| 1 | CISH, PLCG1
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| Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance.
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| Palmer DC, Guittard GC, Franco Z, Crompton JG, Eil RL, Patel SJ, Ji Y, Van Panhuys N, Klebanoff CA, Sukumar M, Clever D, Chichura A, Roychoudhuri R, Varma R, Wang E, Gattinoni L, Marincola FM, Balagopalan L, Samelson LE, Restifo NP.
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| J Exp Med. Nov 16;212(12):2095-113. doi: 10.1084/jem.20150304. Epub 2015 Nov 2 2015
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| 2 | GRAP2, GRB2, LAT, PLCG1
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| The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis.
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| Sullivan SA, Zhu M, Bao S, Lewis CA, Ou-Yang CW, Zhang W.
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| J Immunol 192(6):2865-74. doi: 10.4049/jimmunol.1302493. Epub 2014 Feb 12.
2014
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| 3 | PLCG1, SOCS7
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| Observations on the effects of Suppressor of Cytokine Signaling 7 (SOCS7) knockdown in breast cancer cells: their in vitro response to Insulin Like Growth Factor I (IGF-I).
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| Sasi W, Ye L, Jiang WG, Mokbel K, Sharma A.
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| Clin Transl Oncol 16(5):476-87. doi: 10.1007/s12094-013-1107-0. Epub 2013 Sep 18.
2014
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| 4 | ITK, PLCG1
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| Substrate recognition of PLCγ1 via a specific docking surface on Itk.
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| Xie Q, Joseph RE, Fulton DB, Andreotti AH.
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| J Mol Biol 425(4):683-96. doi: 10.1016/j.jmb.2012.10.023. Epub 2012 Dec 3.
2013
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| 5 | PLCG1, RASGRF1, RASGRF2
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| Ras-guanine-nucleotide-releasing factors 1 and 2 interact with PLCγ at focal adhesions to enable IL-1-induced Ca(2+) signalling, ERK activation and MMP-3 expression.
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| Wang Q, Siminovitch KA, Downey GP, McCulloch CA.
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| Biochem J 449(3):771-82. doi: 10.1042/BJ20121170.
2013
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| 6 | PLCG1
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| Phospholipase C-γ1 involved in brain disorders.
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| Jang HJ, Yang YR, Kim JK, Choi JH, Seo YK, Lee YH, Lee JE, Ryu SH, Suh PG.
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| Adv Biol Regul 53(1):51-62. doi: 10.1016/j.jbior.2012.09.008. Epub 2012 Sep 18. Review.
2013
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| 7 | PLCG1
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| Phospholipase C gamma-1 is required for granulocyte maturation in zebrafish.
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| Jing CB, Chen Y, Dong M, Peng XL, Jia XE, Gao L, Ma K, Deng M, Liu TX, Zon LI, Zhu J, Zhou Y, Zhou Y.
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| Dev Biol 374(1):24-31. doi: 10.1016/j.ydbio.2012.11.032. Epub 2012 Dec 7.
2013
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| 8 | PLCG1
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| Important role of PLC-γ1 in hypoxic increase in intracellular calcium in pulmonary arterial smooth muscle cells.
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| Yadav VR, Song T, Joseph L, Mei L, Zheng YM, Wang YX.
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| Am J Physiol Lung Cell Mol Physiol 304(3):L143-51. doi: 10.1152/ajplung.00310.2012. Epub 2012 Nov 30.
2013
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| 9 | ITK, PLCG1
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| Inhibitors of interleukin-2 inducible T-cell kinase as potential therapeutic candidates for the treatment of various inflammatory disease conditions.
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| Kaur M, Bahia MS, Silakari O.
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| Eur J Pharm Sci 47(3):574-88. doi: 10.1016/j.ejps.2012.07.013. Epub 2012 Jul 20. Review.
2012
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| 10 | PLCG1, VAV1
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| Vav1 oncogenic mutation inhibits T cell receptor-induced calcium mobilization through inhibition of phospholipase Cγ1 activation.
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| Knyazhitsky M, Moas E, Shaginov E, Luria A, Braiman A.
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| J Biol Chem 287(23):19725-35. doi: 10.1074/jbc.M111.309799. Epub 2012 Apr 3.
2012
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| 11 | PDPK1, PLCG1
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| A novel regulatory mechanism links PLCγ1 to PDK1.
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| Raimondi C, Chikh A, Wheeler AP, Maffucci T, Falasca M.
