| 1 | PIKFYVE, PTEN
|
| Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics.
|
| Hazeki K, Nigorikawa K, Takaba Y, Segawa T, Nukuda A, Masuda A, Ishikawa Y, Kubota K, Takasuga S, Hazeki O.
|
| FEBS Lett 586(22):4010-5. doi: 10.1016/j.febslet.2012.09.043. Epub 2012 Oct 12.
2012
|
| 2 | BRRS, CS, PTEN
|
| Analysis of prevalence and degree of macrocephaly in patients with germline PTEN mutations and of brain weight in Pten knock-in murine model.
|
| Mester JL, Tilot AK, Rybicki LA, Frazier TW 2nd, Eng C.
|
| Eur J Hum Genet 19(7):763-8. doi: 10.1038/ejhg.2011.20. Epub 2011 Feb 23.
2011
|
| 3 | CREB1, PTEN
|
| CREB is a novel nuclear target of PTEN phosphatase.
|
| Gu T, Zhang Z, Wang J, Guo J, Shen WH, Yin Y.
|
| Cancer Res 71(8):2821-5. Epub 2011 Mar 8.
2011
|
| 4 | BMPR1A, DEL10Q23, PTEN
|
| Mucinous cystadenoma of ovary in a patient with juvenile polyposis due to 10q23 microdeletion: Expansion of phenotype.
|
| Babovic N, Simmons PS, Moir C, Thorland EC, Scheithauer B, Gliem TJ, Babovic-Vuksanovic D.
|
| Am J Med Genet A 152A(10):2623-7.PMID: 20815035 2010
|
| 5 | EGR1, PTEN
|
| EGR1 reactivation by histone deacetylase inhibitors promotes synovial sarcoma cell death through the PTEN tumor suppressor.
|
| Su L, Cheng H, Sampaio AV, Nielsen TO, Underhill TM.
|
| Oncogene 29(30):4352-61. Epub 2010 May 31.PMID: 20514024 2010
|
| 6 | DLG4, PTEN
|
| PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression.
|
| Jurado S, Benoist M, Lario A, Knafo S, Petrok CN, Esteban JA.
|
| EMBO J 29(16):2827-40. Epub 2010 Jul 13.PMID: 20628354 2010
|
| 7 | CEBPA, CTNNA1, PTEN
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| An evolutionarily conserved PTEN-C/EBPalpha-CTNNA1 axis controls myeloid development and transformation.
|
| Fu CT, Zhu KY, Mi JQ, Liu YF, Murray ST, Fu YF, Ren CG, Dong ZW, Liu YJ, Dong M, Jin Y, Chen Y, Deng M, Zhang W, Chen B, Breslin P, Chen SJ, Chen Z, Becker MW, Zhu J, Zhang JW, Liu TX.
|
| Blood 115(23):4715-24. Epub 2010 Apr 6.
2010
|
| 8 | NEDD4, PTEN
|
| E3 ligase Nedd4 promotes axon branching by downregulating PTEN.
|
| Drinjakovic J, Jung H, Campbell DS, Strochlic L, Dwivedy A, Holt CE.
|
| Neuron 65(3):341-57.
2010
|
| 9 | MCAUTS, PTEN
|
| Novel PTEN mutations in neurodevelopmental disorders and macrocephaly.
|
| Orrico A, Galli L, Buoni S, Orsi A, Vonella G, Sorrentino V.
|
| Clin Genet 75(2):195-8. Epub 2008 Aug 26.
2009
|
| 10 | MCAUTS, PTEN
|
| 1: The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly.
|
| Varga EA, Pastore M, Prior T, Herman GE, McBride KL.
|
| Genet Med 11(2):111-7.
2009
|
| 11 | MCAUTS, PTEN
|
| The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly.
|
| Varga EA, Pastore M, Prior T, Herman GE, McBride KL.
|
| Genet Med 11(2):111-7.
2009
|
| 12 | AKT, ERG, PTEN, TMPRSS2
|
| Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis.
|
| King JC, Xu J, Wongvipat J, Hieronymus H, Carver BS, Leung DH, Taylor BS, Sander C, Cardiff RD, Couto SS, Gerald WL, Sawyers CL.
|
| Nat Genet 41(5):524-6. Epub 2009 Apr 26.
2009
|
| 13 | AKT, ERG, PTEN, TMPRSS2, TMPRSS6
|
| Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate.
|
| Carver BS, Tran J, Gopalan A, Chen Z, Shaikh S, Carracedo A, Alimonti A, Nardella C, Varmeh S, Scardino PT, Cordon-Cardo C, Gerald W, Pandolfi PP.
|
| Nat Genet 41(5):619-24. Epub 2009 Apr 26. 2009
|
| 14 | PTEN, SLC6A4
|
| Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior.
|
| Page DT, Kuti OJ, Prestia C, Sur M.
|
| Proc Natl Acad Sci U S A 106(6):1989-94.
2009
|
| 15 | PAWR, PTEN
|
| Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma.
|
| Fernandez-Marcos PJ, Abu-Baker S, Joshi J, Galvez A, Castilla EA, Cañamero M, Collado M, Saez C, Moreno-Bueno G, Palacios J, Leitges M, Serrano M, Moscat J, Diaz-Meco MT.
|
| Proc Natl Acad Sci U S A 106(31):12962-7. Epub 2009 May 26.
