1 | MCAUTS, PTEN
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| Autism-specific PTEN p.Ile135Leu variant and an autism genetic background combine to dysregulate cortical neurogenesis
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| Fu S, Bury LAD, Eum J, Wynshaw-Boris A.
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| Am J Hum Genet. May 4;110(5):826-845. doi: 10.1016/j.ajhg.2023.03.015. Epub 2023 Apr 24. 2023
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2 | MCAUTS, PTEN
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| Conformational Dynamics and Allosteric Regulation Landscapes of Germline PTEN Mutations Associated with Autism Compared to Those Associated with Cancer.
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| Smith IN, Thacker S, Seyfi M, Cheng F, Eng C.
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| Am J Hum Genet 104(5):861-878. doi: 10.1016/j.ajhg.2019.03.009. Epub 2019 Apr 18.
2019
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3 | MCAUTS, MHAM, PTEN
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| Distinct Alterations in Tricarboxylic Acid Cycle Metabolites Associate with Cancer and Autism Phenotypes in Cowden Syndrome and Bannayan-Riley-Ruvalcaba Syndrome.
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| Yehia L, Ni Y, Feng F, Seyfi M, Sadler T, Frazier TW, Eng C.
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| Am J Hum Genet 105(4):813-821. doi: 10.1016/j.ajhg.2019.09.004. Epub 2019 Sep 26. 2019
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4 | PGK1, PTEN
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| PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1.
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| Qian X, Li X, Shi Z, Xia Y, Cai Q, Xu D, Tan L, Du L, Zheng Y, Zhao D, Zhang C, Lorenzi PL, You Y, Jiang BH, Jiang T, Li H, Lu Z.
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| Mol Cell. Nov 7;76(3):516-527.e7. doi: 10.1016/j.molcel.2019.08.006. Epub 2019 Sep 3 2019
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5 | AKT3, BRWD3, CLOVES, DNMT3A, DNMT3OGS, EZH2, GPC3, HIST1H1E, MCAUTS, MPPH2, MRD35, MRX93, MSMR, MSMS, MTOR, NFIX, NSD1, OGID1, PIK3CA, PPP2R5D, PTEN, SGBS, STOL1, WVSS1, WVSS2
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| Mutations in Epigenetic Regulation Genes Are a Major Cause of Overgrowth with Intellectual Disability.
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| Tatton-Brown K, Loveday C, Yost S, Clarke M, Ramsay E, Zachariou A, Elliott A, Wylie H, Ardissone A, Rittinger O, Stewart F, Temple IK, Cole T; Childhood Overgrowth Collaboration, Mahamdallie S, Seal S, Ruark E, Rahman N.
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| Am J Hum Genet 100(5):725-736. doi: 10.1016/j.ajhg.2017.03.010. 2017
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6 | PIK3R1, PTEN
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| Phosphatidylinositol 3-kinase regulatory subunit 1 and phosphatase and tensin homolog as therapeutic targets in breast cancer.
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| Dirican E, Akkiprik M.
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| Tumour Biol 39(3):1010428317695529. doi: 10.1177/1010428317695529. Review.
2017
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7 | INPP4B, INPP5J, PTEN
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| Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases.
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| Rodgers SJ, Ferguson DT, Mitchell CA, Ooms LM.
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| Biosci Rep 37(1). pii: BSR20160432. doi: 10.1042/BSR20160432. Print 2017 Feb 28. Review.
2017
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8 | PREX2, PTEN
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| Interplay between PREX2 mutations and the PI3K pathway and its effect on epigenetic regulation of gene expression in NRAS-mutant melanoma.
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| Lissanu Deribe Y.
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| Small GTPases mall GTPases. 2016 Apr 25:1-8. [Epub ahead of print]
2016
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9 | CRISP3, PTEN
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| Prognostic value of ERG, PTEN, CRISP3 and SPINK1 in predicting biochemical recurrence in prostate cancer.
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| Noh BJ, Sung JY, Kim YW, Chang SG, Park YK.
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| Oncol Lett 11(6):3621-3630. Epub 2016 Apr 19.
2016
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10 | PTEN, RSL1D1
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| Ribosomal L1 domain and lysine-rich region are essential for CSIG/ RSL1D1 to regulate proliferation and senescence.
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| Ma L, Zhao W, Zheng Q, Chen T, Qi J, Li G, Tong T.
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| Biochem Biophys Res Commun 469(3):593-8. doi: 10.1016/j.bbrc.2015.12.004. Epub 2015 Dec 12.
2016
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11 | KIF11, PTEN
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| PTEN regulates EG5 to control spindle architecture and chromosome congression during mitosis.
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| He J, Zhang Z, Ouyang M, Yang F, Hao H, Lamb KL, Yang J, Yin Y, Shen WH.
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| Nat Commun 7:12355. doi: 10.1038/ncomms12355.
2016
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12 | DLG1, KIF11, PTEN
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| Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes.
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| van Ree JH, Nam HJ, Jeganathan KB, Kanakkanthara A, van Deursen JM.
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| Nat Cell Biol 18(7):814-21. doi: 10.1038/ncb3369. Epub 2016 May 30.
2016
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13 | PREX2, PTEN, RAC1
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| PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion.
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| Mense SM, Barrows D, Hodakoski C, Steinbach N, Schoenfeld D, Su W, Hopkins BD, Su T, Fine B, Hibshoosh H, Parsons R.
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| Sci Signal 8(370):ra32. doi: 10.1126/scisignal.2005840.
2015
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14 | MEF2D, PTEN
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| MEF2D deficiency in neonatal cardiomyocytes triggers cell cycle re-entry and programmed cell death in vitro.
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| Estrella NL, Clark AL, Desjardins CA, Nocco SE, Naya FJ.
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| J Biol Chem 290(40):24367-80. doi: 10.1074/jbc.M115.666461. Epub 2015 Aug 20.
2015
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15 | OTUD3, PTEN
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| Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis.
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| Yuan L, Lv Y, Li H, Gao H, Song S, Zhang Y, Xing G, Kong X, Wang L, Li Y, Zhou T, Gao D, Xiao ZX, Yin Y, Wei W, He F, Zhang L.
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| Nat Cell Biol. Sep;17(9):1169-81. doi: 10.1038/ncb3218. Epub 2015 Aug 17. 2015
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16 | OTUD3, PTEN, TOP2A
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| PTEN stabilizes TOP2A and regulates the DNA decatenation
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| Kang X, Song C, Du X, Zhang C, Liu Y, Liang L, He J, Lamb K, Shen WH, Yin Y.
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| Sci Rep. Dec 10;5:17873. doi: 10.1038/srep17873. 2015
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17 | ERBB2, HOTAIR, MYC, PTEN, RBM38, WIF1
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| The molecular mechanism of HOTAIR in tumorigenesis, metastasis, and drug resistance.
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| Zhou X, Chen J, Tang W.
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| Acta Biochim Biophys Sin (Shanghai) 46(12):1011-5. doi: 10.1093/abbs/gmu104. Epub 2014 Nov 10. Review.
