| 1 | HNRNPH1, PRKAA2
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| AMPKα2 translocates into the nucleus and interacts with hnRNP H: implications in metformin-mediated glucose uptake.
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| Kim N, Lee JO, Lee HJ, Lee SK, Moon JW, Kim SJ, Park SH, Kim HS.
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| Cell Signal 26(9):1800-6. doi: 10.1016/j.cellsig.2014.03.023. Epub 2014 Mar 29. Erratum in: Cell Signal. 2014 Oct;26(10):2298.
2014
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| 2 | PRKAA2
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| Activation of AMPKα2 is not crucial for mitochondrial uncoupling-induced metabolic effects but required to maintain skeletal muscle integrity.
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| Ost M, Werner F, Dokas J, Klaus S, Voigt A.
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| PLoS One 9(4):e94689. doi: 10.1371/journal.pone.0094689. eCollection 2014.
2014
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| 3 | PRKAA2, WWP1
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| E3 ubiquitin ligase, WWP1, interacts with AMPKα2 and down-regulates its expression in skeletal muscle C2C12 cells.
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| Lee JO, Lee SK, Kim N, Kim JH, You GY, Moon JW, Jie S, Kim SJ, Lee YW, Kang HJ, Lim Y, Park SH, Kim HS.
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| J Biol Chem 288(7):4673-80. doi: 10.1074/jbc.M112.406009. Epub 2013 Jan 4.
2013
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| 4 | EEF2, PRKAA2, RPS6KB1
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| Differential regulation of eEF2 and p70S6K by AMPKalpha2 in heart.
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| Demeulder B, Zarrinpashneh E, Ginion A, Viollet B, Hue L, Rider MH, Vanoverschelde JL, Beauloye C, Horman S, Bertrand L.
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| Biochim Biophys Acta 1832(6):780-90. doi: 10.1016/j.bbadis.2013.02.015. Epub 2013 Mar 4.
2013
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| 5 | BCL6, PARP1, PRKAA2
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| AMPKα2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6.
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| Gongol B, Marin T, Peng IC, Woo B, Martin M, King S, Sun W, Johnson DA, Chien S, Shyy JY.
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| Proc Natl Acad Sci U S A 110(8):3161-6. doi: 10.1073/pnas.1222051110. Epub 2013 Feb 4.
2013
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| 6 | PRKAA2, RPS6KB1
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| p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake.
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| Dagon Y, Hur E, Zheng B, Wellenstein K, Cantley LC, Kahn BB.
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| Cell Metab 16(1):104-12. doi: 10.1016/j.cmet.2012.05.010. Epub 2012 Jun 21.
2012
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| 7 | DCLER1C, PRKAA2, STK11
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| The nuclear protein Artemis promotes AMPK activation by stabilizing the LKB1-AMPK complex.
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| Nakagawa K, Uehata Y, Natsuizaka M, Kohara T, Darmanin S, Asaka M, Takeda H, Kobayashi M.
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| Biochem Biophys Res Commun 427(4):790-5. doi: 10.1016/j.bbrc.2012.09.140. Epub 2012 Oct 5.
2012
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| 8 | NPPA, PRKAA2
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| Atrial natriuretic peptide regulates lipid mobilization and oxygen consumption in human adipocytes by activating AMPK.
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| Souza SC, Chau MD, Yang Q, Gauthier MS, Clairmont KB, Wu Z, Gromada J, Dole WP.
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| Biochem Biophys Res Commun 410(3):398-403. Epub 2011 Jun 6.
2011
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| 9 | PRKAA1, PRKAA2, PRKAB1, PRKAG1, PRKAG2, PRKAG3
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| AMP-activated protein kinase: a potential player in Alzheimer's disease.
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| Salminen A, Kaarniranta K, Haapasalo A, Soininen H, Hiltunen M.
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| J Neurochem 118(4):460-74. doi: 10.1111/j.1471-4159.2011.07331.x. Epub 2011 Jun 24. Review.
2011
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| 10 | CLIP1, PRKAA2
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| AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation.
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| Nakano A, Kato H, Watanabe T, Min KD, Yamazaki S, Asano Y, Seguchi O, Higo S, Shintani Y, Asanuma H, Asakura M, Minamino T, Kaibuchi K, Mochizuki N, Kitakaze M, Takashima S.
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| Nat Cell Biol. 12(6):583-90. 2010
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| 11 | PRKAA1, PRKAA2, PRKAB1
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| Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis.
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| Won JS, Im YB, Kim J, Singh AK, Singh I.
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| Biochem Biophys Res Commun 399(4):487-91. Epub 2010 Jul 24.
2010
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| 12 | GFPT1, PRKAA2, PRKAB1
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| AMP-activated protein kinase phosphorylates glutamine : fructose-6-phosphate amidotransferase 1 at Ser243 to modulate its enzymatic activity.
