Citations for
1PTEN
Critical role of increased PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries.
Zhang S, Taghibiglou C, Girling K, Dong Z, Lin SZ, Lee W, Shyu WC, Wang YT.
J Neurosci 33(18):7997-8008. doi: 10.1523/JNEUROSCI.5661-12.2013. 2013
2NCOA3, PTEN
PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha.
Yang C, Li S, Wang M, Chang AK, Liu Y, Zhao F, Xiao L, Han L, Wang D, Li S, Wu H.
Mol Cancer 12:21. doi: 10.1186/1476-4598-12-21. 2013
3MHAM, PTEN
Cowden syndrome-related mutations in PTEN associate with enhanced proteasome activity.
He X, Arrotta N, Radhakrishnan D, Wang Y, Romigh T, Eng C.
Cancer Res 73(10):3029-40. doi: 10.1158/0008-5472.CAN-12-3811. Epub 2013 Mar 8. 2013
4MAP2K1, PTEN
MEK1 is required for PTEN membrane recruitment, AKT regulation, and the maintenance of peripheral tolerance.
Zmajkovicova K, Jesenberger V, Catalanotti F, Baumgartner C, Reyes G, Baccarini M.
Mol Cell 50(1):43-55. doi: 10.1016/j.molcel.2013.01.037. Epub 2013 Feb 28. 2013
5PTEN, PTENP1
A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells.
Johnsson P, Ackley A, Vidarsdottir L, Lui WO, Corcoran M, Grandér D, Morris KV.
Nat Struct Mol Biol 20(4):440-6. doi: 10.1038/nsmb.2516. Epub 2013 Feb 24. 2013
6PTEN
Loss of phosphatase and tensin homolog expression is associated with recurrence and poor prognosis in patients with pancreatic ductal adenocarcinoma.
Foo WC, Rashid A, Wang H, Katz MH, Lee JE, Pisters PW, Wolff RA, Abbruzzese JL, Fleming JB, Wang H.
Hum Pathol 44(6):1024-30. doi: 10.1016/j.humpath.2012.09.001. Epub 2012 Dec 20. 2013
7MYC, PTEN
MYC acts via the PTEN tumor suppressor to elicit autoregulation and genome-wide gene repression by activation of the Ezh2 methyltransferase.
Kaur M, Cole MD.
Cancer Res 73(2):695-705. doi: 10.1158/0008-5472.CAN-12-2522. Epub 2012 Nov 7. 2013
8CHFR, PBK, PTEN
TOPK and PTEN participate in CHFR mediated mitotic checkpoint.
Shinde SR, Gangula NR, Kavela S, Pandey V, Maddika S.
Cell Signal 25(12):2511-7. doi: 10.1016/j.cellsig.2013.08.013. Epub 2013 Sep 3. 2013
9PPP1R10, PTEN
PNUTS functions as a proto-oncogene by sequestering PTEN.
Kavela S, Shinde SR, Ratheesh R, Viswakalyan K, Bashyam MD, Gowrishankar S, Vamsy M, Pattnaik S, Rao S, Sastry RA, Srinivasulu M, Chen J, Maddika S.
Cancer Res 73(1):205-14. doi: 10.1158/0008-5472.CAN-12-1394. Epub 2012 Nov 1. 2013
10PTEN, RAD52
PTEN sumo-wrestles human RAD52 to mystery land.
Shen Z, Huhn S.
Cell Cycle 12(23):3585. doi: 10.4161/cc.26820. Epub 2013 Oct 15. No abstract available. 2013
11PTEN, RAD52
Chromatin PTEN is involved in DNA damage response partly through regulating Rad52 sumoylation.
Choi BH, Chen Y, Dai W.
Cell Cycle 12(21):3442-7. doi: 10.4161/cc.26465. Epub 2013 Sep 18. 2013
12INPP4B, PTEN
Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities.
Lopez SM, Hodgson MC, Packianathan C, Bingol-Ozakpinar O, Uras F, Rosen BP, Agoulnik IU.
Biochem Biophys Res Commun 440(2):277-82. doi: 10.1016/j.bbrc.2013.09.077. Epub 2013 Sep 23. 2013
13PIKFYVE, PTEN
Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics.
Hazeki K, Nigorikawa K, Takaba Y, Segawa T, Nukuda A, Masuda A, Ishikawa Y, Kubota K, Takasuga S, Hazeki O.
FEBS Lett 586(22):4010-5. doi: 10.1016/j.febslet.2012.09.043. Epub 2012 Oct 12. 2012
14PTEN
Regulation of the tumor suppressor PTEN by SUMO.
González-Santamaría J, Campagna M, Ortega-Molina A, Marcos-Villar L, de la Cruz-Herrera CF, González D, Gallego P, Lopitz-Otsoa F, Esteban M, Rodríguez MS, Serrano M, Rivas C.
Cell Death Dis 3:e393. doi: 10.1038/cddis.2012.135. 2012
15PTEN
The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells.
Putz U, Howitt J, Doan A, Goh CP, Low LH, Silke J, Tan SS.
Sci Signal 5(243):ra70. 2012
16PTEN
Regulation of axonal growth and neuromuscular junction formation by neuronal phosphatase and tensin homologue signaling.
Li PP, Peng HB.
Mol Biol Cell 23(20):4109-17. doi: 10.1091/mbc.E12-05-0367. Epub 2012 Aug 23. 2012
17PTEN
SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane.
Huang J, Yan J, Zhang J, Zhu S, Wang Y, Shi T, Zhu C, Chen C, Liu X, Cheng J, Mustelin T, Feng GS, Chen G, Yu J.
Nat Commun 3:911. doi: 10.1038/ncomms1919. 2012
18FBXW7, PTEN
Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development.
