Citations for
1CCND2, CDC25B, PTBP1, PTBP2, RBL1
Polypyrimidine tract-binding proteins are essential for B cell development.
Monzón-Casanova E, Matheson LS, Tabbada K, Zarnack K, Smith CW, Turner M.
Elife 9. pii: e53557. doi: 10.7554/eLife.53557. 2020
2NOVA1, PTBP1, TERT
NOVA1 directs PTBP1 to hTERT pre-mRNA and promotes telomerase activity in cancer cells.
Sayed ME, Yuan L, Robin JD, Tedone E, Batten K, Dahlson N, Wright WE, Shay JW, Ludlow AT.
Oncogene 38(16):2937-2952. doi: 10.1038/s41388-018-0639-8. Epub 2018 Dec 19. 2019
3PTBP1
PTBP1 mRNA isoforms and regulation of their translation.
Arake de Tacca LM, Pulos-Holmes MC, Floor SN, Cate JHD.
RNA 25(10):1324-1336. doi: 10.1261/rna.070193.118. Epub 2019 Jul 1. 2019
4PTBP1
Polypyrimidine tract binding protein 1 promotes lymphatic metastasis and proliferation of bladder cancer via alternative splicing of MEIS2 and PKM.
Xie R, Chen X, Chen Z, Huang M, Dong W, Gu P, Zhang J, Zhou Q, Dong W, Han J, Wang X, Li H, Huang J, Lin T.
Cancer Lett 449:31-44. doi: 10.1016/j.canlet.2019.01.041. Epub 2019 Feb 10. 2019
5PTBP1
RNA-binding protein Ptbp1 is essential for BCR-mediated antibody production.
Sasanuma H, Ozawa M, Yoshida N.
Int Immunol 31(3):157-166. doi: 10.1093/intimm/dxy077. 2019
6PTBP1
PTBP1 contributes to spermatogenesis through regulation of proliferation in spermatogonia.
Senoo M, Takijiri T, Yoshida N, Ozawa M, Ikawa M.
J Reprod Dev 65(1):37-46. doi: 10.1262/jrd.2018-109. Epub 2018 Nov 12. 2019
7PTBP1, PTBP2, PTBP3
PTB/nPTB: master regulators of neuronal fate in mammals.
Hu J, Qian H, Xue Y, Fu XD.
Biophys Rep 4(4):204-214. doi: 10.1007/s41048-018-0066-y. Epub 2018 Aug 28. 2018
8ISCU, PTBP1
PTBP1 acts as a dominant repressor of the aberrant tissue-specific splicing of ISCU in hereditary myopathy with lactic acidosis.
Rawcliffe DFR, Österman L, Nordin A, Holmberg M.
Mol Genet Genomic Med 6(6):887-897. doi: 10.1002/mgg3.413. Epub 2018 Sep 12. 2018
9PTBP1
PTBP1 promotes the growth of breast cancer cells through the PTEN/Akt pathway and autophagy.
Wang X, Li Y, Fan Y, Yu X, Mao X, Jin F.
J Cell Physiol 233(11):8930-8939. doi: 10.1002/jcp.26823. Epub 2018 Jun 1. 2018
10PTBP1
The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers.
Monzón-Casanova E, Screen M, Díaz-Muñoz MD, Coulson RMR, Bell SE, Lamers G, Solimena M, Smith CWJ, Turner M.
Nat Immunol 19(3):267-278. doi: 10.1038/s41590-017-0035-5. Epub 2018 Jan 22. 2018
11CTTN, PTBP1
High expression of PTBP1 promote invasion of colorectal cancer by alternative splicing of cortactin.
Wang ZN, Liu D, Yin B, Ju WY, Qiu HZ, Xiao Y, Chen YJ, Peng XZ, Lu CM.
Oncotarget 8(22):36185-36202. doi: 10.18632/oncotarget.15873. 2017
12PTBP1, PTBP2
PTBP1 and PTBP2 Serve Both Specific and Redundant Functions in Neuronal Pre-mRNA Splicing.
