| 1 | PROK1, PROK2, PROKR1, PROKR2
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| Prokineticins and their G protein-coupled receptors in health and disease.
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| Zhao Y, Wu J, Wang X, Jia H, Chen DN, Li JD.
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| Prog Mol Biol Transl Sci. 161:149-179. doi: 10.1016/bs.pmbts.2018.09.006. Epub 2018 Oct 24 2019
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| 2 | PROK2, PROKR1, TBX20
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| TBX20 Regulates Angiogenesis Through the Prokineticin 2-Prokineticin Receptor 1 Pathway.
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| Meng S, Gu Q, Yang X, Lv J, Owusu I, Matrone G, Chen K, Cooke JP, Fang L.
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| Circulation Aug 28;138(9):913-928. doi: 10.1161/CIRCULATIONAHA.118.033939 2018
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| 3 | PROK1, PROK2
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| Prokineticins in central and peripheral control of human reproduction.
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| Traboulsi W, Brouillet S, Sergent F, Boufettal H, Samouh N, Aboussaouira T, Hoffmann P, Feige JJ, Benharouga M, Alfaidy N.
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| Horm Mol Biol Clin Investig. Nov;24(2):73-81. doi: 10.1515/hmbci-2015-0040 2015
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| 4 | PROK2
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| Absence of central circadian pacemaker abnormalities in humans with loss of function mutation in prokineticin 2.
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| Balasubramanian R, Cohen DA, Klerman EB, Pignatelli D, Hall JE, Dwyer AA, Czeisler CA, Pitteloud N, Crowley WF.
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| J Clin Endocrinol Metab 99(3):E561-6. doi: 10.1210/jc.2013-2096. Epub 2014 Jan 1.
2014
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| 5 | KAL3, KAL4, PROK2, PROKR2
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| PROK2/PROKR2 Signaling and Kallmann Syndrome.
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| Dodé C, Rondard P.
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| Front Endocrinol (Lausanne) 4:19. doi: 10.3389/fendo.2013.00019. eCollection 2013.
2013
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| 6 | PROK2, PROKR2
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| Prokineticin 2 potentiates acid-sensing ion channel activity in rat dorsal root ganglion neurons.
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| Qiu CY, Liu YQ, Qiu F, Wu J, Zhou QY, Hu WP.
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| J Neuroinflammation 9:108. doi: 10.1186/1742-2094-9-108.
2012
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| 7 | PROK2
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| Prokineticin 2 is involved in the thermoregulation and energy expenditure.
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| Zhou W, Li JD, Hu WP, Cheng MY, Zhou QY.
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| Regul Pept 179(1-3):84-90. doi: 10.1016/j.regpep.2012.08.003. Epub 2012 Sep 4.
2012
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| 8 | PROK2
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| Prokineticin 2 is an endangering mediator of cerebral ischemic injury.
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| Cheng MY, Lee AG, Culbertson C, Sun G, Talati RK, Manley NC, Li X, Zhao H, Lyons DM, Zhou QY, Steinberg GK, Sapolsky RM.
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| Proc Natl Acad Sci U S A 109(14):5475-80. doi: 10.1073/pnas.1113363109. Epub 2012 Mar 19.
2012
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| 9 | PROK2
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| Prokineticin 2 regulates the electrical activity of rat suprachiasmatic nuclei neurons.
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| Ren P, Zhang H, Qiu F, Liu YQ, Gu H, O'Dowd DK, Zhou QY, Hu WP.
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| PLoS One 6(6):e20263. doi: 10.1371/journal.pone.0020263. Epub 2011 Jun 8.
2011
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| 10 | CDH7, FGF8, FGFR1, GNRHR, IHH1, IHH2GNRH1, KAL1, KAL1, KAL2, KAL3, KAL4, KISS1R, PCC, PROK2, PROKR2, TAC3, TACR3
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| Genetics basis for GnRH-dependent pubertal disorders in humans.
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| Silveira LF, Trarbach EB, Latronico AC.
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| Mol Cell Endocrinol 324(1-2):30-8. Epub 2010 Feb 25. Review.PMID: 20188792 2010
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| 11 | PROK2, PROKR1, PROKR2
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| Divergent roles of prokineticin receptors in the endothelial cells: angiogenesis and fenestration.
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| Guilini C, Urayama K, Turkeri G, Dedeoglu DB, Kurose H, Messaddeq N, Nebigil CG.
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| Am J Physiol Heart Circ Physiol 298(3):H844-52. doi: 10.1152/ajpheart.00898.2009. Epub 2009 Dec 18.
2010
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| 12 | KAL3, KAL4, PROK2, PROKR2
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| Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum.