Kwon YW, Kim IJ, Wu D, Lu J, Stock WA Jr, Liu Y, Huang Y, Kang HC, DelRosario R, Jen KY, Perez-Losada J, Wei G, Balmain A, Mao JH.
Mol Cancer Res 10(6):834-44. doi: 10.1158/1541-7786.MCR-12-0025. Epub 2012 Apr 18. 2012
19PTEN
Functional analysis of the protein phosphatase activity of PTEN.
Zhang XC, Piccini A, Myers MP, Van Aelst L, Tonks NK.
Biochem J 444(3):457-64. doi: 10.1042/BJ20120098. 2012
20PTEN
Cell-type specific roles for PTEN in establishing a functional retinal architecture.
Cantrup R, Dixit R, Palmesino E, Bonfield S, Shaker T, Tachibana N, Zinyk D, Dalesman S, Yamakawa K, Stell WK, Wong RO, Reese BE, Kania A, Sauvé Y, Schuurmans C.
PLoS One 7(3):e32795. doi: 10.1371/journal.pone.0032795. Epub 2012 Mar 5. 2012
21PTEN
Pten coordinates retinal neurogenesis by regulating Notch signalling.
Jo HS, Kang KH, Joe CO, Kim JW.
EMBO J 31(4):817-28. doi: 10.1038/emboj.2011.443. Epub 2011 Dec 6. 2012
22MIR29B1, PTEN
The mechanism involved in the loss of PTEN expression in NSCLC tumor cells.
Li G, Zhao J, Peng X, Liang J, Deng X, Chen Y.
Biochem Biophys Res Commun 418(3):547-52. doi: 10.1016/j.bbrc.2012.01.065. Epub 2012 Jan 21. 2012
23PHLPP1, PTEN, SLC9A3R1
PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma.
Molina JR, Agarwal NK, Morales FC, Hayashi Y, Aldape KD, Cote G, Georgescu MM.
Oncogene 31(10):1264-74. doi: 10.1038/onc.2011.324. Epub 2011 Aug 1. 2012
24PTEN
Systemic elevation of PTEN induces a tumor-suppressive metabolic state.
Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP.
Cell 149(1):49-62. doi: 10.1016/j.cell.2012.02.030. Epub 2012 Mar 6. 2012
25BRRS, CS, PTEN
Analysis of prevalence and degree of macrocephaly in patients with germline PTEN mutations and of brain weight in Pten knock-in murine model.
Mester JL, Tilot AK, Rybicki LA, Frazier TW 2nd, Eng C.
Eur J Hum Genet 19(7):763-8. doi: 10.1038/ejhg.2011.20. Epub 2011 Feb 23. 2011
26CREB1, PTEN
CREB is a novel nuclear target of PTEN phosphatase.
Gu T, Zhang Z, Wang J, Guo J, Shen WH, Yin Y.
Cancer Res 71(8):2821-5. Epub 2011 Mar 8. 2011
27PPARD, PTEN
PPARδ coordinates angiotensin II-induced senescence in vascular smooth muscle cells through PTEN-mediated inhibition of superoxide generation.
Kim HJ, Ham SA, Kim MY, Hwang JS, Lee H, Kang ES, Yoo T, Woo IS, Yabe-Nishimura C, Paek KS, Kim JH, Seo HG.
J Biol Chem 286(52):44585-93. doi: 10.1074/jbc.M111.222562. Epub 2011 Nov 9. 2011
28PTEN, SOCS3
Sustained axon regeneration induced by co-deletion of PTEN and SOCS3.
Sun F, Park KK, Belin S, Wang D, Lu T, Chen G, Zhang K, Yeung C, Feng G, Yankner BA, He Z.
Nature 480(7377):372-5. doi: 10.1038/nature10594. 2011
29INPP4B, PTEN
INPP4B: the new kid on the PI3K block.
Agoulnik IU, Hodgson MC, Bowden WA, Ittmann MM.
Oncotarget 2(4):321-8. Review. 2011
30BMPR1A, DEL10Q23, PTEN
Mucinous cystadenoma of ovary in a patient with juvenile polyposis due to 10q23 microdeletion: Expansion of phenotype.
Babovic N, Simmons PS, Moir C, Thorland EC, Scheithauer B, Gliem TJ, Babovic-Vuksanovic D.
Am J Med Genet A 152A(10):2623-7.PMID: 20815035 2010
31EGR1, PTEN
EGR1 reactivation by histone deacetylase inhibitors promotes synovial sarcoma cell death through the PTEN tumor suppressor.
Su L, Cheng H, Sampaio AV, Nielsen TO, Underhill TM.
Oncogene 29(30):4352-61. Epub 2010 May 31.PMID: 20514024 2010
32DLG4, PTEN
PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression.
Jurado S, Benoist M, Lario A, Knafo S, Petrok CN, Esteban JA.
EMBO J 29(16):2827-40. Epub 2010 Jul 13.PMID: 20628354 2010
33CEBPA, CTNNA1, PTEN
An evolutionarily conserved PTEN-C/EBPalpha-CTNNA1 axis controls myeloid development and transformation.
Fu CT, Zhu KY, Mi JQ, Liu YF, Murray ST, Fu YF, Ren CG, Dong ZW, Liu YJ, Dong M, Jin Y, Chen Y, Deng M, Zhang W, Chen B, Breslin P, Chen SJ, Chen Z, Becker MW, Zhu J, Zhang JW, Liu TX.
Blood 115(23):4715-24. Epub 2010 Apr 6. 2010
34NEDD4, PTEN
E3 ligase Nedd4 promotes axon branching by downregulating PTEN.
Drinjakovic J, Jung H, Campbell DS, Strochlic L, Dwivedy A, Holt CE.
Neuron 65(3):341-57. 2010
35MCAUTS, PTEN
Novel PTEN mutations in neurodevelopmental disorders and macrocephaly.
