Citations for
1PPAVSD1, PPAVSD2, PRKACA, PRKACB
Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome
Palencia-Campos A, Aoto PC, Machal EMF, Rivera-Barahona A, Soto-Bielicka P, Bertinetti D, Baker B, Vu L, Piceci-Sparascio F, Torrente I, Boudin E, Peeters S, Van Hul W, Huber C, Bonneau D, Hildebrand MS, Coleman M, Bahlo M, Bennett MF, Schneider AL, Scheffer IE, Kibćk M, Kristiansen BS, Issa MY, Mehrez MI, Ismail S, Tenorio J, Li G, Skĺlhegg BS, Otaify GA, Temtamy S, Aglan M, Jřnch AE, De Luca A, Mortier G, Cormier-Daire V, Ziegler A, Wallis M, Lapunzina P, Herberg FW, Taylor SS, Ruiz-Perez VL
Am J Hum Genet. Nov 5;107(5):977-988. doi: 10.1016/j.ajhg.2020.09.005. Epub 2020 Oct 14. 2020
2DNAJB1, PRKACA
Fibrolamellar Carcinoma: What Is New and Why It Matters.
Graham RP.
Surg Pathol Clin 11(2):377-387. doi: 10.1016/j.path.2018.02.006. Epub 2018 Mar 21. Review. 2018
3DNAJB1, PRKACA
Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma.
Tomasini MD, Wang Y, Karamafrooz A, Li G, Beuming T, Gao J, Taylor SS, Veglia G, Simon SM.
Sci Rep 8(1):720. doi: 10.1038/s41598-017-18956-w. 2018
4EZR, GJA1, PRKACA
Ezrin-anchored PKA phosphorylates serine 369 and 373 on connexin 43 to enhance gap junction assembly, communication, and cell fusion.
Dukic AR, Gerbaud P, Guibourdenche J, Thiede B, Taskén K, Pidoux G.
Biochem J 475(2):455-476. doi: 10.1042/BCJ20170529. Erratum in: Biochem J. 2019 Jul 2;476(13):1927. 2018
5PRKACA, PRKACB
Carney complex review: Genetic features.
Bosco Schamun MB, Correa R, Graffigna P, de Miguel V, Fainstein Day P.
Endocrinol Diabetes Nutr. Jan;65(1):52-59. doi: 10.1016/j.endinu.2017.09.006. Epub 2017 Nov 20 2018
6PRKACA, SPATC1L
SPATC1L maintains the integrity of the sperm head-tail junction.
Kim J, Kwon JT, Jeong J, Kim J, Hong SH, Kim J, Park ZY, Chung KH, Eddy EM, Cho C.
EMBO Rep. Sep;19(9):e45991. doi: 10.15252/embr.201845991. Epub 2018 Jul 19 2018
7DNAJB1, PRKACA
Non coding RNA analysis in fibrolamellar hepatocellular carcinoma.
Farber BA, Lalazar G, Simon EP, Hammond WJ, Requena D, Bhanot UK, La Quaglia MP, Simon SM.
Oncotarget 9(12):10211-10227. doi: 10.18632/oncotarget.23325. eCollection 2018 Feb 13. 2017
8PRKACA, PRKACB
Evolution of the cAMP-dependent protein kinase (PKA) catalytic subunit isoforms.
Sřberg K, Moen LV, Skĺlhegg BS, Laerdahl JK.
PLoS One. Jul 25;12(7):e0181091. doi: 10.1371/journal.pone.0181091. eCollection 2017 2017
9CREBBP, GLI2, GLI3, PRKACA
Mutations of the Sonic Hedgehog Pathway Underlie Hypothalamic Hamartoma with Gelastic Epilepsy.
Hildebrand MS, Griffin NG, Damiano JA, Cops EJ, Burgess R, Ozturk E, Jones NC, Leventer RJ, Freeman JL, Harvey AS, Sadleir LG, Scheffer IE, Major H, Darbro BW, Allen AS, Goldstein DB, Kerrigan JF, Berkovic SF, Heinzen EL.
Am J Hum Genet 99(2):423-9. doi: 10.1016/j.ajhg.2016.05.031. Epub 2016 Jul 21. 2016
10IMMT, PINK1, PRKACA, PRKN
PKA Regulates PINK1 Stability and Parkin Recruitment to Damaged Mitochondria through Phosphorylation of MIC60.
Akabane S, Uno M, Tani N, Shimazaki S, Ebara N, Kato H, Kosako H, Oka T.
