1 | ABL1, HIPK2, PML
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| The Tyrosine Kinase c-Abl Promotes Homeodomain-interacting Protein Kinase 2 (HIPK2) Accumulation and Activation in Response to DNA Damage.
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| Reuven N, Adler J, Porat Z, Polonio-Vallon T, Hofmann TG, Shaul Y.
|
| J Biol Chem 290(27):16478-88. doi: 10.1074/jbc.M114.628982. Epub 2015 May 5.
2015
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2 | NACC1, PML
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| Nucleus accumbens associated 1 is recruited within the promyelocytic leukemia nuclear body through SUMO modification.
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| Tatemichi Y, Shibazaki M, Yasuhira S, Kasai S, Tada H, Oikawa H, Suzuki Y, Takikawa Y, Masuda T, Maesawa C.
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| Cancer Sci 106(7):848-56. doi: 10.1111/cas.12680.
2015
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3 | KAT6A, PML, TP53
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| MOZ increases p53 acetylation and premature senescence through its complex formation with PML.
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| Rokudai S, Laptenko O, Arnal SM, Taya Y, Kitabayashi I, Prives C.
|
| Proc Natl Acad Sci U S A 110(10):3895-900. doi: 10.1073/pnas.1300490110. Epub 2013 Feb 19.
2013
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4 | PML
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| PML promotes MHC class II gene expression by stabilizing the class II transactivator.
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| Ulbricht T, Alzrigat M, Horch A, Reuter N, von Mikecz A, Steimle V, Schmitt E, Krämer OH, Stamminger T, Hemmerich P.
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| J Cell Biol 199(1):49-63. doi: 10.1083/jcb.201112015. Epub 2012 Sep 24.
2012
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5 | PML, UHRF1
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| The epigenetic regulator UHRF1 promotes ubiquitination-mediated degradation of the tumor-suppressor protein promyelocytic leukemia protein.
|
| Guan D, Factor D, Liu Y, Wang Z, Kao HY.
|
| Oncogene ncogene. 2012 Sep 3. doi: 10.1038/onc.2012.406. [Epub ahead of print]
2012
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6 | PML
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| A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance.
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| Ito K, Carracedo A, Weiss D, Arai F, Ala U, Avigan DE, Schafer ZT, Evans RM, Suda T, Lee CH, Pandolfi PP.
|
| Nat Med 18(9):1350-8.
2012
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7 | ITGB1, PML
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| Promyelocytic leukemia protein (PML) regulates endothelial cell network formation and migration in response to tumor necrosis factor α (TNFα) and interferon α (IFNα).
|
| Cheng X, Liu Y, Chu H, Kao HY.
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| J Biol Chem 287(28):23356-67. doi: 10.1074/jbc.M112.340505. Epub 2012 May 15.
2012
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8 | PML
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| The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA.
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| Rabellino A, Carter B, Konstantinidou G, Wu SY, Rimessi A, Byers LA, Heymach JV, Girard L, Chiang CM, Teruya-Feldstein J, Scaglioni PP.
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| Cancer Res 72(9):2275-84. doi: 10.1158/0008-5472.CAN-11-3159. Epub 2012 Mar 9.
2012
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9 | PER2, PML
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| PML regulates PER2 nuclear localization and circadian function.
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| Miki T, Xu Z, Chen-Goodspeed M, Liu M, Van Oort-Jansen A, Rea MA, Zhao Z, Lee CC, Chang KS.
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| EMBO J 31(6):1427-39. doi: 10.1038/emboj.2012.1. Epub 2012 Jan 24.
2012
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10 | PML
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| Role of the promyelocytic leukaemia protein in cell death regulation.
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| Salomoni P, Dvorkina M, Michod D.
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| Cell Death Dis 3:e247. doi: 10.1038/cddis.2011.122. Review.
2012
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11 | PML, TBX2
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| Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence.
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| Martin N, Benhamed M, Nacerddine K, Demarque MD, van Lohuizen M, Dejean A, Bischof O.
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| EMBO J 31(1):95-109. doi: 10.1038/emboj.2011.370. Epub 2011 Oct 14.
2012
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12 | CIITA, PML
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| PML promotes MHC class II gene expression by stabilizing the class II transactivator.
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| Ulbricht T, Alzrigat M, Horch A, Reuter N, von Mikecz A, Steimle V, Schmitt E, Krämer OH, Stamminger T, Hemmerich P.
|
| J Cell Biol 199(1):49-63. doi: 10.1083/jcb.201112015. Epub 2012 Sep 24.
