|
| Bigarella CL, Borges L, Costa FF, Saad ST.
|
| Biochim Biophys Acta 1793(5):806-16. doi: 10.1016/j.bbamcr.2009.02.010. Epub 2009 Mar 4.
2009
|
| 55 | AGAP2, PTK2
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| Arf GTPase-activating protein AGAP2 regulates focal adhesion kinase activity and focal adhesion remodeling.
|
| Zhu Y, Wu Y, Kim JI, Wang Z, Daaka Y, Nie Z.
|
| J Biol Chem 284(20):13489-96. doi: 10.1074/jbc.M900469200. Epub 2009 Mar 24.
2009
|
| 56 | PTK2, CTGF
|
| Focal adhesion kinase/Src suppresses early chondrogenesis: central role of CCN2.
|
| Pala D, Kapoor M, Woods A, Kennedy L, Liu S, Chen S, Bursell L, Lyons KM, Carter DE, Beier F, Leask A.
|
| J Biol Chem 283(14):9239-47. Epub 2008 Feb 13. 2008
|
| 57 | PTK2
|
| FAK nuclear export signal sequences.
|
| Ossovskaya V, Lim ST, Ota N, Schlaepfer DD, Ilic D.
|
| FEBS Lett 582(16):2402-6. Epub 2008 Jun 10.
2008
|
| 58 | ARHGAP21, PRKCZ, PTK2
|
| ARHGAP21 associates with FAK and PKCzeta and is redistributed after cardiac pressure overload.
|
| Borges L, Bigarella CL, Baratti MO, Crosara-Alberto DP, Joazeiro PP, Franchini KG, Costa FF, Saad ST.
|
| Biochem Biophys Res Commun 374(4):641-6. Epub 2008 Jul 26.
2008
|
| 59 | PTK2
|
| Biphasic function of focal adhesion kinase in endothelial tube formation induced by fibril-forming collagens.
|
| Nakamura J, Shigematsu S, Yamauchi K, Takeda T, Yamazaki M, Kakizawa T, Hashizume K.
|
| Biochem Biophys Res Commun 374(4):699-703. Epub 2008 Aug 3.
2008
|
| 60 | KLF8, PTK2, SP1
|
| Activation of KLF8 transcription by focal adhesion kinase in human ovarian epithelial and cancer cells.
|
| Wang X, Urvalek AM, Liu J, Zhao J.
|
| J Biol Chem 283(20):13934-42. Epub 2008 Mar 19.
2008
|
| 61 | ELK1, PTK2
|
| Elk-1 associates with FAK, regulates the expression of FAK and MAP kinases as well as apoptosis in HK-2 cells.
|
| Mamali I, Kotsantis P, Lampropoulou M, Marmaras VJ.
|
| J Cell Physiol 216(1):198-206.
2008
|
| 62 | PTK2
|
| Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocytes focal adhesion kinase (FAK) conditional knockout mice.
|
| Peng, X., Wu, X., Druso, J. E., Wei, H., Park, A. Y.-J., Kraus, M. S., Alcaraz, A., Chen, J., Chien, S., Cerione, R. A., Guan, J.-L.
|
| Proc. Nat. Acad. Sci. 105, 6638-6643 2008
|
| 63 | CD4, PTK2
|
| Structural basis for the interaction between focal adhesion kinase and CD4.
|
| Garron ML, Arthos J, Guichou JF, McNally J, Cicala C, Arold ST.
|
| J Mol Biol 375(5):1320-8. Epub 2007 Nov 22.PMID: 18078954 2008
|
| 64 | ARHGEF11, PTK2, ROCK2
|
| FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts.
|
| Iwanicki MP, Vomastek T, Tilghman RW, Martin KH, Banerjee J, Wedegaertner PB, Parsons JT.
|
| J Cell Sci 121(Pt 6):895-905. Epub 2008 Feb 26.PMID: 18303050 2008
|
| 65 | AKT1,PTK2
|
| Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts.
|
| Horowitz JC, Rogers DS, Sharma V, Vittal R, White ES, Cui Z, Thannickal VJ.
|
| Cell Signal 19(4):761-71. Epub 2006 Nov 17. 2007
|
| 66 | EPS8,PTK2
|
| Eps8 facilitates cellular growth and motility of colon cancer cells by increasing the expression and activity of focal adhesion kinase.
|
| Maa MC, Lee JC, Chen YJ, Chen YJ, Lee YC, Wang ST, Huang CC, Chow NH, Leu TH.
|
| J Biol Chem 282(27):19399-409. Epub 2007 May 12. 2007
|
| 67 | KLF8, PTK2
|
| KLF8 transcription factor participates in oncogenic transformation.
|
| Wang X, Zhao J.
|
| Oncogene 26(3):456-61. Epub 2006 Jul 10.
2007
|
| 68 | PTK2, TSC2
|
| Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth.
|
| Gan B, Yoo Y, Guan JL.
|
| J Biol Chem. 281(49):37321-9. 2006
|
| 69 | PTK2
|
| EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of focal adhesion kinase and RhoA activation.
|
| Moeller ML, Shi Y, Reichardt LF, Ethell IM.
|
| J Biol Chem. 281(3):1587-98. 2006
|
| 70 | PTK2
|
| Vascular endothelial growth factor receptor-3 and focal adhesion kinase bind and suppress apoptosis in breast cancer cells.
|
| Garces CA, Kurenova EV, Golubovskaya VM, Cance WG.
|
| Cancer Res. 66(3):1446-54. 2006
|
| 71 | PTK2
|
| Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice.
|
| Peng, X., Kraus, M. S., Wei, H., Shen, T.-L., Pariaut, R., Alcaraz, A., Ji, G., Cheng, L., Yang, Q., Kotlikoff, M. I., Chen, J., Chien, K., Gu, H., Guan, J.-L.
|
| J. Clin. Invest. 116, 217-227 2006
|
| 72 | PTK2
|
| JNK1 and JNK2 oppositely regulate p53 in signaling linked to apoptosis triggered by an altered fibronectin matrix: JNK links FAK and p53.
|
| Tafolla E, Wang S, Wong B, Leong J, Kapila YL.
|
| J Biol Chem 280(20):19992-9. Epub 2005 Mar 18. 2005
|
| 73 | ASAP1, DLGAP3, PTK2
|
| FAK and PYK2 interact with SAP90/PSD-95-Associated Protein-3.
|
| Bongiorno-Borbone L, Kadare G, Benfenati F, Girault JA.
|
| Biochem Biophys Res Commun 337(2):641-6. Epub 2005 Sep 26. 2005
|
| 74 | MAPK8IP3,PTK2
|
| JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration.
|
| Takino T, Nakada M, Miyamori H, Watanabe Y, Sato T, Gantulga D, Yoshioka K, Yamada KM, Sato H.
|
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| 94 | PTK2
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| Focal adhesion kinase is involved in mechanosensing during fibroblast migration.
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| Proc Natl Acad Sci U S A 98(20):11295-300. 2001
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| 95 | PTK2
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| 96 | PTK2
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