1 | IMD14, PIK3CD
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| Early diagnosis of PI3Kδ syndrome in a 2 years old girl with recurrent otitis and enlarged spleen.
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| Saettini F, Pelagatti MA, Sala D, Moratto D, Giliani S, Badolato R, Biondi A.
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| Immunol Lett mmunol Lett. 2017 Aug 22. pii: S0165-2478(17)30282-1. doi: 10.1016/j.imlet.2017.08.021. [Epub ahead of print]
2017
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2 | IMD14, PIK3CD
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| Novel PIK3CD mutations affecting N-terminal residues of p110δ cause activated PI3Kδ syndrome (APDS) in humans.
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| Takeda AJ, Zhang Y, Dornan GL, Siempelkamp BD, Jenkins ML, Matthews HF, McElwee JJ, Bi W, Seeborg FO, Su HC, Burke JE, Lucas CL.
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| J Allergy Clin Immunol Allergy Clin Immunol. 2017 Apr 13. pii: S0091-6749(17)30587-0. doi: 10.1016/j.jaci.2017.03.026. [Epub ahead of print] No abstrac 2017
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3 | AICDA, PIK3CD
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| Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells.
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| Compagno M, Wang Q, Pighi C, Cheong TC, Meng FL, Poggio T, Yeap LS, Karaca E, Blasco RB, Langellotto F, Ambrogio C, Voena C, Wiestner A, Kasar SN, Brown JR, Sun J, Wu CJ, Gostissa M, Alt FW, Chiarle R.
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| Nature 542(7642):489-493. doi: 10.1038/nature21406. Epub 2017 Feb 15.
2017
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4 | IMD14, PIK3CD
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| Genetic defects in PI3Kδ affect B-cell differentiation and maturation leading to hypogammaglobulineamia and recurrent infections.
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| Wentink M, Dalm V, Lankester AC, van Schouwenburg PA, Schölvinck L, Kalina T, Zachova R, Sediva A, Lambeck A, Pico-Knijnenburg I, van Dongen JJ, Pac M, Bernatowska E, van Hagen M, Driessen G, van der Burg M.
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| Clin Immunol 176:77-86. doi: 10.1016/j.clim.2017.01.004. Epub 2017 Jan 17.
2017
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5 | PIK3CD
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| PIK3CD promoted proliferation in diffuse large B cell lymphoma through upregulation of c-myc.
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| Cui W, Zheng S, Li X, Ma Y, Sang W, Liu M, Zhang W, Zhou X.
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| Tumour Biol 37(9):12767-12777. Epub 2016 Jul 22.
2016
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6 | PIK3CD
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| The Role of p110δ in the Development and Activation of B Lymphocytes.
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| Newman R, Turner M.
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| Adv Exp Med Biol 850:119-35. doi: 10.1007/978-3-319-15774-0_9. Review.
2015
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7 | IMD14, PIK3CD
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| Gain of Function Mutations of PIK3CD as a Cause of Primary Sclerosing Cholangitis.
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| Hartman HN, Niemela J, Hintermeyer MK, Garofalo M, Stoddard J, Verbsky JW, Rosenzweig SD, Routes JM.
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| J Clin Immunol 35(1):11-4. doi: 10.1007/s10875-014-0109-1. Epub 2014 Oct 29.
2015
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8 | IMD14, PIK3CD
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| Mutations in PIK3CD can cause hyper IgM syndrome (HIGM) associated with increased cancer susceptibility.
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| Crank MC, Grossman JK, Moir S, Pittaluga S, Buckner CM, Kardava L, Agharahimi A, Meuwissen H, Stoddard J, Niemela J, Kuehn H, Rosenzweig SD.
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| J Clin Immunol 34(3):272-6. doi: 10.1007/s10875-014-0012-9. Epub 2014 Mar 8.
2014
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9 | IMD14, PIK3CD
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| Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency.
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| Lucas CL, Kuehn HS, Zhao F, Niemela JE, Deenick EK, Palendira U, Avery DT, Moens L, Cannons JL, Biancalana M, Stoddard J, Ouyang W, Frucht DM, Rao VK, Atkinson TP, Agharahimi A, Hussey AA, Folio LR, Olivier KN, Fleisher TA, Pittaluga S, Holland SM, Cohen JI, Oliveira JB, Tangye SG, Schwartzberg PL, Lenardo MJ, Uzel G.
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| Nat Immunol 15(1):88-97. doi: 10.1038/ni.2771. Epub 2013 Oct 28.
2014
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10 | PIK3CD
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| Phosphoinositide 3-kinase δ regulates migration and invasion of synoviocytes in rheumatoid arthritis.
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| Bartok B, Hammaker D, Firestein GS.
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| J Immunol 192(5):2063-70. doi: 10.4049/jimmunol.1300950. Epub 2014 Jan 27.
2014
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11 | CD274, PIK3CD
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| PI3K-delta mediates double-stranded RNA-induced upregulation of B7-H1 in BEAS-2B airway epithelial cells.
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| Kan-o K, Matsumoto K, Asai-Tajiri Y, Fukuyama S, Hamano S, Seki N, Nakanishi Y, Inoue H.
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| Biochem Biophys Res Commun 435(2):195-201. doi: 10.1016/j.bbrc.2013.04.082. Epub 2013 May 6.