Orrico A, Galli L, Buoni S, Orsi A, Vonella G, Sorrentino V.
Clin Genet 75(2):195-8. Epub 2008 Aug 26. 2009
36MCAUTS, PTEN
1: The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly.
Varga EA, Pastore M, Prior T, Herman GE, McBride KL.
Genet Med 11(2):111-7. 2009
37MCAUTS, PTEN
The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly.
Varga EA, Pastore M, Prior T, Herman GE, McBride KL.
Genet Med 11(2):111-7. 2009
38AKT, ERG, PTEN, TMPRSS2
Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis.
King JC, Xu J, Wongvipat J, Hieronymus H, Carver BS, Leung DH, Taylor BS, Sander C, Cardiff RD, Couto SS, Gerald WL, Sawyers CL.
Nat Genet 41(5):524-6. Epub 2009 Apr 26. 2009
39AKT, ERG, PTEN, TMPRSS2, TMPRSS6
Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate.
Carver BS, Tran J, Gopalan A, Chen Z, Shaikh S, Carracedo A, Alimonti A, Nardella C, Varmeh S, Scardino PT, Cordon-Cardo C, Gerald W, Pandolfi PP.
Nat Genet 41(5):619-24. Epub 2009 Apr 26. 2009
40PTEN, SLC6A4
Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior.
Page DT, Kuti OJ, Prestia C, Sur M.
Proc Natl Acad Sci U S A 106(6):1989-94. 2009
41PAWR, PTEN
Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma.
Fernandez-Marcos PJ, Abu-Baker S, Joshi J, Galvez A, Castilla EA, Cañamero M, Collado M, Saez C, Moreno-Bueno G, Palacios J, Leitges M, Serrano M, Moscat J, Diaz-Meco MT.
Proc Natl Acad Sci U S A 106(31):12962-7. Epub 2009 May 26. 2009
42HIF1A, PTEN, TSC2
TSC2 deficiency increases PTEN via HIF1alpha.
Mahimainathan L, Ghosh-Choudhury N, Venkatesan B, Das F, Mandal CC, Dey N, Habib SL, Kasinath BS, Abboud HE, Ghosh Choudhury G.
J Biol Chem 284(41):27790-8. Epub 2009 Jul 31.PMID: 19648120 2009
43PRDX1, PTEN
Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity.
Cao J, Schulte J, Knight A, Leslie NR, Zagozdzon A, Bronson R, Manevich Y, Beeson C, Neumann CA.
EMBO J 28(10):1505-17. Epub 2009 Apr 16. 2009
44BMPR1A, ENG, JPS, JPS2, JPS3, JPS4, PTEN, SMAD4
Large genomic deletions of SMAD4, BMPR1A and PTEN in juvenile polyposis.
van Hattem WA, Brosens LA, de Leng WW, Morsink FH, Lens S, Carvalho R, Giardiello FM, Offerhaus GJ.
Gut 57(5):623-7. Epub 2008 Jan 4. 2008
45PTEN, SREBF1
Regulation of the PTEN promoter by statins and SREBP.
Teresi RE, Planchon SM, Waite KA, Eng C.
Hum Mol Genet 17(7):919-28. Epub 2007 Dec 7. 2008
46MXD1, PTEN
Inhibition of apoptosis by MAD1 is mediated by repression of the PTEN tumor suppressor gene.
Rottmann S, Speckgens S, LŸscher-Firzlaff J, LŸscher B.
FASEB J 22(4):1124-34. Epub 2007 Nov 12. 2008
47PTEN, NEDD4
The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4.
Ahn Y, Hwang CY, Lee SR, Kwon KS, Lee C.
Biochem J 412(2):331-8. 2008
48NEDD4, PTEN
The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization.
Fouladkou F, Landry T, Kawabe H, Neeb A, Lu C, Brose N, Stambolic V, Rotin D.
Proc Natl Acad Sci U S A 105(25):8585-90. Epub 2008 Jun 18. 2008
49DEL10Q23, PTEN, BMPRA
Variable phenotypes associated with 10q23 microdeletions involving the PTEN and BMPR1A genes.
Menko FH, Kneepkens CM, de Leeuw N, Peeters EA, Van Maldergem L, Kamsteeg EJ, Davidson R, Rozendaal L, Lasham CA, Peeters-Scholte CM, Jansweijer MC, Hilhorst-Hofstee Y, Gille JJ, Heins YM, Nieuwint AW, Sistermans EA.
Clin Genet 74(2):145-54. Epub 2008 May 28. 2008
50BZS, PTEN
Bannayan-Riley-Ruvalcaba syndrome with posterior subcapsular congenital cataract and a consensus sequence splicing PTEN mutation.
Boccone L, Dessì V, Serra G, Zibordi F, Loudianos G.
Am J Med Genet A 146A(2):257-60. No abstract available. 2008
51APC, BRCA1, BRCA2, CDH1, CDKN2A, MLH1, MSH2, MSH6, PMS2, PRSS1, PTEN, RB1, SPINK1, STK11, TP53
Inherited susceptibility to common cancers.
Foulkes WD.
N Engl J Med 359(20):2143-53. No abstract available. 2008
52FBXW7, MTOR, PTEN
FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.
Mao JH, Kim IJ, Wu D, Climent J, Kang HC, DelRosario R, Balmain A.
Science 321(5895):1499-502. 2008
53ARL4D, PTEN
Increased expression of the glioma-associated antigen ARF4L after loss of the tumor suppressor PTEN. Laboratory investigation.
Chi JH, Panner A, Cachola K, Crane CA, Murray J, Pieper RO, James CD, Parsa AT.
J Neurosurg 108(2):299-303.PMID: 18240926 2008
54PTEN
PTEN acetylation modulates its interaction with PDZ domain.
Ikenoue T, Inoki K, Zhao B, Guan KL.
