| 1 | CCND2, CDC25B, PTBP1, PTBP2, RBL1
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| Polypyrimidine tract-binding proteins are essential for B cell development.
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| Monzón-Casanova E, Matheson LS, Tabbada K, Zarnack K, Smith CW, Turner M.
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| Elife 9. pii: e53557. doi: 10.7554/eLife.53557.
2020
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| 2 | NOVA1, PTBP1, TERT
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| NOVA1 directs PTBP1 to hTERT pre-mRNA and promotes telomerase activity in cancer cells.
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| Sayed ME, Yuan L, Robin JD, Tedone E, Batten K, Dahlson N, Wright WE, Shay JW, Ludlow AT.
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| Oncogene 38(16):2937-2952. doi: 10.1038/s41388-018-0639-8. Epub 2018 Dec 19.
2019
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| 3 | PTBP1
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| PTBP1 mRNA isoforms and regulation of their translation.
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| Arake de Tacca LM, Pulos-Holmes MC, Floor SN, Cate JHD.
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| RNA 25(10):1324-1336. doi: 10.1261/rna.070193.118. Epub 2019 Jul 1.
2019
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| 4 | PTBP1
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| Polypyrimidine tract binding protein 1 promotes lymphatic metastasis and proliferation of bladder cancer via alternative splicing of MEIS2 and PKM.
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| Xie R, Chen X, Chen Z, Huang M, Dong W, Gu P, Zhang J, Zhou Q, Dong W, Han J, Wang X, Li H, Huang J, Lin T.
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| Cancer Lett 449:31-44. doi: 10.1016/j.canlet.2019.01.041. Epub 2019 Feb 10.
2019
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| 5 | PTBP1
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| RNA-binding protein Ptbp1 is essential for BCR-mediated antibody production.
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| Sasanuma H, Ozawa M, Yoshida N.
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| Int Immunol 31(3):157-166. doi: 10.1093/intimm/dxy077.
2019
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| 6 | PTBP1
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| PTBP1 contributes to spermatogenesis through regulation of proliferation in spermatogonia.
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| Senoo M, Takijiri T, Yoshida N, Ozawa M, Ikawa M.
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| J Reprod Dev 65(1):37-46. doi: 10.1262/jrd.2018-109. Epub 2018 Nov 12.
2019
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| 7 | PTBP1, PTBP2, PTBP3
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| PTB/nPTB: master regulators of neuronal fate in mammals.
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| Hu J, Qian H, Xue Y, Fu XD.
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| Biophys Rep 4(4):204-214. doi: 10.1007/s41048-018-0066-y. Epub 2018 Aug 28.
2018
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| 8 | ISCU, PTBP1
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| PTBP1 acts as a dominant repressor of the aberrant tissue-specific splicing of ISCU in hereditary myopathy with lactic acidosis.
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| Rawcliffe DFR, Österman L, Nordin A, Holmberg M.
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| Mol Genet Genomic Med 6(6):887-897. doi: 10.1002/mgg3.413. Epub 2018 Sep 12.
2018
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| 9 | PTBP1
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| PTBP1 promotes the growth of breast cancer cells through the PTEN/Akt pathway and autophagy.
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| Wang X, Li Y, Fan Y, Yu X, Mao X, Jin F.
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| J Cell Physiol 233(11):8930-8939. doi: 10.1002/jcp.26823. Epub 2018 Jun 1.
2018
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| 10 | PTBP1
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| The RNA-binding protein PTBP1 is necessary for B cell selection in germinal centers.
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| Monzón-Casanova E, Screen M, Díaz-Muñoz MD, Coulson RMR, Bell SE, Lamers G, Solimena M, Smith CWJ, Turner M.
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| Nat Immunol 19(3):267-278. doi: 10.1038/s41590-017-0035-5. Epub 2018 Jan 22.
2018
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| 11 | CTTN, PTBP1
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| High expression of PTBP1 promote invasion of colorectal cancer by alternative splicing of cortactin.
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| Wang ZN, Liu D, Yin B, Ju WY, Qiu HZ, Xiao Y, Chen YJ, Peng XZ, Lu CM.
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| Oncotarget 8(22):36185-36202. doi: 10.18632/oncotarget.15873.
2017
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| 12 | PTBP1, PTBP2
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| PTBP1 and PTBP2 Serve Both Specific and Redundant Functions in Neuronal Pre-mRNA Splicing.
