Citations for
1E2F1, NOVA2, PPARG
Gene Expression Profiles Controlled by the Alternative Splicing Factor Nova2 in Endothelial Cells.
Belloni E, Di Matteo A, Pradella D, Vacca M, Wyatt CDR, Alfieri R, Maffia A, Sabbioneda S, Ghigna C.
Cell Nov 23;8(12):1498. doi: 10.3390/cells8121498 2019
2FGF11, PPARG
FGF11 influences 3T3-L1 preadipocyte differentiation by modulating the expression of PPARγ regulators.
Lee KW, Jeong JY, An YJ, Lee JH, Yim HS.
FEBS Open Bio. Mar 12;9(4):769-780. doi: 10.1002/2211-5463.12619. 2019
3MAGED1, PPARG
Inhibition of PPARγ, adipogenesis and insulin sensitivity by MAGED1.
Wang Q, Tang J, Jiang S, Huang Z, Song A, Hou S, Gao X, Ruan HB.
J Endocrinol Endocrinol. 2018 Aug 18. pii: JOE-18-0349. doi: 10.1530/JOE-18-0349. [Epub ahead of print] 2018
4PIAS1, PPARG
PIAS1 protects against myocardial ischemia-reperfusion injury by stimulating PPARγ SUMOylation.
Xie B, Liu X, Yang J, Cheng J, Gu J, Xue S.
BMC Cell Biol 19(1):24. doi: 10.1186/s12860-018-0176-x. 2018
5DLC1, PPARG
Regulation of white and brown adipocyte differentiation by RhoGAP DLC1.
Sim CK, Kim SY, Brunmeir R, Zhang Q, Li H, Dharmasegaran D, Leong C, Lim YY, Han W, Xu F.
PLoS One 12(3):e0174761. doi: 10.1371/journal.pone.0174761. eCollection 2017. 2017
6CACUL1, KDM1A, PPARG, SIRT1
CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARγ and inhibit adipogenesis.
Jang MJ, Park UH, Kim JW, Choi H, Um SJ, Kim EJ.
Cell Death Dis 8(12):3201. doi: 10.1038/s41419-017-0070-z. 2017
7PPARG, ZFP36L1
Zinc finger protein ZFP36L1 promotes osteoblastic differentiation but represses adipogenic differentiation of mouse multipotent cells.
Tseng KY, Chen YH, Lin S.
Oncotarget Mar 28;8(13):20588-20601. doi: 10.18632/oncotarget.15246 2017
8AJUBA, CREBBP, PPARG
The LIM protein Ajuba promotes adipogenesis by enhancing PPARγ and p300/CBP interaction.
Li Q, Peng H, Fan H, Zou X, Liu Q, Zhang Y, Xu H, Chu Y, Wang C, Ayyanathan K, Rauscher FJ, Zhang K, Hou Z.
Cell Death Differ 23(1):158-68. doi: 10.1038/cdd.2015.83. 2016
9CEBPA, MEST, PPARG, SOX6
The transcription factor SOX6 contributes to the developmental origins of obesity by promoting adipogenesis.
Leow SC, Poschmann J, Too PG, Yin J, Joseph R, McFarlane C, Dogra S, Shabbir A, Ingham PW, Prabhakar S, Leow MK, Lee YS, Ng KL, Chong YS, Gluckman PD, Stünkel W.
Development Mar 15;143(6):950-61. doi: 10.1242/dev.131573. Epub 2016 Feb 18 2016
10ATF3, PPARG
ATF3 inhibits PPARγ-stimulated transactivation in adipocyte cells.
Jang MK, Jung MH.
Biochem Biophys Res Commun 456(1):80-5. doi: 10.1016/j.bbrc.2014.11.037. Epub 2014 Nov 21. 2015
11FLII, PPARG
Flightless-1, a novel transcriptional modulator of PPARγ through competing with RXRα.
Choi JS, Choi SS, Kim ES, Seo YK, Seo JK, Kim EK, Suh PG, Choi JH.
Cell Signal 27(3):614-20. doi: 10.1016/j.cellsig.2014.11.035. Epub 2014 Dec 2. 2015
12CD36, PPARG, TCF4, WNT1
Wnt1 positively regulates CD36 expression via TCF4 and PPAR-γ in macrophages.
Wang S, Sun Z, Zhang X, Li Z, Wu M, Zhao W, Wang H, Chen T, Yan H, Zhu J.
Cell Physiol Biochem 35(4):1289-302. doi: 10.1159/000373951. 2015
13PPARG, TRIM23
The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ.
Watanabe M, Takahashi H, Saeki Y, Ozaki T, Itoh S, Suzuki M, Mizushima W, Tanaka K, Hatakeyama S.
Elife 4:e05615. doi: 10.7554/eLife.05615. 2015
14CEBPA, CEBPB, CEBPD, JMJD6, PPARG
Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6.
Hu YJ, Belaghzal H, Hsiao WY, Qi J, Bradner JE, Guertin DA, Sif S, Imbalzano AN.
Nucleic Acids Res 43(16):7790-804. doi: 10.1093/nar/gkv645. Epub 2015 Jun 27. 2015
15ADTRP, PPARG
The coronary artery disease-associated gene C6ORF105 is expressed in human macrophages under the transcriptional control of PPARγ.
Chinetti-Gbaguidi G, Copin C, Derudas B, Vanhoutte J, Zawadzki C, Jude B, Haulon S, Pattou F, Marx N, Staels B.
FEBS Lett 589(4):461-6. doi: 10.1016/j.febslet.2015.01.002. Epub 2015 Jan 14. 2015
16PPARG, SEPTIN2
Activation of peroxisome proliferator-activated receptor-γ (PPARγ) inhibits hepatoma cell growth via downregulation of SEPT2 expression.
