| 1 | PARN, PLD2
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| A feedback mechanism between PLD and deadenylase PARN for the shortening of eukaryotic poly(A) mRNA tails that is deregulated in cancer cells.
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| Miller TE, Gomez-Cambronero J.
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| Biol Open 6(2):176-186. doi: 10.1242/bio.021261.
2017
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| 2 | FES, JAK3, PLD2
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| A new signaling pathway (JAK-Fes-phospholipase D) that is enhanced in highly proliferative breast cancer cells.
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| Ye Q, Kantonen S, Henkels KM, Gomez-Cambronero J.
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| J Biol Chem 288(14):9881-91. doi: 10.1074/jbc.M113.450593. Epub 2013 Feb 12.
2013
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| 3 | PLD1, PLD2
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| Deficiencies of the lipid-signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment.
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| Ali WH, Chen Q, Delgiorno KE, Su W, Hall JC, Hongu T, Tian H, Kanaho Y, Di Paolo G, Crawford HC, Frohman MA.
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| PLoS One 8(1):e55325. doi: 10.1371/journal.pone.0055325. Epub 2013 Jan 28.
2013
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| 4 | ABCA1, PLD2, PRKCH, TLR2
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| TLR2 stimulates ABCA1 expression via PKC-η and PLD2 pathway.
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| Park DW, Lee HK, Lyu JH, Chin H, Kang SW, Kim YJ, Bae YS, Baek SH.
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| Biochem Biophys Res Commun 430(3):933-7. doi: 10.1016/j.bbrc.2012.11.135. Epub 2012 Dec 19.
2013
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| 5 | FES, PLD1, PLD2
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| Phospholipase D2 (PLD2) shortens the time required for myeloid leukemic cell differentiation: mechanism of action.
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| Di Fulvio M, Frondorf K, Henkels KM, Grunwald WC Jr, Cool D, Gomez-Cambronero J.
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| J Biol Chem 287(1):393-407. doi: 10.1074/jbc.M111.259465. Epub 2011 Nov 17.
2012
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| 6 | PLD2
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| Identification of the catalytic site of phospholipase D2 (PLD2) newly described guanine nucleotide exchange factor activity.
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| Mahankali M, Henkels KM, Alter G, Gomez-Cambronero J.
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| J Biol Chem 287(49):41417-31. doi: 10.1074/jbc.M112.383596. Epub 2012 Oct 3.
2012
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| 7 | PLD2
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| Phospholipase D2: a pivotal player modulating RBL-2H3 mast cell structure.
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| Marchini-Alves CM, Nicoletti LM, Mazucato VM, de Souza LB, Hitomi T, Alves Cde P, Jamur MC, Oliver C.
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| J Histochem Cytochem 60(5):386-96. doi: 10.1369/0022155412438886. Epub 2012 Feb 15.
2012
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| 8 | PLD2, RAC2
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| The dual effect of Rac2 on phospholipase D2 regulation that explains both the onset and termination of chemotaxis.
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| Peng HJ, Henkels KM, Mahankali M, Marchal C, Bubulya P, Dinauer MC, Gomez-Cambronero J.
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| Mol Cell Biol 31(11):2227-40. Epub 2011 Mar 28.
2011
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| 9 | PLD2, RAC2
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| Evidence for two CRIB domains in phospholipase D2 (PLD2) that the enzyme uses to specifically bind to the small GTPase Rac2.
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| Peng HJ, Henkels KM, Mahankali M, Dinauer MC, Gomez-Cambronero J.
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| J Biol Chem 286(18):16308-20. Epub 2011 Mar 4.
2011
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| 10 | PLD2, RAC2
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| Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2.
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| Mahankali M, Peng HJ, Henkels KM, Dinauer MC, Gomez-Cambronero J.
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| Proc Natl Acad Sci U S A 108(49):19617-22. doi: 10.1073/pnas.1114692108. Epub 2011 Nov 21.
2011
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| 11 | PLD2
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| A comprehensive model that explains the regulation of phospholipase D2 activity by phosphorylation-dephosphorylation.
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| Henkels KM, Peng HJ, Frondorf K, Gomez-Cambronero J.
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| Mol Cell Biol 30(9):2251-63. Epub 2010 Feb 22.PMID: 20176813 2010
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| 12 | PLD2
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| Non-synonymous single-nucleotide polymorphisms associated with blood pressure and hypertension.
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| Hong KW, Jin HS, Lim JE, Cho YS, Go MJ, Jung J, Lee JE, Choi J, Shin C, Hwang SY, Lee SH, Park HK, Oh B.