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| Vuong JK, Lin CH, Zhang M, Chen L, Black DL, Zheng S.
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| Cell Rep 17(10):2766-2775. doi: 10.1016/j.celrep.2016.11.034.
2016
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| 13 | PTBP1, PTBP2
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| PTBP1 and PTBP2 Repress Nonconserved Cryptic Exons.
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| Ling JP, Chhabra R, Merran JD, Schaughency PM, Wheelan SJ, Corden JL, Wong PC.
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| Cell Rep 17(1):104-113. doi: 10.1016/j.celrep.2016.08.071.
2016
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| 14 | PTBP1, PTBP2, PTBP3
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| Human polypyrimidine tract-binding protein interacts with mitochondrial tRNA(Thr) in the cytosol.
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| Marnef A, Jády BE, Kiss T.
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| Nucleic Acids Res 44(3):1342-53. doi: 10.1093/nar/gkv1355. Epub 2015 Dec 10.
2016
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| 15 | PBX1, PTBP1
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| The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation.
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| Linares AJ, Lin CH, Damianov A, Adams KL, Novitch BG, Black DL.
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| Elife 4:e09268. doi: 10.7554/eLife.09268.
2015
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| 16 | PTBP1, PTBP3
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| Generation of functionally distinct isoforms of PTBP3 by alternative splicing and translation initiation.
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| Tan LY, Whitfield P, Llorian M, Monzon-Casanova E, Diaz-Munoz MD, Turner M, Smith CW.
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| Nucleic Acids Res 43(11):5586-600. doi: 10.1093/nar/gkv429. Epub 2015 May 4.
2015
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| 17 | CDC42, PTBP1
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| Regulation and functional significance of CDC42 alternative splicing in ovarian cancer.
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| He X, Yuan C, Yang J.
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| Oncotarget 6(30):29651-63. doi: 10.18632/oncotarget.4865.
2015
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| 18 | PTBP1, PTBP2
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| Characterization of a novel posttranslational modification in polypyrimidine tract-binding proteins by SUMO1.
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| Han W, Wang L, Yin B, Peng X.
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| BMB Rep 47(4):233-8.
2014
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| 19 | PTBP1
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| De novo prediction of PTBP1 binding and splicing targets reveals unexpected features of its RNA recognition and function.
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| Han A, Stoilov P, Linares AJ, Zhou Y, Fu XD, Black DL.
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| PLoS Comput Biol 10(1):e1003442. doi: 10.1371/journal.pcbi.1003442. eCollection 2014 Jan.
2014
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| 20 | ISCU, MPEI1, PTBP1, RBM39
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| The defective splicing caused by the ISCU intron mutation in patients with myopathy with lactic acidosis is repressed by PTBP1 but can be derepressed by IGF2BP1.
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| Nordin A, Larsson E, Holmberg M.
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| Hum Mutat 33(3):467-70. doi: 10.1002/humu.22002. Epub 2011 Dec 29. 2012
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| 21 | PTBP1, PTBP2
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| Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain.
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| Licatalosi DD, Yano M, Fak JJ, Mele A, Grabinski SE, Zhang C, Darnell RB.
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| Genes Dev 26(14):1626-42. doi: 10.1101/gad.191338.112.
2012
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| 22 | DLG4, PTBP1, PTBP2
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| PSD-95 is post-transcriptionally repressed during early neural development by PTBP1 and PTBP2.
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| Zheng S, Gray EE, Chawla G, Porse BT, O'Dell TJ, Black DL.
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| Nat Neurosci 15(3):381-8, S1. doi: 10.1038/nn.3026.
2012
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| 23 | CELF1, PTBP1, PTBP2, TPM2
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| CELF and PTB proteins modulate the inclusion of the β-tropomyosin exon 6B during myogenic differentiation.
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| Sureau A, Saulière J, Expert-Bezançon A, Marie J.
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| Exp Cell Res 317(1):94-106. Epub 2010 Sep 25.
2011
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| 24 | PTBP1, RAVER1
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| Crystallographic analysis of polypyrimidine tract-binding protein-Raver1 interactions involved in regulation of alternative splicing.
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| Joshi A, Coelho MB, Kotik-Kogan O, Simpson PJ, Matthews SJ, Smith CW, Curry S.
