1 | BTRC, PLK4, TIAM1
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| The RAC1 activator Tiam1 regulates centriole duplication through controlling PLK4 levels
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| Porter AP, Reed H, White GRM, Ogg EL, Whalley HJ, Malliri A.
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| J Cell Sci. Apr 1;134(7):jcs252502. doi: 10.1242/jcs.252502. Epub 2021 Apr 13. 2021
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2 | PCM1, PLK4
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| A non-canonical function of Plk4 in centriolar satellite integrity and ciliogenesis through PCM1 phosphorylation.
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| Hori A, Barnouin K, Snijders AP, Toda T.
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| EMBO Rep 17(3):326-37. doi: 10.15252/embr.201541432. Epub 2016 Jan 11. 2016
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3 | PLK4
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| A PLK4 mutation causing azoospermia in a man with Sertoli cell-only syndrome.
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| Miyamoto T, Bando Y, Koh E, Tsujimura A, Miyagawa Y, Iijima M, Namiki M, Shiina M, Ogata K, Matsumoto N, Sengoku K.
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| Andrology 4(1):75-81. doi: 10.1111/andr.12113. Epub 2015 Oct 9.
2016
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4 | CEP78, PLK4
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| Cep78 is a new centriolar protein involved in Plk4-induced centriole overduplication.
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| Brunk K, Zhu M, Bärenz F, Kratz AS, Haselmann-Weiss U, Antony C, Hoffmann I.
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| J Cell Sci 129(14):2713-8. doi: 10.1242/jcs.184093. Epub 2016 May 31.
2016
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5 | KAT2A, KAT2B, PLK4
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| KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification.
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| Fournier M, Orpinell M, Grauffel C, Scheer E, Garnier JM, Ye T, Chavant V, Joint M, Esashi F, Dejaegere A, Gönczy P, Tora L.
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| Nat Commun 7:13227. doi: 10.1038/ncomms13227.
2016
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6 | PLK4
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| Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse.
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| Coelho PA, Bury L, Shahbazi MN, Liakath-Ali K, Tate PH, Wormald S, Hindley CJ, Huch M, Archer J, Skarnes WC, Zernicka-Goetz M, Glover DM.
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| Open Biol 5(12):150209. doi: 10.1098/rsob.150209.
2015
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7 | PLK4
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| PLK4 trans-Autoactivation Controls Centriole Biogenesis in Space.
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| Lopes CA, Jana SC, Cunha-Ferreira I, Zitouni S, Bento I, Duarte P, Gilberto S, Freixo F, Guerrero A, Francia M, Lince-Faria M, Carneiro J, Bettencourt-Dias M.
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| Dev Cell 35(2):222-35. doi: 10.1016/j.devcel.2015.09.020. Epub 2015 Oct 17.
2015
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8 | PLK4, STIL
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| STIL binding to Polo-box 3 of PLK4 regulates centriole duplication.
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| Arquint C, Gabryjonczyk AM, Imseng S, Böhm R, Sauer E, Hiller S, Nigg EA, Maier T.
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| Elife 4. doi: 10.7554/eLife.07888.
2015
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9 | PLK4, SASS6, STOL
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| Binding of STIL to Plk4 activates kinase activity to promote centriole assembly.
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| Moyer TC, Clutario KM, Lambrus BG, Daggubati V, Holland AJ.
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| J Cell Biol 209(6):863-78. doi: 10.1083/jcb.201502088.
2015
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10 | PLK4
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| Common variants spanning PLK4 are associated with mitotic-origin aneuploidy in human embryos.
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| McCoy RC, Demko Z, Ryan A, Banjevic M, Hill M, Sigurjonsson S, Rabinowitz M, Fraser HB, Petrov DA.
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| Science 348(6231):235-8. doi: 10.1126/science.aaa3337.
2015
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11 | MIB1, PLK4
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| The E3 ubiquitin ligase Mib1 regulates Plk4 and centriole biogenesis.
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| Čajánek L, Glatter T, Nigg EA.
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| J Cell Sci 128(9):1674-82. doi: 10.1242/jcs.166496. Epub 2015 Mar 20.
2015
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12 | PLK2, PLK4, ROCK2
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| Functional relationship among PLK2, PLK4 and ROCK2 to induce centrosome amplification.
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| Ling H, Hanashiro K, Luong TH, Benavides L, Fukasawa K.
