| 1 | IDDGIP, PPM1D
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| De Novo Truncating Mutations in the Last and Penultimate Exons of PPM1D Cause an Intellectual Disability Syndrome.
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| Jansen S, Geuer S, Pfundt R, Brough R, Ghongane P, Herkert JC, Marco EJ, Willemsen MH, Kleefstra T, Hannibal M, Shieh JT, Lynch SA, Flinter F, FitzPatrick DR, Gardham A, Bernhard B, Ragge N, Newbury-Ecob R, Bernier R, Kvarnung M, Magnusson EA, Wessels MW, van Slegtenhorst MA, Monaghan KG, de Vries P, Veltman JA; Deciphering Developmental Disorders Study.
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| Am J Hum Genet 100(4):650-658. doi: 10.1016/j.ajhg.2017.02.005. Epub 2017 Mar 23. 2017
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| 2 | PPM1D
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| DNA damage-induced phosphatase Wip1 in regulation of hematopoiesis, immune system and inflammation.
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| Uyanik B, Grigorash BB, Goloudina AR, Demidov ON.
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| Cell Death Discov 3:17018. doi: 10.1038/cddiscovery.2017.18. eCollection 2017. Review.
2017
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| 3 | CDK5RAP3, PPM1D
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| LZAP is a novel Wip1 binding partner and positive regulator of its phosphatase activity in vitro.
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| Wamsley JJ, Issaeva N, An H, Lu X, Donehower LA, Yarbrough WG.
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| Cell Cycle 16(2):213-223. doi: 10.1080/15384101.2016.1261767. Epub 2016 Dec 27.
2017
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| 4 | PPM1D, ULK1
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| Identification of PPM1D as an essential Ulk1 phosphatase for genotoxic stress-induced autophagy.
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| Torii S, Yoshida T, Arakawa S, Honda S, Nakanishi A, Shimizu S.
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| EMBO Rep 17(11):1552-1564. Epub 2016 Sep 26.
2016
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| 5 | NPM1, PPM1D
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| PPM1D controls nucleolar formation by up-regulating phosphorylation of nucleophosmin.
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| Kozakai Y, Kamada R, Furuta J, Kiyota Y, Chuman Y, Sakaguchi K.
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| Sci Rep 6:33272. doi: 10.1038/srep33272.
2016
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| 6 | PPM1D
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| Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner.
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| Yi W, Hu X, Chen Z, Liu L, Tian Y, Chen H, Cong YS, Yang F, Zhang L, Rudolph KL, Zhang Z, Zhao Y, Ju Z.
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| Blood 126(5):620-8. doi: 10.1182/blood-2015-02-624114. Epub 2015 May 26.
2015
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| 7 | PPM1D
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| Wip1 deficiency impairs haematopoietic stem cell function via p53 and mTORC1 pathways.
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| Chen Z, Yi W, Morita Y, Wang H, Cong Y, Liu JP, Xiao Z, Rudolph KL, Cheng T, Ju Z.
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| Nat Commun 6:6808. doi: 10.1038/ncomms7808.
2015
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| 8 | PPM1D
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| Involvement of dysregulated Wip1 in manganese-induced p53 signaling and neuronal apoptosis.
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| Ma X, Han J, Wu Q, Liu H, Shi S, Wang C, Wang Y, Xiao J, Zhao J, Jiang J, Wan C.
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| Toxicol Lett 235(1):17-27. doi: 10.1016/j.toxlet.2014.12.019. Epub 2015 Mar 16.
2015
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| 9 | PPM1D
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| WIP1 phosphatase as a potential therapeutic target in neuroblastoma.
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| Richter M, Dayaram T, Gilmartin AG, Ganji G, Pemmasani SK, Van Der Key H, Shohet JM, Donehower LA, Kumar R.
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| PLoS One 10(2):e0115635. doi: 10.1371/journal.pone.0115635. eCollection 2015.
2015
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| 10 | DKK3, PPM1D
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| Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging.
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| Zhu Y, Demidov ON, Goh AM, Virshup DM, Lane DP, Bulavin DV.
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| J Clin Invest 124(7):3263-73. doi: 10.1172/JCI73015. Epub 2014 Jun 9.
2014
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| 11 | PPM1D
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| Phosphatase Wip1 negatively regulates neutrophil migration and inflammation.
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| Sun B, Hu X, Liu G, Ma B, Xu Y, Yang T, Shi J, Yang F, Li H, Zhang L, Zhao Y.
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| J Immunol 192(3):1184-95. doi: 10.4049/jimmunol.1300656. Epub 2014 Jan 6.
2014
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| 12 | GLI1, PPM1D
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| WIP1 phosphatase modulates the Hedgehog signaling by enhancing GLI1 function.
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| Pandolfi S, Montagnani V, Penachioni JY, Vinci MC, Olivito B, Borgognoni L, Stecca B.
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| Oncogene 32(40):4737-47. doi: 10.1038/onc.2012.502. Epub 2012 Nov 12.
2013
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| 13 | PPM1D
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| Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer.
