1 | APP, PIKFYVE
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| The amyloid precursor protein (APP) binds the PIKfyve complex and modulates its function.
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| Currinn H, Wassmer T.
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| Biochem Soc Trans 44(1):185-90. doi: 10.1042/BST20150179. Review. 2016
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2 | APP, PIKFYVE
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| APP controls the formation of PI(3,5)P(2) vesicles through its binding of the PIKfyve complex.
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| Currinn H, Guscott B, Balklava Z, Rothnie A, Wassmer T.
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| Cell Mol Life Sci 73(2):393-408. doi: 10.1007/s00018-015-1993-0. Epub 2015 Jul 28. 2016
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3 | APP, PIKFYVE
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| The Amyloid Precursor Protein Controls PIKfyve Function.
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| Balklava Z, Niehage C, Currinn H, Mellor L, Guscott B, Poulin G, Hoflack B, Wassmer T.
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| PLoS One 10(6):e0130485. doi: 10.1371/journal.pone.0130485. eCollection 2015. 2015
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4 | FIG4, PIKFYVE, VAC14
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| The Vac14-interaction network is linked to regulators of the endolysosomal and autophagic pathway.
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| Schulze U, Vollenbröker B, Braun DA, Van Le T, Granado D, Kremerskothen J, Fränzel B, Klosowski R, Barth J, Fufezan C, Wolters DA, Pavenstädt H, Weide T.
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| Mol Cell Proteomics 13(6):1397-411. doi: 10.1074/mcp.M113.034108. Epub 2014 Feb 27.
2014
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5 | PIKFYVE, VAC14
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| Vac14 protein multimerization is a prerequisite step for Fab1 protein complex assembly and function.
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| Alghamdi TA, Ho CY, Mrakovic A, Taylor D, Mao D, Botelho RJ.
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| J Biol Chem 288(13):9363-72. doi: 10.1074/jbc.M113.453712. Epub 2013 Feb 6.
2013
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6 | PIKFYVE
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| Inhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell death.
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| Martin S, Harper CB, May LM, Coulson EJ, Meunier FA, Osborne SL.
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| PLoS One 8(3):e60152. doi: 10.1371/journal.pone.0060152. Epub 2013 Mar 27.
2013
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7 | PIKFYVE
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| Muscle-specific Pikfyve gene disruption causes glucose intolerance, insulin resistance, adiposity and hyperinsulinemia but not muscle fiber-type switching.
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| Ikonomov OC, Sbrissa D, Delvecchio K, Feng HZ, Cartee GD, Jin JP, Shisheva A.
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| Am J Physiol Endocrinol Metab m J Physiol Endocrinol Metab. 2013 May 14. [Epub ahead of print]
2013
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8 | AKT1, PIKFYVE
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| AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve.
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| Er EE, Mendoza MC, Mackey AM, Rameh LE, Blenis J.
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| Sci Signal 6(279):ra45. doi: 10.1126/scisignal.2004015.
2013
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9 | PIKFYVE, PTEN
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| Essential roles of PIKfyve and PTEN on phagosomal phosphatidylinositol 3-phosphate dynamics.
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| Hazeki K, Nigorikawa K, Takaba Y, Segawa T, Nukuda A, Masuda A, Ishikawa Y, Kubota K, Takasuga S, Hazeki O.
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| FEBS Lett 586(22):4010-5. doi: 10.1016/j.febslet.2012.09.043. Epub 2012 Oct 12.
2012
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10 | PIKFYVE, VAC14
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| In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.
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| Zolov SN, Bridges D, Zhang Y, Lee WW, Riehle E, Verma R, Lenk GM, Converso-Baran K, Weide T, Albin RL, Saltiel AR, Meisler MH, Russell MW, Weisman LS.
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| Proc Natl Acad Sci U S A 109(43):17472-7. doi: 10.1073/pnas.1203106109. Epub 2012 Oct 9.
2012
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11 | CFD, PIKFYVE
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| A novel PIKFYVE mutation in fleck corneal dystrophy.