2009
|
| 16 | HIF1A, PTEN, TSC2
|
| TSC2 deficiency increases PTEN via HIF1alpha.
|
| Mahimainathan L, Ghosh-Choudhury N, Venkatesan B, Das F, Mandal CC, Dey N, Habib SL, Kasinath BS, Abboud HE, Ghosh Choudhury G.
|
| J Biol Chem 284(41):27790-8. Epub 2009 Jul 31.PMID: 19648120 2009
|
| 17 | PRDX1, PTEN
|
| Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity.
|
| Cao J, Schulte J, Knight A, Leslie NR, Zagozdzon A, Bronson R, Manevich Y, Beeson C, Neumann CA.
|
| EMBO J 28(10):1505-17. Epub 2009 Apr 16.
2009
|
| 18 | BMPR1A, ENG, JPS, JPS2, JPS3, JPS4, PTEN, SMAD4
|
| Large genomic deletions of SMAD4, BMPR1A and PTEN in juvenile polyposis.
|
| van Hattem WA, Brosens LA, de Leng WW, Morsink FH, Lens S, Carvalho R, Giardiello FM, Offerhaus GJ.
|
| Gut 57(5):623-7. Epub 2008 Jan 4.
2008
|
| 19 | PTEN, SREBF1
|
| Regulation of the PTEN promoter by statins and SREBP.
|
| Teresi RE, Planchon SM, Waite KA, Eng C.
|
| Hum Mol Genet 17(7):919-28. Epub 2007 Dec 7. 2008
|
| 20 | MXD1, PTEN
|
| Inhibition of apoptosis by MAD1 is mediated by repression of the PTEN tumor suppressor gene.
|
| Rottmann S, Speckgens S, LŸscher-Firzlaff J, LŸscher B.
|
| FASEB J 22(4):1124-34. Epub 2007 Nov 12. 2008
|
| 21 | PTEN, NEDD4
|
| The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4.
|
| Ahn Y, Hwang CY, Lee SR, Kwon KS, Lee C.
|
| Biochem J 412(2):331-8. 2008
|
| 22 | NEDD4, PTEN
|
| The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization.
|
| Fouladkou F, Landry T, Kawabe H, Neeb A, Lu C, Brose N, Stambolic V, Rotin D.
|
| Proc Natl Acad Sci U S A 105(25):8585-90. Epub 2008 Jun 18. 2008
|
| 23 | DEL10Q23, PTEN, BMPRA
|
| Variable phenotypes associated with 10q23 microdeletions involving the PTEN and BMPR1A genes.
|
| Menko FH, Kneepkens CM, de Leeuw N, Peeters EA, Van Maldergem L, Kamsteeg EJ, Davidson R, Rozendaal L, Lasham CA, Peeters-Scholte CM, Jansweijer MC, Hilhorst-Hofstee Y, Gille JJ, Heins YM, Nieuwint AW, Sistermans EA.
|
| Clin Genet 74(2):145-54. Epub 2008 May 28. 2008
|
| 24 | BZS, PTEN
|
| Bannayan-Riley-Ruvalcaba syndrome with posterior subcapsular congenital cataract and a consensus sequence splicing PTEN mutation.
|
| Boccone L, Dessì V, Serra G, Zibordi F, Loudianos G.
|
| Am J Med Genet A 146A(2):257-60. No abstract available.
2008
|
| 25 | APC, BRCA1, BRCA2, CDH1, CDKN2A, MLH1, MSH2, MSH6, PMS2, PRSS1, PTEN, RB1, SPINK1, STK11, TP53
|
| Inherited susceptibility to common cancers.
|
| Foulkes WD.
|
| N Engl J Med 359(20):2143-53. No abstract available.
2008
|
| 26 | FBXW7, MTOR, PTEN
|
| FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.
|
| Mao JH, Kim IJ, Wu D, Climent J, Kang HC, DelRosario R, Balmain A.
|
| Science 321(5895):1499-502. 2008
|
| 27 | ARL4D, PTEN
|
| Increased expression of the glioma-associated antigen ARF4L after loss of the tumor suppressor PTEN. Laboratory investigation.
|
| Chi JH, Panner A, Cachola K, Crane CA, Murray J, Pieper RO, James CD, Parsa AT.
|
| J Neurosurg 108(2):299-303.PMID: 18240926 2008
|
| 28 | PTEN
|
| PTEN acetylation modulates its interaction with PDZ domain.
|
| Ikenoue T, Inoki K, Zhao B, Guan KL.
|
| Cancer Res 68(17):6908-12.
2008
|
| 29 | PTEN
|
| PTEN-deficient intestinal stem cells initiate intestinal polyposis.
|
| He XC, Yin T, Grindley JC, Tian Q, Sato T, Tao WA, Dirisina R, Porter-Westpfahl KS, Hembree M, Johnson T, Wiedemann LM, Barrett TA, Hood L, Wu H, Li L.
|
| Nat Genet 39(2):189-98. Epub 2007 Jan 21. 2007
|
| 30 | PTEN, NEDD4
|
| NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN.
|
| Wang X, Trotman LC, Koppie T, Alimonti A, Chen Z, Gao Z, Wang J, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, Pandolfi PP, Jiang X.
|
| Cell 128(1):129-39. 2007
|
| 31 | PTEN
|
| Essential role for nuclear PTEN in maintaining chromosomal integrity.
|
| Shen WH, Balajee AS, Wang J, Wu H, Eng C, Pandolfi PP, Yin Y.
|
| Cell 128(1):157-70. 2007
|
| 32 | MCAUTS, PTEN
|
| Increasing knowledge of PTEN germline mutations: Two additional patients with autism and macrocephaly.
|
| Herman GE, Butter E, Enrile B, Pastore M, Prior TW, Sommer A.
|
| Am J Med Genet A 143(6):589-93. 2007
|
| 33 | PTEN,PROTLS
|
| Segmental overgrowth, lipomatosis, arteriovenous malformation and epidermal nevus (SOLAMEN) syndrome is related to mosaic PTEN nullizygosity.
|
| Caux F, Plauchu H, Chibon F, Faivre L, Fain O, Vabres P, Bonnet F, Selma ZB, Laroche L, Gerard M, Longy M.
|
| Eur J Hum Genet 15(7):767-73. Epub 2007 Mar 28. 2007
|
| 34 | PTEN, MHAM
|
| Cowden Syndrome-Affected Patients with PTEN Promoter Mutations Demonstrate Abnormal Protein Translation.
|
| Teresi RE, Zbuk KM, Pezzolesi MG, Waite KA, Eng C.
|
| Am J Hum Genet 81(4):756-67. Epub 2007 Aug 15. 2007
|
| 35 | PTEN, BZS, MHAM
|
| Cowden syndrome and Bannayan Riley Ruvalcaba syndrome represent one condition with variable expression and age-related penetrance: results of a clinical study of PTEN mutation carriers.
|
| Lachlan KL, Lucassen AM, Bunyan D, Temple IK.
|
| J Med Genet 44(9):579-85. Epub 2007 May 25. 2007
|
| 36 | JPS, JPS2, JPS3, JPHT, HMPS2, SMAD4, BMPR1A, PTEN
|
| High proportion of large genomic deletions and a genotype phenotype update in 80 unrelated families with juvenile polyposis syndrome.
|
| Aretz S, Stienen D, Uhlhaas S, Stolte M, Entius MM, Loff S, Back W, Kaufmann A, Keller KM, Blaas SH, Siebert R, Vogt S, Spranger S, Holinski-Feder E, Sunde L, Propping P, Friedl W.
|
| J Med Genet 44(11):702-9. Epub 2007 Sep 14. 2007
|
| 37 | GLTSCR2, PTEN
|
| The putative tumor suppressor gene GLTSCR2 induces PTEN-modulated cell death.
|
| Yim JH, Kim YJ, Ko JH, Cho YE, Kim SM, Kim JY, Lee S, Park JH.
|
| Cell Death Differ 14(11):1872-9. Epub 2007 Jul 27. 2007
|
| 38 | PTEN, NOTCH1
|
| Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.
|
| Palomero T, Sulis ML, Cortina M, Real PJ, Barnes K, Ciofani M, Caparros E, Buteau J, Brown K, Perkins SL, Bhagat G, Agarwal AM, Basso G, Castillo M, Nagase S, Cordon-Cardo C, Parsons R, Zœ–iga-PflŸcker JC, Dominguez M, Ferrando AA.
|
| Nat Med 13(10):1203-10. Epub 2007 Sep 16. 2007
|
| 39 | MCAUTS, PTEN
|
| Mutation screening of the PTEN gene in patients with autism spectrum disorders and macrocephaly.
|
| Buxbaum JD, Cai G, Chaste P, Nygren G, Goldsmith J, Reichert J, Anckarsäter H, Rastam M, Smith CJ, Silverman JM, Hollander E, Leboyer M, Gillberg C, Verloes A, Betancur C.
|
| Am J Med Genet B Neuropsychiatr Genet 144B(4):484-91.
2007
|
| 40 | PTEN, MHAM, BZS
|
| Distinct Expression Profiles for PTEN Transcript and Its Splice Variants in Cowden Syndrome and Bannayan-Riley-Ruvalcaba Syndrome.
|
| Sarquis MS, Agrawal S, Shen L, Pilarski R, Zhou XP, Eng C.
|
| Am J Hum Genet 79(1):23-30. Epub 2006 May 22. 2006
|
| 41 | PTEN
|
| Regulation of the PTEN phosphatase.
|
| Gericke A, Munson M, Ross AH.
|
| Gene 374:1-9. Epub 2006 Mar 14. 2006
|
| 42 | PTEN, CCND1
|
| The ERK1/2 pathway modulates nuclear PTEN-mediated cell cycle arrest by cyclin D1 transcriptional regulation.
|
| Chung JH, Ostrowski MC, Romigh T, Minaguchi T, Waite KA, Eng C.
|
| Hum Mol Genet 15(17):2553-9. Epub 2006 Jul 18. 2006
|
| 43 | BZS, PTEN
|
| Bannayan-Riley-Ruvalcaba syndrome with reactive nodular lymphoid hyperplasia and autism and a PTEN mutation.
|
| Boccone L, Dessi V, Zappu A, Piga S, Piludu MB, Rais M, Massidda C, De Virgiliis S, Cao A, Loudianos G.
|
| Am J Med Genet A 140(18):1965-9. No abstract available. 2006
|
| 44 | PTEN
|
| Mutation-positive and mutation-negative patients with cowden and bannayan-riley-ruvalcaba syndromes associated with distinct 10q haplotypes.
|
| Pezzolesi MG, Li Y, Zhou XP, Pilarski R, Shen L, Eng C.
|
| Am J Hum Genet 79(5):923-34. Epub 2006 Sep 29. 2006
|
| 45 | PTEN, SPRY2
|
| The tumor suppressor PTEN is necessary for human Sprouty 2-mediated inhibition of cell proliferation.
|
| Edwin F, Singh R, Endersby R, Baker SJ, Patel TB.
|
| J Biol Chem 281(8):4816-22. Epub 2005 Dec 21. 2006
|
| 46 | DEL10Q23, BMPR1A, PTEN, JPS2
|
| Contiguous gene deletion within chromosome arm 10q is associated with juvenile polyposis of infancy, reflecting cooperation between the BMPR1A and PTEN tumor-suppressor genes.
|
| Delnatte C, Sanlaville D, Mougenot JF, Vermeesch JR, Houdayer C, Blois MC, Genevieve D, Goulet O, Fryns JP, Jaubert F, Vekemans M, Lyonnet S, Romana S, Eng C, Stoppa-Lyonnet D.
|
| Am J Hum Genet 78(6):1066-74. Epub 2006 Apr 14. 2006
|
| 47 | PTEN
|
| PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3.
|
| Kerr F, Rickle A, Nayeem N, Brandner S, Cowburn RF, Lovestone S.
|
| FEBS Lett 580(13):3121-8. Epub 2006 May 2. 2006
|
| 48 | BRAF, PTEN
|
| Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma.
|
| Goel VK, Lazar AJ, Warneke CL, Redston MS, Haluska FG.
|
| J Invest Dermatol 126(1):154-60. 2006
|
| 49 | PTEN, MCAUTS
|
| Subset of individuals with autism spectrum disorders and extreme macrocephaly associated with germline PTEN tumour suppressor gene mutations.
|
| Butler MG, Dasouki MJ, Zhou XP, Talebizadeh Z, Brown M, Takahashi TN, Miles JH, Wang CH, Stratton R, Pilarski R, Eng C.
|
| J Med Genet 42(4):318-21. 2005
|
| 50 | PTEN, STK11
|
| LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes.
|
| Mehenni H, Lin-Marq N, Buchet-Poyau K, Reymond A, Collart MA, Picard D, Antonarakis SE.
|
| Hum Mol Genet 14(15):2209-19. Epub 2005 Jun 29. 2005
|
| 51 | MHAM, MTOR, PTEN
|
| Lhermitte-Duclos disease: a report of 31 cases with immunohistochemical analysis of the PTEN/AKT/mTOR pathway.
|
| Abel TW, Baker SJ, Fraser MM, Tihan T, Nelson JS, Yachnis AT, Bouffard JP, Mena H, Burger PC, Eberhart CG.
|
| J Neuropathol Exp Neurol 64(4):341-9. Review. 2005
|
| 52 | CCDC6, PTEN
|
| Characterization of novel non-clonal intrachromosomal rearrangements between the H4 and PTEN genes (H4/PTEN) in human thyroid cell lines and papillary thyroid cancer specimens.
|
| Puxeddu E, Zhao G, Stringer JR, Medvedovic M, Moretti S, Fagin JA.
|
| Mutat Res 570(1):17-32.PMID: 15680400 2005
|
| 53 | BMPR1A, SMAD4, PTEN
|
| BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling.
|
| He XC, Zhang J, Tong WG, Tawfik O, Ross J, Scoville DH, Tian Q, Zeng X, He X, Wiedemann LM, Mishina Y, Li L.
|
| Nat Genet 36(10):1117-21. Epub 2004 Sep 19. 2004
|
| 54 | JPS, JPS2, JPS3, PTEN, BMPR1A, SMAD4
|
| Genetic conditions associated with intestinal juvenile polyps.
|
| Merg A, Howe JR.
|
| Am J Med Genet C Semin Med Genet 129(1):44-55. Review. 2004
|
| 55 | BMP2, PTEN
|
| BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels.
|
| Waite KA, Eng C.
|
| Hum Mol Genet 12(6):679-84. 2003
|
| 56 | PTEN
|
| Germline Inactivation of PTEN and Dysregulation of the Phosphoinositol-3-Kinase/Akt Pathway Cause Human Lhermitte-Duclos Disease in Adults.
|
| Zhou XP, Marsh DJ, Morrison CD, Chaudhury AR, Maxwell M, Reifenberger G, Eng C.
|
| Am J Hum Genet 73(5):1191-1198. Epub 2003 Oct 17. 2003
|
| 57 | PROTLS, PTEN
|
| Proteus syndrome: misdiagnosis with PTEN mutations.
|
| Cohen MM Jr, Turner JT, Biesecker LG.
|
| Am J Med Genet 122A(4):323-4. No abstract available. 2003
|
| 58 | CDKN2A, DLC1, EXT1, MLH1, PTEN, RB1, TP53, TP73
|
| Molecular pathogenesis of human hepatocellular carcinoma.
|
| Thorgeirsson SS, Grisham JW.
|
| Nat Genet 31(4):339-46. 2002
|
| 59 | PTEN
|
| Germline mutations in the PTEN gene in Israeli patients with Bannayan-Riley-Ruvalcaba syndrome and women with familial breast cancer.
|
| Figer A, Kaplan A, Frydman M, Lev D, Paswell J, Papa MZ, Goldman B, Friedman E.
|
| Clin Genet 62(4):298-302. 2002
|
| 60 | MHAM, PTEN
|
| Male breast cancer in Cowden syndrome patients with germline PTEN mutations.
|
| Fackenthal JD, Marsh DJ, Richardson AL, Cummings SA, Eng C, Robinson BG, Olopade OI.
|
| J Med Genet 38(3):159-64. 2001
|
| 61 | PTEN
|
| PTEN induces apoptosis and cell cycle arrest through phosphoinositol-3-kinase/Akt-dependent and -independent pathways.
|
| Weng L, Brown J, Eng C.
|
| Hum Mol Genet 10(3):237-42. 2001
|
| 62 | PTEN
|
| Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death.
|
| Weng LP, Gimm O, Kum JB, Smith WM, Zhou XP, Wynford-Thomas D, Leone G, Eng C.
|
| Hum Mol Genet 10(3):251-8. 2001
|
| 63 | PTEN
|
| PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model.
|
| Weng LP, Brown JL, Eng C.
|
| Hum Mol Genet 10(6):599-604. 2001
|
| 64 | PTEN
|
| PTEN inhibits insulin-stimulated MEK/MAPK activation and cell growth by blocking IRS-1 phosphorylation and IRS-1/Grb-2/Sos complex formation in a breast cancer model.
|
| Weng LP, Smith WM, Brown JL, Eng C.
|
| Hum Mol Genet 10(6):605-16. 2001
|
| 65 | PTEN
|
| PTEN controls tumor-induced angiogenesis.
|
| Wen S, Stolarov J, Myers MP, Su JD, Wigler MH, Tonks NK, Durden DL.
|
| Proc Natl Acad Sci U S A 98(8):4622-7. 2001
|
| 66 | PTEN
|
| Association of germline mutation in the PTEN tumour suppressor gene and Proteus and Proteus-like syndromes.
|
| Zhou X, Hampel H, Thiele H, Gorlin RJ, Hennekam RC, Parisi M, Winter RM, Eng C.
|
| Lancet 358(9277):210-1. 2001
|
| 67 | PTEN
|
| Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression.
|
| Kwabi-Addo B, Giri D, Schmidt K, Podsypanina K, Parsons R, Greenberg N, Ittmann M.
|
| Proc Natl Acad Sci U S A 98(20):11563-8. 2001
|
| 68 | PTEN
|
| A novel germline mutation of the PTEN gene in a patient with macrocephaly, ventricular dilatation, and features of VATER association.
|
| Reardon W, Zhou XP, Eng C.
|
| J Med Genet 38(12):820-3. 2001
|
| 69 | MMP2, PTEN
|
| Suppression of matrix metalloproteinase-2 gene expression and invasion in human glioma cells by MMAC/PTEN.
|
| Koul D, Parthasarathy R, Shen R, Davies MA, Jasser SA, Chintala SK, Rao JS, Sun Y, Benvenisite EN, Liu TJ, Yung WK.
|
| Oncogene 20(46):6669-78. 2001
|
| 70 | PTEN, MHAM
|
| PTEN mutation in a family with Cowden syndrome and autism.
|
| Goffin A, Hoefsloot LH, Bosgoed E, Swillen A, Fryns JP.
|
| Am J Med Genet 105(6):521-4. 2001
|
| 71 | PTEN
|
| Involvement of PTEN mutations in the genetic pathways of colorectal cancerogenesis.
|
| Guanti G, Resta N, Simone C, Cariola F, Demma I, Fiorente P, Gentile M.
|
| Hum Mol Genet 9(2):283-7 2000
|
| 72 | PROTLS, PTEN
|
| Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arteriovenous malformations and lipomatosis.
|
| Zhou XP, Marsh DJ, Hampel H, Mulliken JB, Gimm O, Eng C.
|
| Hum Mol Genet 9(5):765-8. 2000
|
| 73 | PTEN
|
| Mutations of the human PTEN gene.
|
| Bonneau D, Longy M.
|
| Hum Mutat 16(2):109-22. 2000
|
| 74 | PTEN
|
| Expression of the PTEN tumour suppressor protein during human development.
|
| Gimm O, Attie-Bitach T, Lees JA, Vekemans M, Eng C.
|
| Hum Mol Genet 9(11):1633-9. 2000
|
| 75 | MHAM, PTEN
|
| Effect of nonsense mutations on PTEN mRNA stability.
|
| Raizis AM, Ferguson MM, George PM.
|
| Hum Genet 107(1):24-7. 2000
|
| 76 | PTEN
|
| PTEN / MMAC1 mutation and frequent loss of heterozygosity identified in chromosome 10q in a subset of hepatocellular carcinomas.
|
| Fujiwara Y, Hoon DS, Yamada T, Umeshita K, Gotoh M, Sakon M, Nishisho I, Monden M.
|
| Jpn J Cancer Res 91(3):287-92. 2000
|
| 77 | PTEN, TSG10A
|
| Identification of PTEN mutations in metastatic melanoma specimens.
|
| Celebi JT, Shendrik I, Silvers DN, Peacocke M.
|
| J Med Genet 37(9):653-7. 2000
|
| 78 | PTEN, TSG10A
|
| Biallelic inactivating mutations and an occult germline mutation of PTEN in primary cervical carcinomas.
|
| Kurose K, Zhou XP, Araki T, Eng C.
|
| Genes Chromosomes Cancer 29(2):166-72. 2000
|
| 79 | PTEN
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| No evidence of germline PTEN mutations in familial prostate cancer.
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| Forrest MS, Edwards SM, Hamoudi RA, Dearnaley DP, Arden-Jones A, Dowe A, Murkin A, Kelly J, Teare MD, Easton DF, Knowles MA, Bishop DT, Eeles RA.
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| J Med Genet 37(3):210-2. No abstract available. 2000
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| 80 | PTEN
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| Association of splicing defects in PTEN leading to exon skipping or partial intron retention in Cowden syndrome
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| Celebi JT, Wanner M, Ping XL, Zhang H, Peacocke M.
