| 1 | MYOCD, PRKCA
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| Protein kinase Cα inhibits myocardin-induced cardiomyocyte hypertrophy through the promotion of myocardin phosphorylation.
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| Li W, Wang N, Li M, Gong H, Liao X, Yang X, Zhang T.
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| Acta Biochim Biophys Sin (Shanghai) 47(9):687-95. doi: 10.1093/abbs/gmv067. Epub 2015 Jul 22.
2015
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| 2 | ITGAM, PRKCA, VSIG4
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| Protein kinase cα regulates the expression of complement receptor Ig in human monocyte-derived macrophages.
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| Ma Y, Usuwanthim K, Munawara U, Quach A, Gorgani NN, Abbott CA, Hii CS, Ferrante A.
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| J Immunol 194(6):2855-61. doi: 10.4049/jimmunol.1303477. Epub 2015 Feb 16.
2015
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| 3 | AKAP5, PRKCA, TRPV4
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| Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle.
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| Mercado J, Baylie R, Navedo MF, Yuan C, Scott JD, Nelson MT, Brayden JE, Santana LF.
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| J Gen Physiol 143(5):559-75. doi: 10.1085/jgp.201311050.
2014
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| 4 | MARCKS, PRKCA, TRPC1
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| Myristoylated alanine-rich C kinase substrate coordinates native TRPC1 channel activation by phosphatidylinositol 4,5-bisphosphate and protein kinase C in vascular smooth muscle.
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| Shi J, Birnbaumer L, Large WA, Albert AP.
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| FASEB J 28(1):244-55. doi: 10.1096/fj.13-238022.
2014
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| 5 | GSK3A, GSK3B, PRKCA
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| Dual regulation of glycogen synthase kinase 3 (GSK3)α/β by protein kinase C (PKC)α and Akt promotes thrombin-mediated integrin αIIbβ3 activation and granule secretion in platelets.
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| Moore SF, van den Bosch MT, Hunter RW, Sakamoto K, Poole AW, Hers I.
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| J Biol Chem 288(6):3918-28. doi: 10.1074/jbc.M112.429936. Epub 2012 Dec 13.
2013
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| 6 | PRKCA
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| PKCα is genetically linked to memory capacity in healthy subjects and to risk for posttraumatic stress disorder in genocide survivors.
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| de Quervain DJ, Kolassa IT, Ackermann S, Aerni A, Boesiger P, Demougin P, Elbert T, Ertl V, Gschwind L, Hadziselimovic N, Hanser E, Heck A, Hieber P, Huynh KD, Klarhöfer M, Luechinger R, Rasch B, Scheffler K, Spalek K, Stippich C, Vogler C, Vukojevic V, Stetak A, Papassotiropoulos A.
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| Proc Natl Acad Sci U S A 109(22):8746-51. doi: 10.1073/pnas.1200857109. Epub 2012 May 14.
2012
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| 7 | G3BP2, PRKCA
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| PKCα binds G3BP2 and regulates stress granule formation following cellular stress.
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| Kobayashi T, Winslow S, Sunesson L, Hellman U, Larsson C.
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| PLoS One 7(4):e35820. doi: 10.1371/journal.pone.0035820. Epub 2012 Apr 20.
2012
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| 8 | ILK, PRKCA
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| Protein kinase Cα and integrin-linked kinase mediate the negative axon guidance effects of Sonic hedgehog.
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| Guo D, Standley C, Bellve K, Fogarty K, Bao ZZ.
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| Mol Cell Neurosci 50(1):82-92. doi: 10.1016/j.mcn.2012.03.008. Epub 2012 Apr 2.
2012
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| 9 | PRKCA
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| Direct evidence that PKCα positively regulates wound re-epithelialization: correlation with changes in desmosomal adhesiveness.
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| Thomason HA, Cooper NH, Ansell DM, Chiu M, Merrit AJ, Hardman MJ, Garrod DR.
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| J Pathol 227(3):346-56. doi: 10.1002/path.4016. Epub 2012 May 8.
2012
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| 10 | PRKCA
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| Expression of protein kinase C α and the MZF-1 and Elk-1 transcription factors in human breast cancer cells.
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| Yue CH, Chiu YW, Tung JN, Tzang BS, Shiu JJ, Huang WH, Liu JY, Hwang JM.
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| Chin J Physiol 55(1):31-6. doi: 10.4077/CJP.2012.AMM109.
2012
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| 11 | G3BP2, PRKCA
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| PKCá binds G3BP2 and regulates stress granule formation following cellular stress.
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| Kobayashi T, Winslow S, Sunesson L, Hellman U, Larsson C.
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| PLoS One 7(4):e35820. doi: 10.1371/journal.pone.0035820. Epub 2012 Apr 20.
2012
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| 12 | PRKCA, RALB
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| Phosphorylation by protein kinase Cα regulates RalB small GTPase protein activation, subcellular localization, and effector utilization.
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| Martin TD, Mitin N, Cox AD, Yeh JJ, Der CJ.
