Citations for
1PPARG, PTGES
Coordinate functional regulation between microsomal prostaglandin E synthase-1 (mPGES-1) and peroxisome proliferator-activated receptor γ (PPARγ) in the conversion of white-to-brown adipocytes.
García-Alonso V, López-Vicario C, Titos E, Morán-Salvador E, González-Périz A, Rius B, Párrizas M, Werz O, Arroyo V, Clària J.
J Biol Chem 288(39):28230-42. doi: 10.1074/jbc.M113.468603. Epub 2013 Aug 13. 2013
2PTGES
Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily.
Sjögren T, Nord J, Ek M, Johansson P, Liu G, Geschwindner S.
Proc Natl Acad Sci U S A 110(10):3806-11. doi: 10.1073/pnas.1218504110. Epub 2013 Feb 19. 2013
3CEBPB, PTGES
Regulation of human microsomal prostaglandin E synthase-1 by IL-1β requires a distal enhancer element with a unique role for C/EBPβ.
Walters JN, Bickford JS, Newsom KJ, Beachy DE, Barilovits SJ, Herlihy JD, Nick HS.
Biochem J 443(2):561-71. 2012
4EGF, EGFR, PTGES
EGFR signaling upregulates expression of microsomal prostaglandin E synthase-1 in cancer cells leading to enhanced tumorigenicity.
Donnini S, Finetti F, Terzuoli E, Giachetti A, Iñiguez MA, Hanaka H, Fresno M, Rådmark O, Ziche M.
Oncogene 31(29):3457-66. doi: 10.1038/onc.2011.503. Epub 2011 Nov 14. 2012
5PTGES, PTGS2
Upregulation of cyclooxygenase-2 (COX-2) and microsomal prostaglandin E2 synthase-1 (mPGES-1) in wall of ruptured human cerebral aneurysms: preliminary results.
Hasan D, Hashimoto T, Kung D, Macdonald RL, Winn HR, Heistad D.
Stroke 43(7):1964-7. Epub 2012 May 15. 2012
6PTGES
Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis.
Sasaki Y, Kamei D, Ishikawa Y, Ishii T, Uematsu S, Akira S, Murakami M, Hara S.
Oncogene 31(24):2943-52. doi: 10.1038/onc.2011.472. Epub 2011 Oct 10. 2012
7PTGES
Microsomal prostaglandin E synthase-1 promotes hepatocarcinogenesis through activation of a novel EGR1/β-catenin signaling axis.
Lu D, Han C, Wu T.
Oncogene 31(7):842-57. doi: 10.1038/onc.2011.287. Epub 2011 Jul 11. 2012
8PTGES
Induction of human microsomal prostaglandin E synthase 1 by activated oncogene RhoA GTPase in A549 human epithelial cancer cells.
Choi HJ, Lee DH, Park SH, Kim J, Do KH, An TJ, Ahn YS, Park CB, Moon Y.
Biochem Biophys Res Commun 413(3):448-53. Epub 2011 Aug 30. 2011
9PTGES
Location of inhibitor binding sites in the human inducible prostaglandin E synthase, MPGES1.
Prage EB, Pawelzik SC, Busenlehner LS, Kim K, Morgenstern R, Jakobsson PJ, Armstrong RN.
Biochemistry 50(35):7684-93. Epub 2011 Aug 9. 2011
10PTGES
Microsomal prostaglandin E synthase-1 inhibits PTEN and promotes experimental cholangiocarcinogenesis and tumor progression.
Lu D, Han C, Wu T.
Gastroenterology 140(7):2084-94. Epub 2011 Feb 24. 2011
11PTGES
Microsomal prostaglandin e2 synthase-1 modulates the response to vascular injury.
Wang M, Ihida-Stansbury K, Kothapalli D, Tamby MC, Yu Z, Chen L, Grant G, Cheng Y, Lawson JA, Assoian RK, Jones PL, Fitzgerald GA.
Circulation 123(6):631-9. Epub 2011 Jan 31. 2011
12PTGES
Identification of key residues determining species differences in inhibitor binding of microsomal prostaglandin E synthase-1.
Pawelzik SC, Uda NR, Spahiu L, Jegerschöld C, Stenberg P, Hebert H, Morgenstern R, Jakobsson PJ.
J Biol Chem 285(38):29254-61. Epub 2010 Jul 6. 2010
13PTGES, PTGS2
Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity.
Ikeda-Matsuo Y, Hirayama Y, Ota A, Uematsu S, Akira S, Sasaki Y.
