| 1 | LDHA, PKM
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| M-Type Pyruvate Kinase Isoforms and Lactate Dehydrogenase A in the Mammalian Retina: Metabolic Implications.
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| Casson RJ, Wood JP, Han G, Kittipassorn T, Peet DJ, Chidlow G.
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| Invest Ophthalmol Vis Sci 57(1):66-80. doi: 10.1167/iovs.15-17962.
2016
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| 2 | AKT1S1, MTOR, PKM
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| Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1.
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| He CL, Bian YY, Xue Y, Liu ZX, Zhou KQ, Yao CF, Lin Y, Zou HF, Luo FX, Qu YY, Zhao JY, Ye ML, Zhao SM, Xu W.
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| Sci Rep. Feb 15;6:21524. doi: 10.1038/srep21524. 2016
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| 3 | ECM1, PKM
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| ECM1 promotes the Warburg effect through EGF-mediated activation of PKM2.
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| Lee KM, Nam K, Oh S, Lim J, Lee T, Shin I.
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| Cell Signal 27(2):228-35. doi: 10.1016/j.cellsig.2014.11.004. Epub 2014 Nov 11.
2015
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| 4 | PKM, TRIM35
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| Co-expression of PKM2 and TRIM35 predicts survival and recurrence in hepatocellular carcinoma.
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| Chen Z, Lu X, Wang Z, Jin G, Wang Q, Chen D, Chen T, Li J, Fan J, Cong W, Gao Q, He X.
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| Oncotarget 6(4):2538-48.
2015
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| 5 | PKM, TRIM35
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| TRIM35 Interacts with pyruvate kinase isoform M2 to suppress the Warburg effect and tumorigenicity in hepatocellular carcinoma.
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| Chen Z, Wang Z, Guo W, Zhang Z, Zhao F, Zhao Y, Jia D, Ding J, Wang H, Yao M, He X.
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| Oncogene 34(30):3946-56. doi: 10.1038/onc.2014.325. Epub 2014 Sep 29.
2015
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| 6 | PKM, TGM2
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| The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation.
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| Altuntas S, Rossin F, Marsella C, D'Eletto M, Diaz-Hidalgo L, Farrace MG, Campanella M, Antonioli M, Fimia GM, Piacentini M.
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| Oncotarget 6(42):44941-54. doi: 10.18632/oncotarget.6759.
2015
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| 7 | KDM8, PKM
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| JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1α-mediated glucose metabolism.
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| Wang HJ, Hsieh YJ, Cheng WC, Lin CP, Lin YS, Yang SF, Chen CC, Izumiya Y, Yu JS, Kung HJ, Wang WC.
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| Proc Natl Acad Sci U S A 111(1):279-84. doi: 10.1073/pnas.1311249111. Epub 2013 Dec 16.
2014
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| 8 | PKM
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| Pyruvate kinase M2 expression, but not pyruvate kinase activity, is up-regulated in a grade-specific manner in human glioma.
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| Mukherjee J, Phillips JJ, Zheng S, Wiencke J, Ronen SM, Pieper RO.
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| PLoS One 8(2):e57610. doi: 10.1371/journal.pone.0057610. Epub 2013 Feb 25.
2013
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| 9 | PKM
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| Allosteric regulation of PKM2 allows cellular adaptation to different physiological states.
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| Gui DY, Lewis CA, Vander Heiden MG.
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| Sci Signal 6(263):pe7. doi: 10.1126/scisignal.2003925.
2013
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| 10 | PKM
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| M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth.
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| Cortés-Cros M, Hemmerlin C, Ferretti S, Zhang J, Gounarides JS, Yin H, Muller A, Haberkorn A, Chene P, Sellers WR, Hofmann F.
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| Proc Natl Acad Sci U S A 110(2):489-94. doi: 10.1073/pnas.1212780110. Epub 2012 Dec 24.
2013
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| 11 | PKM
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| PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.
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| Israelsen WJ, Dayton TL, Davidson SM, Fiske BP, Hosios AM, Bellinger G, Li J, Yu Y, Sasaki M, Horner JW, Burga LN, Xie J, Jurczak MJ, DePinho RA, Clish CB, Jacks T, Kibbey RG, Wulf GM, Di Vizio D, Mills GB, Cantley LC, Vander Heiden MG.