2014
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18 | NDFIP1, PTEN, RAB5A
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| Rab5 and Ndfip1 are involved in Pten ubiquitination and nuclear trafficking.
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| Li Y, Low LH, Putz U, Goh CP, Tan SS, Howitt J.
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| Traffic 15(7):749-61. doi: 10.1111/tra.12175. Epub 2014 Jun 3.
2014
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19 | PTEN
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| Critical role of increased PTEN nuclear translocation in excitotoxic and ischemic neuronal injuries.
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| Zhang S, Taghibiglou C, Girling K, Dong Z, Lin SZ, Lee W, Shyu WC, Wang YT.
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| J Neurosci 33(18):7997-8008. doi: 10.1523/JNEUROSCI.5661-12.2013.
2013
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20 | NCOA3, PTEN
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| PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha.
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| Yang C, Li S, Wang M, Chang AK, Liu Y, Zhao F, Xiao L, Han L, Wang D, Li S, Wu H.
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| Mol Cancer 12:21. doi: 10.1186/1476-4598-12-21.
2013
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21 | MHAM, PTEN
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| Cowden syndrome-related mutations in PTEN associate with enhanced proteasome activity.
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| He X, Arrotta N, Radhakrishnan D, Wang Y, Romigh T, Eng C.
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| Cancer Res 73(10):3029-40. doi: 10.1158/0008-5472.CAN-12-3811. Epub 2013 Mar 8.
2013
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22 | MAP2K1, PTEN
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| MEK1 is required for PTEN membrane recruitment, AKT regulation, and the maintenance of peripheral tolerance.
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| Zmajkovicova K, Jesenberger V, Catalanotti F, Baumgartner C, Reyes G, Baccarini M.
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| Mol Cell 50(1):43-55. doi: 10.1016/j.molcel.2013.01.037. Epub 2013 Feb 28.
2013
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23 | PTEN, PTENP1
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| A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells.
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| Johnsson P, Ackley A, Vidarsdottir L, Lui WO, Corcoran M, Grandér D, Morris KV.
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| Nat Struct Mol Biol 20(4):440-6. doi: 10.1038/nsmb.2516. Epub 2013 Feb 24.
2013
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24 | PTEN
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| Loss of phosphatase and tensin homolog expression is associated with recurrence and poor prognosis in patients with pancreatic ductal adenocarcinoma.
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| Foo WC, Rashid A, Wang H, Katz MH, Lee JE, Pisters PW, Wolff RA, Abbruzzese JL, Fleming JB, Wang H.
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| Hum Pathol 44(6):1024-30. doi: 10.1016/j.humpath.2012.09.001. Epub 2012 Dec 20.
2013
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25 | MYC, PTEN
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| MYC acts via the PTEN tumor suppressor to elicit autoregulation and genome-wide gene repression by activation of the Ezh2 methyltransferase.
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| Kaur M, Cole MD.
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| Cancer Res 73(2):695-705. doi: 10.1158/0008-5472.CAN-12-2522. Epub 2012 Nov 7.
2013
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26 | CHFR, PBK, PTEN
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| TOPK and PTEN participate in CHFR mediated mitotic checkpoint.
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| Shinde SR, Gangula NR, Kavela S, Pandey V, Maddika S.
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| Cell Signal 25(12):2511-7. doi: 10.1016/j.cellsig.2013.08.013. Epub 2013 Sep 3.
2013
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27 | PPP1R10, PTEN
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| PNUTS functions as a proto-oncogene by sequestering PTEN.
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| Kavela S, Shinde SR, Ratheesh R, Viswakalyan K, Bashyam MD, Gowrishankar S, Vamsy M, Pattnaik S, Rao S, Sastry RA, Srinivasulu M, Chen J, Maddika S.
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| Cancer Res 73(1):205-14. doi: 10.1158/0008-5472.CAN-12-1394. Epub 2012 Nov 1.
2013
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28 | PTEN, RAD52
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| PTEN sumo-wrestles human RAD52 to mystery land.
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| Shen Z, Huhn S.
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| Cell Cycle 12(23):3585. doi: 10.4161/cc.26820. Epub 2013 Oct 15. No abstract available.
2013
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29 | PTEN, RAD52
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| Chromatin PTEN is involved in DNA damage response partly through regulating Rad52 sumoylation.
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| Choi BH, Chen Y, Dai W.
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| Cell Cycle 12(21):3442-7. doi: 10.4161/cc.26465. Epub 2013 Sep 18.
2013
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30 | INPP4B, PTEN
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| Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities.
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| Lopez SM, Hodgson MC, Packianathan C, Bingol-Ozakpinar O, Uras F, Rosen BP, Agoulnik IU.
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| Biochem Biophys Res Commun 440(2):277-82. doi: 10.1016/j.bbrc.2013.09.077. Epub 2013 Sep 23.
2013
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31 | MC1R, PTEN
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| MC1R is a potent regulator of PTEN after UV exposure in melanocytes.
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| Cao J, Wan L, Hacker E, Dai X, Lenna S, Jimenez-Cervantes C, Wang Y, Leslie NR, Xu GX, Widlund HR, Ryu B, Alani RM, Dutton-Regester K, Goding CR, Hayward NK, Wei W, Cui R.
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| Mol Cell 51(4):409-22. doi: 10.1016/j.molcel.2013.08.010.
2013
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32 | PIKFYVE, PTEN
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| Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics.
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| Hazeki K, Nigorikawa K, Takaba Y, Segawa T, Nukuda A, Masuda A, Ishikawa Y, Kubota K, Takasuga S, Hazeki O.
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| FEBS Lett 586(22):4010-5. doi: 10.1016/j.febslet.2012.09.043. Epub 2012 Oct 12.
2012
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33 | PTEN
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| Regulation of the tumor suppressor PTEN by SUMO.
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| González-Santamaría J, Campagna M, Ortega-Molina A, Marcos-Villar L, de la Cruz-Herrera CF, González D, Gallego P, Lopitz-Otsoa F, Esteban M, Rodríguez MS, Serrano M, Rivas C.
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| Cell Death Dis 3:e393. doi: 10.1038/cddis.2012.135.
2012
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34 | PTEN
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| The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells.
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| Putz U, Howitt J, Doan A, Goh CP, Low LH, Silke J, Tan SS.
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| Sci Signal 5(243):ra70.
2012
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35 | PTEN
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| Regulation of axonal growth and neuromuscular junction formation by neuronal phosphatase and tensin homologue signaling.
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| Li PP, Peng HB.
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| Mol Biol Cell 23(20):4109-17. doi: 10.1091/mbc.E12-05-0367. Epub 2012 Aug 23.
2012
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36 | PTEN
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| SUMO1 modification of PTEN regulates tumorigenesis by controlling its association with the plasma membrane.
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| Huang J, Yan J, Zhang J, Zhu S, Wang Y, Shi T, Zhu C, Chen C, Liu X, Cheng J, Mustelin T, Feng GS, Chen G, Yu J.
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| Nat Commun 3:911. doi: 10.1038/ncomms1919.
