1 | PPARG, PTGES
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| Coordinate functional regulation between microsomal prostaglandin E synthase-1 (mPGES-1) and peroxisome proliferator-activated receptor γ (PPARγ) in the conversion of white-to-brown adipocytes.
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| García-Alonso V, López-Vicario C, Titos E, Morán-Salvador E, González-Périz A, Rius B, Párrizas M, Werz O, Arroyo V, Clària J.
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| J Biol Chem 288(39):28230-42. doi: 10.1074/jbc.M113.468603. Epub 2013 Aug 13.
2013
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2 | PTGES
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| Crystal structure of microsomal prostaglandin E2 synthase provides insight into diversity in the MAPEG superfamily.
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| Sjögren T, Nord J, Ek M, Johansson P, Liu G, Geschwindner S.
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| Proc Natl Acad Sci U S A 110(10):3806-11. doi: 10.1073/pnas.1218504110. Epub 2013 Feb 19.
2013
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3 | CEBPB, PTGES
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| Regulation of human microsomal prostaglandin E synthase-1 by IL-1β requires a distal enhancer element with a unique role for C/EBPβ.
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| Walters JN, Bickford JS, Newsom KJ, Beachy DE, Barilovits SJ, Herlihy JD, Nick HS.
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| Biochem J 443(2):561-71.
2012
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4 | EGF, EGFR, PTGES
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| EGFR signaling upregulates expression of microsomal prostaglandin E synthase-1 in cancer cells leading to enhanced tumorigenicity.
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| Donnini S, Finetti F, Terzuoli E, Giachetti A, Iñiguez MA, Hanaka H, Fresno M, Rådmark O, Ziche M.
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| Oncogene 31(29):3457-66. doi: 10.1038/onc.2011.503. Epub 2011 Nov 14.
2012
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5 | PTGES, PTGS2
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| Upregulation of cyclooxygenase-2 (COX-2) and microsomal prostaglandin E2 synthase-1 (mPGES-1) in wall of ruptured human cerebral aneurysms: preliminary results.
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| Hasan D, Hashimoto T, Kung D, Macdonald RL, Winn HR, Heistad D.
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| Stroke 43(7):1964-7. Epub 2012 May 15.
2012
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6 | PTGES
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| Microsomal prostaglandin E synthase-1 is involved in multiple steps of colon carcinogenesis.
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| Sasaki Y, Kamei D, Ishikawa Y, Ishii T, Uematsu S, Akira S, Murakami M, Hara S.
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| Oncogene 31(24):2943-52. doi: 10.1038/onc.2011.472. Epub 2011 Oct 10.
2012
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7 | PTGES
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| Microsomal prostaglandin E synthase-1 promotes hepatocarcinogenesis through activation of a novel EGR1/β-catenin signaling axis.
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| Lu D, Han C, Wu T.
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| Oncogene 31(7):842-57. doi: 10.1038/onc.2011.287. Epub 2011 Jul 11.
2012
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8 | PTGES
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| Induction of human microsomal prostaglandin E synthase 1 by activated oncogene RhoA GTPase in A549 human epithelial cancer cells.
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| Choi HJ, Lee DH, Park SH, Kim J, Do KH, An TJ, Ahn YS, Park CB, Moon Y.
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| Biochem Biophys Res Commun 413(3):448-53. Epub 2011 Aug 30.
2011
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9 | PTGES
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| Location of inhibitor binding sites in the human inducible prostaglandin E synthase, MPGES1.
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| Prage EB, Pawelzik SC, Busenlehner LS, Kim K, Morgenstern R, Jakobsson PJ, Armstrong RN.
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| Biochemistry 50(35):7684-93. Epub 2011 Aug 9.
2011
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10 | PTGES
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| Microsomal prostaglandin E synthase-1 inhibits PTEN and promotes experimental cholangiocarcinogenesis and tumor progression.
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| Lu D, Han C, Wu T.
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| Gastroenterology 140(7):2084-94. Epub 2011 Feb 24.
2011
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11 | PTGES
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| Microsomal prostaglandin e2 synthase-1 modulates the response to vascular injury.
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| Wang M, Ihida-Stansbury K, Kothapalli D, Tamby MC, Yu Z, Chen L, Grant G, Cheng Y, Lawson JA, Assoian RK, Jones PL, Fitzgerald GA.
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| Circulation 123(6):631-9. Epub 2011 Jan 31.
2011
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12 | PTGES
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| Identification of key residues determining species differences in inhibitor binding of microsomal prostaglandin E synthase-1.
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| Pawelzik SC, Uda NR, Spahiu L, Jegerschöld C, Stenberg P, Hebert H, Morgenstern R, Jakobsson PJ.
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| J Biol Chem 285(38):29254-61. Epub 2010 Jul 6.
2010
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13 | PTGES, PTGS2
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| Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity.
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| Ikeda-Matsuo Y, Hirayama Y, Ota A, Uematsu S, Akira S, Sasaki Y.