Mol Cell 62(3):371-384. doi: 10.1016/j.molcel.2016.03.037. 2016
11PRKACA, RCAN1
PKA regulates calcineurin function through the phosphorylation of RCAN1: identification of a novel phosphorylation site
Kim SS, Lee EH, Lee K, Jo SH, Seo SR.
Biochem Biophys Res Commun. Apr 17;459(4):604-9. doi: 10.1016/j.bbrc.2015.02.155. Epub 2015 Mar 7. 2015
12ATR, PRKACA
PKA-Mediated Phosphorylation of ATR Promotes Recruitment of XPA to UV-Induced DNA Damage.
Jarrett SG, Horrell EM, Christian PA, Vanover JC, Boulanger MC, Zou Y, D'Orazio JA.
Mol Cell 54(6):999-1011. doi: 10.1016/j.molcel.2014.05.030. 2014
13DLX3, PRKACA
Protein kinase a phosphorylates Dlx3 and regulates the function of Dlx3 during osteoblast differentiation.
Li H, Jeong HM, Choi YH, Kim JH, Choi JK, Yeo CY, Jeong HG, Jeong TC, Chun C, Lee KY.
J Cell Biochem 115(11):2004-11. doi: 10.1002/jcb.24872. 2014
14AKAP1, PDE4A, PRKACA
Role of AKAP 149-PKA-PDE4A complex in cell survival and cell differentiation processes.
Fernández-Araujo A, Tobío A, Alfonso A, Botana LM.
Int J Biochem Cell Biol 53:89-101. doi: 10.1016/j.biocel.2014.04.028. Epub 2014 May 9. 2014
15DNAJB1, PRKACA
Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma.
Honeyman JN, Simon EP, Robine N, Chiaroni-Clarke R, Darcy DG, Lim II, Gleason CE, Murphy JM, Rosenberg BR, Teegan L, Takacs CN, Botero S, Belote R, Germer S, Emde AK, Vacic V, Bhanot U, LaQuaglia MP, Simon SM.
Science 343(6174):1010-4. doi: 10.1126/science.1249484. 2014
16PRKACA, PRKACB
Sequence analysis of the catalytic subunit of PKA in somatotroph adenomas.
Larkin SJ, Ferraů F, Karavitaki N, Hernández-Ramírez LC, Ansorge O, Grossman AB, Korbonits M.
Eur J Endocrinol. Dec;171(6):705-10. doi: 10.1530/EJE-14-0545. Epub 2014 Sep 15. 2014
17ADCY1, AKAP5, PRKACA
Adenylyl cyclase anchoring by a kinase anchor protein AKAP5 (AKAP79/150) is important for postsynaptic β-adrenergic signaling.
Zhang M, Patriarchi T, Stein IS, Qian H, Matt L, Nguyen M, Xiang YK, Hell JW.
J Biol Chem 288(24):17918-31. doi: 10.1074/jbc.M112.449462. Epub 2013 May 6. 2013
18ADCY1, AKAP5, PRKACA, TRPV1
Scaffolding by A-kinase anchoring protein enhances functional coupling between adenylyl cyclase and TRPV1 channel.
Efendiev R, Bavencoffe A, Hu H, Zhu MX, Dessauer CW.
J Biol Chem 288(6):3929-37. doi: 10.1074/jbc.M112.428144. Epub 2012 Dec 21. 2013
19PRKACA, WEE2
Ser 15 of WEE1B is a potential PKA phosphorylation target in G2/M transition in one-cell stage mouse embryos.
Liu C, Liu Y, Liu Y, Wu D, Luan Z, Wang E, Yu B.
Mol Med Rep 7(6):1929-37. doi: 10.3892/mmr.2013.1437. Epub 2013 Apr 24. 2013
20PP2C2B, PRKACA
PKA negatively regulates PP2Cβ to activate NF-κB-mediated inflammatory signaling.
Choi HK, Park SY, Oh HJ, Han EJ, Lee YH, Lee J, Jun WJ, Choi KC, Yoon HG.
Biochem Biophys Res Commun. Jul 5;436(3):473-7. doi: 10.1016/j.bbrc.2013.05.129. Epub 2013 Jun 10. 2013
21PRKACA, RCAN1
Protein kinase A phosphorylates Down syndrome critical region 1 (RCAN1).
Kim SS, Oh Y, Chung KC, Seo SR.
Biochem Biophys Res Commun 418(4):657-61. doi: 10.1016/j.bbrc.2012.01.071. Epub 2012 Jan 24. 2012
22PRKACA, TAL1
Dynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis.
Li Y, Deng C, Hu X, Patel B, Fu X, Qiu Y, Brand M, Zhao K, Huang S.