2012
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37 | FBXW7, PTEN
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| Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development.
|
| Kwon YW, Kim IJ, Wu D, Lu J, Stock WA Jr, Liu Y, Huang Y, Kang HC, DelRosario R, Jen KY, Perez-Losada J, Wei G, Balmain A, Mao JH.
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| Mol Cancer Res 10(6):834-44. doi: 10.1158/1541-7786.MCR-12-0025. Epub 2012 Apr 18.
2012
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38 | PTEN
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| Functional analysis of the protein phosphatase activity of PTEN.
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| Zhang XC, Piccini A, Myers MP, Van Aelst L, Tonks NK.
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| Biochem J 444(3):457-64. doi: 10.1042/BJ20120098.
2012
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39 | PTEN
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| Cell-type specific roles for PTEN in establishing a functional retinal architecture.
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| Cantrup R, Dixit R, Palmesino E, Bonfield S, Shaker T, Tachibana N, Zinyk D, Dalesman S, Yamakawa K, Stell WK, Wong RO, Reese BE, Kania A, Sauvé Y, Schuurmans C.
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| PLoS One 7(3):e32795. doi: 10.1371/journal.pone.0032795. Epub 2012 Mar 5.
2012
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40 | PTEN
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| Pten coordinates retinal neurogenesis by regulating Notch signalling.
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| Jo HS, Kang KH, Joe CO, Kim JW.
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| EMBO J 31(4):817-28. doi: 10.1038/emboj.2011.443. Epub 2011 Dec 6.
2012
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41 | MIR29B1, PTEN
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| The mechanism involved in the loss of PTEN expression in NSCLC tumor cells.
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| Li G, Zhao J, Peng X, Liang J, Deng X, Chen Y.
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| Biochem Biophys Res Commun 418(3):547-52. doi: 10.1016/j.bbrc.2012.01.065. Epub 2012 Jan 21.
2012
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42 | PHLPP1, PTEN, SLC9A3R1
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| PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma.
|
| Molina JR, Agarwal NK, Morales FC, Hayashi Y, Aldape KD, Cote G, Georgescu MM.
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| Oncogene 31(10):1264-74. doi: 10.1038/onc.2011.324. Epub 2011 Aug 1.
2012
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43 | PTEN
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| Systemic elevation of PTEN induces a tumor-suppressive metabolic state.
|
| Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP.
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| Cell 149(1):49-62. doi: 10.1016/j.cell.2012.02.030. Epub 2012 Mar 6.
2012
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44 | PTEN
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| PTEN, a widely known negative regulator of insulin/PI3K signaling, positively regulates neuronal insulin resistance.
|
| Gupta A, Dey CS.
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| Mol Biol Cell 23(19):3882-98. doi: 10.1091/mbc.E12-05-0337. Epub 2012 Aug 8.
2012
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45 | CBLB, PTEN
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| E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity.
|
| Guo H, Qiao G, Ying H, Li Z, Zhao Y, Liang Y, Yang L, Lipkowitz S, Penninger JM, Langdon WY, Zhang J.
|
| Cell Rep 1(5):472-82.
2012
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46 | MTF1, PTEN
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| PTEN interacts with metal-responsive transcription factor 1 and stimulates its transcriptional activity.
|
| Lin MC, Liu YC, Tam MF, Lu YJ, Hsieh YT, Lin LY.
|
| Biochem J 441(1):367-77. doi: 10.1042/BJ20111257.
2012
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47 | PTEN, TRPC6
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| Involvement of phosphoinositide 3-kinase and PTEN protein in mechanism of activation of TRPC6 protein in vascular smooth muscle cells.
|
| Monet M, Francoeur N, Boulay G.
|
| J Biol Chem 287(21):17672-81. doi: 10.1074/jbc.M112.341354. Epub 2012 Apr 5.
2012
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48 | NDFIP1, PTEN
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| The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells.
|
| Putz U, Howitt J, Doan A, Goh CP, Low LH, Silke J, Tan SS.
|
| Sci Signal 5(243):ra70.
2012
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49 | BRRS, CS, PTEN
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| Analysis of prevalence and degree of macrocephaly in patients with germline PTEN mutations and of brain weight in Pten knock-in murine model.
|
| Mester JL, Tilot AK, Rybicki LA, Frazier TW 2nd, Eng C.
|
| Eur J Hum Genet 19(7):763-8. doi: 10.1038/ejhg.2011.20. Epub 2011 Feb 23.
2011
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50 | CREB1, PTEN
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| CREB is a novel nuclear target of PTEN phosphatase.
|
| Gu T, Zhang Z, Wang J, Guo J, Shen WH, Yin Y.
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| Cancer Res 71(8):2821-5. Epub 2011 Mar 8.
2011
|
51 | PPARD, PTEN
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| PPARδ coordinates angiotensin II-induced senescence in vascular smooth muscle cells through PTEN-mediated inhibition of superoxide generation.
|
| Kim HJ, Ham SA, Kim MY, Hwang JS, Lee H, Kang ES, Yoo T, Woo IS, Yabe-Nishimura C, Paek KS, Kim JH, Seo HG.
|
| J Biol Chem 286(52):44585-93. doi: 10.1074/jbc.M111.222562. Epub 2011 Nov 9.
2011
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52 | PTEN, SOCS3
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| Sustained axon regeneration induced by co-deletion of PTEN and SOCS3.
|
| Sun F, Park KK, Belin S, Wang D, Lu T, Chen G, Zhang K, Yeung C, Feng G, Yankner BA, He Z.
|
| Nature 480(7377):372-5. doi: 10.1038/nature10594.
2011
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53 | INPP4B, PTEN
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| INPP4B: the new kid on the PI3K block.
|
| Agoulnik IU, Hodgson MC, Bowden WA, Ittmann MM.
|
| Oncotarget 2(4):321-8. Review.
2011
|
54 | EIF2S1, PPP1R15B, PTEN
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| Adaptive basal phosphorylation of eIF2α is responsible for resistance to cellular stress-induced cell death in Pten-null hepatocytes.
|
| Zeng N, Li Y, He L, Xu X, Galicia V, Deng C, Stiles BL.
|
| Mol Cancer Res 9(12):1708-17. doi: 10.1158/1541-7786.MCR-11-0299. Epub 2011 Oct 18.
2011
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55 | BMPR1A, DEL10Q23, PTEN
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| Mucinous cystadenoma of ovary in a patient with juvenile polyposis due to 10q23 microdeletion: Expansion of phenotype.
|
| Babovic N, Simmons PS, Moir C, Thorland EC, Scheithauer B, Gliem TJ, Babovic-Vuksanovic D.
|
| Am J Med Genet A 152A(10):2623-7.PMID: 20815035 2010
|
56 | EGR1, PTEN
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| EGR1 reactivation by histone deacetylase inhibitors promotes synovial sarcoma cell death through the PTEN tumor suppressor.
|
| Su L, Cheng H, Sampaio AV, Nielsen TO, Underhill TM.
|
| Oncogene 29(30):4352-61. Epub 2010 May 31.PMID: 20514024 2010
|
57 | DLG4, PTEN
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| PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression.
|
| Jurado S, Benoist M, Lario A, Knafo S, Petrok CN, Esteban JA.
|
| EMBO J 29(16):2827-40. Epub 2010 Jul 13.PMID: 20628354 2010
|
58 | CEBPA, CTNNA1, PTEN
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| An evolutionarily conserved PTEN-C/EBPalpha-CTNNA1 axis controls myeloid development and transformation.
|
| Fu CT, Zhu KY, Mi JQ, Liu YF, Murray ST, Fu YF, Ren CG, Dong ZW, Liu YJ, Dong M, Jin Y, Chen Y, Deng M, Zhang W, Chen B, Breslin P, Chen SJ, Chen Z, Becker MW, Zhu J, Zhang JW, Liu TX.
|
| Blood 115(23):4715-24. Epub 2010 Apr 6.