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| Br J Pharmacol 159(5):1174-86. Epub 2010 Jan 29.
2010
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14 | PTGES
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| Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis.
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| Lee JJ, Natsuizaka M, Ohashi S, Wong GS, Takaoka M, Michaylira CZ, Budo D, Tobias JW, Kanai M, Shirakawa Y, Naomoto Y, Klein-Szanto AJ, Haase VH, Nakagawa H.
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| Carcinogenesis 31(3):427-34. Epub 2009 Dec 30.
2010
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15 | PTGES, PTGES2
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| Microsomal prostaglandin E synthase protein levels correlate with prognosis in colorectal cancer patients.
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| Seo T, Tatsuguchi A, Shinji S, Yonezawa M, Mitsui K, Tanaka S, Fujimori S, Gudis K, Fukuda Y, Sakamoto C.
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| Virchows Arch 454(6):667-76. Epub 2009 May 2.PMID: 19412621 2009
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16 | PTGES
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| Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis.
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| Kamei D, Murakami M, Sasaki Y, Nakatani Y, Majima M, Ishikawa Y, Ishii T, Uematsu S, Akira S, Hara S, Kudo I.
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| Biochem J 425(2):361-71.
2009
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17 | PTGES
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| Microsomal prostaglandin synthase-1-derived prostaglandin E2 protects against angiotensin II-induced hypertension via inhibition of oxidative stress.
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| Jia Z, Guo X, Zhang H, Wang MH, Dong Z, Yang T.
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| Hypertension 52(5):952-9. Epub 2008 Sep 29.
2008
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18 | PTGES
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| Elevated microsomal prostaglandin-E synthase-1 in Alzheimer's disease.
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| Chaudhry UA, Zhuang H, Crain BJ, Doré S.
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| Alzheimers Dement 4(1):6-13. Epub 2007 Dec 21.
2008
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19 | PTGES
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| Genetic deletion of mPGES-1 suppresses intestinal tumorigenesis.
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| Nakanishi M, Montrose DC, Clark P, Nambiar PR, Belinsky GS, Claffey KP, Xu D, Rosenberg DW.
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| Cancer Res 68(9):3251-9.
2008
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20 | PTGES
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| Expression of microsomal prostaglandin E synthase-1 in human hepatocelluar carcinoma.
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| Takii Y, Abiru S, Fujioka H, Nakamura M, Komori A, Ito M, Taniguchi K, Daikoku M, Meda Y, Ohata K, Yano K, Shimoda S, Yatsuhashi H, Ishibashi H, Migita K.
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| Liver Int 27(7):989-96.
2007
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21 | PTGES
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| Role of microsomal prostaglandin E synthase 1 in the kidney.
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| Francois H, Facemire C, Kumar A, Audoly L, Koller B, Coffman T.
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| J Am Soc Nephrol 18(5):1466-75. Epub 2007 Apr 18.
2007
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22 | PTGES
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| Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury.
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| Ikeda-Matsuo Y, Ota A, Fukada T, Uematsu S, Akira S, Sasaki Y.
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| Proc Natl Acad Sci U S A 103(31):11790-5. Epub 2006 Jul 24.
2006
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23 | PTGS1, PTGS2, PTGES
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| Membrane-associated PGE synthase-1 (mPGES-1) is coexpressed with both COX-1 and COX-2 in the kidney.
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| Schneider A, Zhang Y, Zhang M, Lu WJ, Rao R, Fan X, Redha R, Davis L, Breyer RM, Harris R, Guan Y, Breyer MD.
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| Kidney Int 65(4):1205-13. 2004
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24 | PTGES
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| Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination.
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| Thoren S, Weinander R, Saha S, Jegerschold C, Pettersson PL, Samuelsson B, Hebert H, Hamberg M, Morgenstern R, Jakobsson PJ.
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| J Biol Chem 278(25):22199-209. Epub 2003 Apr 02. 2003
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25 | PTGES
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| Human glutathione dependent prostaglandin E synthase: gene structure andregulation.
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| Forsberg L, Leeb L, Thoren S, Morgenstern R, Jakobsson P.
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| FEBS Lett 471(1):78-82. 2000
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26 | PTGES
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| Common structural features of MAPEG -- a widespread superfamily of membraneassociated proteins with highly divergent functions in eicosanoid andglutathione metabolism.
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| Jakobsson PJ, Morgenstern R, Mancini J, Ford-Hutchinson A, Persson B.
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| Protein Sci 8(3):689-92. 1999
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27 | PTGES
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| Identification of human prostaglandin E synthase: a microsomal,glutathione-dependent, inducible enzyme, constituting a potential novel drugtarget.
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| Jakobsson PJ, Thoren S, Morgenstern R, Samuelsson B.
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| Proc Natl Acad Sci U S A 96(13):7220-5. 1999
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28 | ENC1, PTGES, TP53I11
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| A model for p53-induced apoptosis.
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| Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B.
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| Nature 389(6648):300-5. 1997
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