Citations for
1HELLS, POU5F1
Tethering of Lsh at the Oct4 locus promotes gene repression associated with epigenetic changes.
Ren J, Hathaway NA, Crabtree GR, Muegge K.
Epigenetics 13(2):173-181. doi: 10.1080/15592294.2017.1338234. Epub 2018 Feb 6. 2018
2POU2F1, POU5F1
Enforcement of developmental lineage specificity by transcription factor Oct1.
Shen Z, Kang J, Shakya A, Tabaka M, Jarboe EA, Regev A, Tantin D.
Elife 6. pii: e20937. doi: 10.7554/eLife.20937. 2017
3NACC1, POU5F1, SOX2, TCF3
Nac1 Coordinates a Sub-network of Pluripotency Factors to Regulate Embryonic Stem Cell Differentiation.
Malleshaiah M, Padi M, Rué P, Quackenbush J, Martinez-Arias A, Gunawardena J.
Cell Rep 14(5):1181-94. doi: 10.1016/j.celrep.2015.12.101. 2016
4DPF2, POU5F1
Data in support of DPF2 regulates OCT4 protein level and nuclear distribution.
Liu C, Zhang D, Shen Y, Tao X, Liu L, Zhong Y, Fang S.
Data Brief 5:599-604. doi: 10.1016/j.dib.2015.10.010. eCollection 2015 Dec. 2015
5DPF2, POU5F1
DPF2 regulates OCT4 protein level and nuclear distribution.
Liu C, Zhang D, Shen Y, Tao X, Liu L, Zhong Y, Fang S.
Biochim Biophys Acta 1853(12):3279-93. doi: 10.1016/j.bbamcr.2015.09.029. Epub 2015 Sep 28. 2015
6POU5F1, TRIM32
TRIM32 modulates pluripotency entry and exit by directly regulating Oct4 stability.
Bahnassawy L, Perumal TM, Gonzalez-Cano L, Hillje AL, Taher L, Makalowski W, Suzuki Y, Fuellen G, del Sol A, Schwamborn JC.
Sci Rep 5:13456. doi: 10.1038/srep13456. 2015
7DIDO1, NANOG, POU5F1
The death-inducer obliterator 1 (Dido1) gene regulates embryonic stem cell self-renewal.
Liu Y, Kim H, Liang J, Lu W, Ouyang B, Liu D, Songyang Z.
J Biol Chem 289(8):4778-86. doi: 10.1074/jbc.M113.486290. Epub 2013 Dec 17. 2014
8POU5F1, RND1
Overexpression of Oct4 suppresses the metastatic potential of breast cancer cells via Rnd1 downregulation.
Shen L, Qin K, Wang D, Zhang Y, Bai N, Yang S, Luo Y, Xiang R, Tan X.
Biochim Biophys Acta 1842(11):2087-95. doi: 10.1016/j.bbadis.2014.07.015. Epub 2014 Jul 25. 2014
9ETV4, POU5F1
Transcriptional activation of OCT4 by the ETS transcription factor PEA3 in NCCIT human embryonic carcinoma cells.
Park SW, Do HJ, Ha WT, Han MH, Park KH, Song H, Kim NH, Kim JH.
FEBS Lett 588(17):3129-36. doi: 10.1016/j.febslet.2014.06.052. Epub 2014 Jun 28. 2014
10HMGB2, POU5F1
Oct4 Interaction with Hmgb2 Regulates Akt Signaling and Pluripotency.
Campbell PA, Rudnicki MA.
Stem Cells tem Cells. 2013 Mar 14. doi: 10.1002/stem.1365. [Epub ahead of print] 2013
11POU5F1
Differential role for transcription factor Oct4 nucleocytoplasmic dynamics in somatic cell reprogramming and self-renewal of embryonic stem cells.
Oka M, Moriyama T, Asally M, Kawakami K, Yoneda Y.