2010
|
59 | NEDD4, PTEN
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| E3 ligase Nedd4 promotes axon branching by downregulating PTEN.
|
| Drinjakovic J, Jung H, Campbell DS, Strochlic L, Dwivedy A, Holt CE.
|
| Neuron 65(3):341-57.
2010
|
60 | PLXNB1, PTEN, SEMA4D
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| Semaphorin 4D/Plexin-B1 stimulates PTEN activity through R-Ras GTPase-activating protein activity, inducing growth cone collapse in hippocampal neurons.
|
| Oinuma I, Ito Y, Katoh H, Negishi M.
|
| J Biol Chem 285(36):28200-9. doi: 10.1074/jbc.M110.147546. Epub 2010 Jul 7.
2010
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61 | MCAUTS, PTEN
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| Novel PTEN mutations in neurodevelopmental disorders and macrocephaly.
|
| Orrico A, Galli L, Buoni S, Orsi A, Vonella G, Sorrentino V.
|
| Clin Genet 75(2):195-8. Epub 2008 Aug 26.
2009
|
62 | MCAUTS, PTEN
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| 1: The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly.
|
| Varga EA, Pastore M, Prior T, Herman GE, McBride KL.
|
| Genet Med 11(2):111-7.
2009
|
63 | MCAUTS, PTEN
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| The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly.
|
| Varga EA, Pastore M, Prior T, Herman GE, McBride KL.
|
| Genet Med 11(2):111-7.
2009
|
64 | AKT, ERG, PTEN, TMPRSS2
|
| Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis.
|
| King JC, Xu J, Wongvipat J, Hieronymus H, Carver BS, Leung DH, Taylor BS, Sander C, Cardiff RD, Couto SS, Gerald WL, Sawyers CL.
|
| Nat Genet 41(5):524-6. Epub 2009 Apr 26.
2009
|
65 | AKT, ERG, PTEN, TMPRSS2, TMPRSS6
|
| Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate.
|
| Carver BS, Tran J, Gopalan A, Chen Z, Shaikh S, Carracedo A, Alimonti A, Nardella C, Varmeh S, Scardino PT, Cordon-Cardo C, Gerald W, Pandolfi PP.
|
| Nat Genet 41(5):619-24. Epub 2009 Apr 26. 2009
|
66 | PTEN, SLC6A4
|
| Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior.
|
| Page DT, Kuti OJ, Prestia C, Sur M.
|
| Proc Natl Acad Sci U S A 106(6):1989-94.
2009
|
67 | PAWR, PTEN
|
| Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma.
|
| Fernandez-Marcos PJ, Abu-Baker S, Joshi J, Galvez A, Castilla EA, Cañamero M, Collado M, Saez C, Moreno-Bueno G, Palacios J, Leitges M, Serrano M, Moscat J, Diaz-Meco MT.
|
| Proc Natl Acad Sci U S A 106(31):12962-7. Epub 2009 May 26.
2009
|
68 | HIF1A, PTEN, TSC2
|
| TSC2 deficiency increases PTEN via HIF1alpha.
|
| Mahimainathan L, Ghosh-Choudhury N, Venkatesan B, Das F, Mandal CC, Dey N, Habib SL, Kasinath BS, Abboud HE, Ghosh Choudhury G.
|
| J Biol Chem 284(41):27790-8. Epub 2009 Jul 31.PMID: 19648120 2009
|
69 | PRDX1, PTEN
|
| Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity.
|
| Cao J, Schulte J, Knight A, Leslie NR, Zagozdzon A, Bronson R, Manevich Y, Beeson C, Neumann CA.
|
| EMBO J 28(10):1505-17. Epub 2009 Apr 16.
2009
|
70 | BMPR1A, ENG, JPS, JPS2, JPS3, JPS4, PTEN, SMAD4
|
| Large genomic deletions of SMAD4, BMPR1A and PTEN in juvenile polyposis.
|
| van Hattem WA, Brosens LA, de Leng WW, Morsink FH, Lens S, Carvalho R, Giardiello FM, Offerhaus GJ.
|
| Gut 57(5):623-7. Epub 2008 Jan 4.
2008
|
71 | PTEN, SREBF1
|
| Regulation of the PTEN promoter by statins and SREBP.
|
| Teresi RE, Planchon SM, Waite KA, Eng C.
|
| Hum Mol Genet 17(7):919-28. Epub 2007 Dec 7. 2008
|
72 | MXD1, PTEN
|
| Inhibition of apoptosis by MAD1 is mediated by repression of the PTEN tumor suppressor gene.
|
| Rottmann S, Speckgens S, LŸscher-Firzlaff J, LŸscher B.
|
| FASEB J 22(4):1124-34. Epub 2007 Nov 12. 2008
|
73 | PTEN, NEDD4
|
| The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4.
|
| Ahn Y, Hwang CY, Lee SR, Kwon KS, Lee C.
|
| Biochem J 412(2):331-8. 2008
|
74 | NEDD4, PTEN
|
| The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization.
|
| Fouladkou F, Landry T, Kawabe H, Neeb A, Lu C, Brose N, Stambolic V, Rotin D.
|
| Proc Natl Acad Sci U S A 105(25):8585-90. Epub 2008 Jun 18. 2008
|
75 | DEL10Q23, PTEN, BMPRA
|
| Variable phenotypes associated with 10q23 microdeletions involving the PTEN and BMPR1A genes.
|
| Menko FH, Kneepkens CM, de Leeuw N, Peeters EA, Van Maldergem L, Kamsteeg EJ, Davidson R, Rozendaal L, Lasham CA, Peeters-Scholte CM, Jansweijer MC, Hilhorst-Hofstee Y, Gille JJ, Heins YM, Nieuwint AW, Sistermans EA.
|
| Clin Genet 74(2):145-54. Epub 2008 May 28. 2008
|
76 | BZS, PTEN
|
| Bannayan-Riley-Ruvalcaba syndrome with posterior subcapsular congenital cataract and a consensus sequence splicing PTEN mutation.
|
| Boccone L, Dessì V, Serra G, Zibordi F, Loudianos G.
|
| Am J Med Genet A 146A(2):257-60. No abstract available.
2008
|
77 | APC, BRCA1, BRCA2, CDH1, CDKN2A, MLH1, MSH2, MSH6, PMS2, PRSS1, PTEN, RB1, SPINK1, STK11, TP53
|
| Inherited susceptibility to common cancers.
|
| Foulkes WD.
|
| N Engl J Med 359(20):2143-53. No abstract available.