Cao LQ, Shao ZL, Liang HH, Zhang DW, Yang XW, Jiang XF, Xue P.
Cancer Lett 359(1):127-35. doi: 10.1016/j.canlet.2015.01.004. Epub 2015 Jan 12. 2015
17MRTFA, PPARG
Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation.
Nobusue H, Onishi N, Shimizu T, Sugihara E, Oki Y, Sumikawa Y, Chiyoda T, Akashi K, Saya H, Kano K.
Nat Commun 5:3368. doi: 10.1038/ncomms4368. 2014
18ATF3, PPARG
ATF3 represses PPARγ expression and inhibits adipocyte differentiation.
Jang MK, Jung MH.
Biochem Biophys Res Commun 454(1):58-64. doi: 10.1016/j.bbrc.2014.10.028. Epub 2014 Oct 14. 2014
19FABP4, PPARG
FABP4 attenuates PPARγ and adipogenesis and is inversely correlated with PPARγ in adipose tissues.
Garin-Shkolnik T, Rudich A, Hotamisligil GS, Rubinstein M.
Diabetes 63(3):900-11. doi: 10.2337/db13-0436. Epub 2013 Dec 6. 2014
20GATA2, PPARG
GATA binding protein 2 mediates leptin inhibition of PPARγ1 expression in hepatic stellate cells and contributes to hepatic stellate cell activation.
Zhou Q, Guan W, Qiao H, Cheng Y, Li Z, Zhai X, Zhou Y.
Biochim Biophys Acta 1842(12 Pt A):2367-77. doi: 10.1016/j.bbadis.2014.10.001. 2014
21CSF2, PPARG
Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages.
Schneider C, Nobs SP, Kurrer M, Rehrauer H, Thiele C, Kopf M.
Nat Immunol 15(11):1026-37. doi: 10.1038/ni.3005. Epub 2014 Sep 28. 2014
22PPARG, VIM
Cytoskeletal protein vimentin interacts with and regulates peroxisome proliferator-activated receptor gamma via a proteasomal degradation process.
Tsai YC, Tsai SH, Chang EY, Hee SW, Chen WH, Lee SC, Chuang LM.
J Cell Biochem Cell Biochem. 2013 Jan 7. doi: 10.1002/jcb.24497. [Epub ahead of print] 2013
23MAFA, PDX1, PPARG
PPARγ activation attenuates glycated-serum induced pancreatic beta-cell dysfunction through enhancing Pdx1 and Mafa protein stability.
Zhu Y, Ma A, Zhang H, Li C.
PLoS One 8(2):e56386. doi: 10.1371/journal.pone.0056386. Epub 2013 Feb 12. 2013
24PPARG, TAF7L
Dual functions of TAF7L in adipocyte differentiation.
Zhou H, Kaplan T, Li Y, Grubisic I, Zhang Z, Wang PJ, Eisen MB, Tjian R.
Elife 2:e00170. doi: 10.7554/eLife.00170. 2013
25MUC1, PPARG
PPARγ E3 ubiquitin ligase regulates MUC1-C oncoprotein stability.
Hou Y, Gao J, Xu H, Xu Y, Zhang Z, Xu Q, Zhang C.
Oncogene ncogene. 2013 Dec 2. doi: 10.1038/onc.2013.504. [Epub ahead of print] 2013
26LIPE, MC2R, MRAP, PPARG
Transcriptional activation of melanocortin 2 receptor accessory protein by PPARγ in adipocytes.
Kim NS, Kim YJ, Cho SY, Lee TR, Kim SH.
Biochem Biophys Res Commun 439(3):401-6. doi: 10.1016/j.bbrc.2013.08.061. Epub 2013 Aug 28. 2013
27PPARG, PTGES
Coordinate functional regulation between microsomal prostaglandin E synthase-1 (mPGES-1) and peroxisome proliferator-activated receptor γ (PPARγ) in the conversion of white-to-brown adipocytes.
García-Alonso V, López-Vicario C, Titos E, Morán-Salvador E, González-Périz A, Rius B, Párrizas M, Werz O, Arroyo V, Clŕria J.
J Biol Chem 288(39):28230-42. doi: 10.1074/jbc.M113.468603. Epub 2013 Aug 13. 2013
28GPS2, NCOR2, PPARG, TWIST1
SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation.
Toubal A, Clément K, Fan R, Ancel P, Pelloux V, Rouault C, Veyrie N, Hartemann A, Treuter E, Venteclef N.
J Clin Invest 123(1):362-79. doi: 10.1172/JCI64052. Epub 2012 Dec 10. 2013
29FAM57B, PPARG
Fam57b (family with sequence similarity 57, member B), a novel peroxisome proliferator-activated receptor γ target gene that regulates adipogenesis through ceramide synthesis.
Yamashita-Sugahara Y, Tokuzawa Y, Nakachi Y, Kanesaki-Yatsuka Y, Matsumoto M, Mizuno Y, Okazaki Y.
J Biol Chem 288(7):4522-37. doi: 10.1074/jbc.M112.440792. Epub 2012 Dec 28. 2013
30LPIN1, PPARG
Lipin1 regulates PPARγ transcriptional activity.
Kim HE, Bae E, Jeong DY, Kim MJ, Jin WJ, Park SW, Han GS, Carman GM, Koh E, Kim KS.
Biochem J 453(1):49-60. doi: 10.1042/BJ20121598. 2013
31FAM3A, PPARG
FAM3A is a target gene of peroxisome proliferator-activated receptor gamma.
Zhou Y, Jia S, Wang C, Chen Z, Chi Y, Li J, Xu G, Guan Y, Yang J.
Biochim Biophys Acta 1830(8):4160-70. doi: 10.1016/j.bbagen.2013.03.029. Epub 2013 Apr 3. 2013
32PPARG, SIAH2
The ubiquitin ligase Siah2 regulates PPARγ activity in adipocytes.
