| 1 | IECEE, PPP3CA
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| De Novo Mutations in PPP3CA Cause Severe Neurodevelopmental Disease with Seizures.
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| Myers CT, Stong N, Mountier EI, Helbig KL, Freytag S, Sullivan JE, Ben Zeev B, Nissenkorn A, Tzadok M, Heimer G, Shinde DN, Rezazadeh A, Regan BM, Oliver KL, Ernst ME, Lippa NC, Mulhern MS, Ren Z, Poduri A, Andrade DM, Bird LM, Bahlo M, Berkovic SF, Lowenstein DH, Scheffer IE, Sadleir LG, Goldstein DB, Mefford HC, Heinzen EL.
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| Am J Hum Genet 101(4):516-524. doi: 10.1016/j.ajhg.2017.08.013. Epub 2017 Sep 21.
2017
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| 2 | MCOLN1, PPP3CA, TFEB
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| Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB.
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| Medina DL, Di Paola S, Peluso I, Armani A, De Stefani D, Venditti R, Montefusco S, Scotto-Rosato A, Prezioso C, Forrester A, Settembre C, Wang W, Gao Q, Xu H, Sandri M, Rizzuto R, De Matteis MA, Ballabio A.
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| Nat Cell Biol 17(3):288-99.
2015
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| 3 | ATP2B2, ATP2B3, CALM1, GAP43, PPP3CA
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| Regulation of GAP43/calmodulin complex formation via calcineurin-dependent mechanism in differentiated PC12 cells with altered PMCA isoforms composition.
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| Boczek T, Ferenc B, Lisek M, Zylinska L.
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| Mol Cell Biochem 407(1-2):251-62. doi: 10.1007/s11010-015-2473-4.
2015
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| 4 | PPP3CA
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| Oxidation-induced conformational changes in calcineurin determined by covalent labeling and tandem mass spectrometry.
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| Zhou X, Mester C, Stemmer PM, Reid GE.
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| Biochemistry 53(43):6754-65. doi: 10.1021/bi5009744. Epub 2014 Oct 20.
2014
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| 5 | PPP3CA
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| Calcineurin suppresses AMPK-dependent cytoprotective autophagy in cardiomyocytes under oxidative stress.
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| He H, Liu X, Lv L, Liang H, Leng B, Zhao D, Zhang Y, Du Z, Chen X, Li S, Lu Y, Shan H.
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| Cell Death Dis 5:e997. doi: 10.1038/cddis.2013.533.
2014
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| 6 | CALM1, EDF1, NFATC1, PPP3CA
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| EDF-1 downregulates the CaM/Cn/NFAT signaling pathway during adipogenesis.
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| López-Victorio CJ, Velez-delValle C, Beltrán-Langarica A, Kuri-Harcuch W.
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| Biochem Biophys Res Commun 432(1):146-51. doi: 10.1016/j.bbrc.2013.01.069. Epub 2013 Feb 1.
2013
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| 7 | PPP3CA, SLC6A4
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| Calcineurin interacts with the serotonin transporter C-terminus to modulate its plasma membrane expression and serotonin uptake.
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| Seimandi M, Seyer P, Park CS, Vandermoere F, Chanrion B, Bockaert J, Mansuy IM, Marin P.
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| J Neurosci 33(41):16189-99. doi: 10.1523/JNEUROSCI.0076-13.2013.
2013
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| 8 | CALM1, PPP3CA
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| The distal helix in the regulatory domain of calcineurin is important for domain stability and enzyme function.
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| Dunlap TB, Cook EC, Rumi-Masante J, Arvin HG, Lester TE, Creamer TP.
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| Biochemistry 52(48):8643-51. doi: 10.1021/bi400483a. Epub 2013 Nov 15.
2013
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| 9 | CALM1, PPP3CA
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| Structural basis of calcineurin activation by calmodulin.
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| Ye Q, Feng Y, Yin Y, Faucher F, Currie MA, Rahman MN, Jin J, Li S, Wei Q, Jia Z.
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| Cell Signal 25(12):2661-7. doi: 10.1016/j.cellsig.2013.08.033. Epub 2013 Sep 7.
2013
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| 10 | CAMK2D, CFL1, PPP3CA, SSH1
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| Regulation of cofilin activity by CaMKII and calcineurin.
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| Zhao JW, Gao ZL, Ji QY, Wang H, Zhang HY, Yang YD, Xing FJ, Meng LJ, Wang Y.
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| Am J Med Sci 344(6):462-72. doi: 10.1097/MAJ.0b013e318244745b.
2012
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| 11 | CALM1, PPP3CA
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| Structural basis for activation of calcineurin by calmodulin.
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| Rumi-Masante J, Rusinga FI, Lester TE, Dunlap TB, Williams TD, Dunker AK, Weis DD, Creamer TP.
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| J Mol Biol 415(2):307-17. doi: 10.1016/j.jmb.2011.11.008. Epub 2011 Nov 12.
2012
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| 12 | PPP1R12A, PPP3CA
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| Calcineurin regulates endothelial barrier function by interaction with and dephosphorylation of myosin phosphatase.
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| Kolozsvári B, Bakó É, Bécsi B, Kiss A, Czikora Á, Tóth A, Vámosi G, Gergely P, Erdődi F.
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| Cardiovasc Res 96(3):494-503. doi: 10.1093/cvr/cvs255. Epub 2012 Aug 6.
2012
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| 13 | PPP3CA
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| Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivo.
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| Wang L, Chang JH, Paik SY, Tang Y, Eisner W, Spurney RF.
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| Mol Endocrinol 25(8):1376-86. doi: 10.1210/me.2011-0029. Epub 2011 May 26.
