| 1 | GPR39, PAX3, PAX7, PLAGL1
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| Zac1/GPR39 phosphorylating CaMK-II contributes to the distinct roles of Pax3 and Pax7 in myogenic progression.
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| Yang Q, Li Y, Zhang X, Chen D.
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| Biochim Biophys Acta Mol Basis Dis 1864(2):407-419. doi: 10.1016/j.bbadis.2017.10.026. Epub 2017 Nov 2.
2018
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| 2 | CD74, MEF2A, PLAGL1, SLC2A4
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| Macrophage migration inhibitory factor promotes expression of GLUT4 glucose transporter through MEF2 and Zac1 in cardiomyocytes.
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| Liang Y, Yuan W, Zhu W, Zhu J, Lin Q, Zou X, Deng C, Fu Y, Zheng X, Yang M, Wu S, Yu X, Shan Z.
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| Metabolism 64(12):1682-93. doi: 10.1016/j.metabol.2015.09.007. Epub 2015 Sep 12.
2015
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| 3 | PLAGL1, TCF4
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| Zac1 regulates cell cycle arrest in neuronal progenitors via Tcf4.
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| Schmidt-Edelkraut U, Daniel G, Hoffmann A, Spengler D.
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| Mol Cell Biol ol Cell Biol. 2014 Jan 6. [Epub ahead of print]
2014
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| 4 | PLAGL1
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| Imprinting at the PLAGL1 domain is contained within a 70-kb CTCF/cohesin-mediated non-allelic chromatin loop.
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| Iglesias-Platas I, Court F, Camprubi C, Sparago A, Guillaumet-Adkins A, Martin-Trujillo A, Riccio A, Moore GE, Monk D.
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| Nucleic Acids Res 41(4):2171-9. doi: 10.1093/nar/gks1355. Epub 2013 Jan 7.
2013
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| 5 | PLAGL1, SSTR2, SSTR3
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| ZAC1 and SSTR2 are downregulated in non-functioning pituitary adenomas but not in somatotropinomas.
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| Vieria Neto L, Wildemberg LE, Colli LM, Kasuki L, Marques NV, Moraes AB, Gasparetto EL, Takiya CM, Castro M, Gadelha MR.
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| PLoS One 8(10):e77406. doi: 10.1371/journal.pone.0077406. eCollection 2013.
2013
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| 6 | PLAGL1
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| Expression of KCNQ1OT1, CDKN1C, H19, and PLAGL1 and the methylation patterns at the KvDMR1 and H19/IGF2 imprinting control regions is conserved between human and bovine.
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| Robbins KM, Chen Z, Wells KD, Rivera RM.
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| J Biomed Sci 19:95. doi: 10.1186/1423-0127-19-95.
2012
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| 7 | PLAGL1
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| Overexpression of ZAC impairs glucose-stimulated insulin translation and secretion in clonal pancreatic beta-cells.
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| Du X, Ounissi-Benkalha H, Loder MK, Rutter GA, Polychronakos C.
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| Diabetes Metab Res Rev 28(8):645-53. doi: 10.1002/dmrr.2325.
2012
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| 8 | PLAGL1, TNDM
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| Transient neonatal diabetes mellitus gene Zac1 impairs insulin secretion in mice through Rasgrf1.
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| Hoffmann A, Spengler D.
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| Mol Cell Biol 32(13):2549-60. doi: 10.1128/MCB.06637-11. Epub 2012 Apr 30.
2012
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| 9 | CDKN1A, PLAGL1
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| A non-covalent interaction between small ubiquitin-like modifier-1 and Zac1 regulates Zac1 cellular functions.
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| Liu ST, Chang YL, Wang WM, Chung MH, Lin WS, Chou WY, Huang SM.
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| Int J Biochem Cell Biol 44(3):547-55. doi: 10.1016/j.biocel.2011.12.012. Epub 2011 Dec 27.
