Citations for
1BTRC, PLK4, TIAM1
The RAC1 activator Tiam1 regulates centriole duplication through controlling PLK4 levels
Porter AP, Reed H, White GRM, Ogg EL, Whalley HJ, Malliri A.
J Cell Sci. Apr 1;134(7):jcs252502. doi: 10.1242/jcs.252502. Epub 2021 Apr 13. 2021
2PCM1, PLK4
A non-canonical function of Plk4 in centriolar satellite integrity and ciliogenesis through PCM1 phosphorylation.
Hori A, Barnouin K, Snijders AP, Toda T.
EMBO Rep 17(3):326-37. doi: 10.15252/embr.201541432. Epub 2016 Jan 11. 2016
3PLK4
A PLK4 mutation causing azoospermia in a man with Sertoli cell-only syndrome.
Miyamoto T, Bando Y, Koh E, Tsujimura A, Miyagawa Y, Iijima M, Namiki M, Shiina M, Ogata K, Matsumoto N, Sengoku K.
Andrology 4(1):75-81. doi: 10.1111/andr.12113. Epub 2015 Oct 9. 2016
4CEP78, PLK4
Cep78 is a new centriolar protein involved in Plk4-induced centriole overduplication.
Brunk K, Zhu M, Bärenz F, Kratz AS, Haselmann-Weiss U, Antony C, Hoffmann I.
J Cell Sci 129(14):2713-8. doi: 10.1242/jcs.184093. Epub 2016 May 31. 2016
5KAT2A, KAT2B, PLK4
KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification.
Fournier M, Orpinell M, Grauffel C, Scheer E, Garnier JM, Ye T, Chavant V, Joint M, Esashi F, Dejaegere A, Gönczy P, Tora L.
Nat Commun 7:13227. doi: 10.1038/ncomms13227. 2016
6PLK4
Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse.
Coelho PA, Bury L, Shahbazi MN, Liakath-Ali K, Tate PH, Wormald S, Hindley CJ, Huch M, Archer J, Skarnes WC, Zernicka-Goetz M, Glover DM.
Open Biol 5(12):150209. doi: 10.1098/rsob.150209. 2015
7PLK4
PLK4 trans-Autoactivation Controls Centriole Biogenesis in Space.
Lopes CA, Jana SC, Cunha-Ferreira I, Zitouni S, Bento I, Duarte P, Gilberto S, Freixo F, Guerrero A, Francia M, Lince-Faria M, Carneiro J, Bettencourt-Dias M.
Dev Cell 35(2):222-35. doi: 10.1016/j.devcel.2015.09.020. Epub 2015 Oct 17. 2015
8PLK4, STIL
STIL binding to Polo-box 3 of PLK4 regulates centriole duplication.
Arquint C, Gabryjonczyk AM, Imseng S, Böhm R, Sauer E, Hiller S, Nigg EA, Maier T.
Elife 4. doi: 10.7554/eLife.07888. 2015
9PLK4, SASS6, STOL
Binding of STIL to Plk4 activates kinase activity to promote centriole assembly.
Moyer TC, Clutario KM, Lambrus BG, Daggubati V, Holland AJ.
J Cell Biol 209(6):863-78. doi: 10.1083/jcb.201502088. 2015
10PLK4
Common variants spanning PLK4 are associated with mitotic-origin aneuploidy in human embryos.
McCoy RC, Demko Z, Ryan A, Banjevic M, Hill M, Sigurjonsson S, Rabinowitz M, Fraser HB, Petrov DA.
Science 348(6231):235-8. doi: 10.1126/science.aaa3337. 2015
11MIB1, PLK4
The E3 ubiquitin ligase Mib1 regulates Plk4 and centriole biogenesis.
Čajánek L, Glatter T, Nigg EA.
J Cell Sci 128(9):1674-82. doi: 10.1242/jcs.166496. Epub 2015 Mar 20. 2015
12PLK2, PLK4, ROCK2
Functional relationship among PLK2, PLK4 and ROCK2 to induce centrosome amplification.
Ling H, Hanashiro K, Luong TH, Benavides L, Fukasawa K.
