| 1 | PPARA, SLC47A1
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| The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis.
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| Lin Z, Liu J, Long F, Kang R, Kroemer G, Tang D, Yang M.
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| Nat Commun. Dec 27;13(1):7965. doi: 10.1038/s41467-022-35707-2. 2022
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| 2 | ANGPTL6, FGF21, PPARA
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| ANGPTL6 expression is coupled with mitochondrial OXPHOS function to regulate adipose FGF21.
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| Kang SG, Yi HS, Choi MJ, Ryu MJ, Jung S, Chung HK, Chang JY, Kim YK, Lee SE, Kim HW, Choi H, Kim DS, Lee JH, Kim KS, Kim HJ, Lee CH, Oike Y, Shong M.
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| J Endocrinol 233(1):105-118. doi: 10.1530/JOE-16-0549. Epub 2017 Feb 9.
2017
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| 3 | EP300, PPARA, SIK2
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| SIK2 regulates fasting-induced PPARα activity and ketogenesis through p300.
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| Zhang ZN, Gong L, Lv S, Li J, Tai X, Cao W, Peng B, Qu S, Li W, Zhang C, Luan B.
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| Sci Rep 6:23317. doi: 10.1038/srep23317.
2016
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| 4 | IGF1, IGFBP2, PPARA
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| Regulation of IGFBP-2 expression during fasting.
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| Kang HS, Kim MY, Kim SJ, Lee JH, Kim YD, Seo YK, Bae JH, Oh GT, Song DK, Ahn YH, Im SS.
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| Biochem J 467(3):453-60. doi: 10.1042/BJ20141248.
2015
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| 5 | FABP1, FABP2, PPARA
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| Fatty Acid-binding Proteins 1 and 2 Differentially Modulate the Activation of Peroxisome Proliferator-activated Receptor α in a Ligand-selective Manner.
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| Hughes ML, Liu B, Halls ML, Wagstaff KM, Patil R, Velkov T, Jans DA, Bunnett NW, Scanlon MJ, Porter CJ.
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| J Biol Chem 290(22):13895-906. doi: 10.1074/jbc.M114.605998. Epub 2015 Apr 6.
2015
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| 6 | MECR, PPARA
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| A Novel Cytosolic Isoform of Mitochondrial Trans-2-Enoyl-CoA Reductase Enhances Peroxisome Proliferator-Activated Receptor α Activity.
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| Kim DG, Yoo JC, Kim E, Lee YS, Yarishkin OV, Lee DY, Lee KH, Hong SG, Hwang EM, Park JY.
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| Endocrinol Metab (Seoul) 29(2):185-94. doi: 10.3803/EnM.2014.29.2.185.
2014
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| 7 | MLXIPL, PPARA
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| Feedback looping between ChREBP and PPARα in the regulation of lipid metabolism in brown adipose tissues.
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| Iizuka K, Wu W, Horikawa Y, Saito M, Takeda J.
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| Endocr J 60(10):1145-53. Epub 2013 Jul 5.
2013
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| 8 | CEBPA, DDIT3, PPARA, SREBF1
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| C/EBP homologous protein (CHOP) contributes to suppression of metabolic genes during endoplasmic reticulum stress in the liver.
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| Chikka MR, McCabe DD, Tyra HM, Rutkowski DT.
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| J Biol Chem 288(6):4405-15. doi: 10.1074/jbc.M112.432344. Epub 2012 Dec 31.
2013
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| 9 | CYP3A4, PPARA
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| Direct transcriptional regulation of human hepatic cytochrome P450 3A4 (CYP3A4) by peroxisome proliferator-activated receptor alpha (PPARα).
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| Thomas M, Burk O, Klumpp B, Kandel BA, Damm G, Weiss TS, Klein K, Schwab M, Zanger UM.
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| Mol Pharmacol 83(3):709-18. doi: 10.1124/mol.112.082503. Epub 2013 Jan 7.
2013
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| 10 | FNDC5, PPARA, PPARGC1A
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| A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.
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| Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM.
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| Nature 481(7382):463-8. doi: 10.1038/nature10777.
2012
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| 11 | CYP3A4, PPARA
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| PPARA: a novel genetic determinant of CYP3A4 in vitro and in vivo.
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| Klein K, Thomas M, Winter S, Nussler AK, Niemi M, Schwab M, Zanger UM.
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| Clin Pharmacol Ther 91(6):1044-52. doi: 10.1038/clpt.2011.336.