2012
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13 | GNL3, PML, TERF1
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| Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1.
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| Hsu JK, Lin T, Tsai RY.
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| J Cell Biol 197(5):613-24. doi: 10.1083/jcb.201109038.
2012
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14 | AXIN1, PML, TP53
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| AXIN is an essential co-activator for the promyelocytic leukemia protein in p53 activation.
|
| Li Q, He Y, Wei L, Wu X, Wu D, Lin S, Wang Z, Ye Z, Lin SC.
|
| Oncogene 30(10):1194-204. Epub 2010 Nov 8.
2011
|
15 | NUP205, PML, RIN3, TM7SF4
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| Genome-wide association identifies three new susceptibility loci for Paget's disease of bone.
|
| Albagha OM, Wani SE, Visconti MR, Alonso N, Goodman K, Brandi ML, Cundy T, Chung PY, Dargie R, Devogelaer JP, Falchetti A, Fraser WD, Gennari L, Gianfrancesco F, Hooper MJ, Van Hul W, Isaia G, Nicholson GC, Nuti R, Papapoulos S, Montes Jdel P, Ratajczak T, Rea SL, Rendina D, Gonzalez-Sarmiento R, Di Stefano M, Ward LC, Walsh JP, Ralston SH; Genetic Determinants of Paget's Disease (GDPD) Consortium.
|
| Nat Genet 43(7):685-9. doi: 10.1038/ng.845.
2011
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16 | PML
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| PML positively regulates interferon gamma signaling.
|
| El Bougrini J, Dianoux L, Chelbi-Alix MK.
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| Biochimie 93(3):389-98. doi: 10.1016/j.biochi.2010.11.005. Epub 2010 Nov 27.
2011
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17 | PML
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| PML is a key component for the differentiation of myeloid progenitor cells to macrophages.
|
| Khalfin-Rabinovich Y, Weinstein A, Levi BZ.
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| Int Immunol 23(4):287-96. doi: 10.1093/intimm/dxr004. Epub 2011 Mar 22.
2011
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18 | CFLAR, PML, RARA
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| PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo.
|
| Tao RH, Berkova Z, Wise JF, Rezaeian AH, Daniluk U, Ao X, Hawke DH, Karp JE, Lin HK, Molldrem JJ, Samaniego F.
|
| Blood 118(11):3107-18. doi: 10.1182/blood-2011-04-349670. Epub 2011 Jul 29.
2011
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19 | PML
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| PML regulates apoptosis at endoplasmic reticulum by modulating calcium release.
|
| Giorgi C, Ito K, Lin HK, Santangelo C, Wieckowski MR, Lebiedzinska M, Bononi A, Bonora M, Duszynski J, Bernardi R, Rizzuto R, Tacchetti C, Pinton P, Pandolfi PP.
|
| Science 330(6008):1247-51. Epub 2010 Oct 28.
2010
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20 | HIPK2, PML
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| PML tumor suppressor is regulated by HIPK2-mediated phosphorylation in response to DNA damage.
|
| Gresko E, Ritterhoff S, Sevilla-Perez J, Roscic A, Fröbius K, Kotevic I, Vichalkovski A, Hess D, Hemmings BA, Schmitz ML.
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| Oncogene 28(5):698-708. Epub 2008 Nov 17. 2009
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21 | PML, UBE3A
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| E6AP promotes the degradation of the PML tumor suppressor.
|
| Louria-Hayon I, Alsheich-Bartok O, Levav-Cohen Y, Silberman I, Berger M, Grossman T, Matentzoglu K, Jiang YH, Muller S, Scheffner M, Haupt S, Haupt Y.
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| Cell Death Differ 16(8):1156-66. Epub 2009 Mar 27.