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| J Biol Chem 287(18):14827-36. doi: 10.1074/jbc.M112.344986. Epub 2012 Mar 5.
2012
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| 13 | ANXA6, PRKCA
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| Intracellular modulation of signaling pathways by annexin A6 regulates terminal differentiation of chondrocytes.
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| Minashima T, Small W, Moss SE, Kirsch T.
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| J Biol Chem 287(18):14803-15. doi: 10.1074/jbc.M111.297861. Epub 2012 Mar 7.
2012
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| 14 | PRKCA, PRKCB
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| Unravelling the different functions of protein kinase C isoforms in platelets.
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| Heemskerk JW, Harper MT, Cosemans JM, Poole AW.
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| FEBS Lett 585(12):1711-6. Epub 2011 May 13.
2011
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| 15 | EIF4G1, MKNK1, PRKCA
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| Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1.
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| Dobrikov M, Dobrikova E, Shveygert M, Gromeier M.
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| Mol Cell Biol 31(14):2947-59. Epub 2011 May 16.
2011
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| 16 | CTNNB1, HDAC6, PRKCA
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| PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-catenin.
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| Zhu J, Coyne CB, Sarkar SN.
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| EMBO J 30(23):4838-49. doi: 10.1038/emboj.2011.351.
2011
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| 17 | PRKCA, TRPV4
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| PKCα mediates acetylcholine-induced activation of TRPV4-dependent calcium influx in endothelial cells.
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| Adapala RK, Talasila PK, Bratz IN, Zhang DX, Suzuki M, Meszaros JG, Thodeti CK.
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| Am J Physiol Heart Circ Physiol 301(3):H757-65. doi: 10.1152/ajpheart.00142.2011. Epub 2011 Jun 24.
2011
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| 18 | ID1, PRKCA
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| Protein kinase Cα signaling regulates inhibitor of DNA binding 1 in the intestinal epithelium.
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| Hao F, Pysz MA, Curry KJ, Haas KN, Seedhouse SJ, Black AR, Black JD.
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| J Biol Chem 286(20):18104-17. doi: 10.1074/jbc.M110.208488. Epub 2011 Mar 18.
2011
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| 19 | NPHS1, PICK1, PRKCA
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| PKC alpha mediates beta-arrestin2-dependent nephrin endocytosis in hyperglycemia.
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| Quack I, Woznowski M, Potthoff SA, Palmer R, Königshausen E, Sivritas S, Schiffer M, Stegbauer J, Vonend O, Rump LC, Sellin L.
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| J Biol Chem 286(15):12959-70. doi: 10.1074/jbc.M110.204024. Epub 2011 Feb 14.
2011
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| 20 | PRKCA
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| PKCα suppresses osteoblastic differentiation.
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| Nakura A, Higuchi C, Yoshida K, Yoshikawa H.
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| Bone 48(3):476-84. doi: 10.1016/j.bone.2010.09.238. Epub 2010 Oct 14.
2011
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| 21 | PRKCA
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| Protein kinase Cα as a heart failure therapeutic target.
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| Liu Q, Molkentin JD.
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| J Mol Cell Cardiol 51(4):474-8. doi: 10.1016/j.yjmcc.2010.10.004. Epub 2010 Oct 16. Review.
2011
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| 22 | EDN1, PRKCA, PRKCB
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| Novel regulation of endothelin-1 promoter activity by protein kinase C.
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| Stricklett PK, Strait KA, Kohan DE.
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| Cell Biochem Biophys 61(3):643-50. doi: 10.1007/s12013-011-9250-0.
2011
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| 23 | ARPC5, HMMR, PRKCA
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| Rear polarization of the microtubule-organizing center in neointimal smooth muscle cells depends on PKCα, ARPC5, and RHAMM.
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| Silverman-Gavrila R, Silverman-Gavrila L, Hou G, Zhang M, Charlton M, Bendeck MP.
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| Am J Pathol 178(2):895-910. doi: 10.1016/j.ajpath.2010.10.001.
2011
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| 24 | PRKCA, SLC6A5
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| Endocytosis of the neuronal glycine transporter GLYT2: role of membrane rafts and protein kinase C-dependent ubiquitination.
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| de Juan-Sanz J, Zafra F, López-Corcuera B, Aragón C.
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| Traffic 12(12):1850-67. doi: 10.1111/j.1600-0854.2011.01278.x. Epub 2011 Oct 9.
2011
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| 25 | PRKCA, PRKCD, PRKCE
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| PKC{delta} is activated in a dietary model of steatohepatitis and regulates endoplasmic reticulum stress and cell death.
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| Greene MW, Burrington CM, Ruhoff MS, Johnson AK, Chongkrairatanakul T, Kangwanpornsiri A.
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| J Biol Chem 285(53):42115-29. Epub 2010 Oct 22.
2010
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| 26 | PRKCA
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| Protein kinase C alpha enhances sodium-calcium exchange during store-operated calcium entry in mouse platelets.
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| Harper MT, Molkentin JD, Poole AW.
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| Cell Calcium 48(6):333-40. doi: 10.1016/j.ceca.2010.10.006. Epub 2010 Nov 20.
