| 1 | EIF4A1, EIF4E, PHGDH
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| Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E.
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| Ma X, Li B, Liu J, Fu Y, Luo Y.
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| J Exp Clin Cancer Res. Feb 11;38(1):66. doi: 10.1186/s13046-019-1053-y. 2019
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| 2 | NELAS, PHGDH
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| Neu-Laxova Syndrome, an Inborn Error of Serine Metabolism, Is Caused by Mutations in PHGDH.
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| Shaheen R, Rahbeeni Z, Alhashem A, Faqeih E, Zhao Q, Xiong Y, Almoisheer A, Al-Qattan SM, Almadani HA, Al-Onazi N, Al-Baqawi BS, Saleh MA, Alkuraya FS.
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| Am J Hum Genet 94(6):898-904. doi: 10.1016/j.ajhg.2014.04.015. Epub 2014 May 15.
2014
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| 3 | NELAS, NELAS2, PHGDH, PSAT1
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| Neu-laxova syndrome is a heterogeneous metabolic disorder caused by defects in enzymes of the L-serine biosynthesis pathway.
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| Acuna-Hidalgo R, Schanze D, Kariminejad A, Nordgren A, Kariminejad MH, Conner P, Grigelioniene G, Nilsson D, Nordenskjöld M, Wedell A, Freyer C, Wredenberg A, Wieczorek D, Gillessen-Kaesbach G, Kayserili H, Elcioglu N, Ghaderi-Sohi S, Goodarzi P, Setayesh H, van de Vorst M, Steehouwer M, Pfundt R, Krabichler B, Curry C, MacKenzie MG, Boycott KM, Gilissen C, Janecke AR, Hoischen A, Zenker M.
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| Am J Hum Genet 95(3):285-93. doi: 10.1016/j.ajhg.2014.07.012. Epub 2014 Aug 21.
2014
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| 4 | PHGDH
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| L-serine deficiency caused by genetic Phgdh deletion leads to robust induction of 4E-BP1 and subsequent repression of translation initiation in the developing central nervous system.
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| Sayano T, Kawakami Y, Kusada W, Suzuki T, Kawano Y, Watanabe A, Takashima K, Arimoto Y, Esaki K, Wada A, Yoshizawa F, Watanabe M, Okamoto M, Hirabayashi Y, Furuya S.
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| FEBS J 280(6):1502-17. doi: 10.1111/febs.12146. Epub 2013 Feb 24.
2013
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| 5 | PHGDH, PRKCZ, PSAT1
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| Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis.
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| Ma L, Tao Y, Duran A, Llado V, Galvez A, Barger JF, Castilla EA, Chen J, Yajima T, Porollo A, Medvedovic M, Brill LM, Plas DR, Riedl SJ, Leitges M, Diaz-Meco MT, Richardson AD, Moscat J.
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| Cell 152(3):599-611. doi: 10.1016/j.cell.2012.12.028.
2013
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| 6 | PHGDH
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| PHGDH amplification and altered glucose metabolism in human melanoma.
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| Mullarky E, Mattaini KR, Vander Heiden MG, Cantley LC, Locasale JW.
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| Pigment Cell Melanoma Res 24(6):1112-5. doi: 10.1111/j.1755-148X.2011.00919.x. Epub 2011 Oct 28. Review.
2011
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| 7 | HOXA10, PHGDH
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| 3-Phosphoglycerate dehydrogenase expression is regulated by HOXA10 in murine endometrium and human endometrial cells.
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| Du H, Vitiello D, Sarno JL, Taylor HS.
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| Reproduction 139(1):237-45. Epub .PMID: 19778996 2010
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| 8 | PHGDH, PSAT1, PSATD, PSPH, PSPHD
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| L-serine synthesis in the central nervous system: a review on serine deficiency disorders.
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| Tabatabaie L, Klomp LW, Berger R, de Koning TJ.
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| Mol Genet Metab 99(3):256-62. Epub 2009 Oct 25. Review.PMID: 19963421 2010
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| 9 | PHGDH, SRR
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| Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain.
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| Yang JH, Wada A, Yoshida K, Miyoshi Y, Sayano T, Esaki K, Kinoshita MO, Tomonaga S, Azuma N, Watanabe M, Hamase K, Zaitsu K, Machida T, Messing A, Itohara S, Hirabayashi Y, Furuya S.