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| Cell Cycle 14(4):544-53. doi: 10.4161/15384101.2014.989121.
2015
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13 | PLK4
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| A novel role for Plk4 in regulating cell spreading and motility.
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| Rosario CO, Kazazian K, Zih FS, Brashavitskaya O, Haffani Y, Xu RS, George A, Dennis JW, Swallow CJ.
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| Oncogene 34(26):3441-51. doi: 10.1038/onc.2014.275. Epub 2014 Sep 1.
2015
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14 | MCCRP2, PLK4
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| Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy.
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| Martin CA, Ahmad I, Klingseisen A, Hussain MS, Bicknell LS, Leitch A, Nürnberg G, Toliat MR, Murray JE, Hunt D, Khan F, Ali Z, Tinschert S, Ding J, Keith C, Harley ME, Heyn P, Müller R, Hoffmann I, Daire VC, Dollfus H, Dupuis L, Bashamboo A, McElreavey K, Kariminejad A, Mendoza-Londono R, Moore AT, Saggar A, Schlechter C, Weleber R, Thiele H, Altmüller J, Höhne W, Hurles ME, Noegel AA, Baig SM, Nürnberg P, Jackson AP.
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| Nat Genet 46(12):1283-92. doi: 10.1038/ng.3122. Epub 2014 Oct 26.
2014
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15 | MCCRP2, PLK4
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| Mutation in PLK4, encoding a master regulator of centriole formation, defines a novel locus for primordial dwarfism.
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| Shaheen R, Al Tala S, Almoisheer A, Alkuraya FS.
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| J Med Genet 51(12):814-6. doi: 10.1136/jmedgenet-2014-102790. Epub 2014 Oct 15.
2014
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16 | PLK4, SASS6
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| Plk4 phosphorylates Ana2 to trigger Sas6 recruitment and procentriole formation.
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| Dzhindzhev NS, Tzolovsky G, Lipinszki Z, Schneider S, Lattao R, Fu J, Debski J, Dadlez M, Glover DM.
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| Curr Biol 24(21):2526-32. doi: 10.1016/j.cub.2014.08.061. Epub 2014 Sep 25.
2014
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17 | PLK4, SASS6, STIL
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| SAS-6 assembly templated by the lumen of cartwheel-less centrioles precedes centriole duplication.
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| Fong CS, Kim M, Yang TT, Liao JC, Tsou MF.
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| Dev Cell 30(2):238-45. doi: 10.1016/j.devcel.2014.05.008. Epub 2014 Jul 10. Erratum in: Dev Cell. 2014 Aug 25;30(4):488.
2014
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18 | CEP152, CEP192, PLK4
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| Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152.
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| Kim TS, Park JE, Shukla A, Choi S, Murugan RN, Lee JH, Ahn M, Rhee K, Bang JK, Kim BY, Loncarek J, Erikson RL, Lee KS.
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| Proc Natl Acad Sci U S A 110(50):E4849-57. doi: 10.1073/pnas.1319656110. Epub 2013 Nov 25.
2013
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19 | PLK4
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| Spindle formation in the mouse embryo requires Plk4 in the absence of centrioles.
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| Coelho PA, Bury L, Sharif B, Riparbelli MG, Fu J, Callaini G, Glover DM, Zernicka-Goetz M.
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| Dev Cell 27(5):586-97. doi: 10.1016/j.devcel.2013.09.029. Epub 2013 Nov 21.
2013
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20 | NFKB1, PLK4
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| NFκB regulates expression of Polo-like kinase 4.
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| Ledoux AC, Sellier H, Gillies K, Iannetti A, James J, Perkins ND.
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| Cell Cycle 12(18):3052-62. doi: 10.4161/cc.26086. Epub 2013 Aug 21.
2013
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21 | MAP2K4, PLK4
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| SAPK pathways and p53 cooperatively regulate PLK4 activity and centrosome integrity under stress.
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| Nakamura T, Saito H, Takekawa M.
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| Nat Commun 4:1775. doi: 10.1038/ncomms2752.
2013
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22 | CEP152, CEP192, PLK4
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| Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication.
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| Sonnen KF, Gabryjonczyk AM, Anselm E, Stierhof YD, Nigg EA.
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| J Cell Sci 126(Pt 14):3223-33. doi: 10.1242/jcs.129502. Epub 2013 May 2.