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| Ruark E, Snape K, Humburg P, Loveday C, Bajrami I, Brough R, Rodrigues DN, Renwick A, Seal S, Ramsay E, Duarte Sdel V, Rivas MA, Warren-Perry M, Zachariou A, Campion-Flora A, Hanks S, Murray A, Ansari Pour N, Douglas J, Gregory L, Rimmer A, Walker NM, Yang TP, Adlard JW, Barwell J, Berg J, Brady AF, Brewer C, Brice G, Chapman C, Cook J, Davidson R, Donaldson A, Douglas F, Eccles D, Evans DG, Greenhalgh L, Henderson A, Izatt L, Kumar A, Lalloo F, Miedzybrodzka Z, Morrison PJ, Paterson J, Porteous M, Rogers MT, Shanley S, Walker L, Gore M, Houlston R, Brown MA, Caufield MJ, Deloukas P, McCarthy MI, Todd JA; Breast and Ovarian Cancer Susceptibility Collaboration; Wellcome Trust Case Control Consortium, Turnbull C, Reis-Filho JS, Ashworth A, Antoniou AC, Lord CJ, Donnelly P, Rahman N.
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| Nature 493(7432):406-10. doi: 10.1038/nature11725. Epub 2012 Dec 16.
2013
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| 14 | CHEK2, NCOR2, PPM1D
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| The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation.
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| Scafoglio C, Smolka M, Zhou H, Perissi V, Rosenfeld MG.
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| PLoS One 8(5):e59986. doi: 10.1371/journal.pone.0059986. Print 2013.
2013
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| 15 | PPM1D
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| Wip1 controls global heterochromatin silencing via ATM/BRCA1-dependent DNA methylation.
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| Filipponi D, Muller J, Emelyanov A, Bulavin DV.
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| Cancer Cell 24(4):528-41. doi: 10.1016/j.ccr.2013.08.022.
2013
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| 16 | PPM1D
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| Wip1-dependent signaling pathways in health and diseases.
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| Zhu YH, Bulavin DV.
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| Prog Mol Biol Transl Sci 106:307-25. doi: 10.1016/B978-0-12-396456-4.00001-8. Review.
2012
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| 17 | PPM1D
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| Regulation of the Wip1 phosphatase and its effects on the stress response.
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| Lowe J, Cha H, Lee MO, Mazur SJ, Appella E, Fornace AJ Jr.
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| Front Biosci 17:1480-98. Review.
2012
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| 18 | PPM1D
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| A small molecule inhibitor of p53-inducible protein phosphatase PPM1D.
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| Yagi H, Chuman Y, Kozakai Y, Imagawa T, Takahashi Y, Yoshimura F, Tanino K, Sakaguchi K.
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| Bioorg Med Chem Lett 22(1):729-32. Epub 2011 Oct 31.
2012
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| 19 | PPM1D
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| Wip1 contributes to cell homeostasis maintained by the steady-state level of Wtp53.
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| Park HK, Panneerselvam J, Dudimah FD, Dong G, Sebastian S, Zhang J, Fei P.
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| Cell Cycle 10(15):2574-82. Epub 2011 Aug 1.
2011
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| 20 | PPM1D
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| Oncogenic phosphatase Wip1 is a novel prognostic marker for lung adenocarcinoma patient survival.
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| Satoh N, Maniwa Y, Bermudez VP, Nishimura K, Nishio W, Yoshimura M, Okita Y, Ohbayashi C, Hurwitz J, Hayashi Y.
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| Cancer Sci 102(5):1101-6. doi: 10.1111/j.1349-7006.2011.01898.x. Epub 2011 Mar 4.
2011
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| 21 | H2AFX, PPM1D
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| Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition.
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| Macůrek L, Lindqvist A, Voets O, Kool J, Vos HR, Medema RH.
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| Oncogene 29(15):2281-91. Epub 2010 Jan 25.PMID: 20101220 2010
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| 22 | PPM1D
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| Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response.
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| Cha H, Lowe JM, Li H, Lee JS, Belova GI, Bulavin DV, Fornace AJ Jr.
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| Cancer Res 70(10):4112-22. Epub 2010 May 11.
2010
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| 23 | PPM1D
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| The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair.
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| Nguyen TA, Slattery SD, Moon SH, Darlington YF, Lu X, Donehower LA.
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| DNA Repair (Amst) 9(7):813-23. Epub 2010 May 6.
2010
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| 24 | PPM1D
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| WIP1 phosphatase is a negative regulator of NF-kappaB signalling.
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| Chew J, Biswas S, Shreeram S, Humaidi M, Wong ET, Dhillion MK, Teo H, Hazra A, Fang CC, López-Collazo E, Bulavin DV, Tergaonkar V.
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| Nat Cell Biol 11(5):659-66. Epub 2009 Apr 19.
2009
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| 25 | PPM1D
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| Loss of Wip1 sensitizes cells to stress- and DNA damage-induced apoptosis.
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| Xia Y, Ongusaha P, Lee SW, Liou YC.
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| J Biol Chem 284(26):17428-37. Epub 2009 Apr 24. 2009
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| 26 | PPM1D
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| Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites.
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| Rossi M, Demidov ON, Anderson CW, Appella E, Mazur SJ.
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| Nucleic Acids Res 36(22):7168-80. Epub 2008 Nov 10.
2008
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| 27 | PPM1D
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| Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23.
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| Li J, Yang Y, Peng Y, Austin RJ, van Eyndhoven WG, Nguyen KC, Gabriele T, McCurrach ME, Marks JR, Hoey T, Lowe SW, Powers S.
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| Nat Genet 31(2):133-4. 2002
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| 28 | PPM1D
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| Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity.
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| Bulavin DV, Demidov ON, Saito S, Kauraniemi P, Phillips C, Amundson SA, Ambrosino C, Sauter G, Nebreda AR, Anderson CW, Kallioniemi A, Fornace AJ Jr, Appella E.
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| Nat Genet 31(2):210-5. 2002
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