Citations for
1PRG4
Implications of trauma and subsequent articulation on the release of Proteoglycan-4 and tissue response in adult human ankle cartilage.
Shekhawat VK, Schmid TM, Pennekamp PH, Pacione CA, Chubinskaya S, Wimmer MA.
J Orthop Res Orthop Res. 2016 Aug 23. doi: 10.1002/jor.23397. [Epub ahead of print] 2016
2PRG4
Association of lubricin concentration in synovial fluid and clinical status of osteoarthritic knee.
Ogawa H, Matsumoto K, Terabayashi N, Kawashima K, Takeuchi K, Akiyama H.
Mod Rheumatol od Rheumatol. 2016 Jul 20:1-4. [Epub ahead of print] 2016
3CACP, PRG4
Protein-losing enteropathy in camptodactyly-arthropathy-coxa vara-pericarditis (CACP) syndrome.
Peters B, Schuurs-Hoeijmakers JH, Fuijkschot J, Reimer A, van der Flier M, Lugtenberg D, Hoppenreijs EP.
Pediatr Rheumatol Online J 14(1):32. doi: 10.1186/s12969-016-0093-5. 2016
4CD44, PRG4
Lubricin/Proteoglycan 4 binds to and regulates the activity of Toll-Like Receptors In Vitro.
Iqbal SM, Leonard C, Regmi SC, De Rantere D, Tailor P, Ren G, Ishida H, Hsu C, Abubacker S, Pang DS, Salo PT, Vogel HJ, Hart DA, Waterhouse CC, Jay GD, Schmidt TA, Krawetz RJ.
Sci Rep 6:18910. doi: 10.1038/srep18910. 2016
5PRG4, TLR2, TLR4
The interaction of lubricin/proteoglycan 4 (PRG4) with toll-like receptors 2 and 4: an anti-inflammatory role of PRG4 in synovial fluid.
Alquraini A, Garguilo S, D'Souza G, Zhang LX, Schmidt TA, Jay GD, Elsaid KA.
Arthritis Res Ther 17:353. doi: 10.1186/s13075-015-0877-x. 2015
6CD44, PRG4
Lubricin/Proteoglycan 4 Binding to CD44 Receptor: A Mechanism of the Suppression of Proinflammatory Cytokine-Induced Synoviocyte Proliferation by Lubricin.
Al-Sharif A, Jamal M, Zhang LX, Larson K, Schmidt TA, Jay GD, Elsaid KA.
Arthritis Rheumatol 67(6):1503-13. doi: 10.1002/art.39087. 2015
7PRG4
Interaction of lubricin with type II collagen surfaces: adsorption, friction, and normal forces.
Chang DP, Guilak F, Jay GD, Zauscher S.
J Biomech 47(3):659-66. doi: 10.1016/j.jbiomech.2013.11.048. 2014
8CACP, PRG4
CACP syndrome: identification of five novel mutations and of the first case of UPD in the largest European cohort.
Ciullini Mannurita S, Vignoli M, Bianchi L, Kondi A, Gerloni V, Breda L, Ten Cate R, Alessio M, Ravelli A, Falcini F, Gambineri E.
Eur J Hum Genet 22(2):197-201. doi: 10.1038/ejhg.2013.123. 2014
9PRG4
Transcription, translation, and function of lubricin, a boundary lubricant, at the ocular surface.
Schmidt TA, Sullivan DA, Knop E, Richards SM, Knop N, Liu S, Sahin A, Darabad RR, Morrison S, Kam WR, Sullivan BD.
JAMA Ophthalmol 131(6):766-76. doi: 10.1001/jamaophthalmol.2013.2385. 2013
10PRG4
Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis.
Waller KA, Zhang LX, Elsaid KA, Fleming BC, Warman ML, Jay GD.
Proc Natl Acad Sci U S A 110(15):5852-7. doi: 10.1073/pnas.1219289110. 2013
11PRG4, PTH
Proteoglycan 4: a dynamic regulator of skeletogenesis and parathyroid hormone skeletal anabolism.