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| J Hum Hypertens Hum Hypertens. 2010 Feb 11. [Epub ahead of print]PMID: 20147969 2010
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| 13 | PLD2
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| Epidermal growth factor increases lysophosphatidic acid production in human ovarian cancer cells: roles for phospholipase D2 and receptor transactivation.
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| Snider AJ, Zhang Z, Xie Y, Meier KE.
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| Am J Physiol Cell Physiol 298(1):C163-70. Epub 2009 Oct 28.PMID: 19864325 2010
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| 14 | GRB2, PLD2, PTPRC
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| PLD2 has both enzymatic and cell proliferation-inducing capabilities, that are differentially regulated by phosphorylation and dephosphorylation.
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| Henkels KM, Short S, Peng HJ, Di Fulvio M, Gomez-Cambronero J.
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| Biochem Biophys Res Commun 389(2):224-8. Epub 2009 Aug 26.PMID: 19715678 2009
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| 15 | PLD2
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| ADP-ribosylation factor 6 regulates mu-opioid receptor trafficking and signaling via activation of phospholipase D2.
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| Rankovic M, Jacob L, Rankovic V, Brandenburg LO, Schröder H, Höllt V, Koch T.
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| Cell Signal 21(12):1784-93. Epub 2009 Aug 7.PMID: 19666113 2009
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| 16 | PLD2
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| mu-opioid receptor-stimulated synthesis of reactive oxygen species is mediated via phospholipase D2.
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| Koch T, Seifert A, Wu DF, Rankovic M, Kraus J, Börner C, Brandenburg LO, Schröder H, Höllt V.
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| J Neurochem 110(4):1288-96. Epub 2009 Jun 10.PMID: 19519662 2009
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| 17 | PLD2
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| Involvement of Phospholipase D 1 and 2 in the subcellular localization and activity of formyl-peptide-receptors in the human colonic cell line HT29.
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| Brandenburg LO, Seyferth S, Wruck CJ, Koch T, Rosenstiel P, Lucius R, Pufe T.
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| Mol Membr Biol 26(5):371-83. Epub 2009 Aug 21.PMID: 19707939 2009
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| 18 | PLD1, PLD2, PLD5
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| Phospholipase d promotes lipid microdomain-associated signaling events in mast cells.
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| Lisboa FA, Peng Z, Combs CA, Beaven MA.
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| J Immunol 183(8):5104-12. doi: 10.4049/jimmunol.0802728. Epub 2009 Sep 30. 2009
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| 19 | PLD2
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| Cdk5 phosphorylates PLD2 to mediate EGF-dependent insulin secretion.
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| Lee HY, Jung H, Jang IH, Suh PG, Ryu SH.
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| Cell Signal 20(10):1787-94. Epub 2008 Jun 25.PMID: 18625302 2008
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| 20 | PLD2
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| Effects of active and inactive phospholipase D2 on signal transduction, adhesion, migration, invasion, and metastasis in EL4 lymphoma cells.
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| Knoepp SM, Chahal MS, Xie Y, Zhang Z, Brauner DJ, Hallman MA, Robinson SA, Han S, Imai M, Tomlinson S, Meier KE.
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| Mol Pharmacol 74(3):574-84. Epub 2008 Jun 3.PMID: 18523140 2008
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| 21 | PLD2
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| The Grb2/PLD2 interaction is essential for lipase activity, intracellular localization and signaling in response to EGF.
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| Di Fulvio M, Frondorf K, Henkels KM, Lehman N, Gomez-Cambronero J.
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| J Mol Biol. 367(3):814-24. 2007
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| 22 | PLD2
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| PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals.
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| Ha SH, Kim DH, Kim IS, Kim JH, Lee MN, Lee HJ, Kim JH, Jang SK, Suh PG, Ryu SH.
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| Cell Signal. 18(12):2283-91. 2006
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| 23 | PLD2
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| Munc-18-1 inhibits phospholipase D activity by direct interaction in an epidermal growth factor-reversible manner.
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| Lee HY, Park JB, Jang IH, Chae YC, Kim JH, Kim IS, Suh PG, Ryu SH.
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| J Biol Chem. 279(16):16339-48. 2004
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| 24 | PLD2
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| Transmodulation between phospholipase D and c-Src enhances cell proliferation.
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| Ahn BH, Kim SY, Kim EH, Choi KS, Kwon TK, Lee YH, Chang JS, Kim MS, Jo YH, Min DS.