Cancer Res 68(17):6908-12. 2008
55PTEN
PTEN-deficient intestinal stem cells initiate intestinal polyposis.
He XC, Yin T, Grindley JC, Tian Q, Sato T, Tao WA, Dirisina R, Porter-Westpfahl KS, Hembree M, Johnson T, Wiedemann LM, Barrett TA, Hood L, Wu H, Li L.
Nat Genet 39(2):189-98. Epub 2007 Jan 21. 2007
56PTEN, NEDD4
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN.
Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, Gao Z, Wang J, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, Pandolfi PP, Jiang X.
Cell 128(1):129-39. 2007
57PTEN
Essential role for nuclear PTEN in maintaining chromosomal integrity.
Shen WH, Balajee AS, Wang J, Wu H, Eng C, Pandolfi PP, Yin Y.
Cell 128(1):157-70. 2007
58MCAUTS, PTEN
Increasing knowledge of PTEN germline mutations: Two additional patients with autism and macrocephaly.
Herman GE, Butter E, Enrile B, Pastore M, Prior TW, Sommer A.
Am J Med Genet A 143(6):589-93. 2007
59PTEN,PROTLS
Segmental overgrowth, lipomatosis, arteriovenous malformation and epidermal nevus (SOLAMEN) syndrome is related to mosaic PTEN nullizygosity.
Caux F, Plauchu H, Chibon F, Faivre L, Fain O, Vabres P, Bonnet F, Selma ZB, Laroche L, Gerard M, Longy M.
Eur J Hum Genet 15(7):767-73. Epub 2007 Mar 28. 2007
60PTEN, MHAM
Cowden Syndrome-Affected Patients with PTEN Promoter Mutations Demonstrate Abnormal Protein Translation.
Teresi RE, Zbuk KM, Pezzolesi MG, Waite KA, Eng C.
Am J Hum Genet 81(4):756-67. Epub 2007 Aug 15. 2007
61PTEN, BZS, MHAM
Cowden syndrome and Bannayan Riley Ruvalcaba syndrome represent one condition with variable expression and age-related penetrance: results of a clinical study of PTEN mutation carriers.
Lachlan KL, Lucassen AM, Bunyan D, Temple IK.
J Med Genet 44(9):579-85. Epub 2007 May 25. 2007
62JPS, JPS2, JPS3, JPHT, HMPS2, SMAD4, BMPR1A, PTEN
High proportion of large genomic deletions and a genotype phenotype update in 80 unrelated families with juvenile polyposis syndrome.
Aretz S, Stienen D, Uhlhaas S, Stolte M, Entius MM, Loff S, Back W, Kaufmann A, Keller KM, Blaas SH, Siebert R, Vogt S, Spranger S, Holinski-Feder E, Sunde L, Propping P, Friedl W.
J Med Genet 44(11):702-9. Epub 2007 Sep 14. 2007
63GLTSCR2, PTEN
The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death.
Yim JH, Kim YJ, Ko JH, Cho YE, Kim SM, Kim JY, Lee S, Park JH.
Cell Death Differ 14(11):1872-9. Epub 2007 Jul 27. 2007
64PTEN, NOTCH1
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.
Palomero T, Sulis ML, Cortina M, Real PJ, Barnes K, Ciofani M, Caparros E, Buteau J, Brown K, Perkins SL, Bhagat G, Agarwal AM, Basso G, Castillo M, Nagase S, Cordon-Cardo C, Parsons R, Zœ–iga-PflŸcker JC, Dominguez M, Ferrando AA.
Nat Med 13(10):1203-10. Epub 2007 Sep 16. 2007
65MCAUTS, PTEN
Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly.
Buxbaum JD, Cai G, Chaste P, Nygren G, Goldsmith J, Reichert J, Anckarsäter H, Rastam M, Smith CJ, Silverman JM, Hollander E, Leboyer M, Gillberg C, Verloes A, Betancur C.
Am J Med Genet B Neuropsychiatr Genet 144B(4):484-91. 2007
66PTEN, MHAM, BZS
Distinct Expression Profiles for PTEN Transcript and Its Splice Variants in Cowden Syndrome and Bannayan-Riley-Ruvalcaba Syndrome.
Sarquis MS, Agrawal S, Shen L, Pilarski R, Zhou XP, Eng C.
Am J Hum Genet 79(1):23-30. Epub 2006 May 22. 2006
67PTEN
Regulation of the PTEN phosphatase.
Gericke A, Munson M, Ross AH.
Gene 374:1-9. Epub 2006 Mar 14. 2006
68PTEN, CCND1
The ERK1/2 pathway modulates nuclear PTEN-mediated cell cycle arrest by cyclin D1 transcriptional regulation.
Chung JH, Ostrowski MC, Romigh T, Minaguchi T, Waite KA, Eng C.
Hum Mol Genet 15(17):2553-9. Epub 2006 Jul 18. 2006
69BZS, PTEN
Bannayan-Riley-Ruvalcaba syndrome with reactive nodular lymphoid hyperplasia and autism and a PTEN mutation.
Boccone L, Dessi V, Zappu A, Piga S, Piludu MB, Rais M, Massidda C, De Virgiliis S, Cao A, Loudianos G.
Am J Med Genet A 140(18):1965-9. No abstract available. 2006
70PTEN
Mutation-positive and mutation-negative patients with cowden and bannayan-riley-ruvalcaba syndromes associated with distinct 10q haplotypes.
Pezzolesi MG, Li Y, Zhou XP, Pilarski R, Shen L, Eng C.
Am J Hum Genet 79(5):923-34. Epub 2006 Sep 29. 2006
71PTEN, SPRY2
The tumor suppressor PTEN is necessary for human Sprouty 2-mediated inhibition of cell proliferation.
Edwin F, Singh R, Endersby R, Baker SJ, Patel TB.