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| Kotoulas A, Kokotas H, Kopsidas K, Droutsas K, Grigoriadou M, Bajrami H, Schorderet DF, Petersen MB.
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| Mol Vis 17:2776-81. Epub 2011 Oct 25.
2011
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12 | PIKFYVE
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| The nucleophosmin-anaplastic lymphoma kinase oncogene interacts, activates, and uses the kinase PIKfyve to increase invasiveness.
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| Dupuis-Coronas S, Lagarrigue F, Ramel D, Chicanne G, Saland E, Gaits-Iacovoni F, Payrastre B, Tronchère H.
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| J Biol Chem 286(37):32105-14. doi: 10.1074/jbc.M111.227512. Epub 2011 Jul 7.
2011
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13 | PIKFYVE
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| Regulation of PIKfyve phosphorylation by insulin and osmotic stress.
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| Hill EV, Hudson CA, Vertommen D, Rider MH, Tavaré JM.
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| Biochem Biophys Res Commun 397(4):650-5. doi: 10.1016/j.bbrc.2010.05.134. Epub 2010 Jun 1.
2010
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14 | PIKFYVE, SLC1A4
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| Regulation of the glutamate transporter EAAT4 by PIKfyve.
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| Alesutan IS, Ureche ON, Laufer J, Klaus F, Zürn A, Lindner R, Strutz-Seebohm N, Tavaré JM, Boehmer C, Palmada M, Lang UE, Seebohm G, Lang F.
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| Cell Physiol Biochem 25(2-3):187-94. doi: 10.1159/000276569. Epub 2010 Jan 12.
2010
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15 | FIG4, PIKFYVE, VAC14
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| PIKfyve-ArPIKfyve-Sac3 core complex: contact sites and their consequence for Sac3 phosphatase activity and endocytic membrane homeostasis.
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| Ikonomov OC, Sbrissa D, Fenner H, Shisheva A.
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| J Biol Chem 284(51):35794-806. Epub .PMID: 19840946 2009
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16 | PIKFYVE, SLC1A2
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| Regulation of the glutamate transporter EAAT2 by PIKfyve.
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| Gehring EM, Zurn A, Klaus F, Laufer J, Sopjani M, Lindner R, Strutz-Seebohm N, Tavaré JM, Boehmer C, Palmada M, Lang UE, Seebohm G, Lang F.
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| Cell Physiol Biochem 24(5-6):361-8. doi: 10.1159/000257428. Epub 2009 Nov 4.
2009
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17 | FIG4, PIKFYVE, VAC14
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| VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse.
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| Jin N, Chow CY, Liu L, Zolov SN, Bronson R, Davisson M, Petersen JL, Zhang Y, Park S, Duex JE, Goldowitz D, Meisler MH, Weisman LS.
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| EMBO J 27(24):3221-34. Epub 2008 Nov 27.PMID: 19037259 2008
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18 | PIKFYVE, VAC14
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| Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice.
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| Zhang Y, Zolov SN, Chow CY, Slutsky SG, Richardson SC, Piper RC, Yang B, Nau JJ, Westrick RJ, Morrison SJ, Meisler MH, Weisman LS.
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| Proc Natl Acad Sci U S A 104(44):17518-23. Epub 2007 Oct 23. 2007
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19 | CFD, PIKFYVE
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| Mutations in PIP5K3 Are Associated with Francois-Neetens Mouchetee Fleck Corneal Dystrophy.
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| Li S, Tiab L, Jiao X, Munier FL, Zografos L, Frueh BE, Sergeev Y, Smith J, Rubin B, Meallet MA, Forster RK, Hejtmancik JF, Schorderet DF.
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| Am J Hum Genet 77(1):54-63. Epub 2005 May 18. 2005
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20 | PIKFYVE, RABEPK
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| Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40.
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| Ikonomov OC, Sbrissa D, Mlak K, Deeb R, Fligger J, Soans A, Finley RL Jr, Shisheva A.
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| J Biol Chem 278(51):50863-71. Epub 2003 Oct 6. 2003
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