| 1 | GIPC1, NRP1, PLEKHG5, VEGFA
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| VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells.
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| Yoshida A, Shimizu A, Asano H, Kadonosono T, Kondoh SK, Geretti E, Mammoto A, Klagsbrun M, Seo MK.
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| Biol Open. Jul 24;4(9):1063-76. doi: 10.1242/bio.010918 2015
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| 2 | PLEKHG5, RICMTC
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| PLEKHG5 deficiency leads to an intermediate form of autosomal-recessive Charcot-Marie-Tooth disease.
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| Azzedine H, Zavadakova P, Planté-Bordeneuve V, Vaz Pato M, Pinto N, Bartesaghi L, Zenker J, Poirot O, Bernard-Marissal N, Arnaud Gouttenoire E, Cartoni R, Title A, Venturini G, Médard JJ, Makowski E, Schöls L, Claeys KG, Stendel C, Roos A, Weis J, Dubourg O, Leal Loureiro J, Stevanin G, Said G, Amato A, Baraban J, LeGuern E, Senderek J, Rivolta C, Chrast R.
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| Hum Mol Genet 22(20):4224-32. doi: 10.1093/hmg/ddt274. Epub 2013 Jun 17.
2013
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| 3 | PLEKHG5, RICMTC
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| Mutations in the PLEKHG5 gene is relevant with autosomal recessive intermediate Charcot-Marie-Tooth disease.
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| Kim HJ, Hong YB, Park JM, Choi YR, Kim YJ, Yoon BR, Koo H, Yoo JH, Kim SB, Park M, Chung KW, Choi BO.
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| Orphanet J Rare Dis 8:104. doi: 10.1186/1750-1172-8-104. Erratum in: Orphanet J Rare Dis. 2013;8:165.
2013
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| 4 | PLEKHG5
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| Phosphorylation-mediated 14-3-3 protein binding regulates the function of the rho-specific guanine nucleotide exchange factor (RhoGEF) Syx.
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| Ngok SP, Geyer R, Kourtidis A, Storz P, Anastasiadis PZ.
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| J Biol Chem 288(9):6640-50. doi: 10.1074/jbc.M112.432682. Epub 2013 Jan 18.
2013
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| 5 | ANGPT1, PLEKHG5, VEGFA
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| VEGF and Angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx.
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| Ngok SP, Geyer R, Liu M, Kourtidis A, Agrawal S, Wu C, Seerapu HR, Lewis-Tuffin LJ, Moodie KL, Huveldt D, Marx R, Baraban JM, Storz P, Horowitz A, Anastasiadis PZ.
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| J Cell Biol Cell Biol. 2012 Dec 17. [Epub ahead of print]
2012
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| 6 | ARHGAP35, PLEKHG5, RND1, RND2, RND3
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| The GTPase-deficient Rnd proteins are stabilized by their effectors.
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| Goh LL, Manser E.
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| J Biol Chem 287(37):31311-20. doi: 10.1074/jbc.M111.327056. Epub 2012 Jul 17. 2012
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| 7 | LMND2, PLEKHG5
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| Molecular genetics and mechanisms of disease in distal hereditary motor neuropathies: insights directing future genetic studies.
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| Drew AP, Blair IP, Nicholson GA.
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| Curr Mol Med 11(8):650-65. Review.
2011
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| 8 | PLEKHG5, RND3
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| The RhoA GEF Syx is a target of Rnd3 and regulated via a Raf1-like ubiquitin-related domain.
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| Goh LL, Manser E.
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| PLoS One 5(8). pii: e12409.PMID: 20811643 2010
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| 9 | AMOT, INADL, MPDZ, PLEKHG5
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| The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells.
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| Ernkvist M, Luna Persson N, Audebert S, Lecine P, Sinha I, Liu M, Schlueter M, Horowitz A, Aase K, Weide T, Borg JP, Majumdar A, Holmgren L.
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| Blood 113(1):244-53. Epub 2008 Sep 29.
2009
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| 10 | LMND2,PLEKHG5
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| The Nuclear Factor kappa B-Activator Gene PLEKHG5 Is Mutated in a Form of Autosomal Recessive Lower Motor Neuron Disease with Childhood Onset.
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| Maystadt I, Rezsohazy R, Barkats M, Duque S, Vannuffel P, Remacle S, Lambert B, Najimi M, Sokal E, Munnich A, Viollet L, Verellen-Dumoulin C.
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| Am J Hum Genet 81(1):67-76. Epub 2007 May 16. 2007
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| 11 | PLEKHG5
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| Tech: a RhoA GEF selectively expressed in hippocampal and cortical neurons.
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| Marx R, Henderson J, Wang J, Baraban JM.
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| J Neurochem 92(4):850-8.
2005
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| 12 | C18orf32, EEF1D, GPR89A, MAVS, NDFIP1, PLEKHG5, SHISA5, SLC35B2, TIFA, TMED4, TRA2A, TRIM38, USE1, WLS
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| Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.
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| Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T,Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S.
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| Oncogene 22(21):3307-18. 2003
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| 13 | PLEKHG5
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| The gene for a new brain specific RhoA exchange factor maps to the highly unstable chromosomal region 1p36.2-1p36.3.
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| De Toledo M, Coulon V, Schmidt S, Fort P, Blangy A.
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| Oncogene 20(50):7307-17. 2001
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