2009
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22 | PML
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| The tumor suppressor Pml regulates cell fate in the developing neocortex.
|
| Regad T, Bellodi C, Nicotera P, Salomoni P.
|
| Nat Neurosci. 12(2):132-40 2009
|
23 | PML, RARA
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| PML-RARalpha initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors.
|
| Wojiski S, Guibal FC, Kindler T, Lee BH, Jesneck JL, Fabian A, Tenen DG, Gilliland DG.
|
| Leukemia 23(8):1462-71. Epub 2009 Mar 26.PMID: 19322209 2009
|
24 | FMF, MEFV, MID1, MID2, PML, TRIM10, TRIM11, TRIM13, TRIM15, TRIM17, TRIM2, TRIM21, TRIM22, TRIM23, TRIM24, TRIM25, TRIM26, TRIM27, TRIM28, TRIM3, TRIM31, TRIM32, TRIM33, TRIM34, TRIM35, TRIM36, TRIM37, TRIM38, TRIM39, TRIM4, TRIM40, TRIM41, TRIM42, TRIM43, TRIM45, TRIM46, TRIM47, TRIM48, TRIM49, TRIM5, TRIM50, TRIM52, TRIM53, TRIM54, TRIM55, TRIM56, TRIM58, TRIM59, TRIM6, TRIM60, TRIM61, TRIM62, TRIM63, TRIM64, TRIM65, TRIM67, TRIM68, TRIM69, TRIM7, TRIM71, TRIM72, TRIM73, TRIM74, TRIM75, TRIM8, TRIM9, TRIML1
|
| TRIM family proteins and their emerging roles in innate immunity.
|
| Ozato K, Shin DM, Chang TH, Morse HC 3rd.
|
| Nat Rev Immunol 8(11):849-60. Review. 2008
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25 | EP300, HIPK2, PML
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| PML activates transcription by protecting HIPK2 and p300 from SCFFbx3-mediated degradation.
|
| Shima Y, Shima T, Chiba T, Irimura T, Pandolfi PP, Kitabayashi I.
|
| Mol Cell Biol 28(23):7126-38. Epub 2008 Sep 22.
2008
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26 | HDAC7, PML
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| Histone deacetylase 7 promotes PML sumoylation and is essential for PML nuclear body formation.
|
| Gao C, Ho CC, Reineke E, Lam M, Cheng X, Stanya KJ, Liu Y, Chakraborty S, Shih HM, Kao HY.
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| Mol Cell Biol 28(18):5658-67. Epub 2008 Jul 14. 2008
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27 | JAK2, MPD, PML, PRV
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| Essential thrombocythemia, polycythemia vera, and myelofibrosis: current management and the prospect of targeted therapy.
|
| Tefferi A.
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| Am J Hematol 83(6):491-7. Review. 2008
|
28 | PML, RARA
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| Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation.
|
| Nasr R, Guillemin MC, Ferhi O, Soilihi H, Peres L, Berthier C, Rousselot P, Robledo-Sarmiento M, Lallemand-Breitenbach V, Gourmel B, Vitoux D, Pandolfi PP, Rochette-Egly C, Zhu J, de Thé H.
|
| Nat Med 14(12):1333-42. Epub 2008 Nov 23. Erratum in: Nat Med. 2009 Jan;15(1):117. PMID: 19029980 2008
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29 | CSNK1A1, PML
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| PML enhances the regulation of p53 by CK1 in response to DNA damage.
|
| Alsheich-Bartok O, Haupt S, Alkalay-Snir I, Saito S, Appella E, Haupt Y.
|
| Oncogene 27(26):3653-61. Epub 2008 Feb 4.
2008
|
30 | PML, SATB1
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| Functional interaction between PML and SATB1 regulates chromatin-loop architecture and transcription of the MHC class I locus.
|
| Kumar PP, Bischof O, Purbey PK, Notani D, Urlaub H, Dejean A, Galande S.
|
| Nat Cell Biol 9(1):45-56. Epub 2006 Dec 17. 2007
|
31 | ETV6, FOXP1, PAX5, PML, ZNF521
|
| Identification of PML as novel PAX5 fusion partner in childhood acute lymphoblastic leukaemia.
|
| Nebral K, König M, Harder L, Siebert R, Haas OA, Strehl S.
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| Br J Haematol 139(2):269-74. 2007
|
32 | PML, RARA
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| Identification of PML-RARA rearrangement by RT-PCR and sequencing in an acute promyelocytic leukemia without t(15;17) on G-banding and FISH.
|
| Han JY, Kim KE, Kim KH, Park JI, Kim JS.
|
| Leuk Res 31(2):239-43. Epub 2006 Jun 21.PMID: 16797070 2007
|
33 | PML, CSNK2A1
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| A CK2-dependent mechanism for degradation of the PML tumor suppressor.
|
| Scaglioni PP, Yung TM, Cai LF, Erdjument-Bromage H, Kaufman AJ, Singh B, Teruya-Feldstein J, Tempst P, Pandolfi PP.
