| 1 | ARL6IP5, POMC
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| GTRAP3-18 regulates food intake and body weight by interacting with pro-opiomelanocortin
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| Aoyama K, Bhadhprasit W, Watabe M, Wang F, Matsumura N, Nakaki T.
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| FASEB J. 32(1):330-341. doi: 10.1096/fj.201700421R. Epub 2017 Sep 13. 2018
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| 2 | MC1R, POMC
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| Significance of the melanocortin 1 receptor in the DNA damage response of human melanocytes to ultraviolet radiation.
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| Swope V, Alexander C, Starner R, Schwemberger S, Babcock G, Abdel-Malek ZA.
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| Pigment Cell Melanoma Res 27(4):601-10. doi: 10.1111/pcmr.12252. Epub 2014 May 12.
2014
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| 3 | AKT1, MC1R, POMC
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| Alpha-melanocyte stimulating hormone protects retinal pigment epithelium cells from oxidative stress through activation of melanocortin 1 receptor-Akt-mTOR signaling.
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| Cheng LB, Cheng L, Bi HE, Zhang ZQ, Yao J, Zhou XZ, Jiang Q.
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| Biochem Biophys Res Commun 443(2):447-52. doi: 10.1016/j.bbrc.2013.11.113. Epub 2013 Dec 6.
2014
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| 4 | CNTF, POMC
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| The anorexigenic cytokine ciliary neurotrophic factor stimulates POMC gene expression via receptors localized in the nucleus of arcuate neurons.
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| Couvreur O, Aubourg A, Crépin D, Degrouard J, Gertler A, Taouis M, Vacher CM.
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| Am J Physiol Endocrinol Metab 302(4):E458-67. Epub 2011 Dec 6.
2012
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| 5 | MC1R, POMC
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| Alpha-melanocyte-stimulating hormone suppresses oxidative stress through a p53-mediated signaling pathway in human melanocytes.
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| Kadekaro AL, Chen J, Yang J, Chen S, Jameson J, Swope VB, Cheng T, Kadakia M, Abdel-Malek Z.
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| Mol Cancer Res 10(6):778-86. doi: 10.1158/1541-7786.MCR-11-0436. Epub 2012 May 23.
2012
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| 6 | CNR1, MC1R, POMC
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| Endocannabinoids stimulate human melanogenesis via type-1 cannabinoid receptor.
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| Pucci M, Pasquariello N, Battista N, Di Tommaso M, Rapino C, Fezza F, Zuccolo M, Jourdain R, Finazzi Agrò A, Breton L, Maccarrone M.
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| J Biol Chem 287(19):15466-78. doi: 10.1074/jbc.M111.314880. Epub 2012 Mar 19.
2012
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| 7 | ETV1, POMC, TBX19
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| The Ets factor Etv1 interacts with Tpit protein for pituitary pro-opiomelanocortin (POMC) gene transcription.
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| Budry L, Couture C, Balsalobre A, Drouin J.
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| J Biol Chem 286(28):25387-96. Epub 2011 May 26.
2011
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| 8 | POMC, TBX19
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| A pituitary-specific enhancer of the POMC gene with preferential activity in corticotrope cells.
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| Langlais D, Couture C, Sylvain-Drolet G, Drouin J.
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| Mol Endocrinol 25(2):348-59. Epub 2010 Dec 30.
2011
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| 9 | AGRP, NPY, POMC
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| Proliferative hypothalamic neurospheres express NPY, AGRP, POMC, CART and Orexin-A and differentiate to functional neurons.
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| Sousa-Ferreira L, Álvaro AR, Aveleira C, Santana M, Brandão I, Kügler S, de Almeida LP, Cavadas C.
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| PLoS One 6(5):e19745.
2011
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| 10 | POMC, PTPN1
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| Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure.