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| Cell 155(2):397-409. doi: 10.1016/j.cell.2013.09.025.
2013
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| 12 | PKM
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| ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect.
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| Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, Lyssiotis CA, Aldape K, Cantley LC, Lu Z.
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| Nat Cell Biol 14(12):1295-304. doi: 10.1038/ncb2629. Epub 2012 Nov 25. Erratum in: Nat Cell Biol. 2013 Jan;15(1):124.
2012
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| 13 | PKM
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| Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides.
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| Wang Z, Jeon HY, Rigo F, Bennett CF, Krainer AR.
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| Open Biol 2(10):120133. doi: 10.1098/rsob.120133.
2012
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| 14 | PKM
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| Serine is a natural ligand and allosteric activator of pyruvate kinase M2.
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| Chaneton B, Hillmann P, Zheng L, Martin AC, Maddocks OD, Chokkathukalam A, Coyle JE, Jankevics A, Holding FP, Vousden KH, Frezza C, O'Reilly M, Gottlieb E.
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| Nature 491(7424):458-62. doi: 10.1038/nature11540. Epub 2012 Oct 14. Erratum in: Nature. 2013 Apr 18;496(7445):386.
2012
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| 15 | PKM
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| PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis.
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| Yang W, Xia Y, Hawke D, Li X, Liang J, Xing D, Aldape K, Hunter T, Alfred Yung WK, Lu Z.
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| Cell 150(4):685-96. doi: 10.1016/j.cell.2012.07.018.
2012
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| 16 | PKM
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| Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase.
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| Gao X, Wang H, Yang JJ, Liu X, Liu ZR.
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| Mol Cell 45(5):598-609. doi: 10.1016/j.molcel.2012.01.001. Epub 2012 Feb 2.
2012
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| 17 | PKM
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| Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons.
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| Wang Z, Chatterjee D, Jeon HY, Akerman M, Vander Heiden MG, Cantley LC, Krainer AR.
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| J Mol Cell Biol 4(2):79-87. doi: 10.1093/jmcb/mjr030. Epub 2011 Nov 1.
2012
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| 18 | PKM
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| SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions.
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| Keller KE, Tan IS, Lee YS.
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| Science 338(6110):1069-72. doi: 10.1126/science.1224409. Epub 2012 Oct 18.
2012
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| 19 | PKM
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| Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation.
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| Yang W, Xia Y, Ji H, Zheng Y, Liang J, Huang W, Gao X, Aldape K, Lu Z.
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| Nature 480(7375):118-22. doi: 10.1038/nature10598.
2011
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| 20 | PKM
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| Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.
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| Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, Cole RN, Pandey A, Semenza GL.
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| Cell 145(5):732-44. doi: 10.1016/j.cell.2011.03.054.
2011
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| 21 | PKM, PRL
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| Prolactin inhibits activity of pyruvate kinase M2 to stimulate cell proliferation.
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| Varghese B, Swaminathan G, Plotnikov A, Tzimas C, Yang N, Rui H, Fuchs SY.
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| Mol Endocrinol 24(12):2356-65. Epub 2010 Oct 20. 2010
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| 22 | HNRNPA1, HNRNPA2B1, PKM, PTBP1
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| HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.
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| David CJ, Chen M, Assanah M, Canoll P, Manley JL.
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| Nature 463(7279):364-8. Epub 2009 Dec 13.PMID: 20010808 2010
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| 23 | PKM
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| Dominant negative mutations affect oligomerisation of human pyruvate kinase M2 isozyme and promote cellular growth and polyploidy.
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| Gupta V, Kalaiarasan P, Faheem M, Singh N, Iqbal A, Bamezai RN.
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| J Biol Chem Biol Chem. 2010 Mar 19. [Epub ahead of print]PMID: 20304929 2010
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| 24 | PKM
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| Identification of small molecule inhibitors of pyruvate kinase M2.
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| Vander Heiden MG, Christofk HR, Schuman E, Subtelny AO, Sharfi H, Harlow EE, Xian J, Cantley LC.
