| 1 | ARHGEF6, PRKCQ, PYGM, RAC1
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| Guanine nucleotide exchange factor αPIX leads to activation of the Rac 1 GTPase/glycogen phosphorylase pathway in interleukin (IL)-2-stimulated T cells.
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| Llavero F, Urzelai B, Osinalde N, Gálvez P, Lacerda HM, Parada LA, Zugaza JL.
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| J Biol Chem 290(14):9171-82. doi: 10.1074/jbc.M114.608414.
2015
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| 2 | CORO1A, PRKCQ
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| Novel protein kinase C θ: coronin 1A complex in T lymphocytes.
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| Siegmund K, Thuille N, Posch N, Fresser F, Baier G.
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| Cell Commun Signal 13:22. doi: 10.1186/s12964-015-0100-3.
2015
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| 3 | EBF1, KAT2A, PRKCQ
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| Protein kinase Cθ gene expression is oppositely regulated by GCN5 and EBF1 in immature B cells.
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| Kikuchi H, Nakayama M, Kuribayashi F, Imajoh-Ohmi S, Nishitoh H, Takami Y, Nakayama T.
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| FEBS Lett EBS Lett. 2014 Mar 19. pii: S0014-5793(14)00230-0. doi: 10.1016/j.febslet.2014.03.025. [Epub ahead of print]
2014
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| 4 | PRKCQ
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| Protein kinase C-θ promotes Th17 differentiation via upregulation of Stat3.
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| Kwon MJ, Ma J, Ding Y, Wang R, Sun Z.
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| J Immunol 188(12):5887-97. Epub 2012 May 14.
2012
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| 5 | PRKCQ
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| Protein kinase C-θ inhibits inducible regulatory T cell differentiation via an AKT-Foxo1/3a-dependent pathway.
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| Ma J, Ding Y, Fang X, Wang R, Sun Z.
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| J Immunol 188(11):5337-47. Epub 2012 Apr 25.
2012
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| 6 | CARD11, PRKCQ, TNFRSF4, TRAF2
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| Antigen-independent signalosome of CARMA1, PKCθ, and TNF receptor-associated factor 2 (TRAF2) determines NF-κB signaling in T cells.
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| So T, Soroosh P, Eun SY, Altman A, Croft M.
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| Proc Natl Acad Sci U S A 108(7):2903-8. Epub 2011 Jan 31.
2011
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| 7 | PRKCQ
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| An active kinase domain is required for retention of PKCθ at the T cell immunological synapse.
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| Cartwright NG, Kashyap AK, Schaefer BC.
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| Mol Biol Cell 22(18):3491-7. Epub 2011 Jul 27.
2011
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| 8 | PRKCQ
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| Protein kinase C-theta in platelet activation.
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| Cohen S, Braiman A, Shubinsky G, Isakov N.
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| FEBS Lett 585(20):3208-15. Epub 2011 Sep 17. Review.
2011
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| 9 | PRKCQ
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| A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28.
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| Kong KF, Yokosuka T, Canonigo-Balancio AJ, Isakov N, Saito T, Altman A.
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| Nat Immunol 12(11):1105-12. doi: 10.1038/ni.2120.
2011
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| 10 | PRKCQ
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| PKC-θ function at the immunological synapse: prospects for therapeutic targeting.
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| Zanin-Zhorov A, Dustin ML, Blazar BR.
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| Trends Immunol 32(8):358-63. Epub 2011 Jul 4. Review.
2011
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| 11 | PRKCQ
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| Protein kinase Cθ is required for cardiomyocyte survival and cardiac remodeling.
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| Paoletti R, Maffei A, Madaro L, Notte A, Stanganello E, Cifelli G, Carullo P, Molinaro M, Lembo G, Bouché M.
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| Cell Death Dis 1:e45.
2010
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| 12 | PRKCQ
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| Inhibiting the inhibitor of the inhibitor: blocking PKC-theta to enhance regulatory T cell function.
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| Roybal KT, Wülfing C.
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| Sci Signal 3(132):pe24.
2010
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| 13 | PRKCQ
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| PKCtheta is necessary for efficient activation of NFkappaB, NFAT, and AP-1 during positive selection of thymocytes.
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| Gruber T, Pfeifhofer-Obermair C, Baier G.
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| Immunol Lett 132(1-2):6-11. Epub 2010 Apr 28.
