Citations for
WDR26 Functions as a Scaffolding Protein to Promote Gβγ-mediated Phospholipase C β2 (PLCβ2) Activation in Leukocytes.
Sun Z, Smrcka AV, Chen S.
J Biol Chem 288(23):16715-25. doi: 10.1074/jbc.M113.462564. Epub 2013 Apr 26. 2013
γ-Synuclein interacts with phospholipase Cβ2 to modulate G protein activation.
Golebiewska U, Guo Y, Khalikaprasad N, Zurawsky C, Yerramilli VS, Scarlata S.
PLoS One 7(8):e41067. doi: 10.1371/journal.pone.0041067. Epub 2012 Aug 8. 2012
A chemokine receptor CXCR2 macromolecular complex regulates neutrophil functions in inflammatory diseases.
Wu Y, Wang S, Farooq SM, Castelvetere MP, Hou Y, Gao JL, Navarro JV, Oupicky D, Sun F, Li C.
J Biol Chem 287(8):5744-55. doi: 10.1074/jbc.M111.315762. Epub 2011 Dec 27. 2012
WDR36 acts as a scaffold protein tethering a G-protein-coupled receptor, Gαq and phospholipase Cβ in a signalling complex.
Cartier A, Parent A, Labrecque P, Laroche G, Parent JL.
J Cell Sci 124(Pt 19):3292-304. doi: 10.1242/jcs.085795. 2011
The small G protein Rac1 activates phospholipase Cdelta1 through phospholipase Cbeta2.
Guo Y, Golebiewska U, D'Amico S, Scarlata S.
J Biol Chem 285(32):24999-5008. doi: 10.1074/jbc.M110.132654. Epub 2010 Jun 8. 2010
Suppression of PLCbeta2 by endotoxin plays a role in the adenosine A(2A) receptor-mediated switch of macrophages from an inflammatory to an angiogenic phenotype.
Grinberg S, Hasko G, Wu D, Leibovich SJ.
Am J Pathol 175(6):2439-53. doi: 10.2353/ajpath.2009.090290. Epub 2009 Oct 22. 2009
Phospholipase cbeta is critical for T cell chemotaxis.
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS.
J Immunol 179(4):2223-7. 2007
Alternative splice variants of phospholipase C-beta2 are expressed in platelets: effect on Galphaq-dependent activation and localization.
Sun L, Mao G, Kunapuli SP, Dhanasekaran DN, Rao AK.
Platelets 18(3):217-23. 2007
PLC-beta2 activity on actin-associated polyphosphoinositides promotes migration of differentiating tumoral myeloid precursors.
Brugnoli F, Bavelloni A, Benedusi M, Capitani S, Bertagnolo V.
Cell Signal 19(8):1701-12. Epub 2007 Mar 28. 2007
Phospholipase C-beta 2 promotes mitosis and migration of human breast cancer-derived cells.
Bertagnolo V, Benedusi M, Brugnoli F, Lanuti P, Marchisio M, Querzoli P, Capitani S.
Carcinogenesis 28(8):1638-45. Epub 2007 Apr 11. 2007
PLC-beta2 is highly expressed in breast cancer and is associated with a poor outcome: a study on tissue microarrays.
Bertagnolo V, Benedusi M, Querzoli P, Pedriali M, Magri E, Brugnoli F, Capitani S.
Int J Oncol 28(4):863-72. 2006
Phospholipase Cbeta2 binds to and inhibits phospholipase Cdelta1.
Guo Y, Rebecchi M, Scarlata S.
J Biol Chem 280(2):1438-47. Epub 2004 Oct 27. 2005
Assignment of human PLCB2 encoding PLC beta2 to human chromosome 15q15 by fluorescence in situ hybridization.
Park SH, et al.
Cytogenet Cell Genet 83 : 48-49. 1998
Cloning, sequencing, expression, and Gq-independent activation of phospholipase C-beta 2.
Park D, et al.
J Biol Chem 267 : 16048-16055. 1992