2012
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| 12 | PPARA
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| Activation of peroxisome proliferator-activated receptor-α enhances fatty acid oxidation in human adipocytes.
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| Lee JY, Hashizaki H, Goto T, Sakamoto T, Takahashi N, Kawada T.
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| Biochem Biophys Res Commun 407(4):818-22. Epub 2011 Apr 2.
2011
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| 13 | NR1H3, PPARA
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| PPARα-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status.
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| Caton PW, Holness MJ, Bishop-Bailey D, Sugden MC.
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| Biochem J 437(3):521-30.
2011
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| 14 | PPARA
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| Proline- and acidic amino acid-rich basic leucine zipper proteins modulate peroxisome proliferator-activated receptor alpha (PPARalpha) activity.
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| Gachon F, Leuenberger N, Claudel T, Gos P, Jouffe C, Fleury Olela F, de Mollerat du Jeu X, Wahli W, Schibler U.
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| Proc Natl Acad Sci U S A 108(12):4794-9. Epub 2011 Mar 7.
2011
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| 15 | PPARA, SIRT1
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| Sirt1 acts in association with PPARα to protect the heart from hypertrophy, metabolic dysregulation, and inflammation.
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| Planavila A, Iglesias R, Giralt M, Villarroya F.
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| Cardiovasc Res 90(2):276-84. Epub 2010 Nov 29.
2011
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| 16 | PPARA, SREBF1
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| Human SREBP1c expression in liver is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha).
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| Fernández-Alvarez A, Alvarez MS, Gonzalez R, Cucarella C, Muntané J, Casado M.
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| J Biol Chem 286(24):21466-77. Epub 2011 May 2.
2011
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| 17 | PPARA
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| PPARalpha does not suppress muscle-associated gene expression in brown adipocytes but does influence expression of factors that fingerprint the brown adipocyte.
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| Waldén TB, Petrovic N, Nedergaard J.
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| Biochem Biophys Res Commun 397(2):146-51. Epub 2010 May 23.
2010
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| 18 | PPARA
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| PPARalpha: energy combustion, hypolipidemia, inflammation and cancer.
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| Pyper SR, Viswakarma N, Yu S, Reddy JK.
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| Nucl Recept Signal 8:e002. Review.
2010
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| 19 | CYP2J2, PPARA
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| The epoxygenases CYP2J2 activates the nuclear receptor PPARalpha in vitro and in vivo.
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| Wray JA, Sugden MC, Zeldin DC, Greenwood GK, Samsuddin S, Miller-Degraff L, Bradbury JA, Holness MJ, Warner TD, Bishop-Bailey D.
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| PLoS One 4(10):e7421.
2009
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| 20 | PPARA
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| Sumoylated PPARalpha mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice.
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| Leuenberger N, Pradervand S, Wahli W.
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| J Clin Invest 119(10):3138-48.
2009
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| 21 | PPARA
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| Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human.
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| Rakhshandehroo M, Hooiveld G, Müller M, Kersten S.
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| PLoS One 4(8):e6796.
2009
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| 22 | PPARA
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| Identification of a physiologically relevant endogenous ligand for PPARalpha in liver.
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| Chakravarthy MV, Lodhi IJ, Yin L, Malapaka RR, Xu HE, Turk J, Semenkovich CF.
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| Cell 138(3):476-88. Epub 2009 Jul 30.
2009
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| 23 | PPARA
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| Role of peroxisome proliferator-activated receptor-alpha in fasting-mediated oxidative stress.
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| Abdelmegeed MA, Moon KH, Hardwick JP, Gonzalez FJ, Song BJ.
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| Free Radic Biol Med 47(6):767-78. Epub 2009 Jun 17.
2009
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| 24 | ALAS1, PPARA
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| Peroxisome proliferator-activated receptor alpha controls hepatic heme biosynthesis through ALAS1.
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| Degenhardt T, Väisänen S, Rakhshandehroo M, Kersten S, Carlberg C.
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| J Mol Biol 388(2):225-38. Epub 2009 Mar 14. Retraction in: J Mol Biol. 2010 Nov 19;404(1):172.
2009
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| 25 | PDZK1, PPARA
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| Regulation of the human PDZK1 expression by peroxisome proliferator-activated receptor alpha.
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| Tachibana K, Anzai N, Ueda C, Katayama T, Yamasaki D, Kirino T, Takahashi R, Ishimoto K, Komori H, Tanaka T, Hamakubo T, Ueda Y, Arai H, Sakai J, Kodama T, Doi T.
