Citations for
1PREX2, PTEN
Interplay between PREX2 mutations and the PI3K pathway and its effect on epigenetic regulation of gene expression in NRAS-mutant melanoma.
Lissanu Deribe Y.
Small GTPases mall GTPases. 2016 Apr 25:1-8. [Epub ahead of print] 2016
2PREX2
Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma.
Lissanu Deribe Y, Shi Y, Rai K, Nezi L, Amin SB, Wu CC, Akdemir KC, Mahdavi M, Peng Q, Chang QE, Hornigold K, Arold ST, Welch HC, Garraway LA, Chin L.
Proc Natl Acad Sci U S A 113(9):E1296-305. doi: 10.1073/pnas.1513801113. Epub 2016 Feb 16. 2016
3PREX2, RAC1
p21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase.
Barrows D, Schoenfeld SM, Hodakoski C, Silkov A, Honig B, Couvillon A, Shymanets A, Nürnberg B, Asara JM, Parsons R.
J Biol Chem 290(48):28915-31. doi: 10.1074/jbc.M115.668244. Epub 2015 Oct 5. 2015
4PREX2, PTEN, RAC1
PTEN inhibits PREX2-catalyzed activation of RAC1 to restrain tumor cell invasion.
Mense SM, Barrows D, Hodakoski C, Steinbach N, Schoenfeld D, Su W, Hopkins BD, Su T, Fine B, Hibshoosh H, Parsons R.
Sci Signal 8(370):ra32. doi: 10.1126/scisignal.2005840. 2015
5CXCL9, PREX2
The effect of CXCL9 on the invasion ability of hepatocellular carcinoma through up-regulation of PREX2.
Lan X, Xiao F, Ding Q, Liu J, Liu J, Li J, Zhang J, Tian DA.
J Mol Histol 45(6):689-96. doi: 10.1007/s10735-014-9593-0. Epub 2014 Aug 24. 2014
6PREX2
Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis.
Hodakoski C, Hopkins BD, Barrows D, Mense SM, Keniry M, Anderson KE, Kern PA, Hawkins PT, Stephens LR, Parsons R.
Proc Natl Acad Sci U S A 111(1):155-60. doi: 10.1073/pnas.1213773111. Epub 2013 Dec 23. 2014
7PREX2
Molecular pathways: P-Rex in cancer.
Pandiella A, Montero JC.
Clin Cancer Res 19(17):4564-9. doi: 10.1158/1078-0432.CCR-12-1662. Epub 2013 Jun 10. 2013
8PREX2
Melanoma genome sequencing reveals frequent PREX2 mutations.
Berger MF, Hodis E, Heffernan TP, Deribe YL, Lawrence MS, Protopopov A, Ivanova E, Watson IR, Nickerson E, Ghosh P, Zhang H, Zeid R, Ren X, Cibulskis K, Sivachenko AY, Wagle N, Sucker A, Sougnez C, Onofrio R, Ambrogio L, Auclair D, Fennell T, Carter SL, Drier Y, Stojanov P, Singer MA, Voet D, Jing R, Saksena G, Barretina J, Ramos AH, Pugh TJ, Stransky N, Parkin M, Winckler W, Mahan S, Ardlie K, Baldwin J, Wargo J, Schadendorf D, Meyerson M, Gabriel SB, Golub TR, Wagner SN, Lander ES, Getz G, Chin L, Garraway LA.
Nature 485(7399):502-6. doi: 10.1038/nature11071. 2012
9PREX2
P-REX2a driving tumorigenesis by PTEN inhibition.
Leslie NR.
Sci Signal 2(94):pe68. doi: 10.1126/scisignal.294pe68. 2009
10PREX2
P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination.
Donald S, Humby T, Fyfe I, Segonds-Pichon A, Walker SA, Andrews SR, Coadwell WJ, Emson P, Wilkinson LS, Welch HC.
Proc Natl Acad Sci U S A 105(11):4483-8. Epub 2008 Mar 11. 2008
11PREX2
Substrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2.
Joseph RE, Norris FA.
J Biol Chem 280(30):27508-12. Epub 2005 May 16. 2005
12PREX2
P-Rex2, a new guanine-nucleotide exchange factor for Rac.
Donald S, Hill K, Lecureuil C, Barnouin R, Krugmann S, John Coadwell W, Andrews SR, Walker SA, Hawkins PT, Stephens LR, Welch HC.
FEBS Lett 572(1-3):172-6. 2004
13PREX2
P-REX2, a novel PI-3-kinase sensitive Rac exchange factor.
Rosenfeldt H, Vazquez-Prado J, Gutkind JS.
FEBS Lett 572(1-3):167-71. 2004