| 1 | KDM3A, PHF8
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| Histone demethylase PHF8 regulates hypoxia signaling through HIF1α and H3K4me3.
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| Maina PK, Shao P, Jia X, Liu Q, Umesalma S, Marin M, Long D Jr, Concepción-Román S, Qi HH.
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| Biochim Biophys Acta 1860(9):1002-1012. doi: 10.1016/j.bbagrm.2017.07.005. Epub 2017 Jul 20.
2017
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| 2 | PHF8
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| Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice.
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| Walsh RM, Shen EY, Bagot RC, Anselmo A, Jiang Y, Javidfar B, Wojtkiewicz GJ, Cloutier J, Chen JW, Sadreyev R, Nestler EJ, Akbarian S, Hochedlinger K.
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| Nat Commun 8:15142. doi: 10.1038/ncomms15142.
2017
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| 3 | PHF8
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| Structure-Based Design of a New Scaffold for Cell-Penetrating Peptidic Inhibitors of the Histone Demethylase PHF8.
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| Dorosz J, Olsen L, Seger ST, Steinhauer C, Bouras G, Helgstrand C, Wiuf A, Gajhede M.
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| Chembiochem 18(14):1369-1375. doi: 10.1002/cbic.201700109. Epub 2017 Jun 13.
2017
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| 4 | PHF8
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| The histone demethylase PHF8 is a molecular safeguard of the IFNγ response.
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| Asensio-Juan E, Fueyo R, Pappa S, Iