| 1 | PRKAA1
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| The Role of AMPK Pathway in Neuroprotection.
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| Xu L, Ash JD.
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| Adv Exp Med Biol 854:425-30. doi: 10.1007/978-3-319-17121-0_56. Review.
2016
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| 2 | PRKAA1
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| Obesity Impairs Skeletal Muscle Regeneration Through Inhibition of AMPK.
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| Fu X, Zhu M, Zhang S, Foretz M, Viollet B, Du M.
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| Diabetes 65(1):188-200. doi: 10.2337/db15-0647. Epub 2015 Sep 17.
2016
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| 3 | MAP3K11, PRKAA1, STK11
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| MLK3 phophorylates AMPK independently of LKB1.
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| Luo L, Jiang S, Huang D, Lu N, Luo Z.
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| PLoS One 10(4):e0123927. doi: 10.1371/journal.pone.0123927. eCollection 2015.
2015
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| 4 | FLCN, PRKAA1
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| FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores.
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| Possik E, Ajisebutu A, Manteghi S, Gingras MC, Vijayaraghavan T, Flamand M, Coull B, Schmeisser K, Duchaine T, van Steensel M, Hall DH, Pause A.
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| PLoS Genet 11(10):e1005520. doi: 10.1371/journal.pgen.1005520. eCollection 2015 Oct.
2015
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| 5 | PRKAA1
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| AMPKα is essential for acute exercise-induced gene responses but not for exercise training-induced adaptations in mouse skeletal muscle.
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| Fentz J, Kjřbsted R, Kristensen CM, Hingst JR, Birk JB, Gudiksen A, Foretz M, Schjerling P, Viollet B, Pilegaard H, Wojtaszewski JF.
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| Am J Physiol Endocrinol Metab 309(11):E900-14. doi: 10.1152/ajpendo.00157.2015. Epub 2015 Sep 29.
2015
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| 6 | PFKB3, PRKAA1
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| AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest.
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| Doménech E, Maestre C, Esteban-Martínez L, Partida D, Pascual R, Fernández-Miranda G, Seco E, Campos-Olivas R, Pérez M, Megias D, Allen K, López M, Saha AK, Velasco G, Rial E, Méndez R, Boya P, Salazar-Roa M, Malumbres M.
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| Nat Cell Biol 17(10):1304-16. doi: 10.1038/ncb3231. Epub 2015 Aug 31.
2015
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| 7 | DNM1L, PRKAA1
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| Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction.
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| Li J, Wang Y, Wang Y, Wen X, Ma XN, Chen W, Huang F, Kou J, Qi LW, Liu B, Liu K.
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| J Mol Cell Cardiol 86:62-74. doi: 10.1016/j.yjmcc.2015.07.010. Epub 2015 Jul 18.
2015
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| 8 | PRKAA1, ULK1
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| Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy.
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| Tian W, Li W, Chen Y, Yan Z, Huang X, Zhuang H, Zhong W, Chen Y, Wu W, Lin C, Chen H, Hou X, Zhang L, Sui S, Zhao B, Hu Z, Li L, Feng D.
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| FEBS Lett 589(15):1847-54. doi: 10.1016/j.febslet.2015.05.020. Epub 2015 May 14.
2015
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| 9 | FNDC5, MAPK14, PRKAA1
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| Irisin, a Novel Myokine, Regulates Glucose Uptake in Skeletal Muscle Cells via AMPK.
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| Lee HJ, Lee JO, Kim N, Kim JK, Kim HI, Lee YW, Kim SJ, Choi JI, Oh Y, Kim JH, Suyeon-Hwang, Park SH, Kim HS.
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| Mol Endocrinol 29(6):873-81. doi: 10.1210/me.2014-1353. Epub 2015 Mar 31.
2015
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| 10 | GPLD1, PRKAA1
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| Reciprocal regulation of AMP-activated protein kinase and phospholipase D.
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| Mukhopadhyay S, Saqcena M, Chatterjee A, Garcia A, Frias MA, Foster DA.
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| J Biol Chem 290(11):6986-93. doi: 10.1074/jbc.M114.622571. Epub 2015 Jan 29.
2015
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| 11 | GJA1, PRKAA1
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| AMP-activated protein kinase α1 regulates cardiac gap junction protein connexin 43 and electrical remodeling following pressure overload.
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| Alesutan I, Voelkl J, Stöckigt F, Mia S, Feger M, Primessnig U, Sopjani M, Munoz C, Borst O, Gawaz M, Pieske B, Metzler B, Heinzel F, Schrickel JW, Lang F.
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| Cell Physiol Biochem 35(1):406-18. doi: 10.1159/000369706. Epub 2015 Jan 14.
2015
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| 12 | PRKAA1
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| Adenosine 5'-monophosphate-activated protein kinase regulates IL-10-mediated anti-inflammatory signaling pathways in macrophages.
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| Zhu YP, Brown JR, Sag D, Zhang L, Suttles J.
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| J Immunol 194(2):584-94. doi: 10.4049/jimmunol.1401024. Epub 2014 Dec 15.
2015
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| 13 | PRKAA1
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| Activation of AMP-activated protein kinase α1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis.
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| Liu YJ, Ju TC, Chen HM, Jang YS, Lee LM, Lai HL, Tai HC, Fang JM, Lin YL, Tu PH, Chern Y.
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| Hum Mol Genet 24(3):787-801. doi: 10.1093/hmg/ddu497. Epub 2014 Sep 25.
2015
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| 14 | BHLHE40, PRKAA1, STK11
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| DEC1 negatively regulates AMPK activity via LKB1.
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| Sato F, Muragaki Y, Zhang Y.
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| Biochem Biophys Res Commun 467(4):711-6. doi: 10.1016/j.bbrc.2015.10.077. Epub 2015 Oct 20.
2015
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| 15 | PDLIM5, PRKAA1
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| Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5.
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| Yan Y, Tsukamoto O, Nakano A, Kato H, Kioka H, Ito N, Higo S, Yamazaki S, Shintani Y, Matsuoka K, Liao Y, Asanuma H, Asakura M, Takafuji K, Minamino T, Asano Y, Kitakaze M, Takashima S.
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| Nat Commun 6:6137. doi: 10.1038/ncomms7137.
2015
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| 16 | PRKAA1, STK11
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| LKB1 and AMPK differentially regulate pancreatic β-cell identity.
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| Kone M, Pullen TJ, Sun G, Ibberson M, Martinez-Sanchez A, Sayers S, Nguyen-Tu MS, Kantor C, Swisa A, Dor Y, Gorman T, Ferrer J, Thorens B, Reimann F, Gribble F, McGinty JA, Chen L, French PM, Birzele F, Hildebrandt T, Uphues I, Rutter GA.
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| FASEB J 28(11):4972-85. doi: 10.1096/fj.14-257667. Epub 2014 Jul 28.
2014
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| 17 | GLI1, PRKAA1
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| The transcriptional activity of Gli1 is negatively regulated by AMPK through Hedgehog partial agonism in hepatocellular carcinoma.
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| Xu Q, Liu X, Zheng X, Yao Y, Wang M, Liu Q.
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| Int J Mol Med 34(3):733-41. doi: 10.3892/ijmm.2014.1847. Epub 2014 Jul 10.
2014
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| 18 | PRKAA1
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| PRKAA1/AMPKα1 is required for autophagy-dependent mitochondrial clearance during erythrocyte maturation.
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| Zhu H, Foretz M, Xie Z, Zhang M, Zhu Z, Xing J, Leclerc J, Gaudry M, Viollet B, Zou MH.
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| Autophagy 10(9):1522-34. doi: 10.4161/auto.29197. Epub 2014 Jun 19.
2014
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| 19 | PRKAA1
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| Loss of AMPKα1 expression is associated with poor survival in melanoma patients.
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| Bhandaru M, Martinka M, Li G, Rotte A.
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| J Invest Dermatol 134(6):1763-6. doi: 10.1038/jid.2014.26. Epub 2014 Jan 17. No abstract available.
2014
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| 20 | ACACA, PRKAA1
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| AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1.
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| Fraser SA, Choy SW, Pastor-Soler NM, Li H, Davies MR, Cook N, Katerelos M, Mount PF, Gleich K, McRae JL, Dwyer KM, van Denderen BJ, Hallows KR, Kemp BE, Power DA.
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| Am J Physiol Renal Physiol 305(5):F679-90. doi: 10.1152/ajprenal.00407.2012. Epub 2013 Jun 19.
2013
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| 21 | PRKAA1
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| The association of microtubules with tight junctions is promoted by cingulin phosphorylation by AMPK.
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| Yano T, Matsui T, Tamura A, Uji M, Tsukita S.
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| J Cell Biol 203(4):605-14. doi: 10.1083/jcb.201304194.
2013
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| 22 | PRKAA1
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| AMPK regulates mitotic spindle orientation through phosphorylation of myosin regulatory light chain.
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| Thaiparambil JT, Eggers CM, Marcus AI.
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| Mol Cell Biol 32(16):3203-17. doi: 10.1128/MCB.00418-12. Epub 2012 Jun 11.
2012
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| 23 | ACACA, ACACB, PRKAA1
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| AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress.
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| Jeon SM, Chandel NS, Hay N.
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| Nature 485(7400):661-5. doi: 10.1038/nature11066.
2012
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| 24 | PRKAA1, PRKAA2, PRKAB1, PRKAG1, PRKAG2, PRKAG3
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| AMP-activated protein kinase: a potential player in Alzheimer's disease.
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| Salminen A, Kaarniranta K, Haapasalo A, Soininen H, Hiltunen M.