2013
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23 | PLK4, SASS6, STIL
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| Cell-cycle-regulated expression of STIL controls centriole number in human cells.
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| Arquint C, Sonnen KF, Stierhof YD, Nigg EA.
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| J Cell Sci 125(Pt 5):1342-52. doi: 10.1242/jcs.099887. Epub 2012 Feb 20.
2012
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24 | PLK4
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| Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis.
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| Holland AJ, Fachinetti D, Da Cruz S, Zhu Q, Vitre B, Lince-Faria M, Chen D, Parish N, Verma IM, Bettencourt-Dias M, Cleveland DW.
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| Mol Biol Cell 23(10):1838-45. doi: 10.1091/mbc.E11-12-1043. Epub 2012 Mar 28.
2012
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25 | PLK4, TUBGCP6
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| GCP6 is a substrate of Plk4 and required for centriole duplication.
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| Bahtz R, Seidler J, Arnold M, Haselmann-Weiss U, Antony C, Lehmann WD, Hoffmann I.
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| J Cell Sci 125(Pt 2):486-96. doi: 10.1242/jcs.093930. Epub 2012 Feb 2.
2012
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26 | CDC20, FBXW5, PLK4, SASS6
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| FBXW5 controls centrosome number.
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| Pagan J, Pagano M.
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| Nat Cell Biol 13(8):888-90. doi: 10.1038/ncb2312. 2011
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27 | PLK4
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| Plk4 is required for cytokinesis and maintenance of chromosomal stability.
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| Rosario CO, Ko MA, Haffani YZ, Gladdy RA, Paderova J, Pollett A, Squire JA, Dennis JW, Swallow CJ.
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| Proc Natl Acad Sci U S A 107(15):6888-93. Epub 2010 Mar 26. 2010
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28 | CENPJ, CEP152, PLK4
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| Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome.
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| Cizmecioglu O, Arnold M, Bahtz R, Settele F, Ehret L, Haselmann-Weiss U, Antony C, Hoffmann I.
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| J Cell Biol 191(4):731-9. Epub 2010 Nov 8.
2010
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29 | CDC25C, CDK1, MKLP2, MYT1, PLK1, PLK2, PLK3, PLK4, PPA2, PRC1, SGOL1, WEE1
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| Polo-like kinases: conservation and divergence in their functions and regulation.
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| Archambault V, Glover DM.
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| Nat Rev Mol Cell Biol 10(4):265-75. Review. Erratum in: Nat Rev Mol Cell Biol. 2009 May;10(5):364. 2009
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30 | CUL1, PLK4
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| Cullin 1 functions as a centrosomal suppressor of centriole multiplication by regulating polo-like kinase 4 protein levels.
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| Korzeniewski N, Zheng L, Cuevas R, Parry J, Chatterjee P, Anderton B, Duensing A, Münger K, Duensing S.
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| Cancer Res 69(16):6668-75.PMID: 19679553 2009
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31 | PLK4
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| Human Plk4 phosphorylates Cdc25C.
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| Bonni S, Ganuelas ML, Petrinac S, Hudson JW.
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| Cell Cycle 7(4):545-7. Epub 2007 Nov 25. No abstract available. PMID: 18239451 2008
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32 | CENPJ, CEP135, PLK4
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| Plk4-induced centriole biogenesis in human cells.
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| Kleylein-Sohn J, Westendorf J, Le Clech M, Habedanck R, Stierhof YD, Nigg EA.
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| Dev Cell 13(2):190-202.PMID: 17681131 2007
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33 | PLK4
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| Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis.
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| Ko MA, Rosario CO, Hudson JW, Kulkarni S, Pollett A, Dennis JW, Swallow CJ.
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| Nat Genet 37(8):883-8. Epub 2005 Jul 17. 2005
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34 | PLK4
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| SAK/PLK4 is required for centriole duplication and flagella development.
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| Bettencourt-Dias M, Rodrigues-Martins A, Carpenter L, Riparbelli M, Lehmann L, Gatt MK, Carmo N, Balloux F, Callaini G, Glover DM.
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| Curr Biol 15(24):2199-207. Epub 2005 Dec 1.PMID: 16326102 2005
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35 | PLK4
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| Sak kinase gene structure and transcriptional regulation.
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| Hudson JW, Chen L, Fode C, Binkert C, Dennis JW.
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| Gene 241(1):65-73. 2000
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