| 1 | MYC, PIM2, USP27X
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| Phosphorylation of USP27X by PIM2 promotes glycolysis and breast cancer progression via deubiquitylation of MYC.
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| Han X, Ren C, Lu C, Jiang A, Wang X, Liu L, Yu Z.
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| Oncogene. Aug;43(33):2493-2503. doi: 10.1038/s41388-024-03097-y. Epub 2024 Jul 5. 2024
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| 2 | PIM1, PIM2, PIM3
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| The PIM family of serine/threonine kinases in cancer.
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| Narlik-Grassow M, Blanco-Aparicio C, Carnero A.
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| Med Res Rev 34(1):136-59. doi: 10.1002/med.21284. Epub 2013 Apr 10. Review.
2014
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| 3 | EIF4B, PIM2
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| The over-expression of Pim-2 promote the tumorigenesis of prostatic carcinoma through phosphorylating eIF4B.
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| Ren K, Gou X, Xiao M, Wang M, Liu C, Tang Z, He W.
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| Prostate 73(13):1462-9. doi: 10.1002/pros.22693. Epub 2013 Jun 27.
2013
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| 4 | PIM2
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| Activation of cell cycle arrest and apoptosis by the proto-oncogene Pim-2.
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| Levy D, Davidovich A, Zirkin S, Frug Y, Cohen AM, Shalom S, Don J.
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| PLoS One 7(4):e34736. doi: 10.1371/journal.pone.0034736. Epub 2012 Apr 10.
2012
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| 5 | PIM2
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| PIM2 inhibition as a rational therapeutic approach in B-cell lymphoma.
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| Gómez-Abad C, Pisonero H, Blanco-Aparicio C, Roncador G, González-Menchén A, Martinez-Climent JA, Mata E, Rodríguez ME, Muñoz-González G, Sánchez-Beato M, Leal JF, Bischoff JR, Piris MA.
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| Blood 118(20):5517-27. doi: 10.1182/blood-2011-03-344374. Epub 2011 Sep 21.
2011
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| 6 | PIM2
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| The serine/threonine kinase Pim-2 is a novel anti-apoptotic mediator in myeloma cells.
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| Asano J, Nakano A, Oda A, Amou H, Hiasa M, Takeuchi K, Miki H, Nakamura S, Harada T, Fujii S, Kagawa K, Endo I, Yata K, Sakai A, Ozaki S, Matsumoto T, Abe M.
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| Leukemia 25(7):1182-8. doi: 10.1038/leu.2011.60. Epub 2011 Apr 8.
2011
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| 7 | CDKN1A, PIM2
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| Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells.
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| Wang Z, Zhang Y, Gu JJ, Davitt C, Reeves R, Magnuson NS.
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| Int J Biochem Cell Biol 42(6):1030-8. doi: 10.1016/j.biocel.2010.03.012. Epub 2010 Mar 20.
2010
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| 8 | PIM2
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| Serine/threonine kinase Pim-2 promotes liver tumorigenesis induction through mediating survival and preventing apoptosis of liver cell.
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| Gong J, Wang J, Ren K, Liu C, Li B, Shi Y.
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| J Surg Res 153(1):17-22. doi: 10.1016/j.jss.2008.03.033. Epub 2008 Apr 22.
2009
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| 9 | PIM1, PIM2, PIM3
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| Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels.
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| Morishita D, Katayama R, Sekimizu K, Tsuruo T, Fujita N.
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| Cancer Res 68(13):5076-85. doi: 10.1158/0008-5472.CAN-08-0634.
2008
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| 10 | PIM1, PIM2
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| Pim-1 and Pim-2 kinases are required for efficient pre-B-cell transformation by v-Abl oncogene.
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| Chen JL, Limnander A, Rothman PB.
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| Blood 111(3):1677-85. Epub 2007 Nov 27.
2008
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| 11 | PIM2
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| PIM-2 is an independent regulator of chondrocyte survival and autophagy in the epiphyseal growth plate.
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| Bohensky J, Shapiro IM, Leshinsky S, Watanabe H, Srinivas V.
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| J Cell Physiol 213(1):246-51.
2007
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| 12 | PIM1,PIM2,PIM3
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| Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL.
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| Macdonald A, Campbell DG, Toth R, McLauchlan H, Hastie CJ, Arthur JS.
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| BMC Cell Biol 7:1. 2006
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| 13 | PIM1,PIM2,PIM3
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| Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors.
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| Mikkers H, Nawijn M, Allen J, Brouwers C, Verhoeven E, Jonkers J, Berns A.
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| Mol Cell Biol 24(13):6104-15. 2004
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| 14 | BAD, PIM2
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| The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death.
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| Yan B, Zemskova M, Holder S, Chin V, Kraft A, Koskinen PJ, Lilly M.
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| J Biol Chem 278(46):45358-67. Epub 2003 Sep 03. 2003
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| 15 | PIM1, PIM2, SOCS1
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| Pim serine/threonine kinases regulate the stability of Socs-1 protein.
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| Chen XP, Losman JA, Cowan S, Donahue E, Fay S, Vuong BQ, Nawijn MC, Capece D, Cohan VL, Rothman P.
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| Proc Natl Acad Sci U S A 99(4):2175-80. 2002
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| 16 | PIM2
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| The human Pim-2 proto-oncogene and its testicular expression.
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| Baytel D, et al.
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| Biochim Biophys Acta 1442(2-3):274-85 1998
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