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| De Jonghe BC, Hayes MR, Banno R, Skibicka KP, Zimmer DJ, Bowen KA, Leichner TM, Alhadeff AL, Kanoski SE, Cyr NE, Nillni EA, Grill HJ, Bence KK.
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| Am J Physiol Endocrinol Metab 300(6):E1002-11. Epub 2011 Mar 15.
2011
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| 11 | POMC
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| Genetic modifications of mouse proopiomelanocortin peptide processing.
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| Costa JL, Forbes S, Brennan MB, Hochgeschwender U.
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| Mol Cell Endocrinol 336(1-2):14-22. Epub 2010 Dec 30.
2011
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| 12 | POMC
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| Impaired neonatal survival of pro-opiomelanocortin null mutants.
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| Saedler K, Hochgeschwender U.
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| Mol Cell Endocrinol 336(1-2):6-13. Epub 2010 Dec 22.
2011
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| 13 | MC1R, POMC
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| Spatial and temporal localization of the melanocortin 1 receptor and its ligand α-melanocyte-stimulating hormone during cutaneous wound repair.
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| Muffley LA, Zhu KQ, Engrav LH, Gibran NS, Hocking AM.
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| J Histochem Cytochem 59(3):278-88. doi: 10.1369/0022155410397999. Epub 2011 Jan 12.
2011
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| 14 | MC1R, POMC, TUBB3
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| Alpha-MSH regulates intergenic splicing of MC1R and TUBB3 in human melanocytes.
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| Dalziel M, Kolesnichenko M, das Neves RP, Iborra F, Goding C, Furger A.
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| Nucleic Acids Res 39(6):2378-92. doi: 10.1093/nar/gkq1125. Epub 2010 Nov 11.
2011
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| 15 | POMC
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| Peroxisomal localization of the proopiomelanocortin-derived peptides beta-lipotropin and beta-endorphin.
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| Höftberger R, Kunze M, Voigtländer T, Unterberger U, Regelsberger G, Bauer J, Aboul-Enein F, Garzuly F, Forss-Petter S, Bernheimer H, Berger J, Budka H.
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| Endocrinology 151(10):4801-10. Epub 2010 Sep 1.
2010
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| 16 | POMC
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| DNA methylation of the POMC gene promoter is associated with craving in alcohol dependence.
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| Muschler MA, Hillemacher T, Kraus C, Kornhuber J, Bleich S, Frieling H.
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| J Neural Transm 117(4):513-9. Epub 2010 Feb 27.
2010
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| 17 | AGRP, POMC
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| Hormone and glucose signalling in POMC and AgRP neurons.
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| Belgardt BF, Okamura T, Brüning JC.
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| J Physiol 587(Pt 22):5305-14. Epub 2009 Sep 21. Review.
2009
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| 18 | FOXO1, POMC
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| FoxO1 inhibits leptin regulation of pro-opiomelanocortin promoter activity by blocking STAT3 interaction with specificity protein 1.
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| Yang G, Lim CY, Li C, Xiao X, Radda GK, Li C, Cao X, Han W.
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| J Biol Chem 284(6):3719-27. Epub 2008 Dec 2.
2009
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| 19 | POMC
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| Ablation of estrogen receptor alpha (ERalpha) prevents upregulation of POMC by leptin and insulin.
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| Hirosawa M, Minata M, Harada KH, Hitomi T, Krust A, Koizumi A.
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| Biochem Biophys Res Commun 371(2):320-3. Epub 2008 Apr 24.
2008
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| 20 | POMC
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| Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice.
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| Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK.
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| J Clin Invest 118(5):1796-805.
2008
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| 21 | POMC
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| Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis.
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| Rousseau K, Kauser S, Pritchard LE, Warhurst A, Oliver RL, Slominski A, Wei ET, Thody AJ, Tobin DJ, White A.
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| FASEB J 21(8):1844-56. Epub 2007 Feb 22. 2007
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| 22 | POMC, UCP2
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| Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity.