Vuong JK, Lin CH, Zhang M, Chen L, Black DL, Zheng S.
Cell Rep 17(10):2766-2775. doi: 10.1016/j.celrep.2016.11.034. 2016
13PTBP1, PTBP2
PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons.
Ling JP, Chhabra R, Merran JD, Schaughency PM, Wheelan SJ, Corden JL, Wong PC.
Cell Rep 17(1):104-113. doi: 10.1016/j.celrep.2016.08.071. 2016
14PTBP1, PTBP2, PTBP3
Human polypyrimidine tract-binding protein interacts with mitochondrial tRNA(Thr) in the cytosol.
Marnef A, Jády BE, Kiss T.
Nucleic Acids Res 44(3):1342-53. doi: 10.1093/nar/gkv1355. Epub 2015 Dec 10. 2016
15PBX1, PTBP1
The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation.
Linares AJ, Lin CH, Damianov A, Adams KL, Novitch BG, Black DL.
Elife 4:e09268. doi: 10.7554/eLife.09268. 2015
16PTBP1, PTBP3
Generation of functionally distinct isoforms of PTBP3 by alternative splicing and translation initiation.
Tan LY, Whitfield P, Llorian M, Monzon-Casanova E, Diaz-Munoz MD, Turner M, Smith CW.
Nucleic Acids Res 43(11):5586-600. doi: 10.1093/nar/gkv429. Epub 2015 May 4. 2015
17CDC42, PTBP1
Regulation and functional significance of CDC42 alternative splicing in ovarian cancer.
He X, Yuan C, Yang J.
Oncotarget 6(30):29651-63. doi: 10.18632/oncotarget.4865. 2015
18PTBP1, PTBP2
Characterization of a novel posttranslational modification in polypyrimidine tract-binding proteins by SUMO1.
Han W, Wang L, Yin B, Peng X.
BMB Rep 47(4):233-8. 2014
19PTBP1
De novo prediction of PTBP1 binding and splicing targets reveals unexpected features of its RNA recognition and function.
Han A, Stoilov P, Linares AJ, Zhou Y, Fu XD, Black DL.
PLoS Comput Biol 10(1):e1003442. doi: 10.1371/journal.pcbi.1003442. eCollection 2014 Jan. 2014
20ISCU, MPEI1, PTBP1, RBM39
The defective splicing caused by the ISCU intron mutation in patients with myopathy with lactic acidosis is repressed by PTBP1 but can be derepressed by IGF2BP1.
Nordin A, Larsson E, Holmberg M.
Hum Mutat 33(3):467-70. doi: 10.1002/humu.22002. Epub 2011 Dec 29. 2012
21PTBP1, PTBP2
Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain.
Licatalosi DD, Yano M, Fak JJ, Mele A, Grabinski SE, Zhang C, Darnell RB.
Genes Dev 26(14):1626-42. doi: 10.1101/gad.191338.112. 2012
22DLG4, PTBP1, PTBP2
PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2.
Zheng S, Gray EE, Chawla G, Porse BT, O'Dell TJ, Black DL.
Nat Neurosci 15(3):381-8, S1. doi: 10.1038/nn.3026. 2012
23CELF1, PTBP1, PTBP2, TPM2
CELF and PTB proteins modulate the inclusion of the β-tropomyosin exon 6B during myogenic differentiation.
Sureau A, Saulière J, Expert-Bezançon A, Marie J.
Exp Cell Res 317(1):94-106. Epub 2010 Sep 25. 2011
24PTBP1, RAVER1
Crystallographic analysis of polypyrimidine tract-binding protein-Raver1 interactions involved in regulation of alternative splicing.
Joshi A, Coelho MB, Kotik-Kogan O, Simpson PJ, Matthews SJ, Smith CW, Curry S.
