| 1 | PRSS8, SCNN1A
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| Colon-specific deletion of epithelial sodium channel causes sodium loss and aldosterone resistance.
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| Malsure S, Wang Q, Charles RP, Sergi C, Perrier R, Christensen BM, Maillard M, Rossier BC, Hummler E.
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| J Am Soc Nephrol 25(7):1453-64. doi: 10.1681/ASN.2013090936. Epub 2014 Jan 30.
2014
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| 2 | PRSS8
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| The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease nexin-1 (PN-1) inhibition.
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| Crisante G, Battista L, Iwaszkiewicz J, Nesca V, Mérillat AM, Sergi C, Zoete V, Frateschi S, Hummler E.
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| FASEB J ASEB J. 2014 Aug 19. pii: fj.14-253781. [Epub ahead of print]
2014
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| 3 | PRSS8
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| The Membrane-anchored Serine Protease Prostasin (CAP1/PRSS8) Supports Epidermal Development and Postnatal Homeostasis Independent of Its Enzymatic Activity.
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| Peters DE, Szabo R, Friis S, Shylo NA, Uzzun Sales K, Holmbeck K, Bugge TH.
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| J Biol Chem 289(21):14740-9. doi: 10.1074/jbc.M113.541318. Epub 2014 Apr 4.
2014
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| 4 | PRSS8
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| The serine protease prostasin regulates hepatic insulin sensitivity by modulating TLR4 signalling.
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| Uchimura K, Hayata M, Mizumoto T, Miyasato Y, Kakizoe Y, Morinaga J, Onoue T, Yamazoe R, Ueda M, Adachi M, Miyoshi T, Shiraishi N, Ogawa W, Fukuda K, Kondo T, Matsumura T, Araki E, Tomita K, Kitamura K.
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| Nat Commun 5:3428. doi: 10.1038/ncomms4428.
2014
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| 5 | MSMB, PRSS8
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| PSP94, an upstream signaling mediator of prostasin found highly elevated in ovarian cancer.
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| Ma JX, Yan BX, Zhang J, Jiang BH, Guo Y, Riedel H, Mueller MD, Remick SC, Yu JJ.
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| Cell Death Dis 5:e1407. doi: 10.1038/cddis.2014.374.
2014
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| 6 | PRSS8, ST14, TMPRSS11E, TMPRSS13, TMPRSS4
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| TMPRSS13 deficiency impairs stratum corneum formation and epidermal barrier acquisition.
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| Madsen DH, Szabo R, Molinolo AA, Bugge TH.
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| Biochem J 461(3):487-95. doi: 10.1042/BJ20140337.
2014
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| 7 | PRSS8
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| A matriptase-prostasin reciprocal zymogen activation complex with unique features: prostasin as a non-enzymatic co-factor for matriptase activation.
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| Friis S, Uzzun Sales K, Godiksen S, Peters DE, Lin CY, Vogel LK, Bugge TH.
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| J Biol Chem 288(26):19028-39. doi: 10.1074/jbc.M113.469932. Epub 2013 May 14.
2013
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| 8 | PRSS8
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| Mutations of the serine protease CAP1/Prss8 lead to reduced embryonic viability, skin defects, and decreased ENaC activity.
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| Frateschi S, Keppner A, Malsure S, Iwaszkiewicz J, Sergi C, Merillat AM, Fowler-Jaeger N, Randrianarison N, Planès C, Hummler E.
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| Am J Pathol 181(2):605-15. doi: 10.1016/j.ajpath.2012.05.007. Epub 2012 Jun 13.
2012
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| 9 | PRSS8, SPINT1, ST14
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| Regulation of pericellular proteolysis by hepatocyte growth factor activator inhibitor type 1 (HAI-1) in trophoblast cells.
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| Kohama K, Kawaguchi M, Fukushima T, Lin CY, Kataoka H.
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| Hum Cell 25(4):100-10. doi: 10.1007/s13577-012-0055-2. Epub 2012 Dec 18.
2012
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| 10 | PRSS8, SPINT1, SPINT2, ST14
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| Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation.
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| Szabo R, Uzzun Sales K, Kosa P, Shylo NA, Godiksen S, Hansen KK, Friis S, Gutkind JS, Vogel LK, Hummler E, Camerer E, Bugge TH.
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| PLoS Genet 8(8):e1002937. doi: 10.1371/journal.pgen.1002937. Epub 2012 Aug 30.
2012
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| 11 | PRSS8, ST14
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| Transport via the transcytotic pathway makes prostasin available as a substrate for matriptase.
