| 1 | EIF2A, MARK2, PRKCD
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| MARK2 phosphorylates eIF2α in response to proteotoxic stress.
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| Lu YN, Kavianpour S, Zhang T, Zhang X, Nguyen D, Thombre R, He L, Wang J.
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| PLoS Biol. Mar 11;19(3):e3001096. doi: 10.1371/journal.pbio.3001096. 2021
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| 2 | IVL, PRKCD, PRKCD, WDR77
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| MEP50/PRMT5 Reduces Gene Expression by Histone Arginine Methylation and this Is Reversed by PKCδ/p38δ Signaling.
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| Saha K, Adhikary G, Eckert RL.
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| J Invest Dermatol 136(1):214-24. doi: 10.1038/JID.2015.400.
2016
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| 3 | MARCKS, PRKCD
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| In Vitro Neutrophil Migration Requires Protein Kinase C-Delta (δ-PKC)-Mediated Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Phosphorylation.
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| Sheats MK, Sung EJ, Adler KB, Jones SL.
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| Inflammation 38(3):1126-41. doi: 10.1007/s10753-014-0078-9.
2015
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| 4 | BTK, MAL, PRKCD
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| Structural evaluation of BTK and PKCδ mediated phosphorylation of MAL at positions Tyr86 and Tyr106.
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| Paracha RZ, Ali A, Ahmad J, Hussain R, Niazi U, Muhammad SA.
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| Comput Biol Chem 51:22-35. doi: 10.1016/j.compbiolchem.2014.04.001. Epub 2014 Apr 20.
2014
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| 5 | CVID9, PRKCD
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| B-cell deficiency and severe autoimmunity caused by deficiency of protein kinase C δ.
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| Salzer E, Santos-Valente E, Klaver S, Ban SA, Emminger W, Prengemann NK, Garncarz W, Müllauer L, Kain R, Boztug H, Heitger A, Arbeiter K, Eitelberger F, Seidel MG, Holter W, Pollak A, Pickl WF, Förster-Waldl E, Boztug K.
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| Blood 121(16):3112-6. doi: 10.1182/blood-2012-10-460741. Epub 2013 Jan 14.
2013
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| 6 | CTSK, MARCKS, PRKCD
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| Protein kinase C-delta deficiency perturbs bone homeostasis by selective uncoupling of cathepsin K secretion and ruffled border formation in osteoclasts.
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| Cremasco V, Decker CE, Stumpo D, Blackshear PJ, Nakayama KI, Nakayama K, Lupu TS, Graham DB, Novack DV, Faccio R.
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| J Bone Miner Res 27(12):2452-63. doi: 10.1002/jbmr.1701.
2012
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| 7 | PRKCD, TRO
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| Trophinin-mediated cell adhesion induces apoptosis of human endometrial epithelial cells through PKC-δ.
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| Tamura N, Sugihara K, Akama TO, Fukuda MN.
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| Cell Cycle 10(1):135-43. Epub 2011 Jan 1.
2011
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| 8 | CLDN1, PRKCD
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| Claudin-1 acts through c-Abl-protein kinase Cdelta (PKCdelta) signaling and has a causal role in the acquisition of invasive capacity in human liver cells.
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| Yoon CH, Kim MJ, Park MJ, Park IC, Hwang SG, An S, Choi YH, Yoon G, Lee SJ.
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| J Biol Chem 285(1):226-33. Epub 2009 Nov 6.PMID: 19897486 2010
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| 9 | PRKCD
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| Protein kinase C-delta is involved in the inflammatory effect of IL-6 in mouse adipose cells.
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| Wallerstedt E, Smith U, Andersson CX.
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| Diabetologia 53(5):946-54. Epub 2010 Feb 12.PMID: 20151299 2010
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| 10 | PRKCD, PRKCH
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| Protein kinase C delta and eta differently regulate the expression of loricrin and Jun family proteins in human keratinocytes.
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| Kamioka N, Akahane T, Kohno Y, Kuroki T, Iijima M, Honma I, Ohba M.
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| Biochem Biophys Res Commun 394(1):106-11. Epub 2010 Feb 23.
2010
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| 11 | PRKCA, PRKCD, PRKCE
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| PKC{delta} is activated in a dietary model of steatohepatitis and regulates endoplasmic reticulum stress and cell death.
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| Greene MW, Burrington CM, Ruhoff MS, Johnson AK, Chongkrairatanakul T, Kangwanpornsiri A.
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| J Biol Chem 285(53):42115-29. Epub 2010 Oct 22.
2010
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| 12 | PRKCD
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| Caspase-mediated protein kinase C-delta cleavage is necessary for apoptosis of vascular smooth muscle cells.
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| Kato K, Yamanouchi D, Esbona K, Kamiya K, Zhang F, Kent KC, Liu B.
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| Am J Physiol Heart Circ Physiol 297(6):H2253-61. Epub 2009 Oct 16.PMID: 19837952 2009
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| 13 | PRKCD, TERT
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| Protein kinase C delta plays a key role in cellular senescence programs of human normal diploid cells.
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| Katakura Y, Udono M, Katsuki K, Nishide H, Tabira Y, Ikei T, Yamashita M, Fujiki T, Shirahata S.
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| J Biochem 146(1):87-93. Epub 2009 Mar 11.PMID: 19279193 2009
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| 14 | PRKCD
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| Protein kinase C[delta] differentially regulates platelet functional responses.
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| Chari R, Getz T, Nagy B Jr, Bhavaraju K, Mao Y, Bynagari YS, Murugappan S, Nakayama K, Kunapuli SP.
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| Arterioscler Thromb Vasc Biol 29(5):699-705. Epub 2009 Feb 12.PMID: 19213940 2009
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| 15 | PRKCD, PRKCE
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| Diverse roles for protein kinase C delta and protein kinase C epsilon in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C delta.
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| Frangioudakis G, Burchfield JG, Narasimhan S, Cooney GJ, Leitges M, Biden TJ, Schmitz-Peiffer C.
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| Diabetologia 52(12):2616-20. Epub 2009 Oct 7.
2009
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| 16 | DYRK2, ABL1, PRKCD, PRKDC
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| Nuclear trafficking of pro-apoptotic kinases in response to DNA damage.
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| Yoshida K.
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| Trends Mol Med 14(7):305-13. Epub 2008 Jun 6. 2008
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| 17 | PRKCD
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| Protein kinase C delta localizes to secretory lysosomes in CD8+ CTL and directly mediates TCR signals leading to granule exocytosis-mediated cytotoxicity.
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| Ma JS, Haydar TF, Radoja S.
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| J Immunol 181(7):4716-22.PMID: 18802074 2008
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| 18 | PRKCD
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| Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats.
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| Qi X, Inagaki K, Sobel RA, Mochly-Rosen D.
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| J Clin Invest 118(1):173-82.PMID: 18097471 2008
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| 19 | IFIT3, IFNA1, MAPK8, PRKCD
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| Sequential activation of protein kinase C delta and JNK is required for interferon-alpha-induced expression of IFIT4.
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| Huang X, Yang N, Ou X, Li D, Wang Z, Xie Q, Chen Y, Lin H, Yin G, Wen F.
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| Cell Signal 20(1):112-9.
2008
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| 20 | PRKCD,SOCS6
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| Increased SOCS6 stability with PMA requires its N-terminal region and the Erk pathway via Pkcdelta activation.
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| Hwang MN, Ha TH, Park J, Shim J, Lee H, Kim YN, Lee ES, Yoon S.
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| Biochem Biophys Res Commun 354(1):184-9. Epub 2006 Dec 29. 2007
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| 21 | PRKCD
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| Activation of acid sphingomyelinase by protein kinase Cdelta-mediated phosphorylation.
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| Zeidan YH, Hannun YA.
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| J Biol Chem 282(15):11549-61. Epub 2007 Feb 15. 2007
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| 22 | PRKCD, SDC2
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| Dual involvement of protein kinase C delta in apoptosis induced by syndecan-2 in osteoblasts.
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| Orosco A, Fromigue O, Hay E, Marie PJ, Modrowski D.
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| J Cell Biochem 98(4):838-50. 2006
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| 23 | PRKCD
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| Protein kinase PKC delta and c-Abl are required for mitochondrial apoptosis induction by genotoxic stress in the absence of p53, p73 and Fas receptor.
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| Lasfer M, Davenne L, Vadrot N, Alexia C, Sadji-Ouatas Z, Bringuier AF, Feldmann G, Pessayre D, Reyl-Desmars F.
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| FEBS Lett 580(11):2547-52. Epub 2006 Apr 12. 2006
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| 24 | VHL, PRKCD
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| The von Hippel-Lindau tumour-suppressor protein interaction with protein kinase Cdelta.
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| Iturrioz X, Durgan J, Calleja V, Larijani B, Okuda H, Whelan R, Parker PJ.
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| Biochem J 397(1):109-20. 2006
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| 25 | PRKCD
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| Genomic structure and promoter analysis of PKC-delta.
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| Suh KS, Tatunchak TT, Crutchley JM, Edwards LE, Marin KG, Yuspa SH.
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| Genomics 82(1):57-67. 2003
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| 26 | PLSCR3, PRKCD
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| Phospholipid scramblase 3 is the mitochondrial target of protein kinase C delta-induced apoptosis.
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| Liu J, Chen J, Dai Q, Lee RM.
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| Cancer Res 63(6):1153-6.PMID: 12649167 2003
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| 27 | PDP2, PRKCD
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| Activation and mitochondrial translocation of protein kinase Cdelta are necessary for insulin stimulation of pyruvate dehydrogenase complex activity in muscle and liver cells.
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| Caruso M, Maitan MA, Bifulco G, Miele C, Vigliotta G, Oriente F, Formisano P, Beguinot F.
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| J Biol Chem 276(48):45088-97. Epub 2001 Sep 27.
2001
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| 28 | PRKCD
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| A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.
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| Izumi Y, Hirata M, Hasuwa H, Iwamoto R, Umata T, Miyado K, Tamai Y, Kurisaki T, Sehara-Fujisawa A, Ohno S, Mekada E.
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| EMBO J 17 : 7260-7272. 1998
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| 29 | PRKCD
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| Assignment of the protein kinase C delta polypeptide gene (PRKCD) to human chromosome 3 and mouse chromosome 14.
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| Huppi K, et al.
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| Genomics 19 : 161-162. 1994
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