Cell Cycle 14(4):544-53. doi: 10.4161/15384101.2014.989121. 2015
13PLK4
A novel role for Plk4 in regulating cell spreading and motility.
Rosario CO, Kazazian K, Zih FS, Brashavitskaya O, Haffani Y, Xu RS, George A, Dennis JW, Swallow CJ.
Oncogene 34(26):3441-51. doi: 10.1038/onc.2014.275. Epub 2014 Sep 1. 2015
14MCCRP2, PLK4
Mutations in PLK4, encoding a master regulator of centriole biogenesis, cause microcephaly, growth failure and retinopathy.
Martin CA, Ahmad I, Klingseisen A, Hussain MS, Bicknell LS, Leitch A, Nürnberg G, Toliat MR, Murray JE, Hunt D, Khan F, Ali Z, Tinschert S, Ding J, Keith C, Harley ME, Heyn P, Müller R, Hoffmann I, Daire VC, Dollfus H, Dupuis L, Bashamboo A, McElreavey K, Kariminejad A, Mendoza-Londono R, Moore AT, Saggar A, Schlechter C, Weleber R, Thiele H, Altmüller J, Höhne W, Hurles ME, Noegel AA, Baig SM, Nürnberg P, Jackson AP.
Nat Genet 46(12):1283-92. doi: 10.1038/ng.3122. Epub 2014 Oct 26. 2014
15MCCRP2, PLK4
Mutation in PLK4, encoding a master regulator of centriole formation, defines a novel locus for primordial dwarfism.
Shaheen R, Al Tala S, Almoisheer A, Alkuraya FS.
J Med Genet 51(12):814-6. doi: 10.1136/jmedgenet-2014-102790. Epub 2014 Oct 15. 2014
16PLK4, SASS6
Plk4 phosphorylates Ana2 to trigger Sas6 recruitment and procentriole formation.
Dzhindzhev NS, Tzolovsky G, Lipinszki Z, Schneider S, Lattao R, Fu J, Debski J, Dadlez M, Glover DM.
Curr Biol 24(21):2526-32. doi: 10.1016/j.cub.2014.08.061. Epub 2014 Sep 25. 2014
17PLK4, SASS6, STIL
SAS-6 assembly templated by the lumen of cartwheel-less centrioles precedes centriole duplication.
Fong CS, Kim M, Yang TT, Liao JC, Tsou MF.
Dev Cell 30(2):238-45. doi: 10.1016/j.devcel.2014.05.008. Epub 2014 Jul 10. Erratum in: Dev Cell. 2014 Aug 25;30(4):488. 2014
18CEP152, CEP192, PLK4
Hierarchical recruitment of Plk4 and regulation of centriole biogenesis by two centrosomal scaffolds, Cep192 and Cep152.
Kim TS, Park JE, Shukla A, Choi S, Murugan RN, Lee JH, Ahn M, Rhee K, Bang JK, Kim BY, Loncarek J, Erikson RL, Lee KS.
Proc Natl Acad Sci U S A 110(50):E4849-57. doi: 10.1073/pnas.1319656110. Epub 2013 Nov 25. 2013
19PLK4
Spindle formation in the mouse embryo requires Plk4 in the absence of centrioles.
Coelho PA, Bury L, Sharif B, Riparbelli MG, Fu J, Callaini G, Glover DM, Zernicka-Goetz M.
Dev Cell 27(5):586-97. doi: 10.1016/j.devcel.2013.09.029. Epub 2013 Nov 21. 2013
20NFKB1, PLK4
NFκB regulates expression of Polo-like kinase 4.
Ledoux AC, Sellier H, Gillies K, Iannetti A, James J, Perkins ND.
Cell Cycle 12(18):3052-62. doi: 10.4161/cc.26086. Epub 2013 Aug 21. 2013
21MAP2K4, PLK4
SAPK pathways and p53 cooperatively regulate PLK4 activity and centrosome integrity under stress.
Nakamura T, Saito H, Takekawa M.
Nat Commun 4:1775. doi: 10.1038/ncomms2752. 2013
22CEP152, CEP192, PLK4
Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication.
Sonnen KF, Gabryjonczyk AM, Anselm E, Stierhof YD, Nigg EA.