2011
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| 14 | PPP3CA
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| Sustained hemodynamic stress disrupts normal circadian rhythms in calcineurin-dependent signaling and protein phosphorylation in the heart.
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| Sachan N, Dey A, Rotter D, Grinsfelder DB, Battiprolu PK, Sikder D, Copeland V, Oh M, Bush E, Shelton JM, Bibb JA, Hill JA, Rothermel BA.
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| Circ Res 108(4):437-45. doi: 10.1161/CIRCRESAHA.110.235309. Epub 2011 Jan 13.
2011
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| 15 | PPP3CA, PSMA6
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| Calcineurin stimulates the expression of inflammatory factors in RAW 264.7 cells by interacting with proteasome subunit alpha type 6.
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| Zhang W, Wei Q.
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| Biochem Biophys Res Commun 407(4):668-73. doi: 10.1016/j.bbrc.2011.03.071. Epub 2011 Mar 21.
2011
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| 16 | CIB1, CIB2, PPP3CA, PPP3R1
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| CIB1 is a regulator of pathological cardiac hypertrophy.
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| Heineke J, Auger-Messier M, Correll RN, Xu J, Benard MJ, Yuan W, Drexler H, Parise LV, Molkentin JD.
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| Nat Med 16(8):872-9. Epub 2010 Jul 18.PMID: 20639889 2010
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| 17 | EIF2AK3, PPP3CA, PPP3CB
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| Calcineurin interacts with PERK and dephosphorylates calnexin to relieve ER stress in mammals and frogs.
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| Bollo M, Paredes RM, Holstein D, Zheleznova N, Camacho P, Lechleiter JD.
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| PLoS One 5(8):e11925.
2010
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| 18 | PPP3CA, CDK4
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| Mitotic regulation of CDK4 by the serine/threonine phosphatase, calcineurin.
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| Chow R, Olesen J, Onyskiw C, Baksh S.
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| Biochem Biophys Res Commun 363(3):506-12. Epub 2007 Sep 17. 2007
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| 19 | PPP3CA
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| Calcineurin activation is only one calcium-dependent step in cytotoxic T lymphocyte granule exocytosis.
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| Grybko MJ, Bartnik JP, Wurth GA, Pores-Fernando AT, Zweifach A.
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| J Biol Chem 282(25):18009-17. Epub 2007 May 2. 2007
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| 20 | PPP3CA
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| Calcineurin activation is only one calcium-dependent step in cytotoxic T lymphocyte granule exocytosis.
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| Grybko MJ, Bartnik JP, Wurth GA, Pores-Fernando AT, Zweifach A.
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| J Biol Chem 282(25):18009-17. Epub 2007 May 2.
2007
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| 21 | PPP3R1, PPP3R2, PPP3CA, PPP3CB, PPP3CC
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| Calcineurin regulates bone formation by the osteoblast.
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| Sun L, Blair HC, Peng Y, Zaidi N, Adebanjo OA, Wu XB, Wu XY, Iqbal J, Epstein S, Abe E, Moonga BS, Zaidi M.
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| Proc Natl Acad Sci U S A 102(47):17130-5. Epub 2005 Nov 14. 2005
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| 22 | GATA4, NFATC4, PPP3CA, PPP3CB
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| Polymorphisms of genes of the cardiac calcineurin pathway and cardiac hypertrophy.
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| Poirier O, Nicaud V, McDonagh T, Dargie HJ, Desnos M, Dorent R, Roizes G, Schwartz K, Tiret L, Komajda M, Cambien F.
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| Eur J Hum Genet 11(9):659-64. 2003
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| 23 | PPP3CA
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| Calcineurin inhibition and cardiac hypertrophy: a matter of balance.
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| Leinwand LA.
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| Proc Natl Acad Sci U S A 98(6):2947-9. Review. No abstract available. 2001
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| 24 | PPP3CA
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| Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo.
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| De Windt LJ, Lim HW, Bueno OF, Liang Q, Delling U, Braz JC, Glascock BJ, Kimball TF, del Monte F, Hajjar RJ, Molkentin JD.
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| Proc Natl Acad Sci U S A 98(6):3322-7. 2001
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| 25 | PPP3CA
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| Inducible and reversible enhancement of learning, memory, and long-term potentiation by genetic inhibition of calcineurin.
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| Malleret G, Haditsch U, Genoux D, Jones MW, Bliss TV, Vanhoose AM, Weitlauf C, Kandel ER, Winder DG, Mansuy IM.
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| Cell 104(5):675-86. 2001
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| 26 | PPP3CA, PPP3CB
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| Molecular and functional evidence for calcineurin-A alpha and beta isoforms in the osteoclast: novel insights into cyclosporin A action on bone resorption.
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| Awumey EM, et al.
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| Biochem Biophys Res Commun 254(1):248-52. 1999
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| 27 | PPP3CA
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| A selective role of calcineurin aalpha in synaptic depotentiation in hippocampus.
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| Zhuo M, et al.
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| Proc Natl Acad Sci U S A 96(8):4650-5. 1999
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| 28 | PPP3CA
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| Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin.
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| Winder DG, Mansuy IM, Osman M, Moallem TM, Kandel ER.
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| Cell 92(1):25-37. 1998
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| 29 | PPP3CA, PPP3CB, PPP3R1
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| Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21-q22 and 2p16-p15 respectively.
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| Wang MG, et al.
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| Cytogenet Cell Genet 72 : 236-241. 1996
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| 30 | PPP3CA, PPP3CB
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| Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit.
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| Giri PR, et al.
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| Biochem Biophys Res Commun 181 : 252-258. 1991
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| 31 | PPP3CA, PPP3CB, PPP3CC
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| Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain.
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| Guerini D, Klee CB.
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| Proc Natl Acad Sci U S A 86(23):9183-7. 1989
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