Novince CM, Michalski MN, Koh AJ, Sinder BP, Entezami P, Eber MR, Pettway GJ, Rosol TJ, Wronski TJ, Kozloff KM, McCauley LK.
J Bone Miner Res 27(1):11-25. doi: 10.1002/jbmr.508. 2012
12PRG4
Human synovial lubricin expresses sialyl Lewis x determinant and has L-selectin ligand activity.
Jin C, Ekwall AK, Bylund J, Björkman L, Estrella RP, Whitelock JM, Eisler T, Bokarewa M, Karlsson NG.
J Biol Chem 287(43):35922-33. doi: 10.1074/jbc.M112.363119. 2012
13PRG4
Matrix molecule influence on chondrocyte phenotype and proteoglycan 4 expression by alginate-embedded zonal chondrocytes and mesenchymal stem cells.
Coates EE, Riggin CN, Fisher JP.
J Orthop Res 30(12):1886-97. doi: 10.1002/jor.22166. 2012
14PRG4
Immunolocalization and expression of lubricin in the bilaminar zone of the human temporomandibular joint disc.
Leonardi R, Rusu MC, Loreto F, Loreto C, Musumeci G.
Acta Histochem 114(1):1-5. doi: 10.1016/j.acthis.2010.11.011. 2012
15PRG4, PTH
Proteoglycan 4, a novel immunomodulatory factor, regulates parathyroid hormone actions on hematopoietic cells.
Novince CM, Koh AJ, Michalski MN, Marchesan JT, Wang J, Jung Y, Berry JE, Eber MR, Rosol TJ, Taichman RS, McCauley LK.
Am J Pathol 179(5):2431-42. doi: 10.1016/j.ajpath.2011.07.032. 2011
16PRG4
Boundary mode lubrication of articular cartilage by recombinant human lubricin.
Gleghorn JP, Jones AR, Flannery CR, Bonassar LJ.
J Orthop Res 27(6):771-7.PMID: 19058183 2009
17HMGB2, PRG4
Chromatin protein HMGB2 regulates articular cartilage surface maintenance via beta-catenin pathway.
Taniguchi N, Caramés B, Kawakami Y, Amendt BA, Komiya S, Lotz M.
Proc Natl Acad Sci U S A 106(39):16817-22. Epub 2009 Sep 10.PMID: 19805379 2009
18PRG4
Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury.
Elsaid KA, Fleming BC, Oksendahl HL, Machan JT, Fadale PD, Hulstyn MJ, Shalvoy R, Jay GD.
Arthritis Rheum 58(6):1707-15.PMID: 18512776 2008
19PRG4, CACP
Consequences of disease-causing mutations on lubricin protein synthesis, secretion, and post-translational processing.
Rhee DK, Marcelino J, Al-Mayouf S, Schelling DK, Bartels CF, Cui Y, Laxer R, Goldbach-Mansky R, Warman ML.
J Biol Chem 280(35):31325-32. Epub 2005 Jul 5. 2005
20CACP, PRG4
Isolation, characterization and mapping of the mouse and human PRG4 (proteoglycan 4) genes.
Ikegawa S, Sano M, Koshizuka Y, Nakamura Y.
Cytogenet Cell Genet 90(3-4):291-297. 2000
21PRG4
Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and Is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism.
Flannery CR, et al.
Biochem Biophys Res Commun 254(3):535-41 1999
22CACP, PRG4
CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome.
Marcelino J, Carpten JD, Suwairi WM, Gutierrez OM, Schwartz S, Robbins C, Sood R, Makalowska I, Baxevanis A, Johnstone B, Laxer RM, Zemel L, Kim CA, Herd JK, Ihle J, Williams C, Johnson M, Raman V, Alonso LG, Brunoni D, Gerstein A, Papadopoulos N, Bahabri SA, Trent JM, Warman ML.
Nat Genet 23(3):319-22. 1999
23PRG4
The camptodactyly-arthropathy-coxa vara-pericarditis syndrome: clinical features and genetic mapping to human chromosome 1.
Bahabri SA, Suwairi WM, Laxer RM, Polinkovsky A, Dalaan AA, Warman ML.
Arthritis Rheum 41(4):730-5. 1998