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| J Biol Chem 285(53):41380-90. Epub 2010 Oct 21.
2010
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| 10 | PHGDH
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| Novel mutations in 3-phosphoglycerate dehydrogenase (PHGDH) are distributed throughout the protein and result in altered enzyme kinetics.
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| Tabatabaie L, de Koning TJ, Geboers AJ, van den Berg IE, Berger R, Klomp LW.
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| Hum Mutat 30(5):749-56.PMID: 19235232 2009
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| 11 | PHGDH
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| Selective upregulation of 3-phosphoglycerate dehydrogenase (Phgdh) expression in adult subventricular zone neurogenic niche.
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| Kinoshita MO, Shinoda Y, Sakai K, Hashikawa T, Watanabe M, Machida T, Hirabayashi Y, Furuya S.
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| Neurosci Lett 453(1):21-6. Epub 2009 Feb 7.PMID: 19429008 2009
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| 12 | PHGDH
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| Impaired neurogenesis in embryonic spinal cord of Phgdh knockout mice, a serine deficiency disorder model.
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| Kawakami Y, Yoshida K, Yang JH, Suzuki T, Azuma N, Sakai K, Hashikawa T, Watanabe M, Yasuda K, Kuhara S, Hirabayashi Y, Furuya S.
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| Neurosci Res 63(3):184-93. Epub 2008 Dec 11.PMID: 19114063 2009
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| 13 | PHGDH
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| Positive regulation of promoter activity of human 3-phosphoglycerate dehydrogenase (PHGDH) gene is mediated by transcription factors Sp1 and NF-Y.
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| Jun DY, Park HS, Lee JY, Baek JY, Park HK, Fukui K, Kim YH.
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| Gene 414(1-2):106-14. Epub 2008 Mar 4. 2008
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| 14 | PHGDH
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| Functional analysis of mouse 3-phosphoglycerate dehydrogenase (Phgdh) gene promoter in developing brain.
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| Shimizu M, Furuya S, Shinoda Y, Mitoma J, Okamura T, Miyoshi I, Kasai N, Hirabayashi Y, Suzuki Y.
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| J Neurosci Res 76(5):623-32.PMID: 15139021 2004
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| 15 | PHGDH
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| Congenital microcephaly and seizures due to 3-phosphoglycerate dehydrogenase deficiency: outcome of treatment with amino acids.
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| De Koning TJ, Duran M, Van Maldergem L, Pineda M, Dorland L, Gooskens R, Jaeken J, Poll-The BT.
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| J Inherit Metab Dis 25(2):119-25. 2002
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| 16 | CD101, HSD3B1, MAN1A2, PHGDH, TTF2, WARS2
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| Refined localization of twenty-one genes in subregion p13.1 of human chromosome 1.
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| Chelala C, Imbeaud S, Devignes MD, Zoorob R, Auffray C.
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| Cytogenet Cell Genet 92(3-4):209-12. 2001
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| 17 | PHGDH
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| Nucleotide sequence and differential expression of the human 3-phosphoglycerate dehydrogenase gene.
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| Cho HM, Jun DY, Bae MA, Ahn JD, Kim YH.
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| Gene 245(1):193-201. 2000
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| 18 | PHGDH
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| Assignment of human 3-phosphoglycerate dehydrogenase (PHGDH) to human chromosome band 1p12 by fluorescence in situ hybridization.
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| Baek JY, Jun DY, Taub D, Kim YH.
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| Cytogenet Cell Genet 89(1-2):6-7. No abstract available. 2000
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| 19 | PHGDH
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| Molecular characterization of 3-phosphoglycerate dehydrogenase deficiency--a neurometabolic disorder associated with reduced L-serine biosynthesis.
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| Klomp LW, de Koning TJ, Malingre HE, van Beurden EA, Brink M, Opdam FL, Duran M, Jaeken J, Pineda M, van Maldergem L, Poll-The BT, van den Berg IE, Berger R.
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| Am J Hum Genet 67(6):1389-99. 2000
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| 20 | PHGDH
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| 3-Phosphoglycerate dehydrogenase deficiency: an inborn error of serine biosynthesis.
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| Jaeken J, Detheux M, Van Maldergem L, Foulon M, Carchon H, Van Schaftingen E.
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| Arch Dis Child 74(6):542-5. 1996
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