2012
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| 10 | BUD23, PLAGL1
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| The novel metastasis promoter Merm1/Wbscr22 enhances tumor cell survival in the vasculature by suppressing Zac1/p53-dependent apoptosis.
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| Nakazawa Y, Arai H, Fujita N.
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| Cancer Res 71(3):1146-55. Epub 2010 Dec 10. 2011
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| 11 | PLAGL1
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| Zac1 is a histone acetylation-regulated NF-κB suppressor that mediates histone deacetylase inhibitor-induced apoptosis.
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| Shu G, Tang Y, Zhou Y, Wang C, Song JG.
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| Cell Death Differ 18(12):1825-35. doi: 10.1038/cdd.2011.51. Epub 2011 May 6.
2011
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| 12 | PLAGL1, SP1
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| Zac1, an Sp1-like protein, regulates human p21(WAF1/Cip1) gene expression in HeLa cells.
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| Liu PY, Hsieh TY, Liu ST, Chang YL, Lin WS, Wang WM, Huang SM.
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| Exp Cell Res 317(20):2925-37. doi: 10.1016/j.yexcr.2011.09.018. Epub 2011 Oct 6.
2011
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| 13 | PLAGL1, SLC2A4
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| Regulation of cardiomyocyte Glut4 expression by ZAC1.
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| Czubryt MP, Lamoureux L, Ramjiawan A, Abrenica B, Jangamreddy J, Swan K.
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| J Biol Chem 285(22):16942-50. Epub 2010 Apr 2.
2010
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| 14 | PLAGL1
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| Zac1 is an essential transcription factor for cardiac morphogenesis.
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| Yuasa S, Onizuka T, Shimoji K, Ohno Y, Kageyama T, Yoon SH, Egashira T, Seki T, Hashimoto H, Nishiyama T, Kaneda R, Murata M, Hattori F, Makino S, Sano M, Ogawa S, Prall OW, Harvey RP, Fukuda K.
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| Circ Res 106(6):1083-91. doi: 10.1161/CIRCRESAHA.109.214130. Epub 2010 Feb 18.
2010
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| 15 | BWS, GNAS, KCNQ1OT1, PLAGL1
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| Hypomethylation at multiple maternally methylated imprinted regions including PLAGL1 and GNAS loci in Beckwith-Wiedemann syndrome.
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| Bliek J, Verde G, Callaway J, Maas SM, De Crescenzo A, Sparago A, Cerrato F, Russo S, Ferraiuolo S, Rinaldi MM, Fischetto R, Lalatta F, Giordano L, Ferrari P, Cubellis MV, Larizza L, Temple IK, Mannens MM, Mackay DJ, Riccio A.
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| Eur J Hum Genet 17(5):611-9. Epub 2008 Dec 17.
2009
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| 16 | ABCC6, PLAG1, PLAGL1, PXE
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| The human pseudoxanthoma elasticum gene ABCC6 is transcriptionally regulated by PLAG family transcription factors.
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| Ratajewski M, Van de Ven WJ, Bartosz G, Pulaski L.
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| Hum Genet 124(5):451-63. Epub 2008 Oct 12. 2008
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| 17 | PLAGL1
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| Tissue-specific imprinting of the ZAC/PLAGL1 tumour suppressor gene results from variable utilization of monoallelic and biallelic promoters.
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| Valleley EM, Cordery SF, Bonthron DT.
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| Hum Mol Genet 16(8):972-81. Epub 2007 Mar 6. 2007
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| 18 | PLAGL1
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| Zac1 functions through TGFbetaII to negatively regulate cell number in the developing retina.
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| Ma L, Cantrup R, Varrault A, Colak D, Klenin N, Götz M, McFarlane S, Journot L, Schuurmans C.
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| Neural Dev 2:11.
2007
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| 19 | HYMAI, PLAGL1
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| The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice.
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| Arima T, Yamasaki K, John RM, Kato K, Sakumi K, Nakabeppu Y, Wake N, Kono T.