2008
|
78 | FBXW7, MTOR, PTEN
|
| FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.
|
| Mao JH, Kim IJ, Wu D, Climent J, Kang HC, DelRosario R, Balmain A.
|
| Science 321(5895):1499-502. 2008
|
79 | ARL4D, PTEN
|
| Increased expression of the glioma-associated antigen ARF4L after loss of the tumor suppressor PTEN. Laboratory investigation.
|
| Chi JH, Panner A, Cachola K, Crane CA, Murray J, Pieper RO, James CD, Parsa AT.
|
| J Neurosurg 108(2):299-303.PMID: 18240926 2008
|
80 | PTEN
|
| PTEN acetylation modulates its interaction with PDZ domain.
|
| Ikenoue T, Inoki K, Zhao B, Guan KL.
|
| Cancer Res 68(17):6908-12.
2008
|
81 | PTEN, RSL1D1
|
| CSIG inhibits PTEN translation in replicative senescence.
|
| Ma L, Chang N, Guo S, Li Q, Zhang Z, Wang W, Tong T.
|
| Mol Cell Biol 28(20):6290-301. doi: 10.1128/MCB.00142-08. Epub 2008 Aug 4.
2008
|
82 | PTEN
|
| PTEN-deficient intestinal stem cells initiate intestinal polyposis.
|
| He XC, Yin T, Grindley JC, Tian Q, Sato T, Tao WA, Dirisina R, Porter-Westpfahl KS, Hembree M, Johnson T, Wiedemann LM, Barrett TA, Hood L, Wu H, Li L.
|
| Nat Genet 39(2):189-98. Epub 2007 Jan 21. 2007
|
83 | PTEN, NEDD4
|
| NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN.
|
| Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, Gao Z, Wang J, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, Pandolfi PP, Jiang X.
|
| Cell 128(1):129-39. 2007
|
84 | PTEN
|
| Essential role for nuclear PTEN in maintaining chromosomal integrity.
|
| Shen WH, Balajee AS, Wang J, Wu H, Eng C, Pandolfi PP, Yin Y.
|
| Cell 128(1):157-70. 2007
|
85 | MCAUTS, PTEN
|
| Increasing knowledge of PTEN germline mutations: Two additional patients with autism and macrocephaly.
|
| Herman GE, Butter E, Enrile B, Pastore M, Prior TW, Sommer A.
|
| Am J Med Genet A 143(6):589-93. 2007
|
86 | PTEN,PROTLS
|
| Segmental overgrowth, lipomatosis, arteriovenous malformation and epidermal nevus (SOLAMEN) syndrome is related to mosaic PTEN nullizygosity.
|
| Caux F, Plauchu H, Chibon F, Faivre L, Fain O, Vabres P, Bonnet F, Selma ZB, Laroche L, Gerard M, Longy M.
|
| Eur J Hum Genet 15(7):767-73. Epub 2007 Mar 28. 2007
|
87 | PTEN, MHAM
|
| Cowden Syndrome-Affected Patients with PTEN Promoter Mutations Demonstrate Abnormal Protein Translation.
|
| Teresi RE, Zbuk KM, Pezzolesi MG, Waite KA, Eng C.
|
| Am J Hum Genet 81(4):756-67. Epub 2007 Aug 15. 2007
|
88 | PTEN, BZS, MHAM
|
| Cowden syndrome and Bannayan Riley Ruvalcaba syndrome represent one condition with variable expression and age-related penetrance: results of a clinical study of PTEN mutation carriers.
|
| Lachlan KL, Lucassen AM, Bunyan D, Temple IK.
|
| J Med Genet 44(9):579-85. Epub 2007 May 25. 2007
|
89 | JPS, JPS2, JPS3, JPHT, HMPS2, SMAD4, BMPR1A, PTEN
|
| High proportion of large genomic deletions and a genotype phenotype update in 80 unrelated families with juvenile polyposis syndrome.
|
| Aretz S, Stienen D, Uhlhaas S, Stolte M, Entius MM, Loff S, Back W, Kaufmann A, Keller KM, Blaas SH, Siebert R, Vogt S, Spranger S, Holinski-Feder E, Sunde L, Propping P, Friedl W.
|
| J Med Genet 44(11):702-9. Epub 2007 Sep 14. 2007
|
90 | GLTSCR2, PTEN
|
| The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death.
|
| Yim JH, Kim YJ, Ko JH, Cho YE, Kim SM, Kim JY, Lee S, Park JH.
|
| Cell Death Differ 14(11):1872-9. Epub 2007 Jul 27. 2007
|
91 | PTEN, NOTCH1
|
| Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.
|
| Palomero T, Sulis ML, Cortina M, Real PJ, Barnes K, Ciofani M, Caparros E, Buteau J, Brown K, Perkins SL, Bhagat G, Agarwal AM, Basso G, Castillo M, Nagase S, Cordon-Cardo C, Parsons R, Zœ–iga-PflŸcker JC, Dominguez M, Ferrando AA.
|
| Nat Med 13(10):1203-10. Epub 2007 Sep 16. 2007
|
92 | MCAUTS, PTEN
|
| Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly.
|
| Buxbaum JD, Cai G, Chaste P, Nygren G, Goldsmith J, Reichert J, Anckarsäter H, Rastam M, Smith CJ, Silverman JM, Hollander E, Leboyer M, Gillberg C, Verloes A, Betancur C.
|
| Am J Med Genet B Neuropsychiatr Genet 144B(4):484-91.
2007
|
93 | NDUFB8, PTEN
|
| PTEN and NDUFB8 aberrations in cervical cancer tissue.
|
| Hsieh SM, Maguire DJ, Lintell NA, McCabe M, Griffiths LR.
|
| Adv Exp Med Biol 599:31-6.
2007
|
94 | PTEN, MHAM, BZS
|
| Distinct Expression Profiles for PTEN Transcript and Its Splice Variants in Cowden Syndrome and Bannayan-Riley-Ruvalcaba Syndrome.
|
| Sarquis MS, Agrawal S, Shen L, Pilarski R, Zhou XP, Eng C.
|
| Am J Hum Genet 79(1):23-30. Epub 2006 May 22. 2006
|
95 | PTEN
|
| Regulation of the PTEN phosphatase.
|
| Gericke A, Munson M, Ross AH.
|
| Gene 374:1-9. Epub 2006 Mar 14. 2006
|
96 | PTEN, CCND1
|
| The ERK1/2 pathway modulates nuclear PTEN-mediated cell cycle arrest by cyclin D1 transcriptional regulation.
|
| Chung JH, Ostrowski MC, Romigh T, Minaguchi T, Waite KA, Eng C.
|
| Hum Mol Genet 15(17):2553-9. Epub 2006 Jul 18. 2006
|
97 | BZS, PTEN
|
| Bannayan-Riley-Ruvalcaba syndrome with reactive nodular lymphoid hyperplasia and autism and a PTEN mutation.
