1 | NRP1, NRP2, PLXNA1
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| Analysis of PLXNA1, NRP1, and NRP2 variants in a cohort of patients with isolated hypogonadotropic hypogonadism. 2021 PMID:
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| Men M, Chen DN, Li JD, Wang X, Zeng W, Jiang F, Zheng R, Dai W.
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| Mol Genet Genomic Med. Nov;9(11):e1816. doi: 10.1002/mgg3.1816. Epub 2021 Oct 11. 2021
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2 | PLXNA1
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| Neuropathological Findings in a Case of Parkinsonism and Developmental Delay Associated with a Monoallelic Variant in PLXNA1
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| O'Shea SA, Hickman RA, Cortes E, Vonsattel JP, Fahn S, Okur V, Alcalay RN, Chung WK.
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| Mov Disord. Nov;36(11):2681-2687. doi: 10.1002/mds.28756. Epub 2021 Aug 20. 2021
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3 | NRP1, NRP2, PLXNA1, SEMA3A
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| PLXNA1 and PLXNA3 cooperate to pattern the nasal axons that guide gonadotropin-releasing hormone neurons
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| Oleari R, Caramello A, Campinoti S, Lettieri A, Ioannou E, Paganoni A, Fantin A, Cariboni A, Ruhrberg C.
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| Development. Nov 5;146(21):dev176461. doi: 10.1242/dev.176461. 2019
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4 | PLXNA1
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| Prevalence and associated phenotypes of PLXNA1 variants in normosmic and anosmic idiopathic hypogonadotropic hypogonadism
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| Kotan LD, Isik E, Turan I, Mengen E, Akkus G, Tastan M, Gurbuz F, Yuksel B, Topaloglu AK.
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| Clin Genet. Feb;95(2):320-324. doi: 10.1111/cge.13482. Epub 2018 Dec 26. 2019
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5 | PLXNA1
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| PlexinA1 is crucial for the midline crossing of callosal axons during corpus callosum development in BALB/cAJ mice
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| Hossain MM, Tsuzuki T, Sakakibara K, Imaizumi F, Ikegaya A, Inagaki M, Takahashi I, Ito T, Takamatsu H, Kumanogoh A, Negishi T, Yukawa K.
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| PLoS One. Aug 20;14(8):e0221440. doi: 10.1371/journal.pone.0221440. 2019
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6 | PLXNA1, SEMA3A
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| The Sema3A receptor Plexin-A1 suppresses supernumerary axons through Rap1 GTPases. 2018 PMID:
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| Wang N, Dhumale P, Chiang J, Püschel AW.
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| Sci Rep. Oct 23;8(1):15647. doi: 10.1038/s41598-018-34092-5. 2018
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7 | PLXNA1, PLXNA2, PLXNA4
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| Structural Basis for Plexin Activation and Regulation
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| Kong Y, Janssen BJ, Malinauskas T, Vangoor VR, Coles CH, Kaufmann R, Ni T, Gilbert RJ, Padilla-Parra S, Pasterkamp RJ, Jones EY.
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| Neuron. 6 Aug 3;91(3):548-60. doi: 10.1016/j.neuron.2016.06.018. Epub 2016 Jul 7. 2016
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8 | PLXNA1
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| Pediatric Imaging, Neurocognition and Genetics Study. PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure. 2015 PMID:
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| Belyk M, Kraft SJ, Brown S;
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| J Hum Genet. Mar;60(3):147-50. doi: 10.1038/jhg.2014.107. Epub 2014 Dec 18. 2015
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9 | PLXNA1
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| PlexinA1 is a new Slit receptor and mediates axon guidance function of Slit C-terminal fragments
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| Delloye-Bourgeois C, Jacquier A, Charoy C, Reynaud F, Nawabi H, Thoinet K, Kindbeiter K, Yoshida Y, Zagar Y, Kong Y, Jones YE, Falk J, Chédotal A, Castellani V.
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| Nat Neurosci. Jan;18(1):36-45. doi: 10.1038/nn.3893. Epub 2014 Dec 8 2015
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10 | PLXNA1
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| Plexin-A1 is required for Toll-like receptor-mediated microglial activation in the development of lipopolysaccharide-induced encephalopathy.
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| Ito T, Yoshida K, Negishi T, Miyajima M, Takamatsu H, Kikutani H, Kumanogoh A, Yukawa K.
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| Int J Mol Med. May;33(5):1122-30. doi: 10.3892/ijmm.2014.1690. Epub 2014 Mar 7. 2014
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11 | NRP1, PLXNA1
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| Neuropilin-1 biases dendrite polarization in the retina
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| Kita EM, Bertolesi GE, Hehr CL, Johnston J, McFarlane S.
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| Development. Jul;140(14):2933-41. doi: 10.1242/dev.088286. Epub 2013 Jun 5. 2013
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12 | NRP1, PLXNA1, SEMA3A, VAMP2
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| The vesicular SNARE Synaptobrevin is required for Semaphorin 3A axonal repulsion.
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| Zylbersztejn K, Petkovic M, Burgo A, Deck M, Garel S, Marcos S, Bloch-Gallego E, Nothias F, Serini G, Bagnard D, Binz T, Galli T.
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| J Cell Biol 196(1):37-46. doi: 10.1083/jcb.201106113. Epub 2012 Jan 2.