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| Biochem Pharmacol 79(8):1118-24. Epub 2009 Dec 11.PMID: 20005212 2010
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| 25 | HNRNPA1, HNRNPA2B1, PKM, PKM1, PTBP1
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| The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism.
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| Clower CV, Chatterjee D, Wang Z, Cantley LC, Vander Heiden MG, Krainer AR.
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| Proc Natl Acad Sci U S A 107(5):1894-9. Epub 2010 Jan 19.PMID: 20133837 2010
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| 26 | PKM
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| Human pyruvate kinase M2: a multifunctional protein.
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| Gupta V, Bamezai RN.
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| Protein Sci 19(11):2031-44. doi: 10.1002/pro.505. Review.
2010
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| 27 | PKM
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| Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.
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| Hitosugi T, Kang S, Vander Heiden MG, Chung TW, Elf S, Lythgoe K, Dong S, Lonial S, Wang X, Chen GZ, Xie J, Gu TL, Polakiewicz RD, Roesel JL, Boggon TJ, Khuri FR, Gilliland DG, Cantley LC, Kaufman J, Chen J.
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| Sci Signal 2(97):ra73.PMID: 19920251 2009
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| 28 | PKM
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| Pyruvate kinase M2 is a phosphotyrosine-binding protein.
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| Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC.
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| Nature 452(7184):181-6. 2008
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| 29 | PKM
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| New roles for pyruvate kinase M2: working out the Warburg effect.
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| Ferguson EC, Rathmell JC.
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| Trends Biochem Sci 33(8):359-62. Epub 2008 Jul 4.PMID: 18603432 2008
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| 30 | PKM
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| Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis.
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| Dombrauckas JD, Santarsiero BD, Mesecar AD.
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| Biochemistry 44(27):9417-29. 2005
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| 31 | PKM
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| Dominant negative effect of novel mutations in pyruvate kinase-M2.
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| Anitha M, Kaur G, Baquer NZ, Bamezai R.
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| DNA Cell Biol 23(7):442-9. 2004
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| 32 | PKM
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| Isolation and characterization of the human pyruvate kinase M gene.
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| Takenaka M, Noguchi T, Sadahiro S, Hirai H, Yamada K, Matsuda T, Imai E, Tanaka T.
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| Eur J Biochem 198(1):101-6. 1991
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| 33 | PKM
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| Chromosomal localization of the gene for a human cytosolic thyroid hormone binding protein homologous to the subunit of pyruvate kinase, subtype M2.
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| Popescu NC, et al.
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| Somat Cell Mol Genet 16 : 593-598. 1990
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| 34 | PKM
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| Human M2-type pyruvate kinase : cDNA cloning, chromosomal assignment and expression in hepatoma.
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| Tani K, et al.
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| Gene 73 : 509-516. 1988
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| 35 | PKM
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| The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing.
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| Noguchi T, et al.
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| J Biol Chem 261 : 13807-13812. 1986
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| 36 | IDH2, MAN2C1, MPI, PKM
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| Assignment of cytoplasmic alpha-mannosidase (MANN-A) and confirmation of mitochondrial isocitrate dehydrogenase (IDH-M) to the q11-qter region of chromosome 15 in man.
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| Champion MJ, et al.
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| Cytogenet Cell Genet 22 : 498-502. 1978
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| 37 | B2M, HEXA, MPI, PKM
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| Assignment of the structural genes for the alpha subunit of hexosaminidase A, mannosephosphate isomerase and pyruvate kinase to the region q22-qter of human chromosome 15.
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| Chern CJ, et al.
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| Somatic Cell Genet 3 : 553-560. 1977
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| 38 | ESD, MDH2, MPI, PKM
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| Chromosome assignment of some human enzyme loci: mitochondrial malate dehydrogenase to 7, mannosephosphate isomerase and pyruvate kinase to 15 and probably, esterase D to 13.
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| Van Heyningen V, et al.
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| Ann Hum Genet 38 : 295-303. 1975
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| 39 | MPI, PKM
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| Confirmation of the synteny of the human genes for mannose phosphate isomerase and pyruvate kinase and their assignment to chromosome 15.
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| Chern CJ, et al.
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| Cytogenet Cell Genet 15 : 299-305. 1975
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