J Biol Chem 281(8):4816-22. Epub 2005 Dec 21. 2006
72DEL10Q23, BMPR1A, PTEN, JPS2
Contiguous gene deletion within chromosome arm 10q is associated with juvenile polyposis of infancy, reflecting cooperation between the BMPR1A and PTEN tumor-suppressor genes.
Delnatte C, Sanlaville D, Mougenot JF, Vermeesch JR, Houdayer C, Blois MC, Genevieve D, Goulet O, Fryns JP, Jaubert F, Vekemans M, Lyonnet S, Romana S, Eng C, Stoppa-Lyonnet D.
Am J Hum Genet 78(6):1066-74. Epub 2006 Apr 14. 2006
73PTEN
PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3.
Kerr F, Rickle A, Nayeem N, Brandner S, Cowburn RF, Lovestone S.
FEBS Lett 580(13):3121-8. Epub 2006 May 2. 2006
74BRAF, PTEN
Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma.
Goel VK, Lazar AJ, Warneke CL, Redston MS, Haluska FG.
J Invest Dermatol 126(1):154-60. 2006
75PTEN, MCAUTS
Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations.
Butler MG, Dasouki MJ, Zhou XP, Talebizadeh Z, Brown M, Takahashi TN, Miles JH, Wang CH, Stratton R, Pilarski R, Eng C.
J Med Genet 42(4):318-21. 2005
76PTEN, STK11
LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes.
Mehenni H, Lin-Marq N, Buchet-Poyau K, Reymond A, Collart MA, Picard D, Antonarakis SE.
Hum Mol Genet 14(15):2209-19. Epub 2005 Jun 29. 2005
77MHAM, MTOR, PTEN
Lhermitte-Duclos disease: a report of 31 cases with immunohistochemical analysis of the PTEN/AKT/mTOR pathway.
Abel TW, Baker SJ, Fraser MM, Tihan T, Nelson JS, Yachnis AT, Bouffard JP, Mena H, Burger PC, Eberhart CG.
J Neuropathol Exp Neurol 64(4):341-9. Review. 2005
78CCDC6, PTEN
Characterization of novel non-clonal intrachromosomal rearrangements between the H4 and PTEN genes (H4/PTEN) in human thyroid cell lines and papillary thyroid cancer specimens.
Puxeddu E, Zhao G, Stringer JR, Medvedovic M, Moretti S, Fagin JA.
Mutat Res 570(1):17-32.PMID: 15680400 2005
79BMPR1A, SMAD4, PTEN
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling.
He XC, Zhang J, Tong WG, Tawfik O, Ross J, Scoville DH, Tian Q, Zeng X, He X, Wiedemann LM, Mishina Y, Li L.
Nat Genet 36(10):1117-21. Epub 2004 Sep 19. 2004
80JPS, JPS2, JPS3, PTEN, BMPR1A, SMAD4
Genetic conditions associated with intestinal juvenile polyps.
Merg A, Howe JR.
Am J Med Genet C Semin Med Genet 129(1):44-55. Review. 2004
81BMP2, PTEN
BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels.
Waite KA, Eng C.
Hum Mol Genet 12(6):679-84. 2003
82PTEN
Germline Inactivation of PTEN and Dysregulation of the Phosphoinositol-3-Kinase/Akt Pathway Cause Human Lhermitte-Duclos Disease in Adults.
Zhou XP, Marsh DJ, Morrison CD, Chaudhury AR, Maxwell M, Reifenberger G, Eng C.
Am J Hum Genet 73(5):1191-1198. Epub 2003 Oct 17. 2003
83PROTLS, PTEN
Proteus syndrome: misdiagnosis with PTEN mutations.
Cohen MM Jr, Turner JT, Biesecker LG.
Am J Med Genet 122A(4):323-4. No abstract available. 2003
84CDKN2A, DLC1, EXT1, MLH1, PTEN, RB1, TP53, TP73
Molecular pathogenesis of human hepatocellular carcinoma.
Thorgeirsson SS, Grisham JW.
Nat Genet 31(4):339-46. 2002
85PTEN
Germline mutations in the PTEN gene in Israeli patients with Bannayan-Riley-Ruvalcaba syndrome and women with familial breast cancer.
Figer A, Kaplan A, Frydman M, Lev D, Paswell J, Papa MZ, Goldman B, Friedman E.
Clin Genet 62(4):298-302. 2002
86MHAM, PTEN
Male breast cancer in Cowden syndrome patients with germline PTEN mutations.
Fackenthal JD, Marsh DJ, Richardson AL, Cummings SA, Eng C, Robinson BG, Olopade OI.
J Med Genet 38(3):159-64. 2001
87PTEN
PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways.
Weng L, Brown J, Eng C.
Hum Mol Genet 10(3):237-42. 2001
88PTEN
Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death.
Weng LP, Gimm O, Kum JB, Smith WM, Zhou XP, Wynford-Thomas D, Leone G, Eng C.
Hum Mol Genet 10(3):251-8. 2001
89PTEN
PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model.
Weng LP, Brown JL, Eng C.
Hum Mol Genet 10(6):599-604. 2001
90PTEN
PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model.
Weng LP, Smith WM, Brown JL, Eng C.
Hum Mol Genet 10(6):605-16. 2001
91PTEN
PTEN controls tumor-induced angiogenesis.
Wen S, Stolarov J, Myers MP, Su JD, Wigler MH, Tonks NK, Durden DL.
Proc Natl Acad Sci U S A 98(8):4622-7. 2001
92PTEN
Association of germline mutation in the PTEN tumour suppressor gene and Proteus and Proteus-like syndromes.
Zhou X, Hampel H, Thiele H, Gorlin RJ, Hennekam RC, Parisi M, Winter RM, Eng C.
Lancet 358(9277):210-1. 2001
93PTEN
Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression.
