| 1 | PRTN3
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| Proteinase 3: the odd one out that became an autoantigen.
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| Martin KR, Witko-Sarsat V.
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| J Leukoc Biol 102(3):689-698. doi: 10.1189/jlb.3MR0217-069R. Epub 2017 May 25. Review.
2017
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| 2 | MPO, PRTN3
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| Histone modification signature at myeloperoxidase and proteinase 3 in patients with anti-neutrophil cytoplasmic autoantibody-associated vasculitis.
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| Yang J, Ge H, Poulton CJ, Hogan SL, Hu Y, Jones BE, Henderson CD, McInnis EA, Pendergraft WF 3rd, Jennette JC, Falk RJ, Ciavatta DJ.
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| Clin Epigenetics 8:85. doi: 10.1186/s13148-016-0251-0. eCollection 2016.
2016
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| 3 | PRTN3
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| Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance.
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| Toonen EJ, Mirea AM, Tack CJ, Stienstra R, Ballak DB, van Diepen JA, Hijmans A, Chavakis T, Dokter WH, Pham CT, Netea MG, Dinarello CA, Joosten LA.
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| Mol Med 22. doi: 10.2119/molmed.2016.00033.
2016
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| 4 | PRTN3
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| Proteinase 3 Is a Phosphatidylserine-binding Protein That Affects the Production and Function of Microvesicles.
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| Martin KR, Kantari-Mimoun C, Yin M, Pederzoli-Ribeil M, Angelot-Delettre F, Ceroi A, Grauffel C, Benhamou M, Reuter N, Saas P, Frachet P, Boulanger CM, Witko-Sarsat V.
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| J Biol Chem 291(20):10476-89. doi: 10.1074/jbc.M115.698639. Epub 2016 Mar 9.
2016
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| 5 | PRTN3
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| Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis.
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| Millet A, Martin KR, Bonnefoy F, Saas P, Mocek J, Alkan M, Terrier B, Kerstein A, Tamassia N, Satyanarayanan SK, Ariel A, Ribeil JA, Guillevin L, Cassatella MA, Mueller A, Thieblemont N, Lamprecht P, Mouthon L, Perruche S, Witko-Sarsat V.
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| J Clin Invest 125(11):4107-21. doi: 10.1172/JCI78182. Epub 2015 Oct 5.
2015
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| 6 | ADAM17, PRTN3
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| Circulating ADAM17 Level Reflects Disease Activity in Proteinase-3 ANCA-Associated Vasculitis.
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| Bertram A, Lovric S, Engel A, Beese M, Wyss K, Hertel B, Park JK, Becker JU, Kegel J, Haller H, Haubitz M, Kirsch T.
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| J Am Soc Nephrol 26(11):2860-70. doi: 10.1681/ASN.2014050477. Epub 2015 Mar 18.
2015
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| 7 | CASP3, PRTN3
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| Proteinase 3-dependent caspase-3 cleavage modulates neutrophil death and inflammation.
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| Loison F, Zhu H, Karatepe K, Kasorn A, Liu P, Ye K, Zhou J, Cao S, Gong H, Jenne DE, Remold-O'Donnell E, Xu Y, Luo HR.
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| J Clin Invest 124(10):4445-58. doi: 10.1172/JCI76246. Epub 2014 Sep 2.
2014
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| 8 | PRTN3
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| The neutrophil serine protease PR3 induces shape change of platelets via the Rho/Rho kinase and Ca(2+) signaling pathways.
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| Peng X, Ramström S, Kurz T, Grenegård M, Segelmark M.
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| Thromb Res 134(2):418-25. doi: 10.1016/j.thromres.2014.06.001. Epub 2014 Jun 11.
2014
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| 9 | ELANE, NR1I2, PRTN3
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| Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1).
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| Mihara K, Ramachandran R, Renaux B, Saifeddine M, Hollenberg MD.
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| J Biol Chem 288(46):32979-90. doi: 10.1074/jbc.M113.483123. Epub 2013 Sep 19.
2013
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| 10 | PRTN3
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| Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function.
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| Kuckleburg CJ, Newman PJ.
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| Arterioscler Thromb Vasc Biol 33(2):275-84. doi: 10.1161/ATVBAHA.112.300474. Epub 2012 Nov 29.
2013
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| 11 | IL33, PRTN3
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| Contradictory functions (activation/termination) of neutrophil proteinase 3 enzyme (PR3) in interleukin-33 biological activity.
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| Bae S, Kang T, Hong J, Lee S, Choi J, Jhun H, Kwak A, Hong K, Kim E, Jo S, Kim S.
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| J Biol Chem 287(11):8205-13. doi: 10.1074/jbc.M111.295055. Epub 2012 Jan 23.
2012
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| 12 | PRTN3, WG
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| Genetically distinct subsets within ANCA-associated vasculitis.
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| Lyons PA, Rayner TF, Trivedi S, Holle JU, Watts RA, Jayne DR, Baslund B, Brenchley P, Bruchfeld A, Chaudhry AN, Cohen Tervaert JW, Deloukas P, Feighery C, Gross WL, Guillevin L, Gunnarsson I, Harper L, Hrušková Z, Little MA, Martorana D, Neumann T, Ohlsson S, Padmanabhan S, Pusey CD, Salama AD, Sanders JS, Savage CO, Segelmark M, Stegeman CA, Tesař V, Vaglio A, Wieczorek S, Wilde B, Zwerina J, Rees AJ, Clayton DG, Smith KG.
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| N Engl J Med 367(3):214-23. doi: 10.1056/NEJMoa1108735.
