| 1 | GOLPH3, MYO18A, PRKDC
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| DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3.
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| Farber-Katz SE, Dippold HC, Buschman MD, Peterman MC, Xing M, Noakes CJ, Tat J, Ng MM, Rahajeng J, Cowan DM, Fuchs GJ, Zhou H, Field SJ.
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| Cell 156(3):413-27. doi: 10.1016/j.cell.2013.12.023.
2014
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| 2 | IMD26, PRKDC
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| PRKDC mutations in a SCID patient with profound neurological abnormalities.
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| Woodbine L, Neal JA, Sasi NK, Shimada M, Deem K, Coleman H, Dobyns WB, Ogi T, Meek K, Davies EG, Jeggo PA.
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| J Clin Invest 123(7):2969-80. doi: 10.1172/JCI67349. Epub 2013 Jun 3.
2013
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| 3 | LMX1A, PRKDC
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| DNA-dependent protein kinase is a context dependent regulator of Lmx1a and midbrain specification.
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| Hunt CP, Fabb SA, Pouton CW, Haynes JM.
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| PLoS One 8(10):e78759. doi: 10.1371/journal.pone.0078759. eCollection 2013.
2013
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| 4 | NHEJ1, PRKDC
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| Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining.
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| Oksenych V, Kumar V, Liu X, Guo C, Schwer B, Zha S, Alt FW.
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| Proc Natl Acad Sci U S A 110(6):2234-9. doi: 10.1073/pnas.1222573110. Epub 2013 Jan 23.
2013
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| 5 | NR5A1, PRKDC
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| Steroidogenic factor 1 (NR5A1) maintains centrosome homeostasis in steroidogenic cells by restricting centrosomal DNA-dependent protein kinase activation.
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| Wang CY, Kao YH, Lai PY, Chen WY, Chung BC.
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| Mol Cell Biol 33(3):476-84. doi: 10.1128/MCB.01064-12. Epub 2012 Nov 19.
2013
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| 6 | DEAF1, PRKDC, XRCC5, XRCC6
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| Deformed epidermal autoregulatory factor-1 (DEAF1) interacts with the Ku70 subunit of the DNA-dependent protein kinase complex.
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| Jensik PJ, Huggenvik JI, Collard MW.
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| PLoS One 7(3):e33404. doi: 10.1371/journal.pone.0033404. Epub 2012 Mar 19.
2012
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| 7 | NR4A1, NR4A2, PRKDC
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| Essential role for DNA-PK-mediated phosphorylation of NR4A nuclear orphan receptors in DNA double-strand break repair.
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| Malewicz M, Kadkhodaei B, Kee N, Volakakis N, Hellman U, Viktorsson K, Leung CY, Chen B, Lewensohn R, van Gent DC, Chen DJ, Perlmann T.
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| Genes Dev 25(19):2031-40. doi: 10.1101/gad.16872411.
2011
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| 8 | PRKDC
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| A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensitivity in a patient with xeroderma pigmentosum.
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| Abbaszadeh F, Clingen PH, Arlett CF, Plowman PN, Bourton EC, Themis M, Makarov EM, Newbold RF, Green MH, Parris CN.
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| J Med Genet 47(3):176-81. Epub 2009 Sep 24.PMID: 19797196 2010
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| 9 | CENPF, PRKDC
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| Involvement of Cenp-F in interphase chromatin organization possibly through association with DNA-dependent protein kinase.
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| Du J, Zhang Y, Liu Y, Li Y, Zhu X.
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| Acta Biochim Biophys Sin (Shanghai) 42(12):839-46. Epub 2010 Oct 26.
2010
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| 10 | ATM, PRKDC, TDP1
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| Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK.
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| Das BB, Antony S, Gupta S, Dexheimer TS, Redon CE, Garfield S, Shiloh Y, Pommier Y.
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| EMBO J 28(23):3667-80. Epub 2009 Oct 22.PMID: 19851285 2009
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| 11 | HNRNPU, PRKDC
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| hnRNP-U is a specific DNA-dependent protein kinase substrate phosphorylated in response to DNA double-strand breaks.
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| Berglund FM, Clarke PR.
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| Biochem Biophys Res Commun 381(1):59-64. Epub 2009 Feb 11.
2009
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| 12 | PRKDC
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| Variants in DNA double-strand break repair and DNA damage-response genes and susceptibility to lung and head and neck cancers.
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| Danoy P, Michiels S, Dessen P, Pignat C, Boulet T, Monet M, Bouchardy C, Lathrop M, Sarasin A, Benhamou S.
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| Int J Cancer 123(2):457-63. 2008
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| 13 | DYRK2, ABL1, PRKCD, PRKDC
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| Nuclear trafficking of pro-apoptotic kinases in response to DNA damage.
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| Yoshida K.
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| Trends Mol Med 14(7):305-13. Epub 2008 Jun 6. 2008
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| 14 | XRCC6, LIG4, PRKDC, XRCC4, XRCC5
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| Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment.
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| Calsou P, Delteil C, Frit P, Drouet J, Salles B.
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| J Mol Biol 326(1):93-103. 2003
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| 15 | XRCC6, LIG4, POLM, PRKDC, XRCC4, XRCC5
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| Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair.
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| Mahajan KN, Nick McElhinny SA, Mitchell BS, Ramsden DA.
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| Mol Cell Biol 22(14):5194-202. 2002
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| 16 | PRKDC, WRN
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| Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase.
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| Yannone SM, Roy S, Chan DW, Murphy MB, Huang S, Campisi J, Chen DJ.
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| J Biol Chem 276(41):38242-8. 2001
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| 17 | XRCC6, XRCC5, LIG4, PRKDC, XRCC4
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| Binding of inositol phosphate to DNA-PK and stimulation of double-strand break repair.
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| Hanakahi LA, Bartlet-Jones M, Chappell C, Pappin D, West SC.
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| Cell 102(6):721-9. 2000
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| 18 | CLU, XRCC5, PRKDC, XRCC6BP1
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| Isolation of Ku70-binding proteins (KUBs).
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| Yang CR, Yeh S, Leskov K, Odegaard E, Hsu HL, Chang C, Kinsella TJ, ChenDJ, Boothman DA.
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| Nucleic Acids Res 27(10):2165-74. 1999
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| 19 | MCM4, PRKDC
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| The promoters for human DNA-PKcs (PRKDC) and MCM4 : divergently transcribed genes located at chromosome 8 band q11.
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| Connelly MA, Zhang H, Kieleczawa J, Anderson CW.
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| Genomics 47(1):71-83. 1998
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| 20 | PRKDC
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| Characterization of the promoter region, first ten exons and nine intron-exon boundaries of the DNA-dependent protein kinase catalytic subunit gene, DNA-PKcs (XRCC7).
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| Fujimoto M, Matsumoto N, Tsujita T, Tomita H, Kondo S, Miyake N, Nakano M, Niikawa N.
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| DNA Res 4(2):151-4. 1997
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| 21 | PRKDC, MCM4
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| MCM4 and PRKDC, human genes encoding proteins MCM4 and DNA-PKcs, are close neighbours located on chromosome 8q12-->q13.
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| Ladenburger EM, Fackelmayer FO, Hameister H, Knippers R.
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| Cytogenet Cell Genet 77(3-4):268-70. 1997
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| 22 | PRKDC
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| Gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8.
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| Sipley JD, et al.
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| Proc Natl Acad Sci U S A 92 : 7515-7519. 1995
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| 23 | PRKDC
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| Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation.
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| Blunt T, et al.
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| Cell 80 : 813-823. 1995
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| 24 | PRKDC
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| Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells.
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| Peterson SR, et al.
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| Proc Natl Acad Sci U S A 92 : 3171-3174. 1995
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| 25 | ATM, XRCC6, XRCC5, PRKDC
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| DNA-dependent protein kinase catalytic subunit : a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product.
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| Hartley KO, et al.
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| Cell 82 : 849-856. 1995
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| 26 | PRKDC
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| Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus.
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| Miller RD, et al.
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| Proc Natl Acad Sci U S A 92 : 10792-10795. 1995
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| 27 | PRKDC
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| The scid factor on human chromosome 8 restores V(D)J recombination in addition to double-strand break repair.
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| Komatsu K, et al.
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| Cancer Res 55 : 1774-1779. 1995
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| 28 | PRKDC
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| A human gene that restores the DNA-repair defect in SCID mice is locatedon 8p11.1-q11.1.
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| Kurimasa A, et al.
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| Hum Genet 93 : 21-26. 1994
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| 29 | PRKDC
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| Functional complementation in mouse-human radiation hybrids assigns the putative murine scid gene to the pericentric region of human chromosome 8.
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| Komatsu K, et al.
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| Hum Mol Genet 2 : 1031-1034. 1993
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