2013
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12 | PIK3CD
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| PI3Kδ is essential for tumor clearance mediated by cytotoxic T lymphocytes.
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| Putz EM, Prchal-Murphy M, Simma OA, Forster F, Koenig X, Stockinger H, Piekorz RP, Freissmuth M, Müller M, Sexl V, Zebedin-Brandl E.
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| PLoS One 7(7):e40852. doi: 10.1371/journal.pone.0040852. Epub 2012 Jul 13.
2012
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13 | PIK3CD
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| PI3 kinase δ is a key regulator of synoviocyte function in rheumatoid arthritis.
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| Bartok B, Boyle DL, Liu Y, Ren P, Ball ST, Bugbee WD, Rommel C, Firestein GS.
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| Am J Pathol 180(5):1906-16. doi: 10.1016/j.ajpath.2012.01.030. Epub 2012 Mar 17.
2012
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14 | PIK3CD
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| Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter.
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| Whitehead MA, Bombardieri M, Pitzalis C, Vanhaesebroeck B.
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| Biochem J 443(3):857-67. doi: 10.1042/BJ20112214.
2012
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15 | CD38, PIK3CD
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| The PI3K p110δ regulates expression of CD38 on regulatory T cells.
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| Patton DT, Wilson MD, Rowan WC, Soond DR, Okkenhaug K.
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| PLoS One 6(3):e17359. doi: 10.1371/journal.pone.0017359.
2011
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16 | PIK3CD
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| Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretion.
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| Low PC, Misaki R, Schroder K, Stanley AC, Sweet MJ, Teasdale RD, Vanhaesebroeck B, Meunier FA, Taguchi T, Stow JL.
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| J Cell Biol 190(6):1053-65. doi: 10.1083/jcb.201001028. Epub 2010 Sep 13.
2010
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17 | PIK3CD
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| PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans.
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| Soond DR, Bjørgo E, Moltu K, Dale VQ, Patton DT, Torgersen KM, Galleway F, Twomey B, Clark J, Gaston JS, Taskén K, Bunyard P, Okkenhaug K.
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| Blood 115(11):2203-13. doi: 10.1182/blood-2009-07-232330. Epub 2010 Jan 15.
2010
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18 | PIK3CD
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| Regulation of p110delta PI 3-kinase gene expression.
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| Kok K, Nock GE, Verrall EA, Mitchell MP, Hommes DW, Peppelenbosch MP, Vanhaesebroeck B.
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| PLoS One 4(4):e5145. doi: 10.1371/journal.pone.0005145. Epub 2009 Apr 9.
2009
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19 | PIK3CD, TNFSF13B
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| B-cell responses to B-cell activation factor of the TNF family (BAFF) are impaired in the absence of PI3K delta.
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| Henley T, Kovesdi D, Turner M.
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| Eur J Immunol 38(12):3543-8. doi: 10.1002/eji.200838618.
2008
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20 | PIK3CD
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| The effect of deleting p110delta on the phenotype and function of PTEN-deficient B cells.
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| Janas ML, Hodson D, Stamataki Z, Hill S, Welch K, Gambardella L, Trotman LC, Pandolfi PP, Vigorito E, Turner M.
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| J Immunol 180(2):739-46.
2008
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21 | PIK3CD
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| The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion.
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| Kim N, Saudemont A, Webb L, Camps M, Ruckle T, Hirsch E, Turner M, Colucci F.
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| Blood 110(9):3202-8. Epub 2007 Jul 20.
2007
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22 | PIK3CD
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| The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN.
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| Papakonstanti EA, Ridley AJ, Vanhaesebroeck B.
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| EMBO J 26(13):3050-61. Epub 2007 Jun 21.
2007
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23 | PIK3CD
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| Identification of variations in the human phosphoinositide 3-kinase p110delta gene in children with primary B-cell immunodeficiency of unknown aetiology.
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| Jou ST, Chien YH, Yang YH, Wang TC, Shyur SD, Chou CC, Chang ML, Lin DT, Lin KH, Chiang BL.
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| Int J Immunogenet 33(5):361-9. 2006
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24 | PIK3CD
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| Essential role for the p110delta isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia.
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| Sujobert P, Bardet V, Cornillet-Lefebvre P, Hayflick JS, Prie N, Verdier F, Vanhaesebroeck B, Muller O, Pesce F, Ifrah N, Hunault-Berger M, Berthou C, Villemagne B, Jourdan E, Audhuy B, Solary E, Witz B, Harousseau JL, Himberlin C, Lamy T, Lioure B, Cahn JY, Dreyfus F, Mayeux P, Lacombe C, Bouscary D.
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| Blood 106(3):1063-6. Epub 2005 Apr 19. 2005
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25 | PIK3CD
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| Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement.
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| Sadhu C, Masinovsky B, Dick K, Sowell CG, Staunton DE.
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| J Immunol 170(5):2647-54. 2003
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26 | PIK3CD
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| Identification and chromosome assignment of a human gene encoding a novel phosphatidylinositol-3 kinase.
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| Seki N, Nimura Y, Ohira M, Saito T, Ichimiya S, Nomura N, Nakagawara A.
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| DNA Res 4(5):355-8. 1997
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27 | PIK3CD
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| P110delta, a novel phosphoinositide 3-kinase in leukocytes.
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| Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD.
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| Proc Natl Acad Sci U S A 94 : 4330-4335. 1997
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