|
| Cell 126(2):269-83. 2006
|
34 | HIF1A, MTOR, PML
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| PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR.
|
| Bernardi R, Guernah I, Jin D, Grisendi S, Alimonti A, Teruya-Feldstein J, Cordon-Cardo C, Simon MC, Rafii S, Pandolfi PP.
|
| Nature 442(7104):779-85. 2006
|
35 | PML, RARA
|
| PML-RARalpha fusion gene transcripts and biological features in acute promyelocytic leukemia patients.
|
| Melo RA, de Vasconcellos JF, Melo FC, Machado CG, Lacerda TM, Souto FR.
|
| Clin Lab Haematol 28(2):126-9.PMID: 16630218 2006
|
36 | PML
|
| A role for PML3 in centrosome duplication and genome stability.
|
| Xu ZX, Zou WX, Lin P, Chang KS.
|
| Mol Cell. 17(5):721-32 2005
|
37 | PML
|
| PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts.
|
| Cairo S, De Falco F, Pizzo M, Salomoni P, Pandolfi PP, Meroni G.
|
| Oncogene 24(13):2195-203 2005
|
38 | PML
|
| Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein.
|
| Takahashi H, Hatakeyama S, Saitoh H, Nakayama KI.
|
| J Biol Chem. 280(7):5611-21 2005
|
39 | PML
|
| Mutations of the PML tumor suppressor gene in acute promyelocytic leukemia.
|
| Gurrieri C, Nafa K, Merghoub T, Bernardi R, Capodieci P, Biondi A, Nimer S, Douer D, Cordon-Cardo C, Gallagher R, Pandolfi PP.
|
| Blood 103(6):2358-62. Epub 2003 Nov 20. 2004
|
40 | MAPK11, PML
|
| Promyelocytic leukemia is a direct inhibitor of SAPK2/p38 mitogen-activated protein kinase.
|
| Shin J, Park B, Cho S, Lee S, Kim Y, Lee SO, Cho K, Lee S, Jin BS, Ahn JH, Choi EJ, Ahn K.
|
| J Biol Chem 279(39):40994-1003. Epub 2004 Jul 23. 2004
|
41 | MDM2, PML
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| PML regulates p53 stability by sequestering Mdm2 to the nucleolus.
|
| Bernardi R, Scaglioni PP, Bergmann S, Horn HF, Vousden KH, Pandolfi PP.
|
| Nat Cell Biol. 6(7):665-72 2004
|
42 | PML
|
| Cytoplasmic PML function in TGF-beta signalling.
|
| Lin HK, Bergmann S, Pandolfi PP.
|
| Nature 431(7005):205-11 2004
|
43 | PML
|
| PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein.
|
| Daniels MJ, Marson A, Venkitaraman AR.
|
| Nat Struct Mol Biol. 11(11):1114-21 2004
|
44 | PML
|
| c-Myb associates with PML in nuclear bodies in hematopoietic cells.
|
| Dahle Ø, Bakke O, Gabrielsen OS.
|
| Exp Cell Res. 297(1):118-26 2004
|
45 | PML
|
| The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle.
|
| Kojic S, Medeot E, Guccione E, Krmac H, Zara I, Martinelli V, Valle G, Faulkner G.
|
| J Mol Biol. 339(2):313-25 2004
|
46 | PAWR, PML, THAP1
|
| THAP1 is a nuclear proapoptotic factor that links prostate-apoptosis-response-4 (Par-4) to PML nuclear bodies.
|
| Roussigne M, Cayrol C, Clouaire T, Amalric F, Girard JP.
|
| Oncogene 22(16):2432-42. 2003
|
47 | PML, TRIM69
|
| Forced expression of RNF36 induces cell apoptosis.
|
| Shyu HW, Hsu SH, Hsieh-Li HM, Li H.
|
| Exp Cell Res 287(2):301-13. 2003
|
48 | PML
|
| Recruitment of human cyclin T1 to nuclear bodies through direct interaction with the PML protein.
|
| Marcello A, Ferrari A, Pellegrini V, Pegoraro G, Lusic M, Beltram F, Giacca M.
|
| EMBO J. 22(9):2156-66 2003
|
49 | PML
|
| Physical and functional interactions between PML and MDM2
|
| Wei X, Yu ZK, Ramalingam A, Grossman SR, Yu JH, Bloch DB, Maki CG.