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| Structure 19(12):1816-25. doi: 10.1016/j.str.2011.09.020.
2011
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| 25 | HNRNPA1, HNRNPA2B1, PKM, PTBP1
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| HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.
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| David CJ, Chen M, Assanah M, Canoll P, Manley JL.
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| Nature 463(7279):364-8. Epub 2009 Dec 13.PMID: 20010808 2010
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| 26 | HNRNPA1, HNRNPA2B1, PKM, PKM1, PTBP1
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| The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism.
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| Clower CV, Chatterjee D, Wang Z, Cantley LC, Vander Heiden MG, Krainer AR.
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| Proc Natl Acad Sci U S A 107(5):1894-9. Epub 2010 Jan 19.PMID: 20133837 2010
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| 27 | PTBP1
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| Polypyrimidine tract-binding protein influences negative strand RNA synthesis of dengue virus.
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| Jiang L, Yao H, Duan X, Lu X, Liu Y.
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| Biochem Biophys Res Commun 385(2):187-92. Epub 2009 May 18.
2009
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| 28 | PTBP1
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| Roles of polypyrimidine tract binding proteins in major immediate-early gene expression and viral replication of human cytomegalovirus.
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| Cosme RS, Yamamura Y, Tang Q.
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| J Virol 83(7):2839-50. Epub 2009 Jan 14.
2009
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| 29 | HBB, HNRNPH1, PTBP1, PTBP2
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| A physical and functional link between splicing factors promotes pre-mRNA 3' end processing.
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| Millevoi S, Decorsière A, Loulergue C, Iacovoni J, Bernat S, Antoniou M, Vagner S.
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| Nucleic Acids Res 37(14):4672-83. Epub 2009 Jun 8. 2009
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| 30 | HNRNPL, PTBP1, SLC7A1
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| The hnRNA-binding proteins hnRNP L and PTB are required for efficient translation of the Cat-1 arginine/lysine transporter mRNA during amino acid starvation.
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| Majumder M, Yaman I, Gaccioli F, Zeenko VV, Wang C, Caprara MG, Venema RC, Komar AA, Snider MD, Hatzoglou M.
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| Mol Cell Biol 29(10):2899-912. doi: 10.1128/MCB.01774-08. Epub 2009 Mar 9.
2009
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| 31 | PTBP1
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| Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome.
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| Sharma S, Kohlstaedt LA, Damianov A, Rio DC, Black DL.
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| Nat Struct Mol Biol 15(2):183-91. Epub 2008 Jan 13.
2008
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| 32 | PTBP1
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| Polypyrimidine tract-binding protein (PTB) differentially affects malignancy in a cell line-dependent manner.
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| Wang C, Norton JT, Ghosh S, Kim J, Fushimi K, Wu JY, Stack MS, Huang S.
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| J Biol Chem 283(29):20277-87. Epub 2008 May 22.
2008
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| 33 | PTBP1
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| Polypyrimidine tract binding protein induces human papillomavirus type 16 late gene expression by interfering with splicing inhibitory elements at the major late 5' splice site, SD3632.
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| Somberg M, Zhao X, Fröhlich M, Evander M, Schwartz S.
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| J Virol 82(7):3665-78. Epub 2008 Jan 23.
2008
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| 34 | PTBP1
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| Repression of alpha-actinin SM exon splicing by assisted binding of PTB to the polypyrimidine tract.
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| Matlin AJ, Southby J, Gooding C, Smith CW.
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| RNA 13(8):1214-23. Epub 2007 Jun 25.
2007
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| 35 | PTBP1
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| A splicing repressor domain in polypyrimidine tract-binding protein.
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| Robinson F, Smith CW.
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| J Biol Chem 281(2):800-6. Epub 2005 Nov 9.
2006
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| 36 | PTBP1
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| Structure of PTB bound to RNA: specific binding and implications for splicing regulation.
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| Oberstrass FC, Auweter SD, Erat M, Hargous Y, Henning A, Wenter P, Reymond L, Amir-Ahmady B, Pitsch S, Black DL, Allain FH.
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| Science 309(5743):2054-7. 2005
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| 37 | PTBP1
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| Delineation of a novel pathway that regulates CD154 (CD40 ligand) expression.
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| Hamilton BJ, Genin A, Cron RQ, Rigby WF.