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| FEBS Lett 582(28):3884-8. Epub 2008 Oct 26.
2008
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| 26 | MPO, NR1H3, PPARA
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| The human myeloperoxidase gene is regulated by LXR and PPARalpha ligands.
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| Reynolds WF, Kumar AP, Piedrafita FJ.
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| Biochem Biophys Res Commun 349(2):846-54. Epub 2006 Aug 31. 2006
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| 27 | PPARA
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| A potential link between muscle peroxisome proliferator-activated receptor-alpha signaling and obesity-related diabetes
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| Finck BN, et al
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| Cell metabolism 1(2):133-144. 2005
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| 28 | NPHS1, PPARA
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| PPARalpha activation upregulates nephrin expression in human embryonic kidney epithelial cells and podocytes by a dual mechanism.
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| Ren S, Xin C, Beck KF, Saleem MA, Mathieson P, Pavenstadt H, Pfeilschifter J, Huwiler A.
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| Biochem Biophys Res Commun 338(4):1818-24. Epub 2005 Nov 2. 2005
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| 29 | PPARA, PPARGC1A, TRIB3
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| PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.
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| Koo SH, Satoh H, Herzig S, Lee CH, Hedrick S, Kulkarni R, Evans RM, Olefsky J, Montminy M.
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| Nat Med 10(5):530-4. Epub 2004 Apr 25. 2004
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| 30 | PPARA
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| Association between the PPARalpha L162V polymorphism, plasma lipoprotein levels, and atherosclerotic disease in patients with diabetes mellitus type 2 and in nondiabetic controls.
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| Gouni-Berthold I, Giannakidou E, Muller-Wieland D, Faust M, Kotzka J, Berthold HK, Krone W.
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| Am Heart J 147(6):1117-24. 2004
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| 31 | PPARA
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| Molecular characterisation of six alternatively spliced variants and a novel promoter in human peroxisome proliferator-activated receptor alpha.
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| Chew CH, Samian MR, Najimudin N, Tengku-Muhammad TS.
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| Biochem Biophys Res Commun 305(2):235-43. 2003
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| 32 | PPARA
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| Identification of the PPARA locus on chromosome 22q13.3 as a modifier gene in familial combined hyperlipidemia.
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| Eurlings PM, van der Kallen CJ, Geurts JM, Flavell DM, de Bruin TW.
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| Mol Genet Metab 77(4):274-81. 2002
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| 33 | NR1H3, PPARA
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| Fatty acid regulation of liver X receptors (LXR) and peroxisome proliferator-activated receptor alpha (PPARalpha ) in HEK293 cells.
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| Pawar A, Xu J, Jerks E, Mangelsdorf DJ, Jump DB.
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| J Biol Chem 277(42):39243-50. 2002
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| 34 | PPARA
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| Characterization of the human PPARalpha promoter: identification of a functional nuclear receptor response element.
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| Pineda Torra I, Jamshidi Y, Flavell DM, Fruchart JC, Staels B.
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| Mol Endocrinol 16(5):1013-28. 2002
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| 35 | PPARA
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| A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders.
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| Leone TC, et al.
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| Proc Natl Acad Sci U S A 96(13):7473-8. 1999
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| 36 | HMGCS2, PPARA
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| A mitochondrial ketogenic enzyme regulates its gene expression by association with the nuclear hormone receptor PPARalpha.
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| Meertens LM, Miyata KS, Cechetto JD, Rachubinski RA, Capone JP.
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| EMBO J 17(23):6972-8. 1998
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| 37 | PPARA, CDKN1B, VHL
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| Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis.
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| Costet P, et al.
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| J Biol Chem 273(45):29577-85. 1998
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| 38 | PPARA, PPARD, DIDAN
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| Peroxisome proliferator-activated receptors and retinoic acid receptors differentially control the interactions of retinoid X receptor heterodimers with ligands, coactivators, and corepressors.
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| DiRenzo J, et al.
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| Mol Cell Biol 17 : 2166-2176. 1997
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| 39 | PPARA
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| Differential expression of peroxisome proliferator-activated receptors (PPARs) : tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat.
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| Braissant O, et al.
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| Endocrinology 137 : 354-366. 1996
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| 40 | PPARA
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| cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor.
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| Sher T, et al.
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| Biochemistry 32 : 5598-5604. 1993
|