Kilroy G, Kirk-Ballard H, Carter LE, Floyd ZE.
Endocrinology 153(3):1206-18. Epub 2012 Jan 31. 2012
33LPIN1, PPARG
Lipin-1 phosphatidic phosphatase activity modulates phosphatidate levels to promote peroxisome proliferator-activated receptor γ (PPARγ) gene expression during adipogenesis.
Zhang P, Takeuchi K, Csaki LS, Reue K.
J Biol Chem 287(5):3485-94. doi: 10.1074/jbc.M111.296681. Epub 2011 Dec 6. 2012
34PPARG, RXRA
Regulation of the human endogenous retroviral Syncytin-1 and cell-cell fusion by the nuclear hormone receptors PPARγ/RXRα in placentogenesis.
Ruebner M, Langbein M, Strissel PL, Henke C, Schmidt D, Goecke TW, Faschingbauer F, Schild RL, Beckmann MW, Strick R.
J Cell Biochem 113(7):2383-96. doi: 10.1002/jcb.24110. 2012
35MUC1, PPARG
PPARγ inhibits airway epithelial cell inflammatory response through a MUC1-dependent mechanism.
Park YS, Lillehoj EP, Kato K, Park CS, Kim KC.
Am J Physiol Lung Cell Mol Physiol 302(7):L679-87. doi: 10.1152/ajplung.00360.2011. Epub 2012 Jan 20. 2012
36CEBPA, DICER1, PPARG
Dicer has a crucial role in the early stage of adipocyte differentiation, but not in lipid synthesis, in 3T3-L1 cells.
Fujimoto Y, Nakagawa Y, Shingyouchi A, Tokushige N, Nakanishi N, Satoh A, Matsuzaka T, Ishii KA, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yahagi N, Urayama O, Yamada N, Shimano H.
Biochem Biophys Res Commun 420(4):931-6. doi: 10.1016/j.bbrc.2012.03.110. Epub 2012 Mar 26. 2012
37PPARG, SAV1, STK3, STK4
Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte differentiation by activation of PPARγ.
Park BH, Kim DS, Won GW, Jeon HJ, Oh BC, Lee Y, Kim EG, Lee YH.
PLoS One 7(1):e30983. doi: 10.1371/journal.pone.0030983. Epub 2012 Jan 26. 2012
38MGAT1, PPARG
Nuclear receptor PPARγ-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis.
Lee YJ, Ko EH, Kim JE, Kim E, Lee H, Choi H, Yu JH, Kim HJ, Seong JK, Kim KS, Kim JW.
Proc Natl Acad Sci U S A 109(34):13656-61. doi: 10.1073/pnas.1203218109. Epub 2012 Aug 6. 2012
39PPARG, REST, TBX20
Dual transcriptional activator and repressor roles of TBX20 regulate adult cardiac structure and function.
Sakabe NJ, Aneas I, Shen T, Shokri L, Park SY, Bulyk ML, Evans SM, Nobrega MA.
Hum Mol Genet 21(10):2194-204. doi: 10.1093/hmg/dds034. Epub 2012 Feb 10. 2012
40HR, PPARG
Hairless promotes PPARγ expression and is required for white adipogenesis.
Kumpf S, Mihlan M, Goginashvili A, Grandl G, Gehart H, Godel A, Schmidt J, Müller J, Bezzi M, Ittner A, Guccione E, Wolfrum C, Ricci R.
EMBO Rep 13(11):1012-20. doi: 10.1038/embor.2012.133. Epub 2012 Sep 11. 2012
41FGF1, PPARG
A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis.
Jonker JW, Suh JM, Atkins AR, Ahmadian M, Li P, Whyte J, He M, Juguilon H, Yin YQ, Phillips CT, Yu RT, Olefsky JM, Henry RR, Downes M, Evans RM.
Nature 485(7398):391-4. doi: 10.1038/nature10998. 2012
42BHLHE40, PPARG
Differentiated embryo chondrocyte 1 (DEC1) represses PPARγ2 gene through interacting with CCAAT/enhancer binding protein β (C/EBPβ).
Park YK, Park H.
Mol Cells 33(6):575-81. doi: 10.1007/s10059-012-0002-9. Epub 2012 May 18. 2012
43PPARG
Peroxisome proliferator-activated receptor γ is inhibited by histone deacetylase 4 in cortical neurons under oxidative stress.
Yang Y, Qin X, Liu S, Li J, Zhu X, Gao T, Wang X.
J Neurochem. 118(3):429-39. 2011
44PPARG
Brain PPAR-γ promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones.
Lu M, Sarruf DA, Talukdar S, Sharma S, Li P, Bandyopadhyay G, Nalbandian S, Fan W, Gayen JR, Mahata SK, Webster NJ, Schwartz MW, Olefsky JM.
Nat Med. 17(5):618-22. 2011
45PPARG
A role for central nervous system PPAR-γ in the regulation of energy balance.
Ryan KK, Li B, Grayson BE, Matter EK, Woods SC, Seeley RJ.
Nat Med. 17(5):623-6. 2011
46PPARG, SERPINF1, TNFSF10
Pigment epithelium-derived factor (PEDF) promotes tumor cell death by inducing macrophage membrane tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
Ho TC, Chen SL, Shih SC, Chang SJ, Yang SL, Hsieh JW, Cheng HC, Chen LJ, Tsao YP.