|
| J Biol Chem. 278(31):29288-97 2003
|
50 | PML
|
| Promyelocytic leukemia protein sensitizes tumor necrosis factor alpha-induced apoptosis by inhibiting the NF-kappaB survival pathway.
|
| Wu WS, Xu ZX, Hittelman WN, Salomoni P, Pandolfi PP, Chang KS.
|
| J Biol Chem. 278(14):12294-304 2003
|
51 | PML
|
| PML-nuclear bodies are involved in cellular serum response.
|
| Matsuzaki K, Minami T, Tojo M, Honda Y, Saitoh N, Nagahiro S, Saya H, Nakao M.
|
| Genes Cells. 8(3):275-86 2003
|
52 | PML
|
| Opposing effects of PML and PML/RAR alpha on STAT3 activity.
|
| Kawasaki A, Matsumura I, Kataoka Y, Takigawa E, Nakajima K, Kanakura Y.
|
| Blood 101(9):3668-73 2003
|
53 | PML
|
| PML colocalizes with and stabilizes the DNA damage response protein TopBP1.
|
| Xu ZX, Timanova-Atanasova A, Zhao RX, Chang KS.
|
| Mol Cell Biol. 23(12):4247-56 2003
|
54 | PML
|
| PML-RARA-targeted DNA vaccine induces protective immunity in a mouse model of leukemia.
|
| Padua RA, Larghero J, Robin M, le Pogam C, Schlageter MH, Muszlak S, Fric J, West R, Rousselot P, Phan TH, Mudde L, Teisserenc H, Carpentier AF, Kogan S, Degos L, Pla M, Bishop JM, Stevenson F, Charron D, Chomienne C.
|
| Nat Med. 9(11):1413-7 2003
|
55 | PML
|
| The role of PML in tumor suppression.
|
| Salomoni P, Pandolfi PP.
|
| Cell 108(2):165-70. Review. 2002
|
56 | NR4A1, PML
|
| Promyelocytic leukemia protein PML inhibits Nur77-mediated transcription through specific functional interactions.
|
| Wu WS, Xu ZX, Ran R, Meng F, Chang KS.
|
| Oncogene 21(24):3925-33. 2002
|
57 | PML
|
| PML mediates the interferon-induced antiviral state against a complex retrovirus via its association with the viral transactivator.
|
| Regad T, Saib A, Lallemand-Breitenbach V, Pandolfi PP, de The H, Chelbi-Alix MK.
|
| EMBO J 20(13):3495-505. 2001
|
58 | PML
|
| PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA.
|
| Cohen N, Sharma M, Kentsis A, Perez JM, Strudwick S, Borden KL.
|
| EMBO J. 20(16):4547-59 2001
|
59 | HDAC1, HDAC2, PML
|
| The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases.
|
| Wu WS, Vallian S, Seto E, Yang WM, Edmondson D, Roth S, Chang KS.
|
| Mol Cell Biol. 21(7):2259-68 2001
|
60 | PML, SKI
|
| Role of PML and PML-RARalpha in Mad-mediated transcriptional repression.
|
| Khan MM, Nomura T, Kim H, Kaul SC, Wadhwa R, Shinagawa T, Ichikawa-Iwata E, Zhong S, Pandolfi PP, Ishii S.
|
| Mol Cell. 7(6):1233-43 2001
|
61 | PML
|
| The function of PML in p53-dependent apoptosis.
|
| Guo A, Salomoni P, Luo J, Shih A, Zhong S, Gu W, Pandolfi PP.
|
| Nat Cell Biol. 2(10):730-6 2000
|
62 | PML
|
| Two new 3' PML breakpoints in t(15;17)(q22;q21)-positive acute promyelocytic leukemia.
|
| Chillon MC, Gonzalez M, Garcia-Sanz R, Balanzategui A, Gonzalez D, Lopez-Perez R, Mateos MV, Alaejos I, Rayon C, Arbeteta J, Hernandez JM, Orfao A, San Miguel J.
|
| Genes Chromosomes Cancer 27(1):35-43 2000
|
63 | LOXL1, PML, STOML1
|
| Physical linkage of the lysyl oxidase-like (LOXL1) gene to the PML gene on human chromosome 15q22.
|
| Goy A, Gilles F, Remache Y, Zelenetz AD.