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| Mol Cell Biol 23(2):510-25. Erratum in: Mol Cell Biol. 2003 Sep;23(17):6338. 2003
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| 38 | PTBP1
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| Characterization of the nuclear export signal of polypyrimidine tract-binding protein.
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| Li B, Yen TS.
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| J Biol Chem 277(12):10306-14. 2002
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| 39 | PTBP1
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| Chemical shift mapping of RNA interactions with the polypyrimidine tract binding protein.
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| Yuan X, Davydova N, Conte MR, Curry S, Matthews S.
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| Nucleic Acids Res 30(2):456-62. 2002
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| 40 | PTBP1, PTBP2
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| Alternative Splicing of Brain-Specific PTB Defines a Tissue-Specific Isoform Pattern That Predicts Distinct Functional Roles.
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| Rahman L, Bliskovski V, Reinhold W, Zajac-Kaye M.
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| Genomics 80(3):245. 2002
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| 41 | PTBP1
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| Nucleocytoplasmic shuttling of polypyrimidine tract-binding protein is uncoupled from RNA export.
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| Kamath RV, Leary DJ, Huang S.
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| Mol Biol Cell 12(12):3808-20. 2001
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| 42 | PTBP1
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| Cloning and functional characterization of the human heterogeneous nuclear ribonucleoprotein type I promoter.
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| Romanelli MG, Faggioli L, Lorenzi P, Morandi C.
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| Biochim Biophys Acta 1520(1):85-8. 2001
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| 43 | PTBP1
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| Structure of tandem RNA recognition motifs from polypyrimidine tract binding protein reveals novel features of the RRM fold.
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| Conte MR, Grune T, Ghuman J, Kelly G, Ladas A, Matthews S, Curry S.
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| EMBO J 19(12):3132-41. 2000
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| 44 | PTBP1P, PTBP1
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| Organization of the human gene encoding heterogeneous nuclear ribonucleoprotein type I (hnRNP I) and characterization of hnRNP I related pseudogene.
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| Romanelli MG, Lorenzi P, Morandi C.
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| Gene 255(2):267-72. 2000
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| 45 | PTBP1, C14orf53
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| Dual localization of the human gene encoding hnRNP I/PTB protein to chromosomes 19p13.3 and 14q23.
|
| Della Valle V, et al.
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| Hum Genet 98 : 210-213. 1996
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| 46 | NCBP1, PTBP1, SFPQ, SFRS11, SFRS8, SFRS9, SRPK1, SRPK2, SRSF1, SRSF2, SRSF3, SRSF4, SRSF5, SRSF6, SRSF7, TRA2B, U2AF1
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| The structure and function of proteins involved in mammalian pre-mRNA splicing.
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| Kramer A.
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| Annu Rev Biochem 65:367-409. Review. 1996
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| 47 | PTBP1
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| Assignment of the human gene encoding heterogeneous nuclear RNA ribonucleoprotein I (PTB) to chromosome 14q23-q24.1.
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| Raimondi E, Romanelli MG, Moralli D, Gamberi C, Russo MP, Morandi C.
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| Genomics 27(3):553-5. No abstract available. 1995
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| 48 | EWSR1, FMR1, FXR1, FXR2, FYN, GRB2, HDLBP, HNRNPA1, HNRNPA2B1, NCL, PTBP1, RBMXP1, RBMY1A1, RBMY1A2, RBM3, SF1
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| Conserved structures and diversity of functions of RNA-binding proteins.
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| Burd CG, et al.
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| Science 265 : 615-621. 1994
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| 49 | PTBP1, SFPQ
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| Cloning and characterization of PSF, a novel pre-mRNA splicing factor.
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| Patton JG, Porro EB, Galceran J, Tempst P, Nadal-Ginard B.
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| Genes Dev 7(3):393-406 1993
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| 50 | PTBP1
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| hnRNP I, the polypyrimidine tract-binding protein : distinct nuclear localization and association with hnRNAs.
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| Ghetti A, et al.
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| Nucleic Acids Res 20 : 3671-3678. 1992
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| 51 | PTBP1
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| Characterization of cDNAs encoding the polypyrimidine tract-binding protein.
|
| Gil A, Sharp PA, Jamison SF, Garcia-Blanco MA.
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| Genes Dev 5(7):1224-36. 1991
|