Kwabi-Addo B, Giri D, Schmidt K, Podsypanina K, Parsons R, Greenberg N, Ittmann M.
Proc Natl Acad Sci U S A 98(20):11563-8. 2001
94PTEN
A novel germline mutation of the PTEN gene in a patient with macrocephaly, ventricular dilatation, and features of VATER association.
Reardon W, Zhou XP, Eng C.
J Med Genet 38(12):820-3. 2001
95MMP2, PTEN
Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN.
Koul D, Parthasarathy R, Shen R, Davies MA, Jasser SA, Chintala SK, Rao JS, Sun Y, Benvenisite EN, Liu TJ, Yung WK.
Oncogene 20(46):6669-78. 2001
96PTEN, MHAM
PTEN mutation in a family with Cowden syndrome and autism.
Goffin A, Hoefsloot LH, Bosgoed E, Swillen A, Fryns JP.
Am J Med Genet 105(6):521-4. 2001
97PTEN
Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesis.
Guanti G, Resta N, Simone C, Cariola F, Demma I, Fiorente P, Gentile M.
Hum Mol Genet 9(2):283-7 2000
98PROTLS, PTEN
Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis.
Zhou XP, Marsh DJ, Hampel H, Mulliken JB, Gimm O, Eng C.
Hum Mol Genet 9(5):765-8. 2000
99PTEN
Mutations of the human PTEN gene.
Bonneau D, Longy M.
Hum Mutat 16(2):109-22. 2000
100PTEN
Expression of the PTEN tumour suppressor protein during human development.
Gimm O, Attie-Bitach T, Lees JA, Vekemans M, Eng C.
Hum Mol Genet 9(11):1633-9. 2000
101MHAM, PTEN
Effect of nonsense mutations on PTEN mRNA stability.
Raizis AM, Ferguson MM, George PM.
Hum Genet 107(1):24-7. 2000
102PTEN
PTEN / MMAC1 mutation and frequent loss of heterozygosity identified in chromosome 10q in a subset of hepatocellular carcinomas.
Fujiwara Y, Hoon DS, Yamada T, Umeshita K, Gotoh M, Sakon M, Nishisho I, Monden M.
Jpn J Cancer Res 91(3):287-92. 2000
103PTEN, TSG10A
Identification of PTEN mutations in metastatic melanoma specimens.
Celebi JT, Shendrik I, Silvers DN, Peacocke M.
J Med Genet 37(9):653-7. 2000
104PTEN, TSG10A
Biallelic inactivating mutations and an occult germline mutation of PTEN in primary cervical carcinomas.
Kurose K, Zhou XP, Araki T, Eng C.
Genes Chromosomes Cancer 29(2):166-72. 2000
105PTEN
No evidence of germline PTEN mutations in familial prostate cancer.
Forrest MS, Edwards SM, Hamoudi RA, Dearnaley DP, Arden-Jones A, Dowe A, Murkin A, Kelly J, Teare MD, Easton DF, Knowles MA, Bishop DT, Eeles RA.
J Med Genet 37(3):210-2. No abstract available. 2000
106PTEN
Association of splicing defects in PTEN leading to exon skipping or partial intron retention in Cowden syndrome
Celebi JT, Wanner M, Ping XL, Zhang H, Peacocke M.
Hum Genet 107(3):234-8. 2000
107MINPP1, PTEN
Absence of germline mutations in MINPP1, a phosphatase encoding gene centromeric of PTEN, in patients with Cowden and Bannayan-Riley-Ruvalcaba syndrome without germline PTEN mutations.
Dahia PM, Gimm O, Chi H, Marsh DJ, Reynolds PR, Eng C.
J Med Genet 37(9):715-7. No abstract available. 2000
108PTEN
Molecular analysis of PTEN and MXI1 in primary bladder carcinoma.
Wang DS, Rieger-Christ K, Latini JM, Moinzadeh A, Stoffel J, Pezza JA, Saini K, Libertino JA, Summerhayes IC.
Int J Cancer 88(4):620-5. 2000
109PTEN
Alternative splicing of the human PTEN/MMAC1/TEP1 gene.
Sharrard RM, Maitland NJ.
Biochim Biophys Acta 1494(3):282-5. 2000
110AKT1, PTEN
PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanisms in haematological malignancies.
Dahia PLM, et al.
Hum Mol Genet 8 : 185-193. 1999
111MHAM, PTEN
Variant manifestation of Cowden disease in Japan : hamartomatous polyposis of the digestive tract with mutation of the PTEN gene.
Kurose K, et al.
Am J Hum Genet 64 : 308-310. 1999
112PTEN
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway.
Cantley LC, et al.
Proc Natl Acad Sci U S A 96(8):4240-5. 1999
113PTEN
Novel PTEN mutations in patients with Cowden disease: absence of clear genotype-phenotype correlations.
Nelen MR, et al.
Eur J Hum Genet 7(3):267-73. 1999
114BZS, MHAM, PTEN
Phenotypic findings of Cowden syndrome and Bannayan-Zonana syndrome in a family associated with a single germline mutation in PTEN.
Celebi JT, et al.
J Med Genet 36(5):360-4. 1999
115PTEN, TSG10A
Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma.
Feilotter HE, et al.
Br J Cancer 79(5-6):718-23. 1999
116PTEN
Mutational analysis of the PTEN gene in gliomas: molecular and pathological correlations.
Zhou XP, et al.
Int J Cancer 84(2):150-4. 1999
117PTEN
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway.
Sun H, et al.
Proc Natl Acad Sci U S A 96(11):6199-204. 1999
118PTEN
Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis.
Sano T, et al.
Cancer Res 59(8):1820-4. 1999
119BZS, MHAM, PTEN
PTEN mutation spectrum and genotype-phenotype correlations in bannayan-riley-ruvalcaba syndrome suggest a single entity with cowden syndrome.
Marsh DJ, et al.