Oncogene 31(48):5007-18. doi: 10.1038/onc.2012.8. Epub 2012 Feb 6. 2012
23AKAP13, HSPB6, PRKACA
The A-kinase-anchoring protein AKAP-Lbc facilitates cardioprotective PKA phosphorylation of Hsp20 on Ser(16).
Edwards HV, Scott JD, Baillie GS.
Biochem J 446(3):437-43. doi: 10.1042/BJ20120570. 2012
24ABCA1, IL10, PRKACA
ABCA1 protein enhances Toll-like receptor 4 (TLR4)-stimulated interleukin-10 (IL-10) secretion through protein kinase A (PKA) activation.
Ma L, Dong F, Zaid M, Kumar A, Zha X.
J Biol Chem 287(48):40502-12. doi: 10.1074/jbc.M112.413245. Epub 2012 Oct 10. 2012
25AKAP9, PDE4D, PRKACA
PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome.
Terrin A, Monterisi S, Stangherlin A, Zoccarato A, Koschinski A, Surdo NC, Mongillo M, Sawa A, Jordanides NE, Mountford JC, Zaccolo M.
J Cell Biol 198(4):607-21. doi: 10.1083/jcb.201201059. 2012
26PRKACA, PRKACB
Identification and characterization of novel mutations in the human gene encoding the catalytic subunit Calpha of protein kinase A (PKA).
Sřberg K, Larsen AC, Diskar M, Backe PH, Bjřrĺs M, Jahnsen T, Laerdahl JK, Rognes T, Herberg FW, Skĺlhegg BS.
PLoS One. 7(4):e34838. doi: 10.1371/journal.pone.0034838. Epub 2012 Apr 13 2012
27PRKACA
cAMP-dependent protein kinase activated Fyn in spinal dorsal horn to regulate NMDA receptor function during inflammatory pain.
Yang HB, Yang X, Cao J, Li S, Liu YN, Suo ZW, Cui HB, Guo Z, Hu XD.
J Neurochem. 116(1):93-104. 2011
28PRKACA, WASF2
WAVE2 forms a complex with PKA and is involved in PKA enhancement of membrane protrusions.
Yamashita H, Ueda K, Kioka N.
J Biol Chem 286(5):3907-14. Epub 2010 Nov 30. 2011
29BMP2, DLX5, PRKACA
Protein kinase A phosphorylates and regulates the osteogenic activity of Dlx5.
Han Y, Jin YH, Yum J, Jeong HM, Choi JK, Yeo CY, Lee KY.
Biochem Biophys Res Commun 407(3):461-5. Epub 2011 Mar 22. 2011
30PJA2, PRKACA
Control of PKA stability and signalling by the RING ligase praja2.
Lignitto L, Carlucci A, Sepe M, Stefan E, Cuomo O, Nisticň R, Scorziello A, Savoia C, Garbi C, Annunziato L, Feliciello A.
Nat Cell Biol 13(4):412-22. Epub 2011 Mar 20. 2011
31PRKACA
Increased PKA signaling disrupts recognition memory and spatial memory: role in Huntington's disease.
Giralt A, Saavedra A, Carretón O, Xifró X, Alberch J, Pérez-Navarro E.
Hum Mol Genet. 20(21):4232-47. 2011
32HSF1, PRKACA
Protein kinase A binds and activates heat shock factor 1.
Murshid A, Chou SD, Prince T, Zhang Y, Bharti A, Calderwood SK.
PLoS One 5(11):e13830. 2010
33HDAC5, PRKACA
PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy.
Ha CH, Kim JY, Zhao J, Wang W, Jhun BS, Wong C, Jin ZG.
Proc Natl Acad Sci U S A 107(35):15467-72. Epub 2010 Aug 17. 2010
34PRKACA
Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy.
Sarma S, Li N, van Oort RJ, Reynolds C, Skapura DG, Wehrens XH.
Proc Natl Acad Sci U S A 107(29):13165-70. Epub 2010 Jul 6. 2010
35PRKACA
Regulation of arginine transport and metabolism by protein kinase Calpha in endothelial cells: stimulation of CAT2 transporters and arginase activity.
Visigalli R, Barilli A, Parolari A, Sala R, Rotoli BM, Bussolati O, Gazzola GC, Dall'Asta V.
J Mol Cell Cardiol 49(2):260-70. Epub 2010 Apr 26. 2010
36PRKACA
PKCalpha expression is a marker for breast cancer aggressiveness.
Lřnne GK, Cornmark L, Zahirovic IO, Landberg G, Jirström K, Larsson C.
Mol Cancer 9:76. 2010
37PRKACA
PKC-alpha controls MYD88-dependent TLR/IL-1R signaling and cytokine production in mouse and human dendritic cells.