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| Cole LW, Sidis Y, Zhang C, Quinton R, Plummer L, Pignatelli D, Hughes VA, Dwyer AA, Raivio T, Hayes FJ, Seminara SB, Huot C, Alos N, Speiser P, Takeshita A, Van Vliet G, Pearce S, Crowley WF Jr, Zhou QY, Pitteloud N.
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| J Clin Endocrinol Metab 93(9):3551-9. Epub 2008 Jun 17.
2008
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| 13 | KAL3, KAL4, PROK2, PROKR2
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| Loss-of-function mutations in the genes encoding prokineticin-2 or prokineticin receptor-2 cause autosomal recessive Kallmann syndrome.
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| Abreu AP, Trarbach EB, de Castro M, Frade Costa EM, Versiani B, Matias Baptista MT, Garmes HM, Mendonca BB, Latronico AC.
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| J Clin Endocrinol Metab 93(10):4113-8. Epub 2008 Aug 5.
2008
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| 14 | PROKR2, PROK2
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| Prokineticin receptor 2 (Prokr2) is essential for the regulation of circadian behavior by the suprachiasmatic nuclei.
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| Prosser HM, Bradley A, Chesham JE, Ebling FJ, Hastings MH, Maywood ES.
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| Proc Natl Acad Sci U S A 104(2):648-53. Epub 2007 Jan 3. 2007
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| 15 | KAL4, PROK2
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| Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism.
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| Pitteloud N, Zhang C, Pignatelli D, Li JD, Raivio T, Cole LW, Plummer L, Jacobson-Dickman EE, Mellon PL, Zhou QY, Crowley WF Jr.
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| Proc Natl Acad Sci U S A 104(44):17447-52. Epub 2007 Oct 24. 2007
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| 16 | PROK2
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| Bv8 regulates myeloid-cell-dependent tumour angiogenesis.
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| Shojaei F, Wu X, Zhong C, Yu L, Liang XH, Yao J, Blanchard D, Bais C, Peale FV, van Bruggen N, Ho C, Ross J, Tan M, Carano RA, Meng YG, Ferrara N.
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| Nature 450(7171):825-31. 2007
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| 17 | KAL1, KAL2, KAL3, KAL4, PROK2, PROKR2
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| Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2.
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| Dode C, Teixeira L, Levilliers J, Fouveaut C, Bouchard P, Kottler ML, Lespinasse J, Lienhardt-Roussie A, Mathieu M, Moerman A, Morgan G, Murat A, Toublanc JE, Wolczynski S, Delpech M, Petit C, Young J, Hardelin JP.
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| PLoS Genet 2(10):e175. Epub 2006 Sep 1. 2006
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| 18 | PROK2
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| Dependence of olfactory bulb neurogenesis on prokineticin 2 signaling.
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| Ng KL, Li JD, Cheng MY, Leslie FM, Lee AG, Zhou QY.
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| Science 308(5730):1923-7. 2005
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| 19 | PROK2
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| Identification and pharmacological characterization of prokineticin 2 beta as a selective ligand for prokineticin receptor 1.
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| Chen J, Kuei C, Sutton S, Wilson S, Yu J, Kamme F, Mazur C, Lovenberg T, Liu C.
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| Mol Pharmacol 67(6):2070-6. Epub 2005 Mar 16. 2005
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| 20 | PROK2
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| Structural determinants required for the bioactivities of prokineticins and identification of prokineticin receptor antagonists.
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| Bullock CM, Li JD, Zhou QY.
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| Mol Pharmacol 65(3):582-8. 2004
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| 21 | PROK2
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| Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus.
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| Cheng MY, Bullock CM, Li C, Lee AG, Bermak JC, Belluzzi J, Weaver DR, Leslie FM, Zhou QY.
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| Nature 417(6887):405-10. 2002
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| 22 | PROK1, PROK2, PROKR1
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| Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor.
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| Lin DC, Bullock CM, Ehlert FJ, Chen JL, Tian H, Zhou QY.
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| J Biol Chem 277(22):19276-80. Epub 2002 Mar 08. 2002
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| 23 | PROK1, PROK2, PROKR1, PROKR2
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| Molecular cloning and characterization of prokineticin receptors.
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| Soga T, Matsumoto S, Oda T, Saito T, Hiyama H, Takasaki J, Kamohara M, Ohishi T, Matsushime H, Furuichi K.
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| Biochim Biophys Acta 1579(2-3):173-9. 2002
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| 24 | PROK2
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| The mammalian homologue of the novel peptide Bv8 is expressed in the central nervous system and supports neuronal survival by activating the MAP kinase/PI-3-kinase pathways.
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| Melchiorri D, Bruno V, Besong G, Ngomba RT, Cuomo L, De Blasi A, Copani A, Moschella C, Storto M, Nicoletti F, Lepperdinger G, Passarelli F.
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| Eur J Neurosci 13(9):1694-702. 2001
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