Citations for
1APP, PIKFYVE
The amyloid precursor protein (APP) binds the PIKfyve complex and modulates its function.
Currinn H, Wassmer T.
Biochem Soc Trans 44(1):185-90. doi: 10.1042/BST20150179. Review. 2016
2APP, PIKFYVE
APP controls the formation of PI(3,5)P(2) vesicles through its binding of the PIKfyve complex.
Currinn H, Guscott B, Balklava Z, Rothnie A, Wassmer T.
Cell Mol Life Sci 73(2):393-408. doi: 10.1007/s00018-015-1993-0. Epub 2015 Jul 28. 2016
3APP, PIKFYVE
The Amyloid Precursor Protein Controls PIKfyve Function.
Balklava Z, Niehage C, Currinn H, Mellor L, Guscott B, Poulin G, Hoflack B, Wassmer T.
PLoS One 10(6):e0130485. doi: 10.1371/journal.pone.0130485. eCollection 2015. 2015
4FIG4, PIKFYVE, VAC14
The Vac14-interaction network is linked to regulators of the endolysosomal and autophagic pathway.
Schulze U, Vollenbröker B, Braun DA, Van Le T, Granado D, Kremerskothen J, Fränzel B, Klosowski R, Barth J, Fufezan C, Wolters DA, Pavenstädt H, Weide T.
Mol Cell Proteomics 13(6):1397-411. doi: 10.1074/mcp.M113.034108. Epub 2014 Feb 27. 2014
5PIKFYVE, VAC14
Vac14 protein multimerization is a prerequisite step for Fab1 protein complex assembly and function.
Alghamdi TA, Ho CY, Mrakovic A, Taylor D, Mao D, Botelho RJ.
J Biol Chem 288(13):9363-72. doi: 10.1074/jbc.M113.453712. Epub 2013 Feb 6. 2013
6PIKFYVE
Inhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell death.
Martin S, Harper CB, May LM, Coulson EJ, Meunier FA, Osborne SL.
PLoS One 8(3):e60152. doi: 10.1371/journal.pone.0060152. Epub 2013 Mar 27. 2013
7PIKFYVE
Muscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity and hyperinsulinemia but not muscle fiber-type switching.
Ikonomov OC, Sbrissa D, Delvecchio K, Feng HZ, Cartee GD, Jin JP, Shisheva A.
Am J Physiol Endocrinol Metab m J Physiol Endocrinol Metab. 2013 May 14. [Epub ahead of print] 2013
8AKT1, PIKFYVE
AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve.
Er EE, Mendoza MC, Mackey AM, Rameh LE, Blenis J.
Sci Signal 6(279):ra45. doi: 10.1126/scisignal.2004015. 2013
9PIKFYVE, PTEN
Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics.
Hazeki K, Nigorikawa K, Takaba Y, Segawa T, Nukuda A, Masuda A, Ishikawa Y, Kubota K, Takasuga S, Hazeki O.
FEBS Lett 586(22):4010-5. doi: 10.1016/j.febslet.2012.09.043. Epub 2012 Oct 12. 2012
10PIKFYVE, VAC14
In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.
Zolov SN, Bridges D, Zhang Y, Lee WW, Riehle E, Verma R, Lenk GM, Converso-Baran K, Weide T, Albin RL, Saltiel AR, Meisler MH, Russell MW, Weisman LS.
Proc Natl Acad Sci U S A 109(43):17472-7. doi: 10.1073/pnas.1203106109. Epub 2012 Oct 9. 2012
11CFD, PIKFYVE
A novel PIKFYVE mutation in fleck corneal dystrophy.
Kotoulas A, Kokotas H, Kopsidas K, Droutsas K, Grigoriadou M, Bajrami H, Schorderet DF, Petersen MB.
Mol Vis 17:2776-81. Epub 2011 Oct 25. 2011
12PIKFYVE
The nucleophosmin-anaplastic lymphoma kinase oncogene interacts, activates, and uses the kinase PIKfyve to increase invasiveness.
Dupuis-Coronas S, Lagarrigue F, Ramel D, Chicanne G, Saland E, Gaits-Iacovoni F, Payrastre B, Tronchère H.
J Biol Chem 286(37):32105-14. doi: 10.1074/jbc.M111.227512. Epub 2011 Jul 7. 2011
13PIKFYVE
Regulation of PIKfyve phosphorylation by insulin and osmotic stress.
Hill EV, Hudson CA, Vertommen D, Rider MH, Tavaré JM.
Biochem Biophys Res Commun 397(4):650-5. doi: 10.1016/j.bbrc.2010.05.134. Epub 2010 Jun 1. 2010
14PIKFYVE, SLC1A4
Regulation of the glutamate transporter EAAT4 by PIKfyve.
Alesutan IS, Ureche ON, Laufer J, Klaus F, Zürn A, Lindner R, Strutz-Seebohm N, Tavaré JM, Boehmer C, Palmada M, Lang UE, Seebohm G, Lang F.
Cell Physiol Biochem 25(2-3):187-94. doi: 10.1159/000276569. Epub 2010 Jan 12. 2010
15FIG4, PIKFYVE, VAC14
PIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasis.
Ikonomov OC, Sbrissa D, Fenner H, Shisheva A.
J Biol Chem 284(51):35794-806. Epub .PMID: 19840946 2009
16PIKFYVE, SLC1A2
Regulation of the glutamate transporter EAAT2 by PIKfyve.
Gehring EM, Zurn A, Klaus F, Laufer J, Sopjani M, Lindner R, Strutz-Seebohm N, Tavaré JM, Boehmer C, Palmada M, Lang UE, Seebohm G, Lang F.
Cell Physiol Biochem 24(5-6):361-8. doi: 10.1159/000257428. Epub 2009 Nov 4. 2009
17FIG4, PIKFYVE, VAC14
VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse.
Jin N, Chow CY, Liu L, Zolov SN, Bronson R, Davisson M, Petersen JL, Zhang Y, Park S, Duex JE, Goldowitz D, Meisler MH, Weisman LS.
EMBO J 27(24):3221-34. Epub 2008 Nov 27.PMID: 19037259 2008
18PIKFYVE, VAC14
Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice.
Zhang Y, Zolov SN, Chow CY, Slutsky SG, Richardson SC, Piper RC, Yang B, Nau JJ, Westrick RJ, Morrison SJ, Meisler MH, Weisman LS.
Proc Natl Acad Sci U S A 104(44):17518-23. Epub 2007 Oct 23. 2007
19CFD, PIKFYVE
Mutations in PIP5K3 Are Associated with Francois-Neetens Mouchetee Fleck Corneal Dystrophy.
Li S, Tiab L, Jiao X, Munier FL, Zografos L, Frueh BE, Sergeev Y, Smith J, Rubin B, Meallet MA, Forster RK, Hejtmancik JF, Schorderet DF.
Am J Hum Genet 77(1):54-63. Epub 2005 May 18. 2005
20PIKFYVE, RABEPK
Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40.
Ikonomov OC, Sbrissa D, Mlak K, Deeb R, Fligger J, Soans A, Finley RL Jr, Shisheva A.
J Biol Chem 278(51):50863-71. Epub 2003 Oct 6. 2003