2012
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13 | CHN1, DURS2, PLXNA1, PLXNA2
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| Axon guidance in the developing ocular motor system and Duane retraction syndrome depends on Semaphorin signaling via alpha2-chimaerin.
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| Ferrario JE, Baskaran P, Clark C, Hendry A, Lerner O, Hintze M, Allen J, Chilton JK, Guthrie S.
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| Proc Natl Acad Sci U S A 109(36):14669-74. doi: 10.1073/pnas.1116481109.
2012
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14 | HLX, PLXNA1, SEMA3G, UNC5B
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| The VEGF-regulated transcription factor HLX controls the expression of guidance cues and negatively regulates sprouting of endothelial cells.
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| Testori J, Schweighofer B, Helfrich I, Sturtzel C, Lipnik K, Gesierich S, Nasarre P, Hofer-Warbinek R, Bilban M, Augustin HG, Hofer E.
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| Blood 117(9):2735-44. Epub 2011 Jan 11.
2011
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15 | PLXNA1, PLXNA4
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| Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling.
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| Kigel B, Rabinowicz N, Varshavsky A, Kessler O, Neufeld G.
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| Blood 118(15):4285-96. doi: 10.1182/blood-2011-03-341388. Epub 2011 Aug 10.
2011
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16 | PLXNA1, PTK7
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| PlexinA1 interacts with PTK7 and is required for neural crest migration.
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| Wagner G, Peradziryi H, Wehner P, Borchers A.
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| Biochem Biophys Res Commun 402(2):402-7. Epub 2010 Oct 12. 2010
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17 | PLXNA1
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| Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II.
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| Takamatsu H, Takegahara N, Nakagawa Y, Tomura M, Taniguchi M, Friedel RH, Rayburn H, Tessier-Lavigne M, Yoshida Y, Okuno T, Mizui M, Kang S, Nojima S, Tsujimura T, Nakatsuji Y, Katayama I, Toyofuku T, Kikutani H, Kumanogoh A.
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| Nat Immunol 11(7):594-600. Epub 2010 May 30.
2010
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18 | PLXNA1
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| PlexinA1 expression in gastric carcinoma and its relationship with tumor angiogenesis and proliferation.
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| Zhao XY, Chen L, Li YH, Xu Q.
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| World J Gastroenterol 13(48):6558-61.
2007
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19 | PLXNA1
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| PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.
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| Yoshida Y, Han B, Mendelsohn M, Jessell TM.
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| Neuron 52(5):775-88.
2006
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20 | PLXNA1, TYROBP
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| Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.
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| Takegahara N, Takamatsu H, Toyofuku T, Tsujimura T, Okuno T, Yukawa K, Mizui M, Yamamoto M, Prasad DV, Suzuki K, Ishii M, Terai K, Moriya M, Nakatsuji Y, Sakoda S, Sato S, Akira S, Takeda K, Inui M, Takai T, Ikawa M, Okabe M, Kumanogoh A, Kikutani H.
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| Nat Cell Biol 8(6):615-22. Epub 2006 May 21.
2006
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21 | PLXNA1
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| The activity of the plexin-A1 receptor is regulated by Rac.
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| Turner LJ, Nicholls S, Hall A.
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| J Biol Chem 279(32):33199-205. Epub 2004 Jun 8. 2004
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22 | PLXNA1
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| The activity of the plexin-A1 receptor is regulated by Rac.
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| Turner LJ, Nicholls S, Hall A.
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| J Biol Chem 279(32):33199-205. Epub 2004 Jun 8.
2004
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23 | PLXNA1
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| Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains.
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| Usui H, Taniguchi M, Yokomizo T, Shimizu T.
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| Biochem Biophys Res Commun 300(4):927-31. 2003
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24 | PLXNA1
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| Antagonistic effects of Rnd1 and RhoD GTPases regulate receptor activity in Semaphorin 3A-induced cytoskeletal collapse.
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| Zanata SM, Hovatta I, Rohm B, Puschel AW.
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| J Neurosci 22(2):471-7. 2002
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25 | NRP1, PLXNA1, SEMA3A
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| Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors.
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| Takahashi T, et al.
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| Cell 99(1):59-69 1999
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26 | PLXNA1, PLXNA2, PLXNA3, PLXNA4, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PLXND1
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| Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.
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| Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM.
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| Cell 99(1):71-80. Erratum in: Cell 2001 Jan 26;104(2):following 320. 1999
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27 | PLXNA3, PLXNA1, PLXNA2, PLXNB1
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| A family of transmembrane proteins with homology to the MET-Hepatocyte growth factor receptor.
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| Maestrini E, et al.
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| Proc Natl Acad Sci U S A 93 : 674-678. 1996
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28 | PLXNA1, PLXNA2, PLXNA3, PLXNB1
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| Plexin : a novel neuronal cell surface molecule that mediates cell adhesion via a homophilic binding mechanism in the presence of calcium ions.
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| Ohta K, Mizutani A, Kawakami A, Murakami Y, Kasuya Y, Takagi S, Tanaka H, Fujisawa H.
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| Neuron 14 : 1189-1199. 1995
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29 | PLXNA1, CTGF
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| Physical mapping of human loci homologous to the chicken nov proto-oncogene.
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| Martinerie C, et al.
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| Oncogene 7 : 2529-2534. 1992
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