Citations for
Prospero-related homeobox 1 (Prox1) at the crossroads of diverse pathways during adult neural fate specification.
Stergiopoulos A, Elkouris M, Politis PK.
Front Cell Neurosci 8:454. doi: 10.3389/fncel.2014.00454. eCollection 2014. Review. 2015
PROX1 gene is differentially expressed in oral cancer and reduces cellular proliferation.
Rodrigues MF, de Oliveira Rodini C, de Aquino Xavier FC, Paiva KB, Severino P, Moyses RA, López RM, DeCicco R, Rocha LA, Carvalho MB, Tajara EH, Nunes FD.
Medicine (Baltimore) 93(28):e192. doi: 10.1097/MD.0000000000000192. 2014
Prox1 regulates Olig2 expression to modulate binary fate decisions in spinal cord neurons.
Kaltezioti V, Antoniou D, Stergiopoulos A, Rozani I, Rohrer H, Politis PK.
J Neurosci 34(47):15816-31. doi: 10.1523/JNEUROSCI.1865-14.2014. 2014
Prox1 directly interacts with LSD1 and recruits the LSD1/NuRD complex to epigenetically co-repress CYP7A1 transcription.
Ouyang H, Qin Y, Liu Y, Xie Y, Liu J.
PLoS One 8(4):e62192. doi: 10.1371/journal.pone.0062192. Print 2013. 2013
Transcriptional activation of the Prox1 gene by HIF-1α and HIF-2α in response to hypoxia.
Zhou B, Si W, Su Z, Deng W, Tu X, Wang Q.
FEBS Lett 587(6):724-31. doi: 10.1016/j.febslet.2013.01.053. Epub 2013 Feb 8. 2013
Cell-cell interactions influence vascular reprogramming by Prox1 during embryonic development.
Kim H, Cruz M, Bourdeau A, Dumont DJ.
PLoS One 8(1):e52197. doi: 10.1371/journal.pone.0052197. Epub 2013 Jan 14. 2013
Genetic and molecular insights into the role of PROX1 in glucose metabolism.
Lecompte S, Pasquetti G, Hermant X, Grenier-Boley B, Gonzalez-Gross M, De Henauw S, Molnar D, Stehle P, Béghin L, Moreno LA, Amouyel P, Dallongeville J, Meirhaeghe A.
Diabetes 62(5):1738-45. doi: 10.2337/db12-0864. Epub 2012 Dec 28. 2013
Prox1 postmitotically defines dentate gyrus cells by specifying granule cell identity over CA3 pyramidal cell fate in the hippocampus.
Iwano T, Masuda A, Kiyonari H, Enomoto H, Matsuzaki F.
Development 139(16):3051-62. doi: 10.1242/dev.080002. Epub 2012 Jul 12. 2012
The tumor suppressor p53 regulates c-Maf and Prox-1 to control lens differentiation.
Liu FY, Tang XC, Deng M, Chen P, Ji W, Zhang X, Gong L, Woodward Z, Liu J, Zhang L, Sun S, Liu JP, Wu K, Wu MX, Liu XL, Yu MB, Liu Y, Li DW.
Curr Mol Med 12(8):917-28. 2012
10NR1I2, PROX1
PROX1 suppresses vitamin K-induced transcriptional activity of Steroid and Xenobiotic Receptor.
Azuma K, Urano T, Watabe T, Ouchi Y, Inoue S.
Genes Cells 16(11):1063-70. doi: 10.1111/j.1365-2443.2011.01551.x. 2011
Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis.
Karalay O, Doberauer K, Vadodaria KC, Knobloch M, Berti L, Miquelajauregui A, Schwark M, Jagasia R, Taketo MM, Tarabykin V, Lie DC, Jessberger S.
Proc Natl Acad Sci U S A 108(14):5807-12. doi: 10.1073/pnas.1013456108. Epub 2011 Mar 21. 2011
Sox1 maintains the undifferentiated state of cortical neural progenitor cells via the suppression of Prox1-mediated cell cycle exit and neurogenesis
Elkouris M, Balaskas N, Poulou M, Politis PK, Panayiotou E, Malas S, Thomaidou D, Remboutsika E.
Stem Cells. Jan;29(1):89-98. doi: 10.1002/stem.554. 2011
The homeobox protein Prox1 is a negative modulator of ERR{alpha}/PGC-1{alpha} bioenergetic functions.
Charest-Marcotte A, Dufour CR, Wilson BJ, Tremblay AM, Eichner LJ, Arlow DH, Mootha VK, Gigučre V.