2012
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| 13 | F2RL1, PRTN3
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| Membrane-bound proteinase 3 and PAR2 mediate phagocytosis of non-opsonized bacteria in human neutrophils.
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| Kim YC, Shin JE, Lee SH, Chung WJ, Lee YS, Choi BK, Choi Y.
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| Mol Immunol 48(15-16):1966-74. doi: 10.1016/j.molimm.2011.05.026. Epub 2011 Jun 22.
2011
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| 14 | ELANE, PRTN3
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| Neutrophil elastase and proteinase 3 trafficking routes in myelomonocytic cells.
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| Källquist L, Rosén H, Nordenfelt P, Calafat J, Janssen H, Persson AM, Hansson M, Olsson I.
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| Exp Cell Res 316(19):3182-96. doi: 10.1016/j.yexcr.2010.08.016. Epub 2010 Sep 7.
2010
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| 15 | CD177, PRTN3
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| Elevated neutrophil membrane expression of proteinase 3 is dependent upon CD177 expression.
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| Abdgawad M, Gunnarsson L, Bengtsson AA, Geborek P, Nilsson L, Segelmark M, Hellmark T.
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| Clin Exp Immunol 161(1):89-97. doi: 10.1111/j.1365-2249.2010.04154.x. Epub 2010 May 10.
2010
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| 16 | PRTN3
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| Transcription of proteinase 3 and related myelopoiesis genes in peripheral blood mononuclear cells of patients with active Wegener's granulomatosis.
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| Cheadle C, Berger AE, Andrade F, James R, Johnson K, Watkins T, Park JK, Chen YC, Ehrlich E, Mullins M, Chrest F, Barnes KC, Levine SM.
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| Arthritis Rheum 62(6):1744-54. doi: 10.1002/art.27398.
2010
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| 17 | KNG1, PRTN3
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| Neutrophil-derived proteinase 3 induces kallikrein-independent release of a novel vasoactive kinin.
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| Kahn R, Hellmark T, Leeb-Lundberg LM, Akbari N, Todiras M, Olofsson T, Wieslander J, Christensson A, Westman K, Bader M, Müller-Esterl W, Karpman D.
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| J Immunol 182(12):7906-15. doi: 10.4049/jimmunol.0803624.
2009
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| 18 | PRTN3
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| Differences in the substrate binding sites of murine and human proteinase 3 and neutrophil elastase.
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| Hajjar E, Korkmaz B, Reuter N.
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| FEBS Lett 581(29):5685-90. Epub 2007 Nov 20. 2007
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| 19 | CTSG, ELA2, ELANE, ELN, PRTN3
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| Human leukocyte elastase hydrolysis of peptides derived from human elastin exon 24.
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| Lombard C, Arzel L, Bouchu D, Wallach J, Saulnier J.
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| Biochimie 88(12):1915-21. Epub 2006 Aug 10. 2006
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| 20 | PRTN3, WG
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| Proteinase 3, Wegener's autoantigen: from gene to antigen.
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| van der Geld YM, Limburg PC, Kallenberg CG.
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| J Leukoc Biol 69(2):177-90. Review.
2001
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| 21 | CSF3, PRTN3, SPI1
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| Myeloblastin is a granulocyte colony-stimulating factor-responsive gene conferring factor-independent growth to hematopoietic cells.
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| Lutz PG, Moog-Lutz C, Coumau-Gatbois E, Kobari L, Di Gioia Y, Cayre YE.
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| Proc Natl Acad Sci U S A 97(4):1601-1606 2000
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| 22 | PRTN3
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| Proteinase 3 gene polymorphisms and Wegener's granulomatosis.
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| Gencik M, Meller S, Borgmann S, Fricke H.
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| Kidney Int 58(6):2473-7. 2000
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| 23 | PRTN3, WG
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| Proteinase 3 gene polymorphisms and Wegener's granulomatosis.
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| Gencik M, Meller S, Borgmann S, Fricke H.
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| Kidney Int 58(6):2473-7.
2000
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| 24 | PRTN3
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| The proteinase 3 (PRTN3) gene is localized on 19p13.3 and is distal to the E2A gene.
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| Le Coniat M, et al.
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| Ann Genet 38 : 231-233. 1995
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| 25 | PRTN3
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| A myeloblastin/proteinase-3 cDNA clone identifies a BglII and a PvuII restriction fragment length polymorphism.
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| Schwaller J, et al.
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| Hum Genet 92 : 525. 1993
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| 26 | PRTN3
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| Localization of the gene encoding proteinase-3 (the Wegener's granulomatosis autoantigen) to human chromosome band 19p13.3.
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| Sturrock AB, et al.
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| Cytogenet Cell Genet 64 : 33-34. 1993
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| 27 | AZU1, ELANE, PRTN3
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| Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter.
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| Zimmer M, Medcalf RL, Fink TM, Mattmann C, Lichter P, Jenne DE.
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| Proc Natl Acad Sci U S A 89 : 8215-8219. 1992
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| 28 | PRTN3
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| Structure, chromosomal assignment, and expression of the gene for proteinase-3. The Wegener's granulomatosis autoantigen.
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| Sturrock AB, et al.
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| J Biol Chem 267 : 21193-21199. 1992
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| 29 | PRTN3
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| Wegener's autoantigen decoded.
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| Jenne D, et al.
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| Nature 346 : 520. 1990
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| 30 | PRTN3
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| Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells.
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| Bories D, et al.
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| Cell 59 : 959-968. 1989
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