|
| Cytogenet Cell Genet 88(1-2):22-4. 2000
|
64 | GOLGA6, GOLGA2, GOLGA3, GOLGA4, GOLGB1, PML
|
| Cloning and characterization of a Golgin-related gene from the large-scale polymorphism linked to the PML gene.
|
| Gilles F, Goy A, Remache Y, Manova K, Zelenetz AD.
|
| Genomics 70(3):364-74. 2000
|
65 | PML
|
| Sequestration and inhibition of Daxx-mediated transcriptional repression by PML.
|
| Li H, Leo C, Zhu J, Wu X, O'Neil J, Park EJ, Chen JD.
|
| Mol Cell Biol. 20(5):1784-96 2000
|
66 | PML
|
| Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein (PML) and the t(15;17)-generated PML-retinoic acid receptor alpha oncoprotein.
|
| Tsuzuki S, Towatari M, Saito H, Enver T.
|
| Mol Cell Biol. 20(17):6276-86 2000
|
67 | PML
|
| PML regulates p53 acetylation and premature senescence induced by oncogenic Ras.
|
| Pearson, M.; Carbone, R.; Sebastiani, C.; Cioce, M.; Fagioli, M.; Saito, S.; Higashimoto, Y.; Appella, E.; Minucci, S.; Pandolfi, P. P.; Pelicci, P. G.
|
| Nature 406: 207-210 2000
|
68 | CREBBP, PML
|
| Modulation of CREB binding protein function by the promyelocytic (PML) oncoprotein suggests a role for nuclear bodies in hormone signaling.
|
| Doucas V, et al.
|
| Proc Natl Acad Sci U S A 96(6):2627-2632. 1999
|
69 | ANXA2, PML
|
| Annexin II and bleeding in acute promyelocytic leukemia.
|
| Menell JS, et al.
|
| N Engl J Med 340(13):994-1004. 1999
|
70 | PML
|
| Expression and role of PML gene in normal adult hematopoiesis: functional interaction between PML and Rb proteins in erythropoiesis.
|
| Labbaye C, et al.
|
| Oncogene 18(23):3529-40. 1999
|
71 | DAXX, PML
|
| Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs).
|
| Torii S, et al.
|
| EMBO J 18(21):6037-6049 1999
|
72 | ALK, PML, RARA
|
| Identification of novel chromosomal rearrangements in acute myelogenous leukemia involving loci on chromosome 2p23, 15q22 and 17q21.
|
| Melnick A, Fruchtman S, Zelent A, Liu M, Huang Q, Boczkowska B, Calasanz M, Fernandez A, Licht JD, Najfeld V.
|
| Leukemia 13(10):1534-8. 1999
|
73 | BRAF, TRIM24, PML
|
| A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins.
|
| Zhong S, Delva L, Rachez C, Cenciarelli C, Gandini D, Zhang H, Kalantry S, Freedman LP, Pandolfi PP.
|
| Nat Genet 23(3):287-95. 1999
|
74 | PML
|
| The promyelocytic leukemia protein PML interacts with the proline-rich homeodomain protein PRH: a RING may link hematopoiesis and growth control.
|
| Topcu Z, Mack DL, Hromas RA, Borden KL.
|
| Oncogene. 18(50):7091-100 1999
|
75 | PML, RARA, ZBTB16
|
| Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.
|
| He LZ, Guidez F, Tribioli C, Peruzzi D, Ruthardt M, Zelent A, Pandolfi PP.
|
| Nat Genet 18(2):126-35. 1998
|
76 | PML, RARA, ZBTB16
|
| Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia.
|
| Grignani F, De Matteis S, Nervi C, Tomassoni L, Gelmetti V, Cioce M, Fanelli M, Ruthardt M, Ferrara FF, Zamir I, Seiser C, Grignani F, Lazar MA, Minucci S, Pelicci PG.
|
| Nature 391(6669):815-8. 1998
|
77 | HDAC1, HDAC2, PML, RARA, ZBTB16
|
| Role of the histone deacetylase complex in acute promyelocytic leukaemia.
|
| Lin RJ, et al.
|
| Nature 391 : 811-814. 1998
|
78 | PML
|
| PML induces a novel caspase-independent death process.
|
| Quignon F, et al.
|
| Nat Genet 20 : 259-265. 1998
|
79 | PML
|
| Pml is essential for multiple apoptotic pathways.
|
| Wang ZG, et al.
|
| Nat Genet 20 : 266-272. 1998
|
80 | PML
|
| Proto-oncogene PML controls genes devoted to MHC class I antigen presentation.