J Biol Chem 286(41):35943-54. doi: 10.1074/jbc.M111.266064. Epub 2011 Aug 16. 2011
47FTO, HMGA2, HNF1A, IRS1, KCNJ11, KCNQ1, KLF14, PPARG
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C, Aulchenko YS, Thorleifsson G, McCulloch LJ, Ferreira T, Grallert H, Amin N, Wu G, Willer CJ, Raychaudhuri S, McCarroll SA, Langenberg C, Hofmann OM, Dupuis J, Qi L, Segrč AV, van Hoek M, Navarro P, Ardlie K, Balkau B, Benediktsson R, Bennett AJ, Blagieva R, Boerwinkle E, Bonnycastle LL, Bengtsson Boström K, Bravenboer B, Bumpstead S, Burtt NP, Charpentier G, Chines PS, Cornelis M, Couper DJ, Crawford G, Doney AS, Elliott KS, Elliott AL, Erdos MR, Fox CS, Franklin CS, Ganser M, Gieger C, Grarup N, Green T, Griffin S, Groves CJ, Guiducci C, Hadjadj S, Hassanali N, Herder C, Isomaa B, Jackson AU, Johnson PR, Jřrgensen T, Kao WH, Klopp N, Kong A, Kraft P, Kuusisto J, Lauritzen T, Li M, Lieverse A, Lindgren CM, Lyssenko V, Marre M, Meitinger T, Midthjell K, Morken MA, Narisu N, Nilsson P, Owen KR, Payne F, Perry JR, Petersen AK, Platou C, Proença C, Prokopenko I, Rathmann W, Rayner NW, Robertson NR, Rocheleau G, Roden M, Sampson MJ, Saxena R, Shields BM, Shrader P, Sigurdsson G, Sparsř T, Strassburger K, Stringham HM, Sun Q, Swift AJ, Thorand B, Tichet J, Tuomi T, van Dam RM, van Haeften TW, van Herpt T, van Vliet-Ostaptchouk JV, Walters GB, Weedon MN, Wijmenga C, Witteman J, Bergman RN, Cauchi S, Collins FS, Gloyn AL, Gyllensten U, Hansen T, Hide WA, Hitman GA, Hofman A, Hunter DJ, Hveem K, Laakso M, Mohlke KL, Morris AD, Palmer CN, Pramstaller PP, Rudan I, Sijbrands E, Stein LD, Tuomilehto J, Uitterlinden A, Walker M, Wareham NJ, Watanabe RM, Abecasis GR, Boehm BO, Campbell H, Daly MJ, Hattersley AT, Hu FB, Meigs JB, Pankow JS, Pedersen O, Wichmann HE, Barroso I, Florez JC, Frayling TM, Groop L, Sladek R, Thorsteinsdottir U, Wilson JF, Illig T, Froguel P, van Duijn CM, Stefansson K, Altshuler D, Boehnke M, McCarthy MI; MAGIC investigators; GIANT Consortium.
Nat Genet 42(7):579-89.PMID: 20581827 2010
48APMAP, PPARG
Reconstruction of gene association network reveals a transmembrane protein required for adipogenesis and targeted by PPARγ.
Bogner-Strauss JG, Prokesch A, Sanchez-Cabo F, Rieder D, Hackl H, Duszka K, Krogsdam A, Di Camillo B, Walenta E, Klatzer A, Lass A, Pinent M, Wong WC, Eisenhaber F, Trajanoski Z.
Cell Mol Life Sci 67(23):4049-64. Epub 2010 Jun 15. 2010
49PPARG
Transcription of human resistin gene involves an interaction of Sp1 with peroxisome proliferator-activating receptor gamma (PPARgamma).
Singh AK, Battu A, Mohareer K, Hasnain SE, Ehtesham NZ.
PLoS One. 5(3):e9912. 2010
50PPARG, TRH
Peroxisome proliferator-activated receptor-gamma (PPARgamma) modulates hypothalamic Trh regulation in vivo.
Kouidhi S, Seugnet I, Decherf S, Guissouma H, Elgaaied AB, Demeneix B, Clerget-Froidevaux MS.
Mol Cell Endocrinol 317(1-2):44-52. doi: 10.1016/j.mce.2009.11.001. Epub 2009 Nov 10. 2010
51AACS, PPARG
Transcriptional regulation of the human acetoacetyl-CoA synthetase gene by PPARgamma.
Aguiló F, Camarero N, Relat J, Marrero PF, Haro D.
Biochem J 427(2):255-64. doi: 10.1042/BJ20090851. 2010
52AEBP1, NR1H3, PPARG
PPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1.
Majdalawieh A, Ro HS.
Nucl Recept Signal 8:e004. doi: 10.1621/nrs.08004. Review. 2010
53MED14, PPARG
MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis.
Grřntved L, Madsen MS, Boergesen M, Roeder RG, Mandrup S.
Mol Cell Biol. May;30(9):2155-69. doi: 10.1128/MCB.01238-09. Epub 2010 Mar 1 2010
54PPARG, SRSF1
Splicing factor ASF/SF2 and transcription factor PPAR-gamma cooperate to directly regulate transcription of uncoupling protein-3.
Kim DJ, Oh B, Kim YY.
Biochem Biophys Res Commun 378(4):877-82. Epub 2008 Dec 13. 2009
55CDX1, CEBPA, PPARG
Homeodomain transcription factor CDX1 is required for the transcriptional induction of PPARgamma in intestinal cell differentiation.
Park MJ, Kim HY, Kim K, Cheong J.
FEBS Lett 583(1):29-35. Epub 2008 Dec 4. 2009
56MEN1, PPARG
The multiple endocrine neoplasia type 1 (MEN1) tumor suppressor regulates peroxisome proliferator-activated receptor gamma-dependent adipocyte differentiation.
Dreijerink KM, Varier RA, van Beekum O, Jeninga EH, Höppener JW, Lips CJ, Kummer JA, Kalkhoven E, Timmers HT.
Mol Cell Biol 29(18):5060-9. Epub 2009 Jul 13. 2009
57PPARG
Wnt and PPARgamma signaling in osteoblastogenesis and adipogenesis.