Hum Mol Genet 8(8):1461-72. 1999
120PTEN
The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region.
Georgescu MM, et al.
Proc Natl Acad Sci U S A 96(18):10182-10187. 1999
121PTEN, STK11
PTEN and LKB1 genes in laryngeal tumours.
Chen RW, Avizienyte E, Roth S, Elivo I, Makittie AA, Aaltonen LM, Aaltonen LA.
J Med Genet 36(12):943-4. No abstract available 1999
122PTEN
Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways.
Wurmser AE, Gary JD, Emr SD.
J Biol Chem 274(14):9129-32. Review. No abstract available. 1999
123MHAM, PTEN, TSG10A
Allelic imbalance, including deletion of PTEN/MMACI, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation.
Marsh DJ, Dahia PL, Coulon V, Zheng Z, Dorion-Bonnet F, Call KM, Little R, Lin AY, Eeles RA, Goldstein AM, Hodgson SV, Richardson AL, Robinson BG, Weber HC, Longy M, Eng C.
Genes Chromosomes Cancer 21(1):61-9. 1998
124JPS2, PTEN
PTEN germ-line mutations in juvenile polyposis coli.
Olschwang S, Serova-Sinilnikova OM, Lenoir GM, Thomas G.
Nat Genet 18(1):12-4. No abstract available. 1998
125PTEN, PTEN, TSG10A
Sporadic breast cancers exhibit loss of heterozygosity on chromosome segment 10q23 close to the Cowden disease locus.
Singh B, Ittmann MM, Krolewski JJ.
Genes Chromosomes Cancer 21(2):166-71. 1998
126PTEN, PTENP1, TSG9A
Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines.
Kim SK, et al.
Oncogene 16 : 89-93. 1998
127BZS, MHAM, PTEN
Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation.
Marsh DJ, Coulon V, Lunetta KL, Rocca-Serra P, Dahia PL, Zheng Z, Liaw D, Caron S, Duboue B, Lin AY, Richardson AL, Bonnetblanc JM, Bressieux JM, Cabarrot-Moreau A, Chompret A, Demange L, Eeles RA, Yahanda AM, Fearon ER, Fricker JP, Gorlin RJ, Hodgson SV, Huson S, Lacombe D, Eng C, et al.
Hum Mol Genet 7(3):507-15. 1998
128PTEN
PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas.
Chiariello E, et al.
Oncogene 16 : 541-545. 1998
129MHAM, PTEN
The genetic basis of Cowden's syndrome : three novel mutations in PTEN/MMAC1/TEP1.
Tsou HC, et al.
Hum Genet 102 : 467-473. 1998
130PTEN, TSG10A, KLF6
Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades.
Ichimura K, et al.
Genes Chromosomes Cancer 22 : 9-15. 1998
131PTEN
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN.
Tamura M, et al.
Science 280 : 1614-1617. 1998
132PTEN
PTEN mutations in gliomas and glioneuronal tumors.
Duerr EM, et al.
Oncogene 16 : 2259-2264. 1998
133BZS, JPS, SMAD4, MHAM, PTEN
PTEN and inherited hamartoma-cancer syndromes.
Eng C, et al.
Nat Genet 19 : 223. 1998
134PTEN
Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors.
Obata K, et al.
Cancer Res 58 : 2095-2097. 1998
135PTEN
Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias.
Maxwell GL, et al.
Cancer Res 58 : 2500-2503. 1998
136PTEN, TSG10A
Pten is essential for embryonic development and tumour suppression.
Di Cristofano A, et al.
Nat Genet 19 : 348-355. 1998
137MHAM, PTEN
Germline mutations of the PTEN/MMAC1 gene in Japanese patients with Cowden disease.
Kohno T, et al.
Jpn J Cancer Res 89 : 471-474. 1998
138PTEN
Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas.
Maier D, et al.
Oncogene 16 : 3331-3335. 1998
139PTEN, TSG10A
PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers.
Yokomizo A, et al.
Oncogene 17 : 475-479. 1998
140PTEN, TSG10A
Mutational analysis of the PTEN gene in head and neck squamous cell carcinoma.
Shao X, et al.
Int J Cancer 77 : 684-688. 1998
141PTEN, TSG10A, TSG10B
Distinct regions of allelic imbalance on chromosome 10q22-q26 in squamous cell carcinomas of the lung.
Petersen S, et al.
Oncogene 17 : 449-454. 1998
142PTEN, TSG10A
PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas.
Tohma Y, et al.
J Neuropathol Exp Neurol 57 : 684-689. 1998
143PTEN, TSG10A
In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma.
Robertson GP, et al.
Proc Natl Acad Sci U S A 95 : 9418-9423. 1998
144PTEN, STK11
Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromes.
Wang ZJ, Taylor F, Churchman M, Norbury G, Tomlinson I.
Am J Pathol 153 : 363-366. 1998
145PTEN
Somatic mutations of the PTEN tumor suppressor gene in sporadic follicular thyroid tumors.
Halachmi N, Halachmi S, Evron E, Cairns P, Okami K, Saji M, Westra WH, Zeiger MA, Jen J, Sidransky D.
Genes Chromosomes Cancer 23(3):239-43. 1998
146PTEN
PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma.
Levine RL, et al.
Cancer Res 58 : 3254-3258. 1998
147PTEN
The PTEN tumour suppressor gene and malignant melanoma.
Boni R, et al.
Melanoma Res 8 : 300-302. 1998
148BZS, MHAM, PTEN
Germline PTEN mutation in a family with Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome.
Zori RT, et al.
Am J Med Genet 80 : 399-402. 1998
149DMBT1, PTEN
Molecular analysis of two putative tumour suppressor genes, PTEN and DMBT, which have been implicated in gliolastoma multiforme disease progression.
Somerville RP, et al.