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| Hum Genet 107(3):234-8. 2000
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| 81 | MINPP1, PTEN
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| Absence of germline mutations in MINPP1, a phosphatase encoding gene centromeric of PTEN, in patients with Cowden and Bannayan-Riley-Ruvalcaba syndrome without germline PTEN mutations.
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| Dahia PM, Gimm O, Chi H, Marsh DJ, Reynolds PR, Eng C.
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| J Med Genet 37(9):715-7. No abstract available. 2000
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| 82 | PTEN
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| Molecular analysis of PTEN and MXI1 in primary bladder carcinoma.
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| Wang DS, Rieger-Christ K, Latini JM, Moinzadeh A, Stoffel J, Pezza JA, Saini K, Libertino JA, Summerhayes IC.
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| Int J Cancer 88(4):620-5. 2000
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| 83 | PTEN
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| Alternative splicing of the human PTEN/MMAC1/TEP1 gene.
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| Sharrard RM, Maitland NJ.
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| Biochim Biophys Acta 1494(3):282-5. 2000
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| 84 | AKT1, PTEN
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| PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanisms in haematological malignancies.
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| Dahia PLM, et al.
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| Hum Mol Genet 8 : 185-193. 1999
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| 85 | MHAM, PTEN
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| Variant manifestation of Cowden disease in Japan : hamartomatous polyposis of the digestive tract with mutation of the PTEN gene.
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| Kurose K, et al.
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| Am J Hum Genet 64 : 308-310. 1999
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| 86 | PTEN
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| New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway.
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| Cantley LC, et al.
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| Proc Natl Acad Sci U S A 96(8):4240-5. 1999
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| 87 | PTEN
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| Novel PTEN mutations in patients with Cowden disease: absence of clear genotype-phenotype correlations.
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| Nelen MR, et al.
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| Eur J Hum Genet 7(3):267-73. 1999
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| 88 | BZS, MHAM, PTEN
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| Phenotypic findings of Cowden syndrome and Bannayan-Zonana syndrome in a family associated with a single germline mutation in PTEN.
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| Celebi JT, et al.
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| J Med Genet 36(5):360-4. 1999
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| 89 | PTEN, TSG10A
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| Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma.
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| Feilotter HE, et al.
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| Br J Cancer 79(5-6):718-23. 1999
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| 90 | PTEN
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| Mutational analysis of the PTEN gene in gliomas: molecular and pathological correlations.
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| Zhou XP, et al.
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| Int J Cancer 84(2):150-4. 1999
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| 91 | PTEN
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| PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway.
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| Sun H, et al.
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| Proc Natl Acad Sci U S A 96(11):6199-204. 1999
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| 92 | PTEN
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| Differential expression of MMAC/PTEN in glioblastoma multiforme: relationship to localization and prognosis.
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| Sano T, et al.
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| Cancer Res 59(8):1820-4. 1999
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| 93 | BZS, MHAM, PTEN
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| PTEN mutation spectrum and genotype-phenotype correlations in bannayan-riley-ruvalcaba syndrome suggest a single entity with cowden syndrome.
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| Marsh DJ, et al.
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| Hum Mol Genet 8(8):1461-72. 1999
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| 94 | PTEN
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| The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region.
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| Georgescu MM, et al.
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| Proc Natl Acad Sci U S A 96(18):10182-10187. 1999
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| 95 | PTEN, STK11
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| PTEN and LKB1 genes in laryngeal tumours.
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| Chen RW, Avizienyte E, Roth S, Elivo I, Makittie AA, Aaltonen LM, Aaltonen LA.
|
| J Med Genet 36(12):943-4. No abstract available 1999
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| 96 | PTEN
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| Phosphoinositide 3-kinases and their FYVE domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways.
|
| Wurmser AE, Gary JD, Emr SD.
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| J Biol Chem 274(14):9129-32. Review. No abstract available. 1999
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| 97 | MHAM, PTEN, TSG10A
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| Allelic imbalance, including deletion of PTEN/MMACI, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation.
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| Marsh DJ, Dahia PL, Coulon V, Zheng Z, Dorion-Bonnet F, Call KM, Little R, Lin AY, Eeles RA, Goldstein AM, Hodgson SV, Richardson AL, Robinson BG, Weber HC, Longy M, Eng C.
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| Genes Chromosomes Cancer 21(1):61-9. 1998
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| 98 | JPS2, PTEN
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| PTEN germ-line mutations in juvenile polyposis coli.
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| Olschwang S, Serova-Sinilnikova OM, Lenoir GM, Thomas G.
|
| Nat Genet 18(1):12-4. No abstract available. 1998
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| 99 | PTEN, PTEN, TSG10A
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| Sporadic breast cancers exhibit loss of heterozygosity on chromosome segment 10q23 close to the Cowden disease locus.
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| Singh B, Ittmann MM, Krolewski JJ.
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| Genes Chromosomes Cancer 21(2):166-71. 1998
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| 100 | PTEN, PTENP1, TSG9A
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| Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines.
|
| Kim SK, et al.
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| Oncogene 16 : 89-93. 1998
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| 101 | BZS, MHAM, PTEN
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| Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation.
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| Marsh DJ, Coulon V, Lunetta KL, Rocca-Serra P, Dahia PL, Zheng Z, Liaw D, Caron S, Duboue B, Lin AY, Richardson AL, Bonnetblanc JM, Bressieux JM, Cabarrot-Moreau A, Chompret A, Demange L, Eeles RA, Yahanda AM, Fearon ER, Fricker JP, Gorlin RJ, Hodgson SV, Huson S, Lacombe D, Eng C, et al.