Takada I, Kouzmenko AP, Kato S.
Nat Rev Rheumatol 5(8):442-7. Epub 2009 Jul 7. Review.PMID: 19581903 2009
58PPARG
The nuclear receptor PPAR gamma selectively inhibits Th17 differentiation in a T cell-intrinsic fashion and suppresses CNS autoimmunity.
Klotz L, Burgdorf S, Dani I, Saijo K, Flossdorf J, Hucke S, Alferink J, Nowak N, Beyer M, Mayer G, Langhans B, Klockgether T, Waisman A, Eberl G, Schultze J, Famulok M, Kolanus W, Glass C, Kurts C, Knolle PA.
J Exp Med 206(10):2079-89. Epub 2009 Sep 8. Erratum in: J Exp Med. 2009 Dec 21;206(13):3159. Novak, Natalija [corrected to Nowak, Nina]. P 2009
59IDE, PPARG
PPARgamma transcriptionally regulates the expression of insulin-degrading enzyme in primary neurons.
Du J, Zhang L, Liu S, Zhang C, Huang X, Li J, Zhao N, Wang Z.
Biochem Biophys Res Commun 383(4):485-90. Epub 2009 Apr 19.PMID: 19383491 2009
60PPARG
Peroxisome proliferator-activated receptor-gamma in normal human pregnancy and miscarriage.
Toth B, Bastug M, Mylonas I, Scholz C, Makovitzky J, Kunze S, Thaler C, Friese K, Jeschke U.
Acta Histochem 111(4):372-8. Epub 2009 Apr 1.PMID: 19342081 2009
61NR0B1, PPARG
The orphan nuclear receptor DAX-1 acts as a novel transcriptional corepressor of PPARgamma.
Kim GS, Lee GY, Nedumaran B, Park YY, Kim KT, Park SC, Lee YC, Kim JB, Choi HS.
Biochem Biophys Res Commun 370(2):264-8. Epub 2008 Mar 31. 2008
62FGF21, PPARG
Identification of a domain within peroxisome proliferator-activated receptor gamma regulating expression of a group of genes containing fibroblast growth factor 21 that are selectively repressed by SIRT1 in adipocytes.
Wang H, Qiang L, Farmer SR.
Mol Cell Biol 28(1):188-200. Epub 2007 Oct 22.PMID: 17954559 2008
63MED1, PPARG
Alternative mechanisms by which mediator subunit MED1/TRAP220 regulates peroxisome proliferator-activated receptor gamma-stimulated adipogenesis and target gene expression.
Ge K, Cho YW, Guo H, Hong TB, Guermah M, Ito M, Yu H, Kalkum M, Roeder RG.
Mol Cell Biol 28(3):1081-91. Epub 2007 Nov 26.PMID: 18039840 2008
64CXCR2, PPARG
Induction of CXCR2 receptor by peroxisome proliferator-activated receptor gamma in human macrophages.
Rigamonti E, Fontaine C, Lefebvre B, Duhem C, Lefebvre P, Marx N, Staels B, Chinetti-Gbaguidi G.
Arterioscler Thromb Vasc Biol 28(5):932-9. Epub 2008 Feb 21.PMID: 18292390 2008
65PPARG
The insulin receptor: a new anticancer target for peroxisome proliferator-activated receptor-gamma (PPARgamma) and thiazolidinedione-PPARgamma agonists.
Costa V, Foti D, Paonessa F, Chiefari E, Palaia L, Brunetti G, Gulletta E, Fusco A, Brunetti A.
Endocr Relat Cancer. 15(1):325-35. 2008
66PPARG
The adipogenic acetyltransferase Tip60 targets activation function 1 of peroxisome proliferator-activated receptor gamma.
van Beekum O, Brenkman AB, Grřntved L, Hamers N, van den Broek NJ, Berger R, Mandrup S, Kalkhoven E.
Endocrinology. 149(4):1840-9. 2008
67PPARG
Effects of the Type 2 Diabetes-Associated PPARG P12A Polymorphism on Progression to Diabetes and Response to Troglitazone.
Florez JC, Jablonski KA, Sun MW, Bayley N, Kahn SE, Shamoon H, Hamman RF, Knowler WC, Nathan DM, Altshuler D.