|
| Zheng P, et al.
|
| Nature 396 : 373-376. 1998
|
81 | CREBBP, PML
|
| Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body.
|
| LaMorte VJ, et al.
|
| Proc Natl Acad Sci U S A 95(9):4991-6. 1998
|
82 | PML, SP100
|
| Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment.
|
| Seeler JS, et al.
|
| Proc Natl Acad Sci U S A 95(13):7316-21. 1998
|
83 | PML, SUMO1
|
| Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus.
|
| Muller S, et al.
|
| EMBO J 17(1):61-70. 1998
|
84 | PML
|
| Modulation of Fos-mediated AP-1 transcription by the promyelocytic leukemia protein.
|
| Vallian S, Gäken JA, Gingold EB, Kouzarides T, Chang KS, Farzaneh F.
|
| Oncogene 16(22):2843-53 1998
|
85 | PML, RBP1
|
| The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein.
|
| Alcalay M, Tomassoni L, Colombo E, Stoldt S, Grignani F, Fagioli M, Szekely L, Helin K, Pelicci PG.
|
| Mol Cell Biol. 18(2):1084-93 1998
|
86 | PML
|
| The promyelocytic leukemia protein interacts with Sp1 and inhibits its transactivation of the epidermal growth factor receptor promoter.
|
| Vallian S, Chin KV, Chang KS.
|
| Mol Cell Biol. 18(12):7147-56 1998
|
87 | PML
|
| Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML.
|
| Cao T, Duprez E, Borden KL, Freemont PS, Etkin LD.
|
| J Cell Sci. 111 ( Pt 10):1319-29 1998
|
88 | PML, RARA
|
| A retinoid-resistant acute promyelocytic leukemia subclone expresses a dominant negative PML-RARalpha mutation.
|
| Shao W, Benedetti L, Lamph WW, Nervi C, Miller WH Jr.
|
| Blood 89(12):4282-9. 1997
|
89 | PML, SUMO1
|
| Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1.
|
| Sternsdorf T, et al.
|
| J Cell Biol 139(7):1621-34. 1997
|
90 | PML
|
| Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies.
|
| Koken MH, Reid A, Quignon F, Chelbi-Alix MK, Davies JM, Kabarowski JH, Zhu J, Dong S, Chen S, Chen Z, Tan CC, Licht J, Waxman S, de Thé H, Zelent A.
|
| Proc Natl Acad Sci U S A. 94(19):10255-60 1997
|
91 | PML
|
| A PMLRARalpha transgene initiates murine acute promyelocytic leukemia.
|
| Brown D, Kogan S, Lagasse E, Weissman I, Alcalay M, Pelicci PG, Atwater S, Bishop JM.
|
| Proc Natl Acad Sci U S A. 94(6):2551-6 1997
|
92 | PML, SUMO1
|
| PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia.
|
| Boddy MN, Howe K, Etkin LD, Solomon E, Freemont PS
|
| Oncogene. 13(5):971-82 1996
|
93 | PML
|
| Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element.
|
| Stadler M, et al.
|
| Oncogene 11 : 2565-2573. 1995
|
94 | GOLGA6, PML
|
| The PML gene is linked to a megabase-scale insertion/deletion restriction fragment length polymorphism.
|
| Goy A, et al.
|
| Genomics 26 : 327-333. 1995
|
95 | PML, RARA
|
| Analysis of the joining sequences of the t(15;17) translocation in human acute promyelocytic leukemia : sequence non-specific recombination between the PML and RARA genes within identical short stretches.
|
| Yoshida H, et al.
|
| Genes Chromosomes Cancer 12 : 37-44. 1995
|
96 | PML, RARA
|
| Molecular analysis of simple variant translocations in acute promyelocytic leukemia.
|
| Borrow J, et al.
|
| Genes Chromosomes Cancer 9 : 234-243. 1994
|
97 | PML
|
| Breakpoint clusters of the PML gene in acute promyelocytic leukemia : primary structure of the reciprocal products of the PML-RARA gene in a patient with t(15;17).
|
| Dong S, et al.
|
| Genes Chromosomes Cancer 6 : 133-139. 1993
|
98 | PML, RARA
|
| The PML-retinoic acid receptor alpha translocation converts the receptor from an inhibitor to a retinoic acid-dependent activator of transcription factor AP-1.
|
| Doucas V, et al.