|
| Boccone L, Dessi V, Zappu A, Piga S, Piludu MB, Rais M, Massidda C, De Virgiliis S, Cao A, Loudianos G.
|
| Am J Med Genet A 140(18):1965-9. No abstract available. 2006
|
98 | PTEN
|
| Mutation-positive and mutation-negative patients with cowden and bannayan-riley-ruvalcaba syndromes associated with distinct 10q haplotypes.
|
| Pezzolesi MG, Li Y, Zhou XP, Pilarski R, Shen L, Eng C.
|
| Am J Hum Genet 79(5):923-34. Epub 2006 Sep 29. 2006
|
99 | PTEN, SPRY2
|
| The tumor suppressor PTEN is necessary for human Sprouty 2-mediated inhibition of cell proliferation.
|
| Edwin F, Singh R, Endersby R, Baker SJ, Patel TB.
|
| J Biol Chem 281(8):4816-22. Epub 2005 Dec 21. 2006
|
100 | DEL10Q23, BMPR1A, PTEN, JPS2
|
| Contiguous gene deletion within chromosome arm 10q is associated with juvenile polyposis of infancy, reflecting cooperation between the BMPR1A and PTEN tumor-suppressor genes.
|
| Delnatte C, Sanlaville D, Mougenot JF, Vermeesch JR, Houdayer C, Blois MC, Genevieve D, Goulet O, Fryns JP, Jaubert F, Vekemans M, Lyonnet S, Romana S, Eng C, Stoppa-Lyonnet D.
|
| Am J Hum Genet 78(6):1066-74. Epub 2006 Apr 14. 2006
|
101 | PTEN
|
| PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3.
|
| Kerr F, Rickle A, Nayeem N, Brandner S, Cowburn RF, Lovestone S.
|
| FEBS Lett 580(13):3121-8. Epub 2006 May 2. 2006
|
102 | BRAF, PTEN
|
| Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma.
|
| Goel VK, Lazar AJ, Warneke CL, Redston MS, Haluska FG.
|
| J Invest Dermatol 126(1):154-60. 2006
|
103 | PTEN, MCAUTS
|
| Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations.
|
| Butler MG, Dasouki MJ, Zhou XP, Talebizadeh Z, Brown M, Takahashi TN, Miles JH, Wang CH, Stratton R, Pilarski R, Eng C.
|
| J Med Genet 42(4):318-21. 2005
|
104 | PTEN, STK11
|
| LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes.
|
| Mehenni H, Lin-Marq N, Buchet-Poyau K, Reymond A, Collart MA, Picard D, Antonarakis SE.
|
| Hum Mol Genet 14(15):2209-19. Epub 2005 Jun 29. 2005
|
105 | MHAM, MTOR, PTEN
|
| Lhermitte-Duclos disease: a report of 31 cases with immunohistochemical analysis of the PTEN/AKT/mTOR pathway.
|
| Abel TW, Baker SJ, Fraser MM, Tihan T, Nelson JS, Yachnis AT, Bouffard JP, Mena H, Burger PC, Eberhart CG.
|
| J Neuropathol Exp Neurol 64(4):341-9. Review. 2005
|
106 | CCDC6, PTEN
|
| Characterization of novel non-clonal intrachromosomal rearrangements between the H4 and PTEN genes (H4/PTEN) in human thyroid cell lines and papillary thyroid cancer specimens.
|
| Puxeddu E, Zhao G, Stringer JR, Medvedovic M, Moretti S, Fagin JA.
|
| Mutat Res 570(1):17-32.PMID: 15680400 2005
|
107 | BMPR1A, SMAD4, PTEN
|
| BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling.
|
| He XC, Zhang J, Tong WG, Tawfik O, Ross J, Scoville DH, Tian Q, Zeng X, He X, Wiedemann LM, Mishina Y, Li L.
|
| Nat Genet 36(10):1117-21. Epub 2004 Sep 19. 2004
|
108 | JPS, JPS2, JPS3, PTEN, BMPR1A, SMAD4
|
| Genetic conditions associated with intestinal juvenile polyps.
|
| Merg A, Howe JR.
|
| Am J Med Genet C Semin Med Genet 129(1):44-55. Review. 2004
|
109 | BMP2, PTEN
|
| BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels.
|
| Waite KA, Eng C.
|
| Hum Mol Genet 12(6):679-84. 2003
|
110 | PTEN
|
| Germline Inactivation of PTEN and Dysregulation of the Phosphoinositol-3-Kinase/Akt Pathway Cause Human Lhermitte-Duclos Disease in Adults.
|
| Zhou XP, Marsh DJ, Morrison CD, Chaudhury AR, Maxwell M, Reifenberger G, Eng C.
|
| Am J Hum Genet 73(5):1191-1198. Epub 2003 Oct 17. 2003
|
111 | PROTLS, PTEN
|
| Proteus syndrome: misdiagnosis with PTEN mutations.
|
| Cohen MM Jr, Turner JT, Biesecker LG.
|
| Am J Med Genet 122A(4):323-4. No abstract available. 2003
|
112 | CDKN2A, DLC1, EXT1, MLH1, PTEN, RB1, TP53, TP73
|
| Molecular pathogenesis of human hepatocellular carcinoma.
|
| Thorgeirsson SS, Grisham JW.
|
| Nat Genet 31(4):339-46. 2002
|
113 | PTEN
|
| Germline mutations in the PTEN gene in Israeli patients with Bannayan-Riley-Ruvalcaba syndrome and women with familial breast cancer.
|
| Figer A, Kaplan A, Frydman M, Lev D, Paswell J, Papa MZ, Goldman B, Friedman E.
|
| Clin Genet 62(4):298-302. 2002
|
114 | MHAM, PTEN
|
| Male breast cancer in Cowden syndrome patients with germline PTEN mutations.
|
| Fackenthal JD, Marsh DJ, Richardson AL, Cummings SA, Eng C, Robinson BG, Olopade OI.
|
| J Med Genet 38(3):159-64. 2001
|
115 | PTEN
|
| PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways.
|
| Weng L, Brown J, Eng C.
|
| Hum Mol Genet 10(3):237-42. 2001
|
116 | PTEN
|
| Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death.
|
| Weng LP, Gimm O, Kum JB, Smith WM, Zhou XP, Wynford-Thomas D, Leone G, Eng C.
|
| Hum Mol Genet 10(3):251-8. 2001
|
117 | PTEN
|
| PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model.
|
| Weng LP, Brown JL, Eng C.
|
| Hum Mol Genet 10(6):599-604. 2001
|
118 | PTEN
|
| PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model.
|
| Weng LP, Smith WM, Brown JL, Eng C.
|
| Hum Mol Genet 10(6):605-16. 2001
|
119 | PTEN
|
| PTEN controls tumor-induced angiogenesis.
|
| Wen S, Stolarov J, Myers MP, Su JD, Wigler MH, Tonks NK, Durden DL.
|
| Proc Natl Acad Sci U S A 98(8):4622-7. 2001
|
120 | PTEN
|
| Association of germline mutation in the PTEN tumour suppressor gene and Proteus and Proteus-like syndromes.