2010
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| 27 | DGKD, PRKCA
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| Diacylglycerol kinase delta and protein kinase C(alpha) modulate epidermal growth factor receptor abundance and degradation through ubiquitin-specific protease 8.
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| Cai J, Crotty TM, Reichert E, Carraway KL 3rd, Stafforini DM, Topham MK.
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| J Biol Chem 285(10):6952-9. doi: 10.1074/jbc.M109.055731. Epub 2010 Jan 11.
2010
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| 28 | PRKCA, PRKCQ
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| PKC theta cooperates with PKC alpha in alloimmune responses of T cells in vivo.
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| Gruber T, Hermann-Kleiter N, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Thuille N, Letschka T, Barsig J, Baudler M, Li J, Metzler B, Nüsslein-Hildesheim B, Wagner J, Leitges M, Baier G.
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| Mol Immunol 46(10):2071-9. Epub 2009 Apr 7.
2009
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| 29 | NR1H4, PRKCA
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| Phosphorylation of farnesoid X receptor by protein kinase C promotes its transcriptional activity.
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| Gineste R, Sirvent A, Paumelle R, Helleboid S, Aquilina A, Darteil R, Hum DW, Fruchart JC, Staels B.
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| Mol Endocrinol 22(11):2433-47. Epub 2008 Aug 28.
2008
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| 30 | PRKCA
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| PKC-alpha regulates cardiac contractility and propensity toward heart failure.
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| Braz JC, Gregory K, Pathak A, Zhao W, Sahin B, Klevitsky R, Kimball TF, Lorenz JN, Nairn AC, Liggett SB, Bodi I, Wang S, Schwartz A, Lakatta EG, DePaoli-Roach AA, Robbins J, Hewett TE, Bibb JA, Westfall MV, Kranias EG, Molkentin JD.
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| Nat Med 10(3):248-54. Epub 2004 Feb 15. 2004
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| 31 | PRKCA, PRKCB, PRKCZ
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| Phosphorylation of p47phox sites by PKC alpha, beta II, delta, and zeta: effect on binding to p22phox and on NADPH oxidase activation.
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| Fontayne A, Dang PM, Gougerot-Pocidalo MA, El-Benna J.
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| Biochemistry 41(24):7743-50. 2002
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| 32 | ITGB1, MSN, PRKCA, RDX, EZR
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| Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility.
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| Ng T, Parsons M, Hughes WE, Monypenny J, Zicha D, Gautreau A, Arpin M, Gschmeissner S, Verveer PJ, Bastiaens PI, Parker PJ.
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| EMBO J 20(11):2723-2741. 2001
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| 33 | PRKCA
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| Towards a model to predict macular dichromats' naming errors: effects of CIE saturation and dichromatism type.
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| Lillo J, Vitini I, Caballero A, Moreira H.
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| Span J Psychol 4(1):26-36. 2001
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| 34 | PRKCA
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| Isoforms of protein kinase C and their distribution in human adrenal cortex and tumors.
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| Mikosha AS, Tron'ko ND, Staren'kii DV, Rybakov SI.
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| Bull Exp Biol Med 132(3):841-3. 2001
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| 35 | PRKCA, SDPR
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| Targeting of protein kinase Calpha to caveolae.
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| Mineo C, et al.
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| J Cell Biol 141(3):601-10 1998
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| 36 | PRKCA, SDPR, PRKCDBP
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| A protein kinase Cdelta-binding protein SRBC whose expression is induced by serum starvation.
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| Izumi Y, et al.
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| J Biol Chem 272(11):7381-9 1997
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| 37 | PRKCA, PRKCZ
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| Activation and substrate specificity of the human protein kinase C alpha and zeta isoenzymes.
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| Kochs G, Hummel R, Meyer D, Hug H, Marme D, Sarre TF.
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| Eur J Biochem 216(2):597-606. 1993
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| 38 | DCTN2, MARCKS, PRKCA
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| MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin.
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| Hartwig JH, Thelen M, Rosen A, Janmey PA, Nairn AC, Aderem A.
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| Nature 356(6370):618-22. 1992
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| 39 | MPO, PRKCA, D17S61
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| Refinement of localization of the human genes for myeloperoxidase (MPO), protein kinase C, alpha polypeptide, PRKCA, and the DNA fragment D17S21 on chromosome 17q.
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| Latos-Bielenska A, et al.
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| Hereditas 115 : 69-72. 1991
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| 40 | PRKCA, IGF1R, PRKCG
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| Chromosomal mapping of genes involved in growth control.
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| Francke U, et al.
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| Cold Spring Harbor Symp Quant Biol 51 : 855-866. 1986
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| 41 | PRKCA, PRKCB, PRKCG
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| The complete primary structure of protein kinase C : the major phobol ester receptor.
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| Parker PJ, et al.
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| Science 233 : 853-859. 1986
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| 42 | PRKCA, PRKCB, PRKCG
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| Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways.
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| Coussens L, et al.
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| Science 233 : 859-866. 1986
|