Structure 19(12):1816-25. doi: 10.1016/j.str.2011.09.020. 2011
25HNRNPA1, HNRNPA2B1, PKM, PTBP1
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.
David CJ, Chen M, Assanah M, Canoll P, Manley JL.
Nature 463(7279):364-8. Epub 2009 Dec 13.PMID: 20010808 2010
26HNRNPA1, HNRNPA2B1, PKM, PKM1, PTBP1
The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism.
Clower CV, Chatterjee D, Wang Z, Cantley LC, Vander Heiden MG, Krainer AR.
Proc Natl Acad Sci U S A 107(5):1894-9. Epub 2010 Jan 19.PMID: 20133837 2010
27PTBP1
Polypyrimidine tract-binding protein influences negative strand RNA synthesis of dengue virus.
Jiang L, Yao H, Duan X, Lu X, Liu Y.
Biochem Biophys Res Commun 385(2):187-92. Epub 2009 May 18. 2009
28PTBP1
Roles of polypyrimidine tract binding proteins in major immediate-early gene expression and viral replication of human cytomegalovirus.
Cosme RS, Yamamura Y, Tang Q.
J Virol 83(7):2839-50. Epub 2009 Jan 14. 2009
29HBB, HNRNPH1, PTBP1, PTBP2
A physical and functional link between splicing factors promotes pre-mRNA 3' end processing.
Millevoi S, Decorsière A, Loulergue C, Iacovoni J, Bernat S, Antoniou M, Vagner S.
Nucleic Acids Res 37(14):4672-83. Epub 2009 Jun 8. 2009
30HNRNPL, PTBP1, SLC7A1
The hnRNA-binding proteins hnRNP L and PTB are required for efficient translation of the Cat-1 arginine/lysine transporter mRNA during amino acid starvation.
Majumder M, Yaman I, Gaccioli F, Zeenko VV, Wang C, Caprara MG, Venema RC, Komar AA, Snider MD, Hatzoglou M.
Mol Cell Biol 29(10):2899-912. doi: 10.1128/MCB.01774-08. Epub 2009 Mar 9. 2009
31PTBP1
Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome.
Sharma S, Kohlstaedt LA, Damianov A, Rio DC, Black DL.
Nat Struct Mol Biol 15(2):183-91. Epub 2008 Jan 13. 2008
32PTBP1
Polypyrimidine tract-binding protein (PTB) differentially affects malignancy in a cell line-dependent manner.
Wang C, Norton JT, Ghosh S, Kim J, Fushimi K, Wu JY, Stack MS, Huang S.
J Biol Chem 283(29):20277-87. Epub 2008 May 22. 2008
33PTBP1
Polypyrimidine tract binding protein induces human papillomavirus type 16 late gene expression by interfering with splicing inhibitory elements at the major late 5' splice site, SD3632.
Somberg M, Zhao X, Fröhlich M, Evander M, Schwartz S.
J Virol 82(7):3665-78. Epub 2008 Jan 23. 2008
34PTBP1
Repression of alpha-actinin SM exon splicing by assisted binding of PTB to the polypyrimidine tract.
Matlin AJ, Southby J, Gooding C, Smith CW.
RNA 13(8):1214-23. Epub 2007 Jun 25. 2007
35PTBP1
A splicing repressor domain in polypyrimidine tract-binding protein.
Robinson F, Smith CW.
J Biol Chem 281(2):800-6. Epub 2005 Nov 9. 2006
36PTBP1
Structure of PTB bound to RNA: specific binding and implications for splicing regulation.
Oberstrass FC, Auweter SD, Erat M, Hargous Y, Henning A, Wenter P, Reymond L, Amir-Ahmady B, Pitsch S, Black DL, Allain FH.
Science 309(5743):2054-7. 2005
37PTBP1
Delineation of a novel pathway that regulates CD154 (CD40 ligand) expression.
Hamilton BJ, Genin A, Cron RQ, Rigby WF.