J Biol Chem 288(21):15085-97. doi: 10.1074/jbc.M112.448837. Epub 2013 Apr 11. 2013
12POU5F1
A defined Oct4 level governs cell state transitions of pluripotency entry and differentiation into all embryonic lineages.
Radzisheuskaya A, Chia Gle B, dos Santos RL, Theunissen TW, Castro LF, Nichols J, Silva JC.
Nat Cell Biol 15(6):579-90. doi: 10.1038/ncb2742. Epub 2013 Apr 30. 2013
13POU5F1, SOX17, SOX2
Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm.
Aksoy I, Jauch R, Chen J, Dyla M, Divakar U, Bogu GK, Teo R, Leng Ng CK, Herath W, Lili S, Hutchins AP, Robson P, Kolatkar PR, Stanton LW.
EMBO J 32(7):938-53. doi: 10.1038/emboj.2013.31. Epub 2013 Mar 8. 2013
14BIRC5, CCND1, POU5F1
OCT4 increases BIRC5 and CCND1 expression and promotes cancer progression in hepatocellular carcinoma.
Cao L, Li C, Shen S, Yan Y, Ji W, Wang J, Qian H, Jiang X, Li Z, Wu M, Zhang Y, Su C.
BMC Cancer 13:82. doi: 10.1186/1471-2407-13-82. 2013
15ITCH, POU5F1
Itch, an E3 ligase of Oct4, is required for embryonic stem cell self-renewal and pluripotency induction.
Liao B, Zhong X, Xu H, Xiao F, Fang Z, Gu J, Chen Y, Zhao Y, Jin Y.
J Cell Physiol 228(7):1443-51. doi: 10.1002/jcp.24297. 2013
16MBD6, POU5F1
MBD6 is a direct target of Oct4 and controls the stemness and differentiation of adipose tissue-derived stem cells.
Jung JS, Jee MK, Cho HT, Choi JI, Im YB, Kwon OH, Kang SK.
Cell Mol Life Sci 70(4):711-28. doi: 10.1007/s00018-012-1157-4. Epub 2012 Sep 30. 2013
17POU5F1, TAF4, TAF4B
TAF4b and TAF4 differentially regulate mouse embryonic stem cells maintenance and proliferation.
Bahat A, Kedmi R, Gazit K, Richardo-Lax I, Ainbinder E, Dikstein R.
Genes Cells 18(3):225-37. doi: 10.1111/gtc.12030. Epub 2013 Jan 27. 2013
18E4F1, MED24, POU5F1, PRDM14, SON
SON connects the splicing-regulatory network with pluripotency in human embryonic stem cells.
Lu X, Göke J, Sachs F, Jacques PÉ, Liang H, Feng B, Bourque G, Bubulya PA, Ng HH.
Nat Cell Biol 15(10):1141-52. doi: 10.1038/ncb2839. Epub 2013 Sep 8. 2013
19POU5F1
OCT4 and the acquisition of oocyte developmental competence during folliculogenesis.
Zuccotti M, Merico V, Belli M, Mulas F, Sacchi L, Zupan B, Redi CA, Prigione A, Adjaye J, Bellazzi R, Garagna S.
Int J Dev Biol 56(10-12):853-8. doi: 10.1387/ijdb.120174mz. Review. 2012
20BIRC5, POU5F1
OCT4 positively regulates Survivin expression to promote cancer cell proliferation and leads to poor prognosis in esophageal squamous cell carcinoma.
Li C, Yan Y, Ji W, Bao L, Qian H, Chen L, Wu M, Chen H, Li Z, Su C.
PLoS One 7(11):e49693. doi: 10.1371/journal.pone.0049693. Epub 2012 Nov 21. 2012
21CDK1, POU5F1
Cdk1 interplays with Oct4 to repress differentiation of embryonic stem cells into trophectoderm.
Li L, Wang J, Hou J, Wu Z, Zhuang Y, Lu M, Zhang Y, Zhou X, Li Z, Xiao W, Zhang W.