J Clin Endocrinol Metab 92(4):1502-9. Epub 2007 Jan 9. 2007
68PPARG, KCNJ11, TCF7L2, CDKAL1
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, Lango H, Timpson NJ, Perry JR, Rayner NW, Freathy RM, Barrett JC, Shields B, Morris AP, Ellard S, Groves CJ, Harries LW, Marchini JL, Owen KR, Knight B, Cardon LR, Walker M, Hitman GA, Morris AD, Doney AS; Wellcome Trust Case Control Consortium (WTCCC), Burton PR, Clayton DG, Craddock N, Deloukas P, Duncanson A, Kwiatkowski DP, Ouwehand WH, Samani NJ, Todd JA, Donnelly P, Davison D, Easton D, Evans D, Leung HT, Spencer CC, Tobin MD, Attwood AP, Boorman JP, Cant B, Everson U, Hussey JM, Jolley JD, Knight AS, Koch K, Meech E, Nutland S, Prowse CV, Stevens HE, Taylor NC, Walters GR, Walker NM, Watkins NA, Winzer T, Jones RW, McArdle WL, Ring SM, Strachan DP, Pembrey M, Breen G, St Clair D, Caesar S, Gordon-Smith K, Jones L, Fraser C, Green EK, Grozeva D, Hamshere ML, Holmans PA, Jones IR, Kirov G, Moskvina V, Nikolov I, O'donovan MC, Owen MJ, Collier DA, Elkin A, Farmer A, Williamson R, McGuffin P, Young AH, Ferrier IN, Ball SG, Balmforth AJ, Barrett JH, Bishop DT, Iles MM, Maqbool A, Yuldasheva N, Hall AS, Braund PS, Dixon RJ, Mangino M, Stevens S, Thompson JR, Bredin F, Tremelling M, Parkes M, Drummond H, Lees CW, Nimmo ER, Satsangi J, Fisher SA, Forbes A, Lewis CM, Onnie CM, Prescott NJ, Sanderson J, Mathew CG, Barbour J, Mohiuddin MK, Todhunter CE, Mansfield JC, Ahmad T, Cummings FR, Jewell DP, Webster J, Brown MJ, Lathrop GM, Connell J, Dominiczak A, Braga Marcano CA, Burke B, Dobson R, Gungadoo J, Lee KL, Munroe PB, Newhouse SJ, Onipinla A, Wallace C, Xue M, Caulfield M, Farrall M, Barton A, Bruce IN, Donovan H, Eyre S, Gilbert PD, Hider SL, Hinks AM, John SL, Potter C, Silman AJ, Symmons DP, Thomson W, Worthington J, Dunger DB, Widmer B, Newport M, Sirugo G, Lyons E, Vannberg F, Hill AV, Bradbury LA, Farrar C, Pointon JJ, Wordsworth P, Brown MA, Franklyn JA, Heward JM, Simmonds MJ, Gough SC, Seal S, Stratton MR, Rahman N, Ban M, Goris A, Sawcer SJ, Compston A, Conway D, Jallow M, Rockett KA, Bumpstead SJ, Chaney A, Downes K, Ghori MJ, Gwilliam R, Hunt SE, Inouye M, Keniry A, King E, McGinnis R, Potter S, Ravindrarajah R, Whittaker P, Widden C, Withers D, Cardin NJ, Ferreira T, Pereira-Gale J, Hallgrimsdottir IB, Howie BN, Su Z, Teo YY, Vukcevic D, Bentley D, Compston A, Ouwehand NJ, Samani MR, Isaacs JD, Morgan AW, Wilson GD, Ardern-Jones A, Berg J, Brady A, Bradshaw N, Brewer C, Brice G, Bullman B, Campbell J, Castle B, Cetnarsryj R, Chapman C, Chu C, Coates N, Cole T, Davidson R, Donaldson A, Dorkins H, Douglas F, Eccles D, Eeles R, Elmslie F, Evans DG, Goff S, Goodman S, Goudie D, Gray J, Greenhalgh L, Gregory H, Hodgson SV, Homfray T, Houlston RS, Izatt L, Jackson L, Jeffers L, Johnson-Roffey V, Kavalier F, Kirk C, Lalloo F, Langman C, Locke I, Longmuir M, Mackay J, Magee A, Mansour S, Miedzybrodzka Z, Miller J, Morrison P, Murday V, Paterson J, Pichert G, Porteous M, Rahman N, Rogers M, Rowe S, Shanley S, Saggar A, Scott G, Side L, Snadden L, Steel M, Thomas M, Thomas S, McCarthy MI, Hattersley AT.
Science 316(5829):1336-41. Epub 2007 Apr 26. 2007
69FPLD3,PPARG
Familial partial lipodystrophy phenotype resulting from a single-base mutation in deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma.
Monajemi H, Zhang L, Li G, Jeninga EH, Cao H, Maas M, Brouwer CB, Kalkhoven E, Stroes E, Hegele RA, Leff T.
J Clin Endocrinol Metab 92(5):1606-12. Epub 2007 Feb 13. 2007
70PPARG
A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation.
Takada I, Mihara M, Suzawa M, Ohtake F, Kobayashi S, Igarashi M, Youn MY, Takeyama K, Nakamura T, Mezaki Y, Takezawa S, Yogiashi Y, Kitagawa H, Yamada G, Takada S, Minami Y, Shibuya H, Matsumoto K, Kato S.
Nat Cell Biol. 9(11):1273-85. 2007
71PPARG
Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance.
Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, Morel CR, Subramanian V, Mukundan L, Red Eagle A, Vats D, Brombacher F, Ferrante AW, Chawla A.
Nature. 447(7148):1116-20. 2007
72PPARG
PPAR-gamma regulates osteoclastogenesis in mice.
Wan Y, Chong LW, Evans RM.
Nat Med. 13(12):1496-503. 2007
73PPARG, FPLD3
Peroxisomal proliferator activated receptor-gamma deficiency in a Canadian kindred with familial partial lipodystrophy type 3 (FPLD3).
Francis GA, Li G, Casey R, Wang J, Cao H, Leff T, Hegele RA.
BMC Med Genet 7:3. 2006
74PPARG
Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity.
Uno K, Katagiri H, Yamada T, Ishigaki Y, Ogihara T, Imai J, Hasegawa Y, Gao J, Kaneko K, Iwasaki H, Ishihara H, Sasano H, Inukai K, Mizuguchi H, Asano T, Shiota M, Nakazato M, Oka Y.
Science 312(5780):1656-9. 2006
75FPLD3, PPARG
A frameshift mutation in peroxisome-proliferator-activated receptor-gamma in familial partial lipodystrophy subtype 3 (FPLD3; MIM 604367).
Hegele RA, Ur E, Ransom TP, Cao H.
Clin Genet 70(4):360-2. No abstract available. 2006
76NCOA3, PPARG, CREBBP
Oncogenic steroid receptor coactivator-3 is a key regulator of the white adipogenic program.
Louet JF, Coste A, Amazit L, Tannour-Louet M, Wu RC, Tsai SY, Tsai MJ, Auwerx J, O'Malley BW.