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| J Cell Sci 125(Pt 13):3153-63. doi: 10.1242/jcs.100511. Epub 2012 Mar 27.
2012
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| 12 | LAT, PLCG1, STK11
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| LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection.
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| Cao Y, Li H, Liu H, Zhang M, Hua Z, Ji H, Liu X.
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| EMBO J 30(10):2083-93. doi: 10.1038/emboj.2011.116. Epub 2011 Apr 12.
2011
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| 13 | PDGFA, PEA15, PLCG1
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| A phospholipase Cγ1-activated pathway regulates transcription in human vascular smooth muscle cells.
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| Hunter I, Mascall KS, Ramos JW, Nixon GF.
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| Cardiovasc Res 90(3):557-64. doi: 10.1093/cvr/cvr039. Epub 2011 Feb 1.
2011
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| 14 | CBL, PLCG1
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| c-Cbl inhibits angiogenesis and tumor growth by suppressing activation of PLCγ1.
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| Meyer RD, Husain D, Rahimi N.
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| Oncogene 30(19):2198-206. doi: 10.1038/onc.2010.597. Epub 2011 Jan 17.
2011
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| 15 | NFAT5, PLCG1
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| Phospholipase C-gamma1 is involved in signaling the activation by high NaCl of the osmoprotective transcription factor TonEBP/OREBP.
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| Irarrazabal CE, Gallazzini M, Schnetz MP, Kunin M, Simons BL, Williams CK, Burg MB, Ferraris JD.
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| Proc Natl Acad Sci U S A 107(2):906-11. Epub 2009 Dec 22.PMID: 20080774 2010
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| 16 | NFAT5, PLCG1, PTPN6
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| Contribution of SHP-1 protein tyrosine phosphatase to osmotic regulation of the transcription factor TonEBP/OREBP.
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| Zhou X, Gallazzini M, Burg MB, Ferraris JD.
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| Proc Natl Acad Sci U S A 107(15):7072-7. Epub 2010 Mar 29.PMID: 20351292 2010
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| 17 | PLCG1
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| The SH3 domain, but not the catalytic domain, is required for phospholipase C-gamma1 to mediate epidermal growth factor-induced mitogenesis.
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| Xie Z, Chen Y, Pennypacker SD, Zhou Z, Peng D.
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| Biochem Biophys Res Commun 398(4):719-22. Epub 2010 Jul 16. 2010
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| 18 | NTRK2, PLCG1
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| Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis.
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| He XP, Pan E, Sciarretta C, Minichiello L, McNamara JO.
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| J Neurosci 30(18):6188-96.PMID: 20445044 2010
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| 19 | FGFR1, GRB14, PLCG1
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| Grb14 inhibits FGF receptor signaling through the regulation of PLCγ recruitment and activation.
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| Browaeys-Poly E, Blanquart C, Perdereau D, Antoine AF, Goenaga D, Luzy JP, Chen H, Garbay C, Issad T, Cailliau K, Burnol AF.
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| FEBS Lett 584(21):4383-8. Epub 2010 Oct 8.
2010
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| 20 | PLCG1, PLCG2
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| Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling.
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| Sandebring A, Dehvari N, Perez-Manso M, Thomas KJ, Karpilovski E, Cookson MR, Cowburn RF, Cedazo-Mínguez A.
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| FEBS J 276(18):5041-52. Epub 2009 Aug 3.
2009
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| 21 | PLCG1, PLCG2, PLXNB1, SEMA4D
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| Semaphorin 4D signaling requires the recruitment of phospholipase C gamma into the plexin-B1 receptor complex.
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| Swiercz JM, Worzfeld T, Offermanns S.
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| Mol Cell Biol 29(23):6321-34. Epub 2009 Oct 5. 2009
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| 22 | CFL1, ERBB2, MEMO1, PLCG1
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| Memo is a cofilin-interacting protein that influences PLCgamma1 and cofilin activities, and is essential for maintaining directionality during ErbB2-induced tumor-cell migration.
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| Meira M, Masson R, Stagljar I, Lienhard S, Maurer F, Boulay A, Hynes NE.
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| J Cell Sci 122(Pt 6):787-97. Epub 2009 Feb 17.
2009
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| 23 | ITK, PLCG1
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| Itk tyrosine kinase substrate docking is mediated by a nonclassical SH2 domain surface of PLCgamma1.
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| Min L, Joseph RE, Fulton DB, Andreotti AH.
