| 1 | CARD9, DNMT3A, ERAP2, FUT2, PTGER4, TNFSF11 |
| Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. | |
| Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, Lees CW, Balschun T, Lee J, Roberts R, Anderson CA, Bis JC, Bumpstead S, Ellinghaus D, Festen EM, Georges M, Green T, Haritunians T, Jostins L, Latiano A, Mathew CG, Montgomery GW, Prescott NJ, Raychaudhuri S, Rotter JI, Schumm P, Sharma Y, Simms LA, Taylor KD, Whiteman D, Wijmenga C, Baldassano RN, Barclay M, Bayless TM, Brand S, Büning C, Cohen A, Colombel JF, Cottone M, Stronati L, Denson T, De Vos M, D'Inca R, Dubinsky M, Edwards C, Florin T, Franchimont D, Gearry R, Glas J, Van Gossum A, Guthery SL, Halfvarson J, Verspaget HW, Hugot JP, Karban A, Laukens D, Lawrance I, Lemann M, Levine A, Libioulle C, Louis E, Mowat C, Newman W, Panés J, Phillips A, Proctor DD, Regueiro M, Russell R, Rutgeerts P, Sanderson J, Sans M, Seibold F, Steinhart AH, Stokkers PC, Torkvist L, Kullak-Ublick G, Wilson D, Walters T, Targan SR, Brant SR, Rioux JD, D'Amato M, Weersma RK, Kugathasan S, Griffiths AM, Mansfield JC, Vermeire S, Duerr RH, Silverberg MS, Satsangi J, Schreiber S, Cho JH, Annese V, Hakonarson H, Daly MJ, Parkes M. | |
| Nat Genet 42(12):1118-25. 2010 | |
| 2 | PTGER4 |
| The prostaglandin E2 receptor EP4 is expressed by human platelets and potently inhibits platelet aggregation and thrombus formation. | |
| Philipose S, Konya V, Sreckovic I, Marsche G, Lippe IT, Peskar BA, Heinemann A, Schuligoi R. | |
| Arterioscler Thromb Vasc Biol 30(12):2416-23. Epub 2010 Nov 11. 2010 | |
| 3 | PTGER4 |
| Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study. | |
| Lee JJ, Essers JB, Kugathasan S, Escher JC, Lettre G, Butler JL, Stephens MC, Ramoni MF, Grand RJ, Hirschhorn J. | |
| Ann Hum Genet 74(6):489-97. doi: 10.1111/j.1469-1809.2010.00606.x. Epub 2010 Sep 15. 2010 | |
| 4 | PTGER4 |
| Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis. | |
| Esaki Y, Li Y, Sakata D, Yao C, Segi-Nishida E, Matsuoka T, Fukuda K, Narumiya S. | |
| Proc Natl Acad Sci U S A 107(27):12233-8. Epub 2010 Jun 21. 2010 | |
| 5 | PTGER4 |
| Prostaglandin E receptor subtype EP4 agonist protects cochleae against noise-induced trauma. | |
| Hori R, Nakagawa T, Sugimoto Y, Sakamoto T, Yamamoto N, Hamaguchi K, Ito J. | |
| Neuroscience 160(4):813-9. Epub 2009 Mar 19. 2009 | |
| 6 | PTGER4 |
| Molecular and pharmacological blockade of the EP4 receptor selectively inhibits both proliferation and invasion of human inflammatory breast cancer cells. | |
| Robertson FM, Simeone AM, Mazumdar A, Shah AH, McMurray JS, Ghosh S, Cristofanilli M. | |
| J Exp Ther Oncol 7(4):299-312. 2008 | |
| 7 | PTGER4 |
| Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis. | |
| Babaev VR, Chew JD, Ding L, Davis S, Breyer MD, Breyer RM, Oates JA, Fazio S, Linton MF. | |
| Cell Metab 8(6):492-501. 2008 | |
| 8 | PTGER4 |
| EP4 receptor regulates collagen type-I, MMP-1, and MMP-3 gene expression in human tendon fibroblasts in response to IL-1 beta treatment. | |
| Thampatty BP, Li H, Im HJ, Wang JH. | |
| Gene 386(1-2):154-61. Epub 2006 Sep 15. 2007 | |
| 9 | PTGER1, PTGER3, PTGER4, TBXA2R |
| Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma. | |
| Kim SH, Kim YK, Park HW, Jee YK, Kim SH, Bahn JW, Chang YS, Kim SH, Ye YM, Shin ES, Lee JE, Park HS, Min KU. | |
| Pharmacogenet Genomics 17(4):295-304.PMID: 17496729 2007 | |
| 10 | PTGER4 |
| The structure of the prostaglandin EP4 receptor gene and related pseudogenes. | |
| Foord SM, Marks B, Stolz M, Bufflier E, Fraser NJ, Lee MG. | |
| Genomics 35(1):182-8 1996 | |
| 11 | PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, TBXA2R |
| Chromosomal localization of the human prostanoid receptor gene family. | |
| Duncan AMV, et al. | |
| Genomics 25 : 740-742. 1995 | |
| 12 | PTGER4 |
| Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype. | |
| Bastien L, et al. | |
| J Biol Chem 269 : 11873-1877. 1994 | |
| 13 | PTGER4 |
| Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2. | |
| An S, Yang J, Xia M, Goetzl EJ. | |
| Biochem Biophys Res Commun 197(1):263-70 1993 | |