|
| Proc Natl Acad Sci U S A 90 : 9345-9349. 1993
|
99 | HYKPP, PML, SCN4A
|
| Molecular genetic and genetic correlations in sodium channelopathies : lack of founder effect and evidence for a second gene.
|
| Wang J, et al.
|
| Am J Hum Genet 52 : 1074-1084. 1993
|
100 | PML, RARA
|
| Delineation of translocation t(15;17) in acute promyelocytic leukemia by chromosomal in situ suppression hybridization.
|
| Speicher MR, et al.
|
| Leuk Res 17 : 359-364. 1993
|
101 | PML
|
| Rearrangements of the RARA and PML genes in a cytogenetic variant of acute promyelocytic leukemia.
|
| Baranger L, et al.
|
| Genes Chromosomes Cancer 6 : 118-120. 1993
|
102 | PML
|
| The t(15;17) breakpoint in acute promyelocytic leukemia cluster within two different sites of the myl gene : targets for the detection of minimal residual disease by the polymerase chain reaction.
|
| Chang KS, et al.
|
| Blood 79 : 554-558. 1992
|
103 | PML
|
| Structure, localization, and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL) : structural similarities with a new family of oncoproteins.
|
| Kastner P, et al.
|
| EMBO J 11 : 629-642. 1992
|
104 | RARA, PML
|
| Characterization of a fusion cDNA (RARA/myl) transcribed from the t(15;17) translocation breakpoint in acute promyelocytic leukemia.
|
| Chang KS, et al.
|
| Mol Cell Biol 12 : 800-810. 1992
|
105 | PML
|
| Molecular rearrangements of the MYL gene in acute promyelocytic leukemia (APL,M3) define a breakpoint cluster region as well as some molecular variants.
|
| Tong JH, et al.
|
| Oncogene 7 : 311-316. 1992
|
106 | PML
|
| Occurence of distinct PML-RAR-alpha fusion gene isoforms in patients with acute promyelocytic leukemia detected by reverse transcriptase/polymerase chain reaction.
|
| Chen SJ, et al.
|
| Oncogene 7 : 1223-1232. 1992
|
107 | PML
|
| A PML/retinoic acid receptor alpha fusion transcript is constantly detected by RNA-based polymerase chain reaction in acute promyelocytic leukemia.
|
| Castaigne S, et al.
|
| Blood 79 : 3110-3115. 1992
|
108 | PML
|
| Identification of DNA rearrangements at the retinoic acid receptor-alpha (RAR-alpha) locus in all patients with acute promyelocytic leukemia (APL) and mapping of APL breakpoints within the RAR-alpha second intron.
|
| Diverio D, et al.
|
| Blood 79 : 3331-3336. 1992
|
109 | PML
|
| Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia.
|
| Pandolfi PP, et al.
|
| EMBO J 11 : 1397-1407. 1992
|
110 | PML, RARA
|
| Expression pattern of the RARalpha-PML fusion gene in acute promyelocytic leukemia.
|
| Alcalay M, et al.
|
| Proc Natl Acad Sci U S A 89 : 4840-4844. 1992
|
111 | PML, RARA
|
| Molecular monitoring of the myl/retinoic acid receptor-alpha fusion gene in acute promyelocytic leukemia by polymerase chain reaction.
|
| Biondi A, et al.
|
| Blood 80 : 492-497. 1992
|
112 | RARA, PML
|
| Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locus.
|
| Alcalay M, et al.
|
| Proc Natl Acad Sci U S A 88 : 1977-1981. 1991
|
113 | PML
|
| Characterization of a zinc finger gene disrupted by the t(15;17) in acute promyelocytic leukemia.
|
| Goddard AD, et al.
|
| Science 254 : 1371-1374. 1991
|
114 | PML
|
| Structure and origin of acute promyelocytic leukemia myl/RARalpha cDNA and characterization of its retinoid-binding and transactivation properties.
|
| Pandolfi PP, et al.
|
| Oncogene 6 : 1285-1292. 1991
|
115 | PML, RARA
|
| The T(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus.
|
| ThŽ H de, et al.
|
| Nature 347 : 558-561. 1990
|
116 | MIC7, PML, RARA
|
| Genetic analysis of the 15;17 chromosome translocation associated with acute promyelocytic leukemia.
|
| Sheer D, et al.
|
| Proc Natl Acad Sci U S A 80 : 5007-5011. 1983
|