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| Hum Mol Genet 7(3):507-15. 1998
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| 102 | PTEN
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| PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas.
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| Chiariello E, et al.
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| Oncogene 16 : 541-545. 1998
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| 103 | MHAM, PTEN
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| The genetic basis of Cowden's syndrome : three novel mutations in PTEN/MMAC1/TEP1.
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| Tsou HC, et al.
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| Hum Genet 102 : 467-473. 1998
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| 104 | PTEN, TSG10A, KLF6
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| Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades.
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| Ichimura K, et al.
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| Genes Chromosomes Cancer 22 : 9-15. 1998
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| 105 | PTEN
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| Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN.
|
| Tamura M, et al.
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| Science 280 : 1614-1617. 1998
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| 106 | PTEN
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| PTEN mutations in gliomas and glioneuronal tumors.
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| Duerr EM, et al.
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| Oncogene 16 : 2259-2264. 1998
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| 107 | BZS, JPS, SMAD4, MHAM, PTEN
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| PTEN and inherited hamartoma-cancer syndromes.
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| Eng C, et al.
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| Nat Genet 19 : 223. 1998
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| 108 | PTEN
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| Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors.
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| Obata K, et al.
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| Cancer Res 58 : 2095-2097. 1998
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| 109 | PTEN
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| Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias.
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| Maxwell GL, et al.
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| Cancer Res 58 : 2500-2503. 1998
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| 110 | PTEN, TSG10A
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| Pten is essential for embryonic development and tumour suppression.
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| Di Cristofano A, et al.
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| Nat Genet 19 : 348-355. 1998
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| 111 | MHAM, PTEN
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| Germline mutations of the PTEN/MMAC1 gene in Japanese patients with Cowden disease.
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| Kohno T, et al.
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| Jpn J Cancer Res 89 : 471-474. 1998
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| 112 | PTEN
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| Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas.
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| Maier D, et al.
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| Oncogene 16 : 3331-3335. 1998
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| 113 | PTEN, TSG10A
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| PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers.
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| Yokomizo A, et al.
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| Oncogene 17 : 475-479. 1998
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| 114 | PTEN, TSG10A
|
| Mutational analysis of the PTEN gene in head and neck squamous cell carcinoma.
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| Shao X, et al.
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| Int J Cancer 77 : 684-688. 1998
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| 115 | PTEN, TSG10A, TSG10B
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| Distinct regions of allelic imbalance on chromosome 10q22-q26 in squamous cell carcinomas of the lung.
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| Petersen S, et al.
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| Oncogene 17 : 449-454. 1998
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| 116 | PTEN, TSG10A
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| PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas.
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| Tohma Y, et al.
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| J Neuropathol Exp Neurol 57 : 684-689. 1998
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| 117 | PTEN, TSG10A
|
| In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma.
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| Robertson GP, et al.
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| Proc Natl Acad Sci U S A 95 : 9418-9423. 1998
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| 118 | PTEN, STK11
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| Genetic pathways of colorectal carcinogenesis rarely involve the PTEN and LKB1 genes outside the inherited hamartoma syndromes.
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| Wang ZJ, Taylor F, Churchman M, Norbury G, Tomlinson I.
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| Am J Pathol 153 : 363-366. 1998
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| 119 | PTEN
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| Somatic mutations of the PTEN tumor suppressor gene in sporadic follicular thyroid tumors.
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| Halachmi N, Halachmi S, Evron E, Cairns P, Okami K, Saji M, Westra WH, Zeiger MA, Jen J, Sidransky D.
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| Genes Chromosomes Cancer 23(3):239-43. 1998
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| 120 | PTEN
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| PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma.
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| Levine RL, et al.
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| Cancer Res 58 : 3254-3258. 1998
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| 121 | PTEN
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| The PTEN tumour suppressor gene and malignant melanoma.
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| Boni R, et al.
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| Melanoma Res 8 : 300-302. 1998
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| 122 | BZS, MHAM, PTEN
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| Germline PTEN mutation in a family with Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome.
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| Zori RT, et al.
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| Am J Med Genet 80 : 399-402. 1998
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| 123 | DMBT1, PTEN
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| Molecular analysis of two putative tumour suppressor genes, PTEN and DMBT, which have been implicated in gliolastoma multiforme disease progression.
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| Somerville RP, et al.
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| Oncogene 17 : 1755-1757. 1998
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| 124 | PTEN, TSG10A
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| The lipid phosphatase activity of PTEN is critical for its tumor suppressor function.
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| Myers MP, Pass I, Batty IH, Van der Kaay J, Stolarov JP, Hemmings BA, Wigler MH, Downes CP, Tonks NK.
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| Proc Natl Acad Sci U S A 95 : 13513-13518. 1998
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| 125 | PTEN
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| PTEN gene alterations in lymphoid neoplasms.
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| Sakai A, Thieblemont C, Wellmann A, Jaffe ES, Raffeld M.
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| Blood 92 : 3410-3415. 1998
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| 126 | PTEN, TSG10A
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| Mutation and expression analysis of the putative prostate tumour-suppressor gene PTEN.
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| Gray IC, et al.
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| Br J Cancer 78 : 1296-1300. 1998
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| 127 | PTEN
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| The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway.
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| Wu X, et al.