FEBS Lett 586(23):4100-7. doi: 10.1016/j.febslet.2012.10.030. Epub 2012 Oct 26. 2012
22POU5F1
Transcriptional activation by Oct4 is sufficient for the maintenance and induction of pluripotency.
Hammachi F, Morrison GM, Sharov AA, Livigni A, Narayan S, Papapetrou EP, O'Malley J, Kaji K, Ko MS, Ptashne M, Brickman JM.
Cell Rep 1(2):99-109. doi: 10.1016/j.celrep.2011.12.002. Epub 2012 Feb 16. 2012
23NANOG, POU5F1
Oct4 and Nanog directly regulate Dnmt1 to maintain self-renewal and undifferentiated state in mesenchymal stem cells.
Tsai CC, Su PF, Huang YF, Yew TL, Hung SC.
Mol Cell 47(2):169-82. doi: 10.1016/j.molcel.2012.06.020. Epub 2012 Jul 12. 2012
24POU5F1
Phosphorylation regulates human OCT4.
Brumbaugh J, Hou Z, Russell JD, Howden SE, Yu P, Ledvina AR, Coon JJ, Thomson JA.
Proc Natl Acad Sci U S A 109(19):7162-8. doi: 10.1073/pnas.1203874109. Epub 2012 Apr 2. 2012
25POU5F1
Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation.
Kumar SM, Liu S, Lu H, Zhang H, Zhang PJ, Gimotty PA, Guerra M, Guo W, Xu X.
Oncogene 31(47):4898-911. doi: 10.1038/onc.2011.656. Epub 2012 Jan 30. 2012
26EP300, KDM5A, KDM6A, KDM6B, KLF4, POU5F1
The EP300, KDM5A, KDM6A and KDM6B chromatin regulators cooperate with KLF4 in the transcriptional activation of POU5F1.
Wang WP, Tzeng TY, Wang JY, Lee DC, Lin YH, Wu PC, Chen YP, Chiu IM, Chi YH.
PLoS One 7(12):e52556. doi: 10.1371/journal.pone.0052556. Epub 2012 Dec 18. 2012
27CITED2, NFATC4, NKX2-5, POU5F1
Cited2 gene controls pluripotency and cardiomyocyte differentiation of murine embryonic stem cells through Oct4 gene.
Li Q, Ramírez-Bergeron DL, Dunwoodie SL, Yang YC.
J Biol Chem 287(34):29088-100. doi: 10.1074/jbc.M112.378034. Epub 2012 Jul 3. 2012
28NR5A2, POU5F1
Regulation of OCT4 gene expression by liver receptor homolog-1 in human embryonic carcinoma cells.
Sung B, Do HJ, Park SW, Huh SH, Oh JH, Chung HJ, Kang MJ, Kim JH, Kim NH, Kim JH.
Biochem Biophys Res Commun 427(2):315-20. doi: 10.1016/j.bbrc.2012.09.049. Epub 2012 Sep 18. 2012
29POU5F1
Serine 111 phosphorylation regulates OCT4A protein subcellular distribution and degradation.
Spelat R, Ferro F, Curcio F.
J Biol Chem 287(45):38279-88. doi: 10.1074/jbc.M112.386755. Epub 2012 Sep 28. 2012
30POU5F1
Transient expression of OCT4 is sufficient to allow human keratinocytes to change their differentiation pathway.
Racila D, Winter M, Said M, Tomanek-Chalkley A, Wiechert S, Eckert RL, Bickenbach JR.
Gene Ther 18(3):294-303. Epub 2010 Oct 28. 2011
31POU5F1, WDR5
Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network.
Ang YS, Tsai SY, Lee DF, Monk J, Su J, Ratnakumar K, Ding J, Ge Y, Darr H, Chang B, Wang J, Rendl M, Bernstein E, Schaniel C, Lemischka IR.
Cell 145(2):183-97. Epub 2011 Apr 7. 2011
32POU5F1
Pou5f1 contributes to dorsoventral patterning by positive regulation of vox and modulation of fgf8a expression.