2010
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| 14 | PRKCQ
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| Protein kinase C-theta mediates negative feedback on regulatory T cell function.
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| Zanin-Zhorov A, Ding Y, Kumari S, Attur M, Hippen KL, Brown M, Blazar BR, Abramson SB, Lafaille JJ, Dustin ML.
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| Science 328(5976):372-6. Epub 2010 Mar 25. Erratum in: Science. 2010 May 21;328(5981):974.
2010
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| 15 | PRKCQ
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| PKCtheta is required for hemostasis and positive regulation of thrombin-induced platelet aggregation and alpha-granule secretion.
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| Cohen S, Braiman A, Shubinsky G, Ohayon A, Altman A, Isakov N.
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| Biochem Biophys Res Commun 385(1):22-7. Epub 2009 May 9.
2009
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| 16 | PRKCA, PRKCQ
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| PKC theta cooperates with PKC alpha in alloimmune responses of T cells in vivo.
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| Gruber T, Hermann-Kleiter N, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Thuille N, Letschka T, Barsig J, Baudler M, Li J, Metzler B, Nüsslein-Hildesheim B, Wagner J, Leitges M, Baier G.
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| Mol Immunol 46(10):2071-9. Epub 2009 Apr 7.
2009
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| 17 | PRKCI, PRKCQ
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| PKCtheta cooperates with atypical PKCzeta and PKCiota in NF-kappaB transactivation of T lymphocytes.
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| Gruber T, Fresser F, Jenny M, Uberall F, Leitges M, Baier G.
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| Mol Immunol 45(1):117-26. Epub 2007 Jun 22. 2008
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| 18 | PRKCQ
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| Protein kinase C theta activation induces insulin-mediated constriction of muscle resistance arteries.
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| Bakker W, Sipkema P, Stehouwer CD, Serne EH, Smulders YM, van Hinsbergh VW, Eringa EC.
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| Diabetes 57(3):706-13. Epub 2007 Dec 17.
2008
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| 19 | CD40, CDK6, MMEL1, PRKCQ
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| Common variants at CD40 and other loci confer risk of rheumatoid arthritis.
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| Raychaudhuri S, Remmers EF, Lee AT, Hackett R, Guiducci C, Burtt NP, Gianniny L, Korman BD, Padyukov L, Kurreeman FA, Chang M, Catanese JJ, Ding B, Wong S, van der Helm-van Mil AH, Neale BM, Coblyn J, Cui J, Tak PP, Wolbink GJ, Crusius JB, van der Horst-Bruinsma IE, Criswell LA, Amos CI, Seldin MF, Kastner DL, Ardlie KG, Alfredsson L, Costenbader KH, Altshuler D, Huizinga TW, Shadick NA, Weinblatt ME, de Vries N, Worthington J, Seielstad M, Toes RE, Karlson EW, Begovich AB, Klareskog L, Gregersen PK, Daly MJ, Plenge RM.
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| Nat Genet 40(10):1216-23. Epub 2008 Sep 14.
2008
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| 20 | PRKCQ
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| Novel role for mitochondria: protein kinase Ctheta-dependent oxidative signaling organelles in activation-induced T-cell death.
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| Kaminski M, Kiessling M, Süss D, Krammer PH, Gülow K.
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| Mol Cell Biol 27(10):3625-39. Epub 2007 Mar 5.
2007
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| 21 | FLNA, PRKCQ
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| Filamin A is required for T cell activation mediated by protein kinase C-theta.
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| Hayashi K, Altman A.
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| J Immunol 177(3):1721-8.
2006
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| 22 | CD28, PRKCQ
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| CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse.
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| Huang J, Lo PF, Zal T, Gascoigne NR, Smith BA, Levin SD, Grey HM.
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| Proc Natl Acad Sci U S A 99(14):9369-73. 2002
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| 23 | PRKCQ
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| Molecular characterization of the human protein kinase C theta gene locus (PRKCQ).
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| Kofler K, Kochl S, Parson W, Erdel M, Utermann G, Baier G.
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| Mol Gen Genet 259 : 398-403. 1998
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| 24 | PRKCQ
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| Mapping of the human protein kinase C-theta (PRKCQ) gene locus to the short arm of chromosome 10 (10p15) by FISH.
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| Erdel M, et al.
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| Genomics 25 : 595-597. 1995
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