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| J Neurochem 118(4):460-74. doi: 10.1111/j.1471-4159.2011.07331.x. Epub 2011 Jun 24. Review.
2011
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| 25 | PRKAA1, PRKAB1, PRKAG1
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| The AMPK signalling pathway coordinates cell growth, autophagy and metabolism.
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| Mihaylova MM, Shaw RJ.
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| Nat Cell Biol 13(9):1016-23. doi: 10.1038/ncb2329. Review.
2011
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| 26 | CRBN, PRKAA1
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| Functional modulation of AMP-activated protein kinase by cereblon.
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| Lee KM, Jo S, Kim H, Lee J, Park CS.
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| Biochim Biophys Acta 1813(3):448-55. doi: 10.1016/j.bbamcr.2011.01.005. Epub 2011 Jan 11.
2011
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| 27 | PRKAA1, SPARC
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| SPARC interacts with AMPK and regulates GLUT4 expression.
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| Song H, Guan Y, Zhang L, Li K, Dong C.
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| Biochem Biophys Res Commun 396(4):961-6. Epub 2010 May 10. 2010
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| 28 | PRKAA1, PRKAA2, PRKAB1
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| Involvement of AMP-activated-protein-kinase (AMPK) in neuronal amyloidogenesis.
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| Won JS, Im YB, Kim J, Singh AK, Singh I.
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| Biochem Biophys Res Commun 399(4):487-91. Epub 2010 Jul 24.
2010
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| 29 | PRKAA1, PRKAB1, PRKAG1, ULK1
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| The association of AMPK with ULK1 regulates autophagy.
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| Lee JW, Park S, Takahashi Y, Wang HG.
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| PLoS One 5(11):e15394.
2010
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| 30 | LEP, PRKAA1
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| Leptin regulates tau phosphorylation and amyloid through AMPK in neuronal cells.
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| Greco SJ, Sarkar S, Johnston JM, Tezapsidis N.
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| Biochem Biophys Res Commun 380(1):98-104. Epub 2009 Jan 21.
2009
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| 31 | PRKAA1, PRKAA2
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| alpha2 But not alpha1 AMP-activated protein kinase mediates oxidative stress-induced inhibition of retinal pigment epithelium cell phagocytosis of photoreceptor outer segments.
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| Qin S, De Vries GW.
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| J Biol Chem 283(11):6744-51. Epub 2008 Jan 14.
2008
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| 32 | PRKAA1, PRKAB1, PRKAG1
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| AMP-activated protein kinase subunit interactions: beta1:gamma1 association requires beta1 Thr-263 and Tyr-267.
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| Iseli TJ, Oakhill JS, Bailey MF, Wee S, Walter M, van Denderen BJ, Castelli LA, Katsis F, Witters LA, Stapleton D, Macaulay SL, Michell BJ, Kemp BE.
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| J Biol Chem 283(8):4799-807. Epub 2007 Dec 13.
2008
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| 33 | PRKAA1
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| Pharmacological activators of AMP-activated protein kinase have different effects on Na+ transport processes across human lung epithelial cells.
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| Woollhead AM, Sivagnanasundaram J, Kalsi KK, Pucovsky V, Pellatt LJ, Scott JW, Mustard KJ, Hardie DG, Baines DL.
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| Br J Pharmacol 151(8):1204-15. Epub 2007 Jul 2.
2007
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| 34 | IL6, PRKAA1
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| Upregulation of IL-6 mRNA by IL-6 in skeletal muscle cells: role of IL-6 mRNA stabilization and Ca2+-dependent mechanisms.
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| Weigert C, Düfer M, Simon P, Debre E, Runge H, Brodbeck K, Häring HU, Schleicher ED.
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| Am J Physiol Cell Physiol 293(3):C1139-47. Epub 2007 Jul 5. 2007
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| 35 | NME1, PRKAA1
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| Understanding the molecular basis of the interaction between NDPK-A and AMPK alpha 1.
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| Crawford RM, Treharne KJ, Arnaud-Dabernat S, Daniel JY, Foretz M, Viollet B, Mehta A.
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| Mol Cell Biol 26(15):5921-31. Retraction in: Mol Cell Biol. 2008 Sep;28(18):5827.
2006
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| 36 | PRKAA1
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| IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner.
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| Suzuki A, Kusakai G, Kishimoto A, Shimojo Y, Ogura T, Lavin MF, Esumi H.
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| Biochem Biophys Res Commun 324(3):986-92. 2004
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| 37 | PRKAA1, PRKAB1, PRKAG1, PRKAG2, PRKAA2
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| AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location.
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| Stapleton D, Woollatt E, Mitchelhill KI, Nicholl JK, Fernandez CS, Michell BJ, Witters LA, Power DA, Sutherland GR, Kemp BE.
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| FEBS Lett 409(3):452-6. 1997
|