|
| Zhou X, Hampel H, Thiele H, Gorlin RJ, Hennekam RC, Parisi M, Winter RM, Eng C.
|
| Lancet 358(9277):210-1. 2001
|
121 | PTEN
|
| Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression.
|
| Kwabi-Addo B, Giri D, Schmidt K, Podsypanina K, Parsons R, Greenberg N, Ittmann M.
|
| Proc Natl Acad Sci U S A 98(20):11563-8. 2001
|
122 | PTEN
|
| A novel germline mutation of the PTEN gene in a patient with macrocephaly, ventricular dilatation, and features of VATER association.
|
| Reardon W, Zhou XP, Eng C.
|
| J Med Genet 38(12):820-3. 2001
|
123 | MMP2, PTEN
|
| Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN.
|
| Koul D, Parthasarathy R, Shen R, Davies MA, Jasser SA, Chintala SK, Rao JS, Sun Y, Benvenisite EN, Liu TJ, Yung WK.
|
| Oncogene 20(46):6669-78. 2001
|
124 | PTEN, MHAM
|
| PTEN mutation in a family with Cowden syndrome and autism.
|
| Goffin A, Hoefsloot LH, Bosgoed E, Swillen A, Fryns JP.
|
| Am J Med Genet 105(6):521-4. 2001
|
125 | PTEN
|
| Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesis.
|
| Guanti G, Resta N, Simone C, Cariola F, Demma I, Fiorente P, Gentile M.
|
| Hum Mol Genet 9(2):283-7 2000
|
126 | PROTLS, PTEN
|
| Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis.
|
| Zhou XP, Marsh DJ, Hampel H, Mulliken JB, Gimm O, Eng C.
|
| Hum Mol Genet 9(5):765-8. 2000
|
127 | PTEN
|
| Mutations of the human PTEN gene.
|
| Bonneau D, Longy M.
|
| Hum Mutat 16(2):109-22. 2000
|
128 | PTEN
|
| Expression of the PTEN tumour suppressor protein during human development.
|
| Gimm O, Attie-Bitach T, Lees JA, Vekemans M, Eng C.
|
| Hum Mol Genet 9(11):1633-9. 2000
|
129 | MHAM, PTEN
|
| Effect of nonsense mutations on PTEN mRNA stability.
|
| Raizis AM, Ferguson MM, George PM.
|
| Hum Genet 107(1):24-7. 2000
|
130 | PTEN
|
| PTEN / MMAC1 mutation and frequent loss of heterozygosity identified in chromosome 10q in a subset of hepatocellular carcinomas.
|
| Fujiwara Y, Hoon DS, Yamada T, Umeshita K, Gotoh M, Sakon M, Nishisho I, Monden M.
|
| Jpn J Cancer Res 91(3):287-92. 2000
|
131 | PTEN, TSG10A
|
| Identification of PTEN mutations in metastatic melanoma specimens.
|
| Celebi JT, Shendrik I, Silvers DN, Peacocke M.
|
| J Med Genet 37(9):653-7. 2000
|
132 | PTEN, TSG10A
|
| Biallelic inactivating mutations and an occult germline mutation of PTEN in primary cervical carcinomas.
|
| Kurose K, Zhou XP, Araki T, Eng C.
|
| Genes Chromosomes Cancer 29(2):166-72. 2000
|
133 | PTEN
|
| No evidence of germline PTEN mutations in familial prostate cancer.
|
| Forrest MS, Edwards SM, Hamoudi RA, Dearnaley DP, Arden-Jones A, Dowe A, Murkin A, Kelly J, Teare MD, Easton DF, Knowles MA, Bishop DT, Eeles RA.
|
| J Med Genet 37(3):210-2. No abstract available. 2000
|
134 | PTEN
|
| Association of splicing defects in PTEN leading to exon skipping or partial intron retention in Cowden syndrome
|
| Celebi JT, Wanner M, Ping XL, Zhang H, Peacocke M.
|
| Hum Genet 107(3):234-8. 2000
|
135 | MINPP1, PTEN
|
| Absence of germline mutations in MINPP1, a phosphatase encoding gene centromeric of PTEN, in patients with Cowden and Bannayan-Riley-Ruvalcaba syndrome without germline PTEN mutations.
|
| Dahia PM, Gimm O, Chi H, Marsh DJ, Reynolds PR, Eng C.
|
| J Med Genet 37(9):715-7. No abstract available. 2000
|
136 | PTEN
|
| Molecular analysis of PTEN and MXI1 in primary bladder carcinoma.
|
| Wang DS, Rieger-Christ K, Latini JM, Moinzadeh A, Stoffel J, Pezza JA, Saini K, Libertino JA, Summerhayes IC.
|
| Int J Cancer 88(4):620-5. 2000
|
137 | PTEN
|
| Alternative splicing of the human PTEN/MMAC1/TEP1 gene.
|
| Sharrard RM, Maitland NJ.
|
| Biochim Biophys Acta 1494(3):282-5. 2000
|
138 | AKT1, PTEN
|
| PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanisms in haematological malignancies.
|
| Dahia PLM, et al.
|
| Hum Mol Genet 8 : 185-193. 1999
|
139 | MHAM, PTEN
|
| Variant manifestation of Cowden disease in Japan : hamartomatous polyposis of the digestive tract with mutation of the PTEN gene.
|
| Kurose K, et al.
|
| Am J Hum Genet 64 : 308-310. 1999
|
140 | PTEN
|
| New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway.
|
| Cantley LC, et al.
|
| Proc Natl Acad Sci U S A 96(8):4240-5. 1999
|
141 | PTEN
|
| Novel PTEN mutations in patients with Cowden disease: absence of clear genotype-phenotype correlations.
|
| Nelen MR, et al.
|
| Eur J Hum Genet 7(3):267-73. 1999
|
142 | BZS, MHAM, PTEN
|
| Phenotypic findings of Cowden syndrome and Bannayan-Zonana syndrome in a family associated with a single germline mutation in PTEN.
|
| Celebi JT, et al.
|
| J Med Genet 36(5):360-4. 1999
|
143 | PTEN, TSG10A
|
| Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma.
|
| Feilotter HE, et al.
|
| Br J Cancer 79(5-6):718-23. 1999
|
144 | PTEN
|
| Mutational analysis of the PTEN gene in gliomas: molecular and pathological correlations.
|
| Zhou XP, et al.
|
| Int J Cancer 84(2):150-4. 1999
|
145 | PTEN
|
| PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway.
|
| Sun H, et al.
|
| Proc Natl Acad Sci U S A 96(11):6199-204. 1999
|
146 | PTEN
|
| Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis.
|
| Sano T, et al.
|
| Cancer Res 59(8):1820-4. 1999
|
147 | BZS, MHAM, PTEN
|
| PTEN mutation spectrum and genotype-phenotype correlations in bannayan-riley-ruvalcaba syndrome suggest a single entity with cowden syndrome.
|
| Marsh DJ, et al.
|
| Hum Mol Genet 8(8):1461-72. 1999
|
148 | PTEN
|
| The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region.
|
| Georgescu MM, et al.