Proc Natl Acad Sci U S A 103(47):17868-73. Epub 2006 Nov 10. 2006
77CYPHB1, CYPHB2, NR3C2, HSD11B2, SCNN1B, SCNN1G, PSALD, PHA2C, WNK1, PHA2B, WNK4, DIDAN, PPARG, MTHHH, MT-TI
The genetic dissection of essential hypertension.
Cowley AW Jr.
Nat Rev Genet 7(11):829-40. Epub 2006 Oct 10. Review. 2006
78PAX8, PPARG
PAX8-peroxisome proliferator-activated receptor gamma (PPARgamma) disrupts normal PAX8 or PPARgamma transcriptional function and stimulates follicular thyroid cell growth.
Au AY, McBride C, Wilhelm KG Jr, Koenig RJ, Speller B, Cheung L, Messina M, Wentworth J, Tasevski V, Learoyd D, Robinson BG, Clifton-Bligh RJ.
Endocrinology 147(1):367-76. Epub 2005 Sep 22. 2006
79PPARG
Isolation and characterization of a transcriptional cofactor and its novel isoform that bind the deoxyribonucleic acid-binding domain of peroxisome proliferator-activated receptor-gamma.
Tomaru T, Satoh T, Yoshino S, Ishizuka T, Hashimoto K, Monden T, Yamada M, Mori M.
Endocrinology. 147(1):377-88. 2006
80ADIPOQ, IRS1, PPARG
Common polymorphisms in the PPARgamma2 and IRS-1 genes and their interaction influence serum adiponectin concentration in young Finnish men.
Mousavinasab F, Tahtinen T, Jokelainen J, Koskela P, Vanhala M, Oikarinen J, Keinanen-Kiukaanniemi S, Laakso M.
Mol Genet Metab 84(4):344-8. Epub 2005 Jan 25. 2005
81PPARG
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma.
Pascual G, Fong AL, Ogawa S, Gamliel A, Li AC, Perissi V, Rose DW, Willson TM, Rosenfeld MG, Glass CK.
Nature 437(7059):759-63. Epub 2005 Aug 28. 2005
82CYP27A1, PPARG
Expression and regulation of sterol 27-hydroxylase (CYP27A1) in human macrophages: a role for RXR and PPARgamma ligands.
Quinn CM, Jessup W, Wong J, Kritharides L, Brown AJ.
Biochem J 385(Pt 3):823-30. 2005
83PAX8, PPARG
Expression profiling reveals a distinct transcription signature in follicular thyroid carcinomas with a PAX8-PPAR(gamma) fusion oncogene.
Lui WO, Foukakis T, Liden J, Thoppe SR, Dwight T, Hoog A, Zedenius J, Wallin G, Reimers M, Larsson C.
Oncogene 24(8):1467-76. 2005
84CEP350, PPARG
Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350.
Patel H, Truant R, Rachubinski RA, Capone JP.
J Cell Sci 118(Pt 1):175-86. 2005
85PPARG, KLF15
Role of Kruppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis.
Mori T, Sakaue H, Iguchi H, Gomi H, Okada Y, Takashima Y, Nakamura K, Nakamura T, Yamauchi T, Kubota N, Kadowaki T, Matsuki Y, Ogawa W, Hiramatsu R, Kasuga M.
J Biol Chem 280(13):12867-75. Epub 2005 Jan 20. 2005
86PPARG
Selective disruption of PPARgamma 2 impairs the development of adipose tissue and insulin sensitivity.
Zhang J, Fu M, Cui T, Xiong C, Xu K, Zhong W, Xiao Y, Floyd D, Liang J, Li E, Song Q, Chen YE.
Proc Natl Acad Sci U S A 101(29):10703-8. Epub 2004 Jul 12. 2004
87PPARG
Impact of genetic variation of PPARgamma in humans.
Meirhaeghe A, Amouyel P.
Mol Genet Metab 83(1-2):93-102. 2004
88PPARG
PPARs and the complex journey to obesity.
Evans RM, Barish GD, Wang YX.
Nat Med. 10(4):355-61 2004
89PPARG
Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma.
Tsai YS, Kim HJ, Takahashi N, Kim HS, Hagaman JR, Kim JK, Maeda N.
J Clin Invest. 114(2):240-9. 2004
90PPARD, PPARG
PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages.
Welch JS, Ricote M, Akiyama TE, Gonzalez FJ, Glass CK.
Proc Natl Acad Sci U S A 100(11):6712-7. Epub 2003 May 09. 2003
91PPARG, RUNX2
Activation of peroxisome proliferator-activated receptor-gamma inhibits the Runx2-mediated transcription of osteocalcin in osteoblasts.
Jeon MJ, Kim JA, Kwon SH, Kim SW, Park KS, Park SW, Kim SY, Shin CS.
J Biol Chem 278(26):23270-7. Epub 2003 Apr 18. 2003
92PPARG
The human peroxisome proliferator-activated receptor gamma2 (PPARgamma2) Pro12Ala polymorphism is associated with decreased risk of diabetic nephropathy in patients with type 2 diabetes.
Caramori ML, Canani LH, Costa LA, Gross JL.
Diabetes 52(12):3010-3. 2003
93PPARG
Convergence of peroxisome proliferator-activated receptor gamma and Foxo1 signaling pathways.
Dowell P, Otto TC, Adi S, Lane MD.
J Biol Chem. 278(46):45485-91. 2003
94PPARG
Genetic deficiency in Pparg does not alter development of experimental prostate cancer
Saez E, Olson P, Evans RM.
Nat Med. 9(10):1265-6 2003
95PPARG
Muscle-specific Pparg deletion causes insulin resistance.
Hevener AL, He W, Barak Y, Le J, Bandyopadhyay G, Olson P, Wilkes J, Evans RM, Olefsky J.
Nat Med. 9(12):1491-7. 2003
96PPARG
Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle.