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| Mol Cell Biol. 23(9):3103-15. 2003
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| 25 | PLD2
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| Phospholipase D2 directly interacts with aldolase via Its PH domain.
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| Kim JH, Lee S, Kim JH, Lee TG, Hirata M, Suh PG, Ryu SH.
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| Biochemistry. 41(10):3414-21. 2002
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| 26 | PLD2
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| Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction.
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| Lee S, Kim JH, Lee CS, Kim JH, Kim Y, Heo K, Ihara Y, Goshima Y, Suh PG, Ryu SH.
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| J Biol Chem. 277(8):6542-9. 2002
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| 27 | PLD2
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| Actin directly interacts with phospholipase D, inhibiting its activity.
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| Lee S, Park JB, Kim JH, Kim Y, Kim JH, Shin KJ, Lee JS, Ha SH, Suh PG, Ryu SH.
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| J Biol Chem. 276(30):28252-60. 2001
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| 28 | PLD2
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| Regulation of mammalian phospholipase D2: interaction with and stimulation by G(M2) activator.
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| Sarkar S, Miwa N, Kominami H, Igarashi N, Hayashi S, Okada T, Jahangeer S, Nakamura S.
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| Biochem J. 359(Pt 3):599-604. 2001
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| 29 | PLD1, PLD2
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| Regulation of human PLD1 and PLD2 by calcium and protein kinase C.
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| Siddiqi AR, Srajer GE, Leslie CC.
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| Biochim Biophys Acta 1497(1):103-14. 2000
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| 30 | PLD2
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| Cardiac phospholipase D2 localizes to sarcolemmal membranes and is inhibited by alpha-actinin in an ADP-ribosylation factor-reversible manner.
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| Park JB, Kim JH, Kim Y, Ha SH, Yoo JS, Du G, Frohman MA, Suh PG, Ryu SH.
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| J Biol Chem. 275(28):21295-301. 2000
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| 31 | PLD2
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| Inhibition of phospholipase D by amphiphysins.
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| Lee C, Kim SR, Chung JK, Frohman MA, Kilimann MW, Rhee SG.
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| J Biol Chem. 275(25):18751-8. 2000
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| 32 | CAV1, PLD2
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| Phospholipase D2: functional interaction with caveolin in low-density membrane microdomains.
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| Czarny M, Fiucci G, Lavie Y, Banno Y, Nozawa Y, Liscovitch M.
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| FEBS Lett. 467(2-3):326-32. 2000
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| 33 | PEA15, PLD2
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| Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them.
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| Zhang Y, Redina O, Altshuller YM, Yamazaki M, Ramos J, Chneiweiss H, Kanaho Y, Frohman MA.
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| J Biol Chem. 275(45):35224-32. 2000
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| 34 | PLD2
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| Interaction of the type Ialpha PIPkinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity.
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| Divecha N, Roefs M, Halstead JR, D'Andrea S, Fernandez-Borga M, Oomen L, Saqib KM, Wakelam MJ, D'Santos C.
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| EMBO J. 19(20):5440-9. 2000
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| 35 | PLD2
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| Insulin-induced phospholipase D1 and phospholipase D2 activity in human embryonic kidney-293 cells mediated by the phospholipase C gamma and protein kinase C alpha signalling cascade.
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| Slaaby R, Du G, Altshuller YM, Frohman MA, Seedorf K.
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| Biochem J. 351 Pt 3:613-9. 2000
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| 36 | PLD2
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| Assignment of human PLD2 to chromosome band 17p13.1 by fluorescence in situ hybridization.
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| Park SH, et al.
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| Cytogenet Cell Genet 82 : 225. 1998
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| 37 | PLD2
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| Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2.
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| Lopez I, Arnold RS, Lambeth JD.
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| J Biol Chem 273 : 12846-12852. 1998
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| 38 | PLD1, PLD2
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| Characterization of human PLD2 and the analysis of PLD isoform splice variants.
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| Steed PM, Clark KL, Boyar WC, Lasala DJ.
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| FASEB J 12 : 1309-1317. 1998
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| 39 | PLD2
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| PLD2 complexes with the EGF receptor and undergoes tyrosine phosphorylation at a single site upon agonist stimulation.
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| Slaaby R, Jensen T, Hansen HS, Frohman MA, Seedorf K.
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| J Biol Chem. 273(50):33722-7. 1998
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| 40 | PLD1, PLD2
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| Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization.
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| Colley WC, Sung TC, Roll R, Jenco J, Hammond SM, Altshuller Y, Bar-Sagi D, Morris AJ, Frohman MA.
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| Curr Biol 7(3):191-201. 1997
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