| 1 | BRKS2, PLOD2
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| Phenotypic Consequences of PLOD2 Mutations in Bruck Syndrome Inform a Collagen Lysyl Hydroxylase Crystal Structure.
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| Guo HF, Kurie J.
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| J Bone Miner Res Bone Miner Res. 2018 Jun 7. doi: 10.1002/jbmr.3459. [Epub ahead of print] No abstract available.
2018
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| 2 | BRKS2, PLOD2
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| Genotype-Phenotype Correlation of PLOD2 Skeletal Dysplasias Using Structural Information.
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| Tham E, Grigelionis G, Hammarsjö A, Grigelioniene G.
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| J Bone Miner Res Bone Miner Res. 2018 Jun 7. doi: 10.1002/jbmr.3460. [Epub ahead of print] No abstract available.
2018
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| 3 | PLOD2
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| PLOD2 as a potential regulator of peritoneal dissemination in gastric cancer.
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| Kiyozumi Y, Iwatsuki M, Kurashige J, Ogata Y, Yamashita K, Koga Y, Toihata T, Hiyoshi Y, Ishimoto T, Baba Y, Miyamoto Y, Yoshida N, Yanagihara K, Mimori K, Baba H.
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| Int J Cancer nt J Cancer. 2018 Mar 30. doi: 10.1002/ijc.31410. [Epub ahead of print]
2018
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| 4 | BRKS2, PLOD2
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| Expanding the Clinical Spectrum of Phenotypes Caused by Pathogenic Variants in PLOD2.
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| Leal GF, Nishimura G, Voss U, Bertola DR, Ĺström E, Svensson J, Yamamoto GL, Hammarsjö A, Horemuzova E, Papadiogannakis N, Iwarsson E, Grigelioniene G, Tham E.
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| J Bone Miner Res 33(4):753-760. doi: 10.1002/jbmr.3348. Epub 2018 Jan 4.
2018
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| 5 | PLOD2
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| Procollagen-lysine 2-oxoglutarate 5-dioxygenase 2 promotes hypoxia-induced glioma migration and invasion.
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| Xu Y, Zhang L, Wei Y, Zhang X, Xu R, Han M, Huang B, Chen A, Li W, Zhang Q, Li G, Wang J, Zhao P, Li X.
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| Oncotarget 8(14):23401-23413. doi: 10.18632/oncotarget.15581.
2017
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| 6 | PLOD2
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| Lysyl Hydroxylase 2 Is Secreted by Tumor Cells and Can Modify Collagen in the Extracellular Space.
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| Chen Y, Guo H, Terajima M, Banerjee P, Liu X, Yu J, Momin AA, Katayama H, Hanash SM, Burns AR, Fields GB, Yamauchi M, Kurie JM.
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| J Biol Chem 291(50):25799-25808. Epub 2016 Nov 1.
2016
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| 7 | FKBP10, PLOD1, PLOD2, PLOD3
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| Disentangling mechanisms involved in collagen pyridinoline cross-linking: The immunophilin FKBP65 is critical for dimerization of lysyl hydroxylase 2.
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| Gjaltema RA, van der Stoel MM, Boersema M, Bank RA.
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| Proc Natl Acad Sci U S A 113(26):7142-7. doi: 10.1073/pnas.1600074113. Epub 2016 Jun 13.
2016
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| 8 | PLOD2
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| Procollagen Lysyl Hydroxylase 2 Expression Is Regulated by an Alternative Downstream Transforming Growth Factor β-1 Activation Mechanism.
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| Gjaltema RA, de Rond S, Rots MG, Bank RA.
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| J Biol Chem 290(47):28465-76. doi: 10.1074/jbc.M114.634311. Epub 2015 Oct 2.
2015
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| 9 | BRKS1, FKBP10, PLOD2, SERPINH1
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| Mutations in FKBP10, which result in Bruck syndrome and recessive forms of osteogenesis imperfecta, inhibit the hydroxylation of telopeptide lysines in bone collagen.
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| Schwarze U, Cundy T, Pyott SM, Christiansen HE, Hegde MR, Bank RA, Pals G, Ankala A, Conneely K, Seaver L, Yandow SM, Raney E, Babovic-Vuksanovic D, Stoler J, Ben-Neriah Z, Segel R, Lieberman S, Siderius L, Al-Aqeel A, Hannibal M, Hudgins L, McPherson E, Clemens M, Sussman MD, Steiner RD, Mahan J, Smith R, Anyane-Yeboa K, Wynn J, Chong K, Uster T, Aftimos S, Sutton VR, Davis EC, Kim LS, Weis MA, Eyre D, Byers PH.
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| Hum Mol Genet 22(1):1-17. doi: 10.1093/hmg/dds371. Epub 2012 Sep 4. 2013
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| 10 | HIF1A, P4HA1, P4HA2, PLOD2
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| Hypoxia-inducible factor 1 (HIF-1) promotes extracellular matrix remodeling under hypoxic conditions by inducing P4HA1, P4HA2, and PLOD2 expression in fibroblasts.
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| Gilkes DM, Bajpai S, Chaturvedi P, Wirtz D, Semenza GL.
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| J Biol Chem 288(15):10819-29. doi: 10.1074/jbc.M112.442939.
2013
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| 11 | BRKS2, PLOD2
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| Mutations in PLOD2 cause autosomal-recessive connective tissue disorders within the Bruck syndrome--osteogenesis imperfecta phenotypic spectrum.