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| Eguchi S, Oshiro N, Miyamoto T, Yoshino K, Okamoto S, Ono T, Kikkawa U, Yonezawa K.
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| Genes Cells 14(2):179-89. Epub 2008 Jan 6. 2009
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| 13 | PRKAA1, PRKAA2
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| alpha2 But not alpha1 AMP-activated protein kinase mediates oxidative stress-induced inhibition of retinal pigment epithelium cell phagocytosis of photoreceptor outer segments.
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| Qin S, De Vries GW.
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| J Biol Chem 283(11):6744-51. Epub 2008 Jan 14.
2008
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| 14 | PRKAA2
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| LKB1 and AMPK in cell polarity and division.
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| Williams T, Brenman JE.
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| Trends Cell Biol. 18(4):193-8. 2008
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| 15 | PRKAA2
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| AMP-kinase alpha2 subunit gene PRKAA2 variants are associated with total cholesterol, low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol in normal women.
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| Spencer-Jones NJ, Ge D, Snieder H, Perks U, Swaminathan R, Spector TD, Carter ND, O'Dell SD.
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| J Med Genet 43(12):936-42. Epub 2006 Jun 26.
2006
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| 16 | PRKAA2
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| A polymorphism in the AMPKalpha2 subunit gene is associated with insulin resistance and type 2 diabetes in the Japanese population.
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| Horikoshi M, Hara K, Ohashi J, Miyake K, Tokunaga K, Ito C, Kasuga M, Nagai R, Kadowaki T.
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| Diabetes 55(4):919-23.
2006
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| 17 | PRKAA2
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| AMP-activated protein kinase regulates the assembly of epithelial tight junctions.
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| Zhang L, Li J, Young LH, Caplan MJ.
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| Proc Natl Acad Sci U S A. 103(46):17272-7. 2006
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| 18 | PRKAA2, ADIPOQ
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| Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells.
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| Ouchi N, Kobayashi H, Kihara S, Kumada M, Sato K, Inoue T, Funahashi T, Walsh K.
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| J Biol Chem 279(2):1304-9. Epub 2003 Oct 13. 2004
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| 19 | PRKAA2
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| The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress.
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| Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC.
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| Proc Natl Acad Sci U S A. 101(10):3329-35. 2004
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| 20 | PRKAA2
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| Hypertrophic cardiomyopathy:a paradigm for myocardial energy depletion.
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| Ashrafian H, Redwood C, Blair E, Watkins H.
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| Trends Genet 19(5):263-8. Review. 2003
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| 21 | PRKAA2
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| Exercise increases nuclear AMPK alpha2 in human skeletal muscle.
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| McGee SL, Howlett KF, Starkie RL, Cameron-Smith D, Kemp BE, Hargreaves M.
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| Diabetes 52(4):926-8.
2003
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| 22 | PRKAA2
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| AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability.
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| Hong YH, Varanasi US, Yang W, Leff T
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| J Biol Chem. 278(30):27495-501. 2003
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| 23 | PRKAA2
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| The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity.
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| Viollet B, Andreelli F, Jørgensen SB, Perrin C, Geloen A, Flamez D, Mu J, Lenzner C, Baud O, Bennoun M, Gomas E, Nicolas G, Wojtaszewski JF, Kahn A, Carling D, Schuit FC, Birnbaum MJ, Richter EA, Burcelin R, Vaulont S.
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| J Clin Invest. 111(1):91-8. 2003
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| 24 | PRKAA2
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| Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase.
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| Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Muller C, Carling D, Kahn BB.
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| Nature 415(6869):339-43. 2002
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| 25 | PRKAA2
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| AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation.
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| Chen ZP, McConell GK, Michell BJ, Snow RJ, Canny BJ, Kemp BE.
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| Am J Physiol Endocrinol Metab. 279(5):E1202-6. 2000
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| 26 | PRKAA1, PRKAB1, PRKAG1, PRKAG2, PRKAA2
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| AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location.
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| Stapleton D, Woollatt E, Mitchelhill KI, Nicholl JK, Fernandez CS, Michell BJ, Witters LA, Power DA, Sutherland GR, Kemp BE.
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| FEBS Lett 409(3):452-6. 1997
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| 27 | PRKAA2
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| Molecular cloning, expression and chromosomal localisation of human AMP-activated protein kinase.
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| Beri RK, et al.
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| FEBS Lett 356 : 117-121. 1994
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| 28 | PRKAA2
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| Characterization and chromosomal localization of the human homologue of a rat AMP-activated protein kinase-encoding gene : a major regulator of lipid metabolism in mammals.
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| Aguan K, et al.
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| Gene 149 : 345-350. 1994
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