Br J Pharmacol 159(5):1174-86. Epub 2010 Jan 29. 2010
14PTGES
Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis.
Lee JJ, Natsuizaka M, Ohashi S, Wong GS, Takaoka M, Michaylira CZ, Budo D, Tobias JW, Kanai M, Shirakawa Y, Naomoto Y, Klein-Szanto AJ, Haase VH, Nakagawa H.
Carcinogenesis 31(3):427-34. Epub 2009 Dec 30. 2010
15PTGES, PTGES2
Microsomal prostaglandin E synthase protein levels correlate with prognosis in colorectal cancer patients.
Seo T, Tatsuguchi A, Shinji S, Yonezawa M, Mitsui K, Tanaka S, Fujimori S, Gudis K, Fukuda Y, Sakamoto C.
Virchows Arch 454(6):667-76. Epub 2009 May 2.PMID: 19412621 2009
16PTGES
Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis.
Kamei D, Murakami M, Sasaki Y, Nakatani Y, Majima M, Ishikawa Y, Ishii T, Uematsu S, Akira S, Hara S, Kudo I.
Biochem J 425(2):361-71. 2009
17PTGES
Microsomal prostaglandin synthase-1-derived prostaglandin E2 protects against angiotensin II-induced hypertension via inhibition of oxidative stress.
Jia Z, Guo X, Zhang H, Wang MH, Dong Z, Yang T.
Hypertension 52(5):952-9. Epub 2008 Sep 29. 2008
18PTGES
Elevated microsomal prostaglandin-E synthase-1 in Alzheimer's disease.
Chaudhry UA, Zhuang H, Crain BJ, Doré S.
Alzheimers Dement 4(1):6-13. Epub 2007 Dec 21. 2008
19PTGES
Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis.
Nakanishi M, Montrose DC, Clark P, Nambiar PR, Belinsky GS, Claffey KP, Xu D, Rosenberg DW.
Cancer Res 68(9):3251-9. 2008
20PTGES
Expression of microsomal prostaglandin E synthase-1 in human hepatocelluar carcinoma.
Takii Y, Abiru S, Fujioka H, Nakamura M, Komori A, Ito M, Taniguchi K, Daikoku M, Meda Y, Ohata K, Yano K, Shimoda S, Yatsuhashi H, Ishibashi H, Migita K.
Liver Int 27(7):989-96. 2007
21PTGES
Role of microsomal prostaglandin E synthase 1 in the kidney.
Francois H, Facemire C, Kumar A, Audoly L, Koller B, Coffman T.
J Am Soc Nephrol 18(5):1466-75. Epub 2007 Apr 18. 2007
22PTGES
Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury.
Ikeda-Matsuo Y, Ota A, Fukada T, Uematsu S, Akira S, Sasaki Y.
Proc Natl Acad Sci U S A 103(31):11790-5. Epub 2006 Jul 24. 2006
23PTGS1, PTGS2, PTGES
Membrane-associated PGE synthase-1 (mPGES-1) is coexpressed with both COX-1 and COX-2 in the kidney.
Schneider A, Zhang Y, Zhang M, Lu WJ, Rao R, Fan X, Redha R, Davis L, Breyer RM, Harris R, Guan Y, Breyer MD.
Kidney Int 65(4):1205-13. 2004
24PTGES
Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination.
Thoren S, Weinander R, Saha S, Jegerschold C, Pettersson PL, Samuelsson B, Hebert H, Hamberg M, Morgenstern R, Jakobsson PJ.
J Biol Chem 278(25):22199-209. Epub 2003 Apr 02. 2003
25PTGES
Human glutathione dependent prostaglandin E synthase: gene structure andregulation.
Forsberg L, Leeb L, Thoren S, Morgenstern R, Jakobsson P.
FEBS Lett 471(1):78-82. 2000
26PTGES
Common structural features of MAPEG -- a widespread superfamily of membraneassociated proteins with highly divergent functions in eicosanoid andglutathione metabolism.
Jakobsson PJ, Morgenstern R, Mancini J, Ford-Hutchinson A, Persson B.
Protein Sci 8(3):689-92. 1999
27PTGES
Identification of human prostaglandin E synthase: a microsomal,glutathione-dependent, inducible enzyme, constituting a potential novel drugtarget.
Jakobsson PJ, Thoren S, Morgenstern R, Samuelsson B.
Proc Natl Acad Sci U S A 96(13):7220-5. 1999
28ENC1, PTGES, TP53I11
A model for p53-induced apoptosis.
Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B.
Nature 389(6648):300-5. 1997