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| Proc Natl Acad Sci U S A 95 : 15587-15591. 1998
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| 128 | PTEN
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| PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells.
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| Li DM, et al.
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| Proc Natl Acad Sci U S A 95 : 15406-15411. 1998
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| 129 | BAX, IGF2R, PTEN
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| The PTEN, BAX, and IGFIIR genes are mutated in endometrial atypical hyperplasia.
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| Yoshinaga K, et al.
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| Jpn J Cancer Res 89 : 985-990. 1998
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| 130 | DEL10Q23, JPS, PTEN, PTEN, TSG10A
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| Deletion 10q23.2-q23.33 in a patient with gastrointestinal juvenile polyposis and other features of a Cowden-like syndrome.
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| Tsuchiya KD, Wiesner G, Cassidy SB, Limwongse C, Boyle JT, Schwartz S.
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| Genes Chromosomes Cancer 21(2):113-8. 1998
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| 131 | PTEN, TSG10A
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| PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer.
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| Li J, et al.
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| Science 275 : 1943-1947. 1997
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| 132 | PTEN, TSG10A
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| Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers.
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| Steck PA, et al.
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| Nat Genet 15 : 356-362. 1997
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| 133 | MHAM, PTEN
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| Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome.
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| Liaw D, et al.
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| Nat Genet 16 : 64-67. 1997
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| 134 | MHAM, PTEN
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| Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.
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| Nelen MR, van Staveren WC, Peeters EA, Hassel MB, Gorlin RJ, Hamm H, Lindboe CF, Fryns JP, Sijmons RH, Woods DG, Mariman EC, Padberg GW, Kremer H.
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| Hum Mol Genet 6(8):1383-7. 1997
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| 135 | BZS, PTEN
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| Germline mutations in PTEN are present in Bannayan-Zonana syndrome.
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| Marsh DJ, Dahia PL, Zheng Z, Liaw D, Parsons R, Gorlin RJ, Eng C.
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| Nat Genet 16(4):333-4. No abstract available. 1997
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| 136 | PTEN
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| P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase.
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| Myers MP, Stolarov JP, Eng C, Li J, Wang SI, Wigler MH, Parsons R, Tonks NK.
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| Proc Natl Acad Sci U S A 94(17):9052-7. 1997
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| 137 | PTEN
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| PTEN1 is frequently mutated in primary endometrial carcinomas.
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| Kong D, Suzuki A, Zou TT, Sakurada A, Kemp LW, Wakatsuki S, Yokoyama T, Yamakawa H, Furukawa T, Sato M, Ohuchi N, Sato S, Yin J, Wang S, Abraham JM, Souza RF, Smolinski KN, Meltzer SJ, Horii A.
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| Nat Genet 17(2):143-4. 1997
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| 138 | BZS, PTEN
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| Deletion of 10q23.2-q24.1 including PTEN in a patient with Bannayan-Riley-Ruvalcaba syndrome suggests allelism with Cowden disease. (abstr)
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| Arch EM, et al.
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| Am J Hum Genet 61 : A118. 1997
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| 139 | PTEN, TSG10A
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| PTEN gene mutations are seen in high-grade but not in low-grade gliomas.
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| Rasheed BK, Stenzel TT, McLendon RE, Parsons R, Friedman AH, Friedman HS, Bigner DD, Bigner SH.
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| Cancer Res 57(19):4187-90. 1997
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| 140 | PTEN
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| The role of MMAC1 mutations in early-onset breast cancer: causative in association with Cowden syndrome and excluded in BRCA1-negative cases.
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| Tsou HC, Teng DH, Ping XL, Brancolini V, Davis T, Hu R, Xie XX, Gruener AC, Schrager CA, Christiano AM, Eng C, Steck P, Ott J, Tavtigian SV, Peacocke M.
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| Am J Hum Genet 61(5):1036-43. 1997
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| 141 | MHAM, PTEN, TSG10A
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| Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors.
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| Dahia PL, Marsh DJ, Zheng Z, Zedenius J, Komminoth P, Frisk T, Wallin G, Parsons R, Longy M, Larsson C, Eng C.
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| Cancer Res 57(21):4710-3. 1997
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| 142 | PTEN
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| Exclusion of PTEN and 10q22-24 as the susceptibility locus for juvenile polyposis syndrome.
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| Marsh DJ, Roth S, Lunetta KL, Hemminki A, Dahia PL, Sistonen P, Zheng Z, Caron S, van Orsouw NJ, Bodmer WF, Cottrell SE, Dunlop MG, Eccles D, Hodgson SV, Jarvinen H, Kellokumpu I, Markie D, Neale K, Phillips R, Rozen P, Syngal S, Vijg J, Tomlinson IP, Aaltonen LA, Eng C.
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| Cancer Res 57(22):5017-21. 1997
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| 143 | MHAM, PTEN, TSG10A
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| Inherited mutations in PTEN that are associated with breast cancer, Cowden disease, and juvenile polyposis.
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| Lynch ED, Ostermeyer EA, Lee MK, Arena JF, Ji H, Dann J, Swisshelm K, Suchard D, MacLeod PM, Kvinnsland S, Gjertsen BT, Heimdal K, Lubs H, Moller P, King MC.
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| Am J Hum Genet 61(6):1254-60. 1997
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| 144 | CDC14A, PTEN, CDC14B
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| A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast.
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| Li L, Ernsting BR, Wishart MJ, Lohse DL, Dixon JE.
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| J Biol Chem 272(47):29403-6. 1997
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