Belting HG, Wendik B, Lunde K, Leichsenring M, Mössner R, Driever W, Onichtchouk D.
Dev Biol 356(2):323-36. Epub 2011 May 20. 2011
33NANOG, POU5F1, SOX2
A DNA repair complex functions as an Oct4/Sox2 coactivator in embryonic stem cells.
Fong YW, Inouye C, Yamaguchi T, Cattoglio C, Grubisic I, Tjian R.
Cell 147(1):120-31. 2011
34MYOD1, POU5F1
MyoD gene suppression by Oct4 is required for reprogramming in myoblasts to produce induced pluripotent stem cells.
Watanabe S, Hirai H, Asakura Y, Tastad C, Verma M, Keller C, Dutton JR, Asakura A.
Stem Cells 29(3):505-16. doi: 10.1002/stem.598. 2011
35CDKN1A, POU5F1
Oct-4 controls cell-cycle progression of embryonic stem cells.
Lee J, Go Y, Kang I, Han YM, Kim J.
Biochem J 426(2):171-81. 2010
36LIN28A, POU5F1
Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells.
Qiu C, Ma Y, Wang J, Peng S, Huang Y.
Nucleic Acids Res 38(4):1240-8. Epub 2009 Dec 4. 2010
37POU5F1
Mapping of the minimal internal ribosome entry site element in the human embryonic stem cell gene OCT4B mRNA.
Zhang W, Wang X, Xiao Z, Liu W, Chen B, Dai J.
Biochem Biophys Res Commun 394(3):750-4. Epub 2010 Mar 15. 2010
38POU5F1
Natural immunity to pluripotency antigen OCT4 in humans.
Dhodapkar KM, Feldman D, Matthews P, Radfar S, Pickering R, Turkula S, Zebroski H, Dhodapkar MV.
Proc Natl Acad Sci U S A 107(19):8718-23. Epub 2010 Apr 19.PMID: 20404147 2010
39FBXO15, NANOG, POU5F1, SALL4, SOX15, SPP1
Constitutive expression of pluripotency-associated genes in mesodermal progenitor cells (MPCs).
Pacini S, Carnicelli V, Trombi L, Montali M, Fazzi R, Lazzarini E, Giannotti S, Petrini M.
PLoS One 5(3):e9861.PMID: 20360837 2010
40POU5F1, POUF1
Single-molecule analysis reveals changes in the DNA replication program for the POU5F1 locus upon human embryonic stem cell differentiation.
Schultz SS, Desbordes SC, Du Z, Kosiyatrakul S, Lipchina I, Studer L, Schildkraut CL.
Mol Cell Biol 30(18):4521-34. Epub 2010 Jul 20. 2010
41POU5F1, TSIX, XIST
Retinoic acid accelerates downregulation of the Xist repressor, Oct4, and increases the likelihood of Xist activation when Tsix is deficient.
Ahn JY, Lee JT.
BMC Dev Biol 10:90. 2010
42POU2F1, POU5F1
A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress.
Kang J, Gemberling M, Nakamura M, Whitby FG, Handa H, Fairbrother WG, Tantin D.
Genes Dev 23(2):208-22. 2009
43PLXNA2, POU5F1
Implication of human OCT4 transactivation domains for self-regulatory transcription.
Lim HY, Do HJ, Lee WY, Kim DK, Seo HG, Chung HJ, Park JK, Chang WK, Kim JH, Kim JH.
Biochem Biophys Res Commun 385(2):148-53. Epub 2009 May 13. 2009
44NANOG, POU5F1
Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells.
Liang J, Wan M, Zhang Y, Gu P, Xin H, Jung SY, Qin J, Wong J, Cooney AJ, Liu D, Songyang Z.
Nat Cell Biol 10(6):731-9. Epub 2008 May 4. 2008
45KPNA2, POU5F1
Identification of karyopherin-alpha 2 as an Oct4 associated protein.