Oncogene 17 : 1755-1757. 1998
150PTEN, TSG10A
The lipid phosphatase activity of PTEN is critical for its tumor suppressor function.
Myers MP, Pass I, Batty IH, Van der Kaay J, Stolarov JP, Hemmings BA, Wigler MH, Downes CP, Tonks NK.
Proc Natl Acad Sci U S A 95 : 13513-13518. 1998
151PTEN
PTEN gene alterations in lymphoid neoplasms.
Sakai A, Thieblemont C, Wellmann A, Jaffe ES, Raffeld M.
Blood 92 : 3410-3415. 1998
152PTEN, TSG10A
Mutation and expression analysis of the putative prostate tumour-suppressor gene PTEN.
Gray IC, et al.
Br J Cancer 78 : 1296-1300. 1998
153PTEN
The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway.
Wu X, et al.
Proc Natl Acad Sci U S A 95 : 15587-15591. 1998
154PTEN
PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells.
Li DM, et al.
Proc Natl Acad Sci U S A 95 : 15406-15411. 1998
155BAX, IGF2R, PTEN
The PTEN, BAX, and IGFIIR genes are mutated in endometrial atypical hyperplasia.
Yoshinaga K, et al.
Jpn J Cancer Res 89 : 985-990. 1998
156DEL10Q23, JPS, PTEN, PTEN, TSG10A
Deletion 10q23.2-q23.33 in a patient with gastrointestinal juvenile polyposis and other features of a Cowden-like syndrome.
Tsuchiya KD, Wiesner G, Cassidy SB, Limwongse C, Boyle JT, Schwartz S.
Genes Chromosomes Cancer 21(2):113-8. 1998
157PTEN, TSG10A
PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.
Li J, et al.
Science 275 : 1943-1947. 1997
158PTEN, TSG10A
Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers.
Steck PA, et al.
Nat Genet 15 : 356-362. 1997
159MHAM, PTEN
Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome.
Liaw D, et al.
Nat Genet 16 : 64-67. 1997
160MHAM, PTEN
Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.
Nelen MR, van Staveren WC, Peeters EA, Hassel MB, Gorlin RJ, Hamm H, Lindboe CF, Fryns JP, Sijmons RH, Woods DG, Mariman EC, Padberg GW, Kremer H.
Hum Mol Genet 6(8):1383-7. 1997
161BZS, PTEN
Germline mutations in PTEN are present in Bannayan-Zonana syndrome.
Marsh DJ, Dahia PL, Zheng Z, Liaw D, Parsons R, Gorlin RJ, Eng C.
Nat Genet 16(4):333-4. No abstract available. 1997
162PTEN
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase.
Myers MP, Stolarov JP, Eng C, Li J, Wang SI, Wigler MH, Parsons R, Tonks NK.
Proc Natl Acad Sci U S A 94(17):9052-7. 1997
163PTEN
PTEN1 is frequently mutated in primary endometrial carcinomas.
Kong D, Suzuki A, Zou TT, Sakurada A, Kemp LW, Wakatsuki S, Yokoyama T, Yamakawa H, Furukawa T, Sato M, Ohuchi N, Sato S, Yin J, Wang S, Abraham JM, Souza RF, Smolinski KN, Meltzer SJ, Horii A.
Nat Genet 17(2):143-4. 1997
164BZS, PTEN
Deletion of 10q23.2-q24.1 including PTEN in a patient with Bannayan-Riley-Ruvalcaba syndrome suggests allelism with Cowden disease. (abstr)
Arch EM, et al.
Am J Hum Genet 61 : A118. 1997
165PTEN, TSG10A
PTEN gene mutations are seen in high-grade but not in low-grade gliomas.
Rasheed BK, Stenzel TT, McLendon RE, Parsons R, Friedman AH, Friedman HS, Bigner DD, Bigner SH.
Cancer Res 57(19):4187-90. 1997
166PTEN
The role of MMAC1 mutations in early-onset breast cancer: causative in association with Cowden syndrome and excluded in BRCA1-negative cases.
Tsou HC, Teng DH, Ping XL, Brancolini V, Davis T, Hu R, Xie XX, Gruener AC, Schrager CA, Christiano AM, Eng C, Steck P, Ott J, Tavtigian SV, Peacocke M.
Am J Hum Genet 61(5):1036-43. 1997
167MHAM, PTEN, TSG10A
Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors.
Dahia PL, Marsh DJ, Zheng Z, Zedenius J, Komminoth P, Frisk T, Wallin G, Parsons R, Longy M, Larsson C, Eng C.
Cancer Res 57(21):4710-3. 1997
168PTEN
Exclusion of PTEN and 10q22-24 as the susceptibility locus for juvenile polyposis syndrome.
Marsh DJ, Roth S, Lunetta KL, Hemminki A, Dahia PL, Sistonen P, Zheng Z, Caron S, van Orsouw NJ, Bodmer WF, Cottrell SE, Dunlop MG, Eccles D, Hodgson SV, Jarvinen H, Kellokumpu I, Markie D, Neale K, Phillips R, Rozen P, Syngal S, Vijg J, Tomlinson IP, Aaltonen LA, Eng C.
Cancer Res 57(22):5017-21. 1997
169MHAM, PTEN, TSG10A
Inherited mutations in PTEN that are associated with breast cancer, Cowden disease, and juvenile polyposis.
Lynch ED, Ostermeyer EA, Lee MK, Arena JF, Ji H, Dann J, Swisshelm K, Suchard D, MacLeod PM, Kvinnsland S, Gjertsen BT, Heimdal K, Lubs H, Moller P, King MC.
Am J Hum Genet 61(6):1254-60. 1997
170CDC14A, PTEN, CDC14B
A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast.
Li L, Ernsting BR, Wishart MJ, Lohse DL, Dixon JE.
J Biol Chem 272(47):29403-6. 1997