He W, Barak Y, Hevener A, Olson P, Liao D, Le J, Nelson M, Ong E, Olefsky JM, Evans RM.
Proc Natl Acad Sci U S A. 100(26):15712-7. 2003
97PPARG
Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis.
Rosen ED, Kulkarni RN, Sarraf P, Ozcan U, Okada T, Hsu CH, Eisenman D, Magnuson MA, Gonzalez FJ, Kahn CR, Spiegelman BM.
Mol Cell Biol. 23(20):7222-9. 2003
98FPLD3, PPARG
PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy.
Hegele RA, Cao H, Frankowski C, Mathews ST, Leff T.
Diabetes 51(12):3586-90. 2002
99EDF1, PPARG
Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism.
Brendel C, Gelman L, Auwerx J.
Mol Endocrinol 16(6):1367-77. 2002
100PPARG, FPLD3
A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy.
Agarwal AK, Garg A.
J Clin Endocrinol Metab 87(1):408-11. 2002
101PPARG
Small heterodimer partner, an orphan nuclear receptor, augments peroxisome proliferator-activated receptor gamma transactivation.
Nishizawa H, Yamagata K, Shimomura I, Takahashi M, Kuriyama H, Kishida K, Hotta K, Nagaretani H, Maeda N, Matsuda M, Kihara S, Nakamura T, Nishigori H, Tomura H, Moore DD, Takeda J, Funahashi T, Matsuzawa Y.
J Biol Chem. 277(2):1586-92. 2002
102PPARG
Loss of the peroxisome proliferation-activated receptor gamma (PPARgamma ) does not affect mammary development and propensity for tumor formation but leads to reduced fertility.
Cui Y, Miyoshi K, Claudio E, Siebenlist UK, Gonzalez FJ, Flaws J, Wagner KU, Hennighausen L.
J Biol Chem. 277(20):17830-5. 2002
103PPARG
Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha - and gamma-mediated gene expression via liver fatty acid binding protein: a signaling path to the nucleus.
Wolfrum C, Borrmann CM, Borchers T, Spener F.
Proc Natl Acad Sci U S A. 98(5):2323-8. 2001
104PPARG
Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice.
Michalik L, Desvergne B, Tan NS, Basu-Modak S, Escher P, Rieusset J, Peters JM, Kaya G, Gonzalez FJ, Zakany J, Metzger D, Chambon P, Duboule D, Wahli W.
J Cell Biol. 154(4):799-814. 2001
105PPARG
Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators.
Kodera Y, Takeyama K, Murayama A, Suzawa M, Masuhiro Y, Kato S.
J Biol Chem. 275(43):33201-4. 2000
106PPARG
Suppression of rat thromboxane synthase gene transcription by peroxisome proliferator-activated receptor gamma in macrophages via an interaction with NRF2.
Ikeda Y, Sugawara A, Taniyama Y, Uruno A, Igarashi K, Arima S, Ito S, Takeuchi K.
J Biol Chem. 275(42):33142-50. 2000
107PPARG
Discrete roles for peroxisome proliferator-activated receptor gamma and retinoid X receptor in recruiting nuclear receptor coactivators.
Yang W, Rachez C, Freedman LP.
Mol Cell Biol. 20(21):8008-17. 2000
108PPARG
Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors.
Gampe RT Jr, Montana VG, Lambert MH, Miller AB, Bledsoe RK, Milburn MV, Kliewer SA, Willson TM, Xu HE.
Mol Cell. 5(3):545-55. 2000
109PPARG
Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency.
Miles PD, Barak Y, He W, Evans RM, Olefsky JM.
J Clin Invest. 105(3):287-92. 2000
110PPARG
p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers.
Monden T, Kishi M, Hosoya T, Satoh T, Wondisford FE, Hollenberg AN, Yamada M, Mori M.
Mol Endocrinol. 13(10):1695-703. 1999
111PPARG
Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma.
Heinlein CA, Ting HJ, Yeh S, Chang C.
J Biol Chem. 274(23):16147-52. 1999
112DIDAN, PPARG
PPAR gamma is required for placental, cardiac, and adipose tissue development.
Barak Y, Nelson MC, Ong ES, Jones YZ, Ruiz-Lozano P, Chien KR, Koder A, Evans RM.
Mol Cell. 4(4):585-95. 1999
113DIDAN, PPARG
PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance.
Kubota N, Terauchi Y, Miki H, Tamemoto H, Yamauchi T, Komeda K, Satoh S, Nakano R, Ishii C, Sugiyama T, Eto K, Tsubamoto Y, Okuno A, Murakami K, Sekihara H, Hasegawa G, Naito M, Toyoshima Y, Tanaka S, Shiota K, Kitamura T, Fujita T, Ezaki O, Aizawa S, Kadowaki T, et al.
Mol Cell. 4(4):597-609. 1999
114DIDAN, PPARG
PPAR gamma is required for the differentiation of adipose tissue in vivo and in vitro.
Rosen ED, Sarraf P, Troy AE, Bradwin G, Moore K, Milstone DS, Spiegelman BM, Mortensen RM.
Mol Cell. 4(4):611-7. 1999
115PPARG
Transcriptional activation by peroxisome proliferator-activated receptor gamma is inhibited by phosphorylation at a consensus mitogen-activated protein kinase site.
Adams M, Reginato MJ, Shao D, Lazar MA, Chatterjee VK.
J Biol Chem 272(8):5128-32.PMID: 9030579 1997
116PPARG
Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors gamma 1 and gamma 2.
Elbrecht A, Chen Y, Cullinan CA, Hayes N, Leibowitz M, Moller DE, Berger J.
Biochem Biophys Res Commun. 224(2):431-7. 1996
117PPARG
Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk.
Wan Y, Saghatelian A, Chong LW, Zhang CL, Cravatt BF, Evans RM.
Genes Dev.