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| Friis S, Godiksen S, Bornholdt J, Selzer-Plon J, Rasmussen HB, Bugge TH, Lin CY, Vogel LK.
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| J Biol Chem 286(7):5793-802. doi: 10.1074/jbc.M110.186874. Epub 2010 Dec 10.
2011
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| 12 | HPN, PRSS8
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| Hepsin activates prostasin and cleaves the extracellular domain of the epidermal growth factor receptor.
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| Chen M, Chen LM, Lin CY, Chai KX.
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| Mol Cell Biochem 337(1-2):259-66. doi: 10.1007/s11010-009-0307-y. 2010
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| 13 | PRSS8
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| Prostasin regulates human placental trophoblast cell proliferation via the epidermal growth factor receptor signaling pathway.
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| Fu YY, Gao WL, Chen M, Chai KX, Wang YL, Chen LM.
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| Hum Reprod 25(3):623-32. doi: 10.1093/humrep/dep457. Epub 2010 Jan 20.
2010
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| 14 | PRSS8
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| Loss of prostasin (PRSS8) in human bladder transitional cell carcinoma cell lines is associated with epithelial-mesenchymal transition (EMT).
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| Chen LM, Verity NJ, Chai KX.
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| BMC Cancer 9:377. doi: 10.1186/1471-2407-9-377.
2009
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| 15 | PRSS8
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| Structure of human prostasin, a target for the regulation of hypertension.
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| Rickert KW, Kelley P, Byrne NJ, Diehl RE, Hall DL, Montalvo AM, Reid JC, Shipman JM, Thomas BW, Munshi SK, Darke PL, Su HP.
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| J Biol Chem 283(50):34864-72. doi: 10.1074/jbc.M805262200. Epub 2008 Oct 14.
2008
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| 16 | PRSS8, SPINT1, ST14
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| Hepatocyte growth factor activator inhibitor-1 has a complex subcellular itinerary.
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| Godiksen S, Selzer-Plon J, Pedersen ED, Abell K, Rasmussen HB, Szabo R, Bugge TH, Vogel LK.
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| Biochem J 413(2):251-9. doi: 10.1042/BJ20071496.
2008
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| 17 | PRSS8
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| Prostasin induces protease-dependent and independent molecular changes in the human prostate carcinoma cell line PC-3.
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| Chen M, Fu YY, Lin CY, Chen LM, Chai KX.
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| Biochim Biophys Acta 1773(7):1133-40. Epub 2007 May 1. 2007
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| 18 | PRSS8
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| Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase.
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| List K, Hobson JP, Molinolo A, Bugge TH.
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| J Cell Physiol 213(1):237-45.
2007
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| 19 | PRSS8, SNAI2
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| Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG.
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| Chen M, Chen LM, Chai KX.
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| Prostate 66(9):911-20. 2006
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| 20 | GPLD1, PRSS8
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| Prostasin regulates epithelial monolayer function: cell-specific Gpld1-mediated secretion and functional role for GPI anchor.
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| Verghese GM, Gutknecht MF, Caughey GH.
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| Am J Physiol Cell Physiol 291(6):C1258-70. Epub 2006 Jul 5.
2006
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| 21 | SPINT1, PRSS8
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| Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin.
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| Fan B, Wu TD, Li W, Kirchhofer D.
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| J Biol Chem 280(41):34513-20. Epub 2005 Aug 15. 2005
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| 22 | PRSS8
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| Biochemical characterization of prostasin, a channel activating protease.
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| Shipway A, Danahay H, Williams JA, Tully DC, Backes BJ, Harris JL.
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| Biochem Biophys Res Commun 324(2):953-63. 2004
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| 23 | PRSS8
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| Prostasin is a glycosylphosphatidylinositol-anchored active serine protease.
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| Chen LM, Skinner ML, Kauffman SW, Chao J, Chao L, Thaler CD, Chai KX.
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| J Biol Chem 276(24):21434-42. 2001
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| 24 | PRSS8
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| Structure and chromosomal localization of the human prostasin (PRSS8) gene.
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| Yu JX, et al.
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| Genomics 32 : 334-340. 1996
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| 25 | PRSS8
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| Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA.
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| Yu JX, et al.
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| J Biol Chem 270 : 13483-13489. 1995
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| 26 | PRSS8
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| Prostasin is a novel human serine proteinase from seminal fluid.
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| Yu JX, et al.
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| J Biol Chem 269 : 18843-18848. 1994
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