Li X, Sun L, Jin Y.
J Genet Genomics 35(12):723-8. 2008
46NANOG, POU5F1, SOX2, ZNF281
The transcription factor Zfp281 controls embryonic stem cell pluripotency by direct activation and repression of target genes.
Wang ZX, Teh CH, Chan CM, Chu C, Rossbach M, Kunarso G, Allapitchay TB, Wong KY, Stanton LW.
Stem Cells 26(11):2791-9. doi: 10.1634/stemcells.2008-0443. Epub 2008 Aug 28. 2008
47POU5F1, POU5F1B
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.
Zanke BW, Greenwood CM, Rangrej J, Kustra R, Tenesa A, Farrington SM, Prendergast J, Olschwang S, Chiang T, Crowdy E, Ferretti V, Laflamme P, Sundararajan S, Roumy S, Olivier JF, Robidoux F, Sladek R, Montpetit A, Campbell P, Bezieau S, O'Shea AM, Zogopoulos G, Cotterchio M, Newcomb P, McLaughlin J, Younghusband B, Green R, Green J, Porteous ME, Campbell H, Blanche H, Sahbatou M, Tubacher E, Bonaiti-Pellie C, Buecher B, Riboli E, Kury S, Chanock SJ, Potter J, Thomas G, Gallinger S, Hudson TJ, Dunlop MG.
Nat Genet 39(8):989-94. Epub 2007 Jul 8. 2007
48POU5F1, POU5F1B
A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21.
Tomlinson I, Webb E, Carvajal-Carmona L, Broderick P, Kemp Z, Spain S, Penegar S, Chandler I, Gorman M, Wood W, Barclay E, Lubbe S, Martin L, Sellick G, Jaeger E, Hubner R, Wild R, Rowan A, Fielding S, Howarth K; CORGI Consortium, Silver A, Atkin W, Muir K, Logan R, Kerr D, Johnstone E, Sieber O, Gray R, Thomas H, Peto J, Cazier JB, Houlston R.
Nat Genet 39(8):984-8. Epub 2007 Jul 8. 2007
49NANOG, POU5F1, SOX2, ZIC3
Zic3 is required for maintenance of pluripotency in embryonic stem cells.
Lim LS, Loh YH, Zhang W, Li Y, Chen X, Wang Y, Bakre M, Ng HH, Stanton LW.
Mol Biol Cell 18(4):1348-58. Epub 2007 Jan 31. 2007
50JMJD1A, JMJD1C, KDM3B, POU5F1
Comparative integromics on JMJD1C gene encoding histone demethylase: conserved POU5F1 binding site elucidating mechanism of JMJD1C expression in undifferentiated ES cells and diffuse-type gastric cancer.
Katoh M, Katoh M.
Int J Oncol 31(1):219-23. 2007
51EWSR1, POU5F1
The EWS-Oct-4 fusion gene encodes a transforming gene.
Lee J, Kim JY, Kang IY, Kim HK, Han YM, Kim J.
Biochem J 406(3):519-26.PMID: 17564582 2007
52KLF4, POU5F1, LEFTY1
Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells.
Nakatake Y, Fukui N, Iwamatsu Y, Masui S, Takahashi K, Yagi R, Yagi K, Miyazaki J, Matoba R, Ko MS, Niwa H.
Mol Cell Biol 26(20):7772-82. Epub 2006 Sep 5. 2006
53EWSR1, POU5F1
EWSR1 is fused to POU5F1 in a bone tumor with translocation t(6;22)(p21;q12).
Yamaguchi S, Yamazaki Y, Ishikawa Y, Kawaguchi N, Mukai H, Nakamura T.
Genes Chromosomes Cancer 43(2):217-22. 2005
54FN1, POU5F1, MMP7, EGR1, AFP, IRX1, NR6A1
Gene expression profiling differentiates germ cell tumors from other cancers and defines subtype-specific signatures.