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| Parton LE, Ye CP, Coppari R, Enriori PJ, Choi B, Zhang CY, Xu C, Vianna CR, Balthasar N, Lee CE, Elmquist JK, Cowley MA, Lowell BB.
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| Nature 449(7159):228-32. Epub 2007 Aug 29. 2007
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| 23 | PENK, POMC
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| The opioid system in alcohol and drug dependence: family-based association study.
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| Xuei X, Flury-Wetherill L, Bierut L, Dick D, Nurnberger J Jr, Foroud T, Edenberg HJ.
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| Am J Med Genet B Neuropsychiatr Genet 144(7):877-84. 2007
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| 24 | POMC
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| A role for beta-melanocyte-stimulating hormone in human body-weight regulation.
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| Biebermann H, Castaneda TR, van Landeghem F, von Deimling A, Escher F, Brabant G, Hebebrand J, Hinney A, Tschop MH, Gruters A, Krude H.
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| Cell Metab 3(2):141-6. 2006
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| 25 | POMC
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| Proopiomelanocortin gene variants are associated with serum leptin and body fat in a normal female population.
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| Chen Y, Snieder H, Wang X, Kaviya B, McCaffrey C, Spector TD, Carter ND, O'Dell SD.
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| Eur J Hum Genet 13(6):772-80. 2005
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| 26 | POMC, OARH
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| Obesity due to proopiomelanocortin deficiency: three new cases and treatment trials with thyroid hormone and ACTH4-10.
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| Krude H, Biebermann H, Schnabel D, Tansek MZ, Theunissen P, Mullis PE, Gruters A.
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| J Clin Endocrinol Metab 88(10):4633-40. 2003
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| 27 | POMC
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| A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism.
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| Challis BG, Pritchard LE, Creemers JW, Delplanque J, Keogh JM, Luan J, Wareham NJ, Yeo GS, Bhattacharyya S, Froguel P, White A, Farooqi IS, O'Rahilly S.
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| Hum Mol Genet 11(17):1997-2004. 2002
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| 28 | POMC, OARH
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| Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans.
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| Krude H, et al.
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| Nat Genet 19 : 155-157. 1998
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| 29 | POMC
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| Systematic mutation screening of the pro-opiomelanocortin gene : identification of several genetic variants including three different insertions, one nonsense and two missense point mutations in probands of different weight extremes.
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| Hinney A, et al.
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| J Clin Endocrinol Metab 83 : 3737-3741. 1998
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| 30 | AGRP, CLU, CPE, MC4R, NPY5R, NPY6R, PCSK1, POMC, DIDAN, TUB, UCP2
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| Microsatellite marker content mapping of 12 candidate genes for obesity: assembly of seven obesity screening panels for automated genotyping.
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| Winick JD, Friedman JM.
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| Genome Res 8(9):985-94. 1998
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| 31 | POMC
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| Subregional assignment of the proopiomelanocortin gene (POMC) to human chromosome band 2p23.3 by fluorescence in situ hybridization.
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| Satoh H, Mori S.
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| Cytogenet Cell Genet 76(3-4):221-2. 1997
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| 32 | POMC
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| Cryptic trinucleotide repeat polymorphism in the POMC gene.
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| Morris JC, et al.
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| Hum Mol Genet 3 : 2080. 1994
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| 33 | POMC, TBP
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| Cryptic repeating triplets of purines and pyrimidines (cRRY(i)) are frequent and polymorphic : analysis of coding cRRY(i) in the proopiomelanocortin (POMC) and TATA-binding protein (GTF2D) genes.
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| Gostout B, et al.
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| Am J Hum Genet 52 : 1182-1190. 1993
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| 34 | POMC, SST
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| High-resolution chromosomal localization of human genes for amylase,proopiomelanocortin, somatostatin, and a DNA fragment (D3S1) by in situhybridization.
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| Zabel BU, et al.
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| Proc Natl Acad Sci U S A 80 : 6932-6936. 1983
|