J Cell Sci 126(Pt 14):3223-33. doi: 10.1242/jcs.129502. Epub 2013 May 2. 2013
23PLK4, SASS6, STIL
Cell-cycle-regulated expression of STIL controls centriole number in human cells.
Arquint C, Sonnen KF, Stierhof YD, Nigg EA.
J Cell Sci 125(Pt 5):1342-52. doi: 10.1242/jcs.099887. Epub 2012 Feb 20. 2012
24PLK4
Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis.
Holland AJ, Fachinetti D, Da Cruz S, Zhu Q, Vitre B, Lince-Faria M, Chen D, Parish N, Verma IM, Bettencourt-Dias M, Cleveland DW.
Mol Biol Cell 23(10):1838-45. doi: 10.1091/mbc.E11-12-1043. Epub 2012 Mar 28. 2012
25PLK4, TUBGCP6
GCP6 is a substrate of Plk4 and required for centriole duplication.
Bahtz R, Seidler J, Arnold M, Haselmann-Weiss U, Antony C, Lehmann WD, Hoffmann I.
J Cell Sci 125(Pt 2):486-96. doi: 10.1242/jcs.093930. Epub 2012 Feb 2. 2012
26CDC20, FBXW5, PLK4, SASS6
FBXW5 controls centrosome number.
Pagan J, Pagano M.
Nat Cell Biol 13(8):888-90. doi: 10.1038/ncb2312. 2011
27PLK4
Plk4 is required for cytokinesis and maintenance of chromosomal stability.
Rosario CO, Ko MA, Haffani YZ, Gladdy RA, Paderova J, Pollett A, Squire JA, Dennis JW, Swallow CJ.
Proc Natl Acad Sci U S A 107(15):6888-93. Epub 2010 Mar 26. 2010
28CENPJ, CEP152, PLK4
Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome.
Cizmecioglu O, Arnold M, Bahtz R, Settele F, Ehret L, Haselmann-Weiss U, Antony C, Hoffmann I.
J Cell Biol 191(4):731-9. Epub 2010 Nov 8. 2010
29CDC25C, CDK1, MKLP2, MYT1, PLK1, PLK2, PLK3, PLK4, PPA2, PRC1, SGOL1, WEE1
Polo-like kinases: conservation and divergence in their functions and regulation.
Archambault V, Glover DM.
Nat Rev Mol Cell Biol 10(4):265-75. Review. Erratum in: Nat Rev Mol Cell Biol. 2009 May;10(5):364. 2009
30CUL1, PLK4
Cullin 1 functions as a centrosomal suppressor of centriole multiplication by regulating polo-like kinase 4 protein levels.
Korzeniewski N, Zheng L, Cuevas R, Parry J, Chatterjee P, Anderton B, Duensing A, Münger K, Duensing S.
Cancer Res 69(16):6668-75.PMID: 19679553 2009
31PLK4
Human Plk4 phosphorylates Cdc25C.
Bonni S, Ganuelas ML, Petrinac S, Hudson JW.
Cell Cycle 7(4):545-7. Epub 2007 Nov 25. No abstract available. PMID: 18239451 2008
32CENPJ, CEP135, PLK4
Plk4-induced centriole biogenesis in human cells.
Kleylein-Sohn J, Westendorf J, Le Clech M, Habedanck R, Stierhof YD, Nigg EA.
Dev Cell 13(2):190-202.PMID: 17681131 2007
33PLK4
Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis.
Ko MA, Rosario CO, Hudson JW, Kulkarni S, Pollett A, Dennis JW, Swallow CJ.
Nat Genet 37(8):883-8. Epub 2005 Jul 17. 2005
34PLK4
SAK/PLK4 is required for centriole duplication and flagella development.
Bettencourt-Dias M, Rodrigues-Martins A, Carpenter L, Riparbelli M, Lehmann L, Gatt MK, Carmo N, Balloux F, Callaini G, Glover DM.
Curr Biol 15(24):2199-207. Epub 2005 Dec 1.PMID: 16326102 2005
35PLK4
Sak kinase gene structure and transcriptional regulation.
Hudson JW, Chen L, Fode C, Binkert C, Dennis JW.
Gene 241(1):65-73. 2000