Juric D, Sale S, Hromas RA, Yu R, Wang Y, Duran GE, Tibshirani R, Einhorn LH, Sikic BI.
Proc Natl Acad Sci U S A 102(49):17763-8. Epub 2005 Nov 23. 2005
55POU5F1
Identification of the 'NORE' (N-Oct-3 responsive element), a novel structural motif and composite element.
Alazard R, Blaud M, Elbaz S, Vossen C, Icre G, Joseph G, Nieto L, Erard M.
Nucleic Acids Res 33(5):1513-23. Print 2005. 2005
56NANOG, POU5F1
Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells.
Chambers I, Colby D, Robertson M, Nichols J, Lee S, Tweedie S, Smith A.
Cell 113(5):643-55. 2003
57POU5F1, FOXD3, DNMT3B, FZD7, SDC4, GABRB3, GPC4, TERF1
Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors.
Sperger JM, Chen X, Draper JS, Antosiewicz JE, Chon CH, Jones SB, Brooks JD, Andrews PW, Brown PO, Thomson JA.
Proc Natl Acad Sci U S A 100(23):13350-5. Epub 2003 Oct 31. 2003
58POU5F1
POU5F1 (OCT3/4) identifies cells with pluripotent potential in human germ cell tumors.
Looijenga LH, Stoop H, de Leeuw HP, de Gouveia Brazao CA, Gillis AJ, van Roozendaal KE, van Zoelen EJ, Weber RF, Wolffenbuttel KP, van Dekken H, Honecker F, Bokemeyer C, Perlman EJ, Schneider DT, Kononen J, Sauter G, Oosterhuis JW.
Cancer Res 63(9):2244-50. 2003
59POU5F1
The OTF3 gene polymorphism confers susceptibility to psoriasis independent of the association of HLA-Cw*0602.
Gonzalez S, Martinez-Borra J, Del Rio JS, Santos-Juanes J, Lopez-Vazquez A, Blanco-Gelaz M, Lopez-Larrea C.
J Invest Dermatol 115(5):824-8. 2000
60POU5F1
N-Oct 5 is generated by in vitro proteolysis of the neural POU-domain protein N-Oct 3.
Atanasoski S, Schreiber E, Fontana A, Herr W.
Oncogene 14(11):1287-94. 1997
61HFEC@, HLA-F, HTFAG@, IFITM3, ARHGAP25, MHC1, POU5F1
Identification of new HLA class I region genes by sample sequencing.
Goldsworthy M, Sampath A, Wilkinson JM, Powis SH.
Immunogenetics 46(3):206-12. 1997
62POU5F1, TCF19, CDSN
Feature mapping of the HLA class I region : localization of the POU5F1 and TCF19 genes.
Krishnan BR, et al.
Genomics 30 : 53-58. 1995
63POU5F1
Localization of the OTF3 gene within the human MHC class I region by physical and meiotic mapping.
Crouau-Roy B, et al.
Genomics 21 : 241-243. 1994
64CPHD1, POU2F1, POU2F2, POU3F2, POU3F4, POU4F1, POU5F1, POU5F1B, POU5F1P3, POU6F1
Chromosomal organization of mammalian POU domain factors.
Xia YR, et al.
Genomics 18 : 126-130. 1993
65POU5F1, POU5F1P3
In situ hybridization localizes the human OTF3 to chromosome 6p21.3-p22 and OTF3L to 12p13.
Guillaudeux T, et al.
Cytogenet Cell Genet 63 : 212-214. 1993
66POU5F1, POU5F1B
Human Oct3 gene family : cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues.
Takeda J, et al.
Nucleic Acids Res 20 : 4613-4620. 1992
67POU2F1, POU2F2, POU5F1
Chromosomal location of the octamer transcription factors, Otf-1, Otf-2, and Otf-3, defines multiple Otf-3-related sequences dispersed in the mouse genome.
Siracusa LD, et al.
Genomics 10 : 313-326. 1991