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| Puig-Hervás MT, Temtamy S, Aglan M, Valencia M, Martínez-Glez V, Ballesta-Martínez MJ, López-González V, Ashour AM, Amr K, Pulido V, Guillén-Navarro E, Lapunzina P, Caparrós-Martín JA, Ruiz-Perez VL.
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| Hum Mutat 33(10):1444-9. doi: 10.1002/humu.22133. Epub 2012 Jul 5.
2012
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| 12 | PLOD2, RBFOX2
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| Fox-2 protein regulates the alternative splicing of scleroderma-associated lysyl hydroxylase 2 messenger RNA.
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| Seth P, Yeowell HN.
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| Arthritis Rheum 62(4):1167-75. doi: 10.1002/art.27315.
2010
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| 13 | BRKS2, PLOD2
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| Missense mutations that cause Bruck syndrome affect enzymatic activity, folding, and oligomerization of lysyl hydroxylase 2.
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| Hyry M, Lantto J, Myllyharju J.
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| J Biol Chem 284(45):30917-24. Epub 2009 Sep 17.
2009
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| 14 | PLOD2, TIA1, TIAL1
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| TIA nuclear proteins regulate the alternate splicing of lysyl hydroxylase 2.
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| Yeowell HN, Walker LC, Mauger DM, Seth P, Garcia-Blanco MA.
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| J Invest Dermatol 129(6):1402-11. Epub 2008 Dec 25.PMID: 19110540 2009
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| 15 | PITX2, PLOD2
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| Involvement of Pitx2, a homeodomain transcription factor, in hypothyroidism associated reproductive disorders.
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| Ghosh P, Saha SK, Nandi SS, Bhattacharya S, Roy SS.
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| Cell Physiol Biochem 20(6):887-98.PMID: 17982271 2007
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| 16 | PLOD2
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| Functional diversity of lysyl hydroxylase 2 in collagen synthesis of human dermal fibroblasts.
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| Wu J, Reinhardt DP, Batmunkh C, Lindenmaier W, Far RK, Notbohm H, Hunzelmann N, Brinckmann J.
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| Exp Cell Res 312(18):3485-94. Epub 2006 Jul 28.PMID: 16934803 2006
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| 17 | PLOD2
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| Tissue-specific expression and regulation of the alternatively-spliced forms of lysyl hydroxylase 2 (LH2) in human kidney cells and skin fibroblasts.
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| Walker LC, Overstreet MA, Yeowell HN.
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| Matrix Biol 23(8):515-23. Epub 2004 Dec 10. 2005
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| 18 | PLOD2
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| Elevated formation of pyridinoline cross-links by profibrotic cytokines is associated with enhanced lysyl hydroxylase 2b levels.
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| van der Slot AJ, van Dura EA, de Wit EC, De Groot J, Huizinga TW, Bank RA, Zuurmond AM.
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| Biochim Biophys Acta 1741(1-2):95-102. Epub 2004 Oct 5. 2005
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| 19 | PLOD2, BRKS2, BRKS1
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| Phenotypic and molecular characterization of Bruck syndrome (osteogenesis imperfecta with contractures of the large joints) caused by a recessive mutation in PLOD2.
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| Ha-Vinh R, Alanay Y, Bank RA, Campos-Xavier AB, Zankl A, Superti-Furga A, Bonafe L.
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| Am J Med Genet A 131A(2):115-20. 2004
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| 20 | PLOD2, BRKS2
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| Decreased expression of lysyl hydroxylase 2 (LH2) in skin fibroblasts from three Ehlers-Danlos patients does not result from mutations in either the coding or proximal promoter region of the LH2 gene.
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| Walker LC, Teebi AS, Marini JC, De Paepe A, Malfait F, Atsawasuwan P, Yamauchi M, Yeowell HN.
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| Mol Genet Metab 83(4):312-21. 2004
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| 21 | PLOD2, BRKS2
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| Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis.
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| van der Slot AJ, Zuurmond AM, Bardoel AF, Wijmenga C, Pruijs HE, Sillence DO, Brinckmann J, Abraham DJ, Black CM, Verzijl N, DeGroot J, Hanemaaijer R, TeKoppele JM, Huizinga TW, Bank RA.
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| J Biol Chem 278(42):40967-72. Epub 2003 Jul 24. 2003
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| 22 | PLOD1, PLOD2, PLOD3
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| Retrieval-independent localization of lysyl hydroxylase in the endoplasmic reticulum via a peptide fold in its iron-binding domain.
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| Suokas M, Lampela O, Juffer AH, Myllyla R, Kellokumpu S.
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| Biochem J 370(Pt 3):913-20. 2003
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| 23 | PLOD1, PLOD2, PLOD3
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| Characterization of three fragments that constitute the monomers of the human lysyl hydroxylase isoenzymes 1-3. The 30-kDa N-terminal fragment is not required for lysyl hydroxylase activity.
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| Rautavuoma K, Takaluoma K, Passoja K, Pirskanen A, Kvist AP, Kivirikko KI, Myllyharju J.
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| J Biol Chem 277(25):23084-91. Epub 2002 Apr 15. 2002
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| 24 | PLOD2
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| Localization of the gene encoding a novel isoform of lysyl hydroxylase.
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| Szpirer C, Szpirer J, Riviere M, Vanvooren P, Valtavaara M, Myllyla R.
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| Mamm Genome 8(9):707-8. 1997
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