| 1 | HSP90AA1, PRKD2
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| HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization.
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| Azoitei N, Diepold K, Brunner C, Rouhi A, Genze F, Becher A, Kestler H, van Lint J, Chiosis G, Koren J 3rd, Fröhling S, Scholl C, Seufferlein T.
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| Cancer Res 74(23):7125-36. doi: 10.1158/0008-5472.CAN-14-1017. Epub 2014 Oct 8. 2014
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| 2 | MMP9, PRKD2, VEGFA
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| Protein kinase D2 induces invasion of pancreatic cancer cells by regulating matrix metalloproteinases.
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| Wille C, Köhler C, Armacki M, Jamali A, Gössele U, Pfizenmaier K, Seufferlein T, Eiseler T.
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| Mol Biol Cell 25(3):324-36. doi: 10.1091/mbc.E13-06-0334. Epub 2013 Dec 11.
2014
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| 3 | GOLPH3, PRKD2
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| Protein kinase D2 promotes the proliferation of glioma cells by regulating Golgi phosphoprotein 3.
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| Zhou X, Xue P, Yang M, Shi H, Lu D, Wang Z, Shi Q, Hu J, Xie S, Zhan W, Yu R.
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| Cancer Lett 355(1):121-9. doi: 10.1016/j.canlet.2014.09.008. Epub 2014 Sep 16.
2014
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| 4 | PRKD2
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| HSP90 supports tumor growth and angiogenesis through PRKD2 protein stabilization.
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| Azoitei N, Diepold K, Brunner C, Rouhi A, Genze F, Becher A, Kestler H, van Lint J, Chiosis G, Koren J 3rd, Fröhling S, Scholl C, Seufferlein T.
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| Cancer Res 74(23):7125-36. doi: 10.1158/0008-5472.CAN-14-1017. Epub 2014 Oct 8.
2014
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| 5 | CIB1, PRKD2
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| A novel splice variant of calcium and integrin-binding protein 1 mediates protein kinase D2-stimulated tumour growth by regulating angiogenesis.
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| Armacki M, Joodi G, Nimmagadda SC, de Kimpe L, Pusapati GV, Vandoninck S, Van Lint J, Illing A, Seufferlein T.
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| Oncogene 33(9):1167-80. doi: 10.1038/onc.2013.43. Epub 2013 Mar 18.
2014
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| 6 | GABPA, GABPB1, GABPB2, PRKD2
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| GABP transcription factor is required for development of chronic myelogenous leukemia via its control of PRKD2.
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| Yang ZF, Zhang H, Ma L, Peng C, Chen Y, Wang J, Green MR, Li S, Rosmarin AG.
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| Proc Natl Acad Sci U S A 110(6):2312-7. doi: 10.1073/pnas.1212904110. Epub 2013 Jan 23. 2013
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| 7 | BCL6B, HSP90AB1, PRKD2, VEGFA
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| Protein kinase D2 and heat shock protein 90 beta are required for BCL6-associated zinc finger protein mRNA stabilization induced by vascular endothelial growth factor-A.
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| Miwa D, Sakaue T, Inoue H, Takemori N, Kurokawa M, Fukuda S, Omi K, Goishi K, Higashiyama S.
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| Angiogenesis 16(3):675-88. doi: 10.1007/s10456-013-9345-x. Epub 2013 Mar 21.
2013
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| 8 | PRKD1, PRKD2, PRKD3, RHOA, RTKN
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| Protein kinase D regulates RhoA activity via rhotekin phosphorylation.
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| Pusapati GV, Eiseler T, Rykx A, Vandoninck S, Derua R, Waelkens E, Van Lint J, von Wichert G, Seufferlein T.
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| J Biol Chem 287(12):9473-83. doi: 10.1074/jbc.M112.339564. Epub 2012 Jan 6.
2012
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| 9 | PRKD2
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| Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells.
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| Navarro MN, Sinclair LV, Feijoo-Carnero C, Clarke R, Matthews SA, Cantrell DA.
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| Biochem J 442(3):649-59. doi: 10.1042/BJ20111700.