|
| Proc Natl Acad Sci U S A 96(18):10182-10187. 1999
|
149 | PTEN, STK11
|
| PTEN and LKB1 genes in laryngeal tumours.
|
| Chen RW, Avizienyte E, Roth S, Elivo I, Makittie AA, Aaltonen LM, Aaltonen LA.
|
| J Med Genet 36(12):943-4. No abstract available 1999
|
150 | PTEN
|
| Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways.
|
| Wurmser AE, Gary JD, Emr SD.
|
| J Biol Chem 274(14):9129-32. Review. No abstract available. 1999
|
151 | MHAM, PTEN, TSG10A
|
| Allelic imbalance, including deletion of PTEN/MMACI, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation.
|
| Marsh DJ, Dahia PL, Coulon V, Zheng Z, Dorion-Bonnet F, Call KM, Little R, Lin AY, Eeles RA, Goldstein AM, Hodgson SV, Richardson AL, Robinson BG, Weber HC, Longy M, Eng C.
|
| Genes Chromosomes Cancer 21(1):61-9. 1998
|
152 | JPS2, PTEN
|
| PTEN germ-line mutations in juvenile polyposis coli.
|
| Olschwang S, Serova-Sinilnikova OM, Lenoir GM, Thomas G.
|
| Nat Genet 18(1):12-4. No abstract available. 1998
|
153 | PTEN, PTEN, TSG10A
|
| Sporadic breast cancers exhibit loss of heterozygosity on chromosome segment 10q23 close to the Cowden disease locus.
|
| Singh B, Ittmann MM, Krolewski JJ.
|
| Genes Chromosomes Cancer 21(2):166-71. 1998
|
154 | PTEN, PTENP1, TSG9A
|
| Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines.
|
| Kim SK, et al.
|
| Oncogene 16 : 89-93. 1998
|
155 | BZS, MHAM, PTEN
|
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156 | PTEN
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157 | MHAM, PTEN
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158 | PTEN, TSG10A, KLF6
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159 | PTEN
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160 | PTEN
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161 | BZS, JPS, SMAD4, MHAM, PTEN
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162 | PTEN
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163 | PTEN
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164 | PTEN, TSG10A
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165 | MHAM, PTEN
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166 | PTEN
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| Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas.
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167 | PTEN, TSG10A
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168 | PTEN, TSG10A
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| Mutational analysis of the PTEN gene in head and neck squamous cell carcinoma.
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169 | PTEN, TSG10A, TSG10B
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| Distinct regions of allelic imbalance on chromosome 10q22-q26 in squamous cell carcinomas of the lung.
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170 | PTEN, TSG10A
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171 | PTEN, TSG10A
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| In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma.
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172 | PTEN, STK11
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| Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromes.
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| Wang ZJ, Taylor F, Churchman M, Norbury G, Tomlinson I.
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| Am J Pathol 153 : 363-366. 1998
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173 | PTEN
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| Somatic mutations of the PTEN tumor suppressor gene in sporadic follicular thyroid tumors.
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174 | PTEN
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| PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma.
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175 | PTEN
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| The PTEN tumour suppressor gene and malignant melanoma.
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176 | BZS, MHAM, PTEN
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| Germline PTEN mutation in a family with Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome.
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177 | DMBT1, PTEN
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| Molecular analysis of two putative tumour suppressor genes, PTEN and DMBT, which have been implicated in gliolastoma multiforme disease progression.
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| Oncogene 17 : 1755-1757. 1998
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178 | PTEN, TSG10A
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| The lipid phosphatase activity of PTEN is critical for its tumor suppressor function.
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179 | PTEN
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180 | PTEN, TSG10A
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| Mutation and expression analysis of the putative prostate tumour-suppressor gene PTEN.
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| Br J Cancer 78 : 1296-1300. 1998
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181 | PTEN
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| The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway.
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| Proc Natl Acad Sci U S A 95 : 15587-15591. 1998
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182 | PTEN
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| PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells.
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| Proc Natl Acad Sci U S A 95 : 15406-15411. 1998
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183 | BAX, IGF2R, PTEN
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| The PTEN, BAX, and IGFIIR genes are mutated in endometrial atypical hyperplasia.
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184 | DEL10Q23, JPS, PTEN, PTEN, TSG10A
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| Deletion 10q23.2-q23.33 in a patient with gastrointestinal juvenile polyposis and other features of a Cowden-like syndrome.
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185 | PTEN, TSG10A
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| PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.
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186 | PTEN, TSG10A
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| Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers.
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187 | MHAM, PTEN
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| Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome.
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188 | MHAM, PTEN
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| Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.
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189 | BZS, PTEN
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| Germline mutations in PTEN are present in Bannayan-Zonana syndrome.
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| Nat Genet 16(4):333-4. No abstract available. 1997
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190 | PTEN
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| P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase.
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| Proc Natl Acad Sci U S A 94(17):9052-7. 1997
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191 | PTEN
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| PTEN1 is frequently mutated in primary endometrial carcinomas.
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| Nat Genet 17(2):143-4. 1997
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192 | BZS, PTEN
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| Deletion of 10q23.2-q24.1 including PTEN in a patient with Bannayan-Riley-Ruvalcaba syndrome suggests allelism with Cowden disease. (abstr)
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| Am J Hum Genet 61 : A118. 1997
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193 | PTEN, TSG10A
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| PTEN gene mutations are seen in high-grade but not in low-grade gliomas.
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| Cancer Res 57(19):4187-90. 1997
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194 | PTEN
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| The role of MMAC1 mutations in early-onset breast cancer: causative in association with Cowden syndrome and excluded in BRCA1-negative cases.
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| Tsou HC, Teng DH, Ping XL, Brancolini V, Davis T, Hu R, Xie XX, Gruener AC, Schrager CA, Christiano AM, Eng C, Steck P, Ott J, Tavtigian SV, Peacocke M.
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195 | MHAM, PTEN, TSG10A
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| Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors.
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| Dahia PL, Marsh DJ, Zheng Z, Zedenius J, Komminoth P, Frisk T, Wallin G, Parsons R, Longy M, Larsson C, Eng C.
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| Cancer Res 57(21):4710-3. 1997
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196 | PTEN
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| Exclusion of PTEN and 10q22-24 as the susceptibility locus for juvenile polyposis syndrome.
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| Marsh DJ, Roth S, Lunetta KL, Hemminki A, Dahia PL, Sistonen P, Zheng Z, Caron S, van Orsouw NJ, Bodmer WF, Cottrell SE, Dunlop MG, Eccles D, Hodgson SV, Jarvinen H, Kellokumpu I, Markie D, Neale K, Phillips R, Rozen P, Syngal S, Vijg J, Tomlinson IP, Aaltonen LA, Eng C.
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| Cancer Res 57(22):5017-21. 1997
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197 | MHAM, PTEN, TSG10A
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| Inherited mutations in PTEN that are associated with breast cancer, Cowden disease, and juvenile polyposis.
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| Am J Hum Genet 61(6):1254-60. 1997
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198 | CDC14A, PTEN, CDC14B
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| A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast.
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