Langlet C, Springael C, Johnson J, Thomas S, Flamand V, Leitges M, Goldman M, Aksoy E, Willems F.
Eur J Immunol 40(2):505-15. 2010
38PRKACA
PKC alpha affects cell cycle progression and proliferation in human RPE cells through the downregulation of p27kip1.
Gao Q, Tan J, Ma P, Ge J, Liu Y, Sun X, Zhou L.
Mol Vis 15:2683-95. 2009
39PRKACA, RPS6KA1
Regulation of protein kinase A activity by p90 ribosomal S6 kinase 1.
Gao X, Patel TB.
J Biol Chem 284(48):33070-8. Epub 2009 Oct 5. 2009
40PRKACA
PKA-mediated stabilization of FoxH1 negatively regulates ERalpha activity.
Yum J, Jeong HM, Kim S, Seo JW, Han Y, Lee KY, Yeo CY.
Mol Cells 28(1):67-71. Epub 2009 Jul 8. 2009
41PRKACA
Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis.
Haughian JM, Reno EM, Thorne AM, Bradford AP.
Int J Cancer 125(11):2556-64. 2009
42PRKACA
A new mechanism of SOX9 action to regulate PKCalpha expression in the intestine epithelium.
Dupasquier S, Abdel-Samad R, Glazer RI, Bastide P, Jay P, Joubert D, Cavaillčs V, Blache P, Quittau-Prévostel C.
J Cell Sci 122(Pt 13):2191-6. Epub 2009 Jun 9. 2009
43PRKACA
Role for protein kinase C-alpha in keratinocyte growth arrest.
Jerome-Morais A, Rahn HR, Tibudan SS, Denning MF.
J Invest Dermatol 129(10):2365-75. Epub 2009 Apr 2. Erratum in: J Invest Dermatol. 2010 Mar;130(3):908. 2009
44PRKACA
Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.
Haughian JM, Bradford AP.
J Cell Physiol 220(1):112-8. 2009
45AKAP12, PRKACA
Gravin dynamics regulates the subcellular distribution of PKA.
Yan X, Walkiewicz M, Carlson J, Leiphon L, Grove B.
Exp Cell Res 315(7):1247-59. Epub 2009 Jan 13. 2009
46AKAP5, AKT1, PRKACA, RAPGEF3
Neuronal AKAP150 coordinates PKA and Epac-mediated PKB/Akt phosphorylation.
Nijholt IM, Dolga AM, Ostroveanu A, Luiten PG, Schmidt M, Eisel UL.
Cell Signal 20(10):1715-24. Epub 2008 May 16. 2008
47PRKACA
Androgens transduce the G alphas-mediated activation of protein kinase A in prostate cells.
Bagchi G, Wu J, French J, Kim J, Moniri NH, Daaka Y.
Cancer Res 68(9):3225-31. 2008
48PRKACA, AICDA
PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells.
Pasqualucci L, Kitaura Y, Gu H, Dalla-Favera R.
Proc Natl Acad Sci U S A 103(2):395-400. Epub 2005 Dec 30. 2006
49AKAP5, PRKACA, ADCY5, ADCY6
Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes.
Bauman AL, Soughayer J, Nguyen BT, Willoughby D, Carnegie GK, Wong W, Hoshi N, Langeberg LK, Cooper DM, Dessauer CW, Scott JD.
Mol Cell 23(6):925-31. 2006
50PRKACA
A-kinase-interacting protein localizes protein kinase A in the nucleus.
Sastri M, Barraclough DM, Carmichael PT, Taylor SS.
Proc Natl Acad Sci U S A. 102(2):349-54. 2005
51PRKACA
Deletion analysis of protein kinase calpha reveals a novel regulatory segment.
Rotenberg SA, Zhu J, Hansen H, Li XD, Sun XG, Michels CA, Riedel H.
J Biochem 124 : 756-763. 1998
52PRKACA
The RIalpha subunit of protein kinase A (PKA) binds to Grb2 and allows PKA interaction with the activated EGF-receptor.
Tortora G, Damiano V, Bianco C, Baldassarre G, Bianco AR, Lanfrancone L, Pelicci PG, Ciardiello F.
Oncogene. 14(8):923-8. 1997
53PRKACA
The gene encoding the catalytic subunit Calpha of cAMP-dependent protein kinase (locus PRKACA) localizes to human chromosome region 19p13.1.
Tasken K, et al.
Genomics 36 : 535-538. 1996
54PRKACA
A cDNA clone encoding human cAMP-dependent protein kinase catalytic subunit Calpha.
Maldonado F, et al.
Nucleic Acids Res 16 : 8189-8190. 1988