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| Genomics 88(5):650-8. Epub 2006 Aug 22. 2006
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| 20 | KCNQ1OT1, PLAGL1, CDKN1C
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| ZAC, LIT1 (KCNQ1OT1) and p57KIP2 (CDKN1C) are in an imprinted gene network that may play a role in Beckwith-Wiedemann syndrome.
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| Arima T, Kamikihara T, Hayashida T, Kato K, Inoue T, Shirayoshi Y, Oshimura M, Soejima H, Mukai T, Wake N.
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| Nucleic Acids Res 33(8):2650-60. Print 2005. 2005
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| 21 | PLAGL1
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| The PLAGL1 gene is down-regulated in human extraskeletal myxoid chondrosarcoma tumors.
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| Poulin H, Labelle Y.
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| Cancer Lett 227(2):185-91. Epub 2005 Jan 8. 2005
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| 22 | HYMAI, PLAGL1, TNDM, UPD6P
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| A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitus.
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| Arima T, Drewell RA, Arney KL, Inoue J, Makita Y, Hata A, Oshimura M, Wake N, Surani MA.
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| Hum Mol Genet 10(14):1475-83. 2001
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| 23 | PLAGL1
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| Alternative splicing of the imprinted candidate tumor suppressor gene ZAC regulates its antiproliferative and DNA binding activities.
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| Bilanges B, Varrault A, Mazumdar A, Pantaloni C, Hoffmann A, Bockaert J, Spengler D, Journot L.
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| Oncogene 20(10):1246-53. 2001
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| 24 | PLAGL1
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| The cell cycle control gene ZAC/PLAGL1 is imprinted-a strong candidate gene for transient neonatal diabetes.
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| Kamiya M, Judson H, Okazaki Y, Kusakabe M, Muramatsu M, Takada S, Takagi N, Arima T, Wake N, Kamimura K, Satomura K, Hermann R, Bonthron DT, Hayashizaki Y.
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| Hum Mol Genet 9(3):453-60 2000
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| 25 | HYMAI, PLAGL1
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| A novel imprinted gene, HYMAI, is located within an imprinted domain on human chromosome 6 containing ZAC.
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| Arima T, Drewell RA, Oshimura M, Wake N, Surani MA.
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| Genomics 67(3):248-55. 2000
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| 26 | PLAGL1, ST8
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| Loss of expression of the candidate tumor suppressor gene ZAC in breast cancer cell lines and primary tumors.
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| Bilanges B, et al.
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| Oncogene 18(27):3979-88 1999
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| 27 | PLAGL1
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| LOT1 is a growth suppressor gene down-regulated by the epidermal growth factor receptor ligands and encodes a nuclear zinc-finger protein.
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| Abdollahi A, Bao R, Hamilton TC.
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| Oncogene 18(47):6477-87 1999
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| 28 | PLAGL1
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| hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer.
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| Varrault A, et al.
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| Proc Natl Acad Sci U S A 95 : 8835-8840. 1998
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| 29 | PLAG1, PLAGL1
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| Transcriptional activation capacity of the novel PLAG family of zinc finger proteins.
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| Kas K, et al.
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| J Biol Chem 273 : 23026-23032. 1998
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| 30 | ST8, PLAGL1
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| Identification of a zinc-finger gene at 6q25 : a chromosomal region implicated in development of many solid tumors.
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| Abdollahi A, Roberts D, Godwin AK, Schultz DC, Sonoda G, Testa JR, Hamilton TC.
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| Oncogene 14(16):1973-9. 1997
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| 31 | PLAGL1
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| Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain.
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| Spengler D, et al.
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| EMBO J 16 : 2814-2825. 1997
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| 32 | PLAGL1
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| Identification of a gene containing zinc-finger motifs based on lost expression in malignantly transformed rat ovarian surface epithelial cells.
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| Abdollahi A, et al.
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| Cancer Res 57 : 2029-2034. 1997
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