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| Proc Natl Acad Sci U S A 106(50):21143-8. doi: 10.1073/pnas.0911309106. Epub 2009 Dec 1.
2009
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| 24 | APBB1IP, PLCG1
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| RIAM regulates the cytoskeletal distribution and activation of PLC-gamma1 in T cells.
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| Patsoukis N, Lafuente EM, Meraner P, Kim Js, Dombkowski D, Li L, Boussiotis VA.
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| Sci Signal 2(99):ra79. doi: 10.1126/scisignal.2000409.
2009
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| 25 | PLCG1
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| Phospholipase Cgamma1 is required for metastasis development and progression.
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| Sala G, Dituri F, Raimondi C, Previdi S, Maffucci T, Mazzoletti M, Rossi C, Iezzi M, Lattanzio R, Piantelli M, Iacobelli S, Broggini M, Falasca M.
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| Cancer Res 68(24):10187-96.
2008
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| 26 | PLCG1, ¨PARK2
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| Parkin-mediated Ubiquitination Regulates Phospholipase C-gamma1.
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| Dehvari N, Sandebring A, Flores-Morales A, Mateos L, Chuan YC, Goldberg MS, Cookson MR, Cowburn RF, Cedazo-Mínguez A.
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| J Cell Mol Med Cell Mol Med. 2008 Jul 30. [Epub ahead of print]
2008
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| 27 | PLCG1
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| Role of phospholipase Cgamma1 in cell spreading requires association with a beta-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1.
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| Jones NP, Katan M.
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| Mol Cell Biol 27(16):5790-805. Epub 2007 Jun 11.
2007
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| 28 | PLCG1
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| Phospholipase Cgamma1 controls surface expression of TRPC3 through an intermolecular PH domain.
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| van Rossum DB, Patterson RL, Sharma S, Barrow RK, Kornberg M, Gill DL, Snyder SH.
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| Nature 434(7029):99-104. 2005
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| 29 | PLCG1, PLCG2
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| The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors.
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| Upshaw JL, Schoon RA, Dick CJ, Billadeau DD, Leibson PJ.
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| J Immunol 175(1):213-8.
2005
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| 30 | PLCG1, PLCG2
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| Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases.
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| Piechulek T, Rehlen T, Walliser C, Vatter P, Moepps B, Gierschik P.
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| J Biol Chem 280(47):38923-31. Epub 2005 Sep 19.
2005
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| 31 | PLCG1, PTK2
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| Focal adhesion kinase promotes phospholipase C-gamma1 activity.
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| Zhang X, et al.
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| Proc Natl Acad Sci U S A 96(16):9021-6. 1999
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| 32 | PLCB1, PLCB3, PLCB4, PLCD1, PLCD3,PLCD4, PLCG1, PLCG2
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| Genetic mapping of the human and mouse phospholipase C genes.
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| Lyu MS, et al.
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| Mamm Genome 7 : 501-504. 1996
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| 33 | PLCG2, PLCG1
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| Phospholipase C gamma-2 (Plcg2) and phospholipase C gamma-1 (Plcg1) map to distinct regions in the human and mouse genomes.
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| Argeson AC, et al.
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| Genomics 25 : 29-35. 1995
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| 34 | PLCG1, PLCG2
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| Mapping the gene that encodes phosphatidylinositol-specific phospholipase C-gamma2 in the human and the mouse.
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| Hernandez D, et al.
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| Genomics 23 : 504-507. 1994
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| 35 | PLCG1, MODY1
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| A microsatellite polymorphism associated with the PLC1 (phospholipase C) locus: identification, mapping, and linkage to the MODY locus on chromosome 20.
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| Rothschild CB, et al.
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| Genomics 13 : 560-564. 1992
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| 36 | PLCG1
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| Localization of phospholipase C-gamma 1 to mouse chromosome 2.
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| Nelson KK, et al.
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| Mamm Genome 3 : 597-600. 1992
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| 37 | PLCG1, FGF1
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| Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.
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| Burgess WH, et al.
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| Mol Cell Biol 10 : 4770-4777. 1990
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| 38 | PLCG1
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| Phospholipase C-148 : chromosomal location and deletion mapping of functional domains.
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| Bristol A, et al.
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| Cold Spring Harbor Symp Quant Biol 1988
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| 39 | PLCG1
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| Sequence similarity of phospholipase C with the non-catalytic region of src.
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| Stahl ML, et al.
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| Nature 332 : 269-272. 1988
|