Mol Cell Biol 23(2):510-25. Erratum in: Mol Cell Biol. 2003 Sep;23(17):6338. 2003
38PTBP1
Characterization of the nuclear export signal of polypyrimidine tract-binding protein.
Li B, Yen TS.
J Biol Chem 277(12):10306-14. 2002
39PTBP1
Chemical shift mapping of RNA interactions with the polypyrimidine tract binding protein.
Yuan X, Davydova N, Conte MR, Curry S, Matthews S.
Nucleic Acids Res 30(2):456-62. 2002
40PTBP1, PTBP2
Alternative Splicing of Brain-Specific PTB Defines a Tissue-Specific Isoform Pattern That Predicts Distinct Functional Roles.
Rahman L, Bliskovski V, Reinhold W, Zajac-Kaye M.
Genomics 80(3):245. 2002
41PTBP1
Nucleocytoplasmic shuttling of polypyrimidine tract-binding protein is uncoupled from RNA export.
Kamath RV, Leary DJ, Huang S.
Mol Biol Cell 12(12):3808-20. 2001
42PTBP1
Cloning and functional characterization of the human heterogeneous nuclear ribonucleoprotein type I promoter.
Romanelli MG, Faggioli L, Lorenzi P, Morandi C.
Biochim Biophys Acta 1520(1):85-8. 2001
43PTBP1
Structure of tandem RNA recognition motifs from polypyrimidine tract binding protein reveals novel features of the RRM fold.
Conte MR, Grune T, Ghuman J, Kelly G, Ladas A, Matthews S, Curry S.
EMBO J 19(12):3132-41. 2000
44PTBP1P, PTBP1
Organization of the human gene encoding heterogeneous nuclear ribonucleoprotein type I (hnRNP I) and characterization of hnRNP I related pseudogene.
Romanelli MG, Lorenzi P, Morandi C.
Gene 255(2):267-72. 2000
45PTBP1, C14orf53
Dual localization of the human gene encoding hnRNP I/PTB protein to chromosomes 19p13.3 and 14q23.
Della Valle V, et al.
Hum Genet 98 : 210-213. 1996
46NCBP1, PTBP1, SFPQ, SFRS11, SFRS8, SFRS9, SRPK1, SRPK2, SRSF1, SRSF2, SRSF3, SRSF4, SRSF5, SRSF6, SRSF7, TRA2B, U2AF1
The structure and function of proteins involved in mammalian pre-mRNA splicing.
Kramer A.
Annu Rev Biochem 65:367-409. Review. 1996
47PTBP1
Assignment of the human gene encoding heterogeneous nuclear RNA ribonucleoprotein I (PTB) to chromosome 14q23-q24.1.
Raimondi E, Romanelli MG, Moralli D, Gamberi C, Russo MP, Morandi C.
Genomics 27(3):553-5. No abstract available. 1995
48EWSR1, FMR1, FXR1, FXR2, FYN, GRB2, HDLBP, HNRNPA1, HNRNPA2B1, NCL, PTBP1, RBMXP1, RBMY1A1, RBMY1A2, RBM3, SF1
Conserved structures and diversity of functions of RNA-binding proteins.
Burd CG, et al.
Science 265 : 615-621. 1994
49PTBP1, SFPQ
Cloning and characterization of PSF, a novel pre-mRNA splicing factor.
Patton JG, Porro EB, Galceran J, Tempst P, Nadal-Ginard B.
Genes Dev 7(3):393-406 1993
50PTBP1
hnRNP I, the polypyrimidine tract-binding protein : distinct nuclear localization and association with hnRNAs.
Ghetti A, et al.
Nucleic Acids Res 20 : 3671-3678. 1992
51PTBP1
Characterization of cDNAs encoding the polypyrimidine tract-binding protein.
Gil A, Sharp PA, Jamison SF, Garcia-Blanco MA.
Genes Dev 5(7):1224-36. 1991