Genes Dev 24(6):537-42. Epub 2010 Mar 1.PMID: 20194433 2010
Prox1 regulates the notch1-mediated inhibition of neurogenesis.
Kaltezioti V, Kouroupi G, Oikonomaki M, Mantouvalou E, Stergiopoulos A, Charonis A, Rohrer H, Matsas R, Politis PK.
PLoS Biol 8(12):e1000565. doi: 10.1371/journal.pbio.1000565. 2010
Separation of the PROX1 gene from upstream conserved elements in a complex inversion/translocation patient with hypoplastic left heart.
Gill HK, Parsons SR, Spalluto C, Davies AF, Knorz VJ, Burlinson CE, Ng BL, Carter NP, Ogilvie CM, Wilson DI, Roberts RG.
Eur J Hum Genet 17(11):1423-31. Epub 2009 May 27. 2009
Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis.
Harada K, Yamazaki T, Iwata C, Yoshimatsu Y, Sase H, Mishima K, Morishita Y, Hirashima M, Oike Y, Suda T, Miura N, Watabe T, Miyazono K.
J Cell Sci 122(Pt 21):3923-30. Epub 2009 Oct 13.PMID: 19825936 2009
Sumoylation of Prox1 controls its ability to induce VEGFR3 expression and lymphatic phenotypes in endothelial cells.
Pan MR, Chang TM, Chang HC, Su JL, Wang HW, Hung WC.
J Cell Sci 122(Pt 18):3358-64. Epub 2009 Aug 25.PMID: 19706680 2009
18NR2F2, PROX1
COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction.
Yamazaki T, Yoshimatsu Y, Morishita Y, Miyazono K, Watabe T.
Genes Cells 14(3):425-34. Epub 2009 Feb 4.PMID: 19210544 2009
19NR2F2, PROX1
Prox1 physically and functionally interacts with COUP-TFII to specify lymphatic endothelial cell fate.
Lee S, Kang J, Yoo J, Ganesan SK, Cook SC, Aguilar B, Ramu S, Lee J, Hong YK.
Blood 113(8):1856-9. Epub 2008 Sep 24.PMID: 18815287 2009
Repression of interferon-gamma expression in T cells by Prospero-related homeobox protein.
Wang L, Zhu J, Shan S, Qin Y, Kong Y, Liu J, Wang Y, Xie Y.
Cell Res 18(9):911-20.PMID: 19160541 2008
Modulation of transcriptional corepressor activity of prospero-related homeobox protein (Prox1) by SUMO modification.
Shan SF, Wang LF, Zhai JW, Qin Y, Ouyang HF, Kong YY, Liu J, Wang Y, Xie YH.
FEBS Lett 582(27):3723-8. Epub 2008 Oct 21.PMID: 18948102 2008
Prox-1 promotes invasion of kaposiform hemangioendotheliomas.
Dadras SS, Skrzypek A, Nguyen L, Shin JW, Schulz MM, Arbiser J, Mihm MC, Detmar M.
J Invest Dermatol 128(12):2798-806. Epub 2008 Jun 26.PMID: 18580962 2008
Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity.
Harvey NL, Srinivasan RS, Dillard ME, Johnson NC, Witte MH, Boyd K, Sleeman MW, Oliver G.
Nat Genet 37(10):1072-81. Epub 2005 Sep 18. 2005
Lymphangiogenesis in development and human disease.
Alitalo K, Tammela T, Petrova TV.
Nature 438(7070):946-53. Review. 2005
Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina.
Dyer MA, Livesey FJ, Cepko CL, Oliver G.
Nat Genet 34(1):53-8. 2003
Regulation of proliferation, cell fate specification and differentiation by the homeodomain proteins prox1, six3, and chx10 in the developing retina.
Dyer MA.
Cell Cycle 2(4):350-7. 2003
Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies.
Nagai H, Li Y, Hatano S, Toshihito O, Yuge M, Ito E, Utsumi M, Saito H, Kinoshita T.
Genes Chromosomes Cancer 38(1):13-21. 2003
Prox1, master regulator of the lymphatic vasculature phenotype.
Hong YK, Detmar M.
Cell Tissue Res 314(1):85-92. Epub 2003 Jul 22. Review.PMID: 12883994 2003
Prox1 function is crucial for mouse lens-fibre elongation.
Wigle JT, Chowdhury K, Gruss P, Oliver G.
Nat Genet 21(3):318-22. 1999
Structure and chromosomal localization of the human homeobox gene Prox 1.
Zinovieva RD, et al.
Genomics 35 : 517-522. 1996