2012
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| 10 | PRKD2, SET
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| Phosphorylation of SET protein at Ser171 by protein kinase D2 diminishes its inhibitory effect on protein phosphatase 2A.
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| Irie A, Harada K, Araki N, Nishimura Y.
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| PLoS One 7(12):e51242. doi: 10.1371/journal.pone.0051242. Epub 2012 Dec 14.
2012
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| 11 | ASAP1, PRKD2, RAB5C
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| Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion.
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| Onodera Y, Nam JM, Hashimoto A, Norman JC, Shirato H, Hashimoto S, Sabe H.
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| J Cell Biol 197(7):983-96. doi: 10.1083/jcb.201201065.
2012
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| 12 | PRKD1, PRKD2
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| Protein kinase D isoforms are activated in an agonist-specific manner in cardiomyocytes.
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| Guo J, Gertsberg Z, Ozgen N, Sabri A, Steinberg SF.
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| J Biol Chem 286(8):6500-9. Epub 2010 Dec 14.
2011
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| 13 | IFNAR1, PRKD2
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| Ligand-stimulated downregulation of the alpha interferon receptor: role of protein kinase D2.
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| Zheng H, Qian J, Varghese B, Baker DP, Fuchs S.
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| Mol Cell Biol 31(4):710-20. doi: 10.1128/MCB.01154-10. Epub 2010 Dec 20.
2011
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| 14 | PRKD1, PRKD2
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| Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells.
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| Matthews SA, Navarro MN, Sinclair LV, Emslie E, Feijoo-Carnero C, Cantrell DA.
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| Biochem J 432(1):153-63. doi: 10.1042/BJ20101188.
2010
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| 15 | PRKD1, PRKD2, SLC9A3R1, SLC9A3R2
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| The protein scaffold NHERF-1 controls the amplitude and duration of localized protein kinase D activity.
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| Kunkel MT, Garcia EL, Kajimoto T, Hall RA, Newton AC.
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| J Biol Chem 284(36):24653-61. Epub 2009 Jul 6.PMID: 19581308 2009
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| 16 | LCK, PRKD2
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| PKD2 interacts with Lck and regulates NFAT activity in T cells.
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| Li Q, Sun X, Wu J, Lin Z, Luo Y.
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| BMB Rep 42(1):35-40. 2009
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| 17 | PRKD2
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| Protein kinase D2 regulates chromogranin A secretion in human BON neuroendocrine tumour cells.
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| von Wichert G, Edenfeld T, von Blume J, Krisp H, Krndija D, Schmid H, Oswald F, Lother U, Walther P, Adler G, Seufferlein T.
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| Cell Signal 20(5):925-34. Epub 2008 Jan 16. 2008
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| 18 | PRKD2
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| Overexpression of wild-type PKD2 leads to increased proliferation and invasion of BON endocrine cells.
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| Jackson LN, Li J, Chen LA, Townsend CM, Evers BM.
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| Biochem Biophys Res Commun 348(3):945-9. Epub 2006 Jul 31. 2006
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| 19 | PRKD2
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| Role of the regulatory domain of protein kinase D2 in phorbol ester binding, catalytic activity, and nucleocytoplasmic shuttling.
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| Auer A, von Blume J, Sturany S, von Wichert G, Van Lint J, Vandenheede J, Adler G, Seufferlein T.
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| Mol Biol Cell 16(9):4375-85. Epub 2005 Jun 22. 2005
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| 20 | PRKD2
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| Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network.
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| Yeaman C, Ayala MI, Wright JR, Bard F, Bossard C, Ang A, Maeda Y, Seufferlein T, Mellman I, Nelson WJ, Malhotra V.
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| Nat Cell Biol 6(2):106-12. Epub 2004 Jan 25. 2004
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| 21 | PRKD2
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| Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases.
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| Sturany S, Van Lint J, Muller F, Wilda M, Hameister H, Hocker M, Brey A,Gern U, Vandenheede J, Gress T, Adler G, Seufferlein T.
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| J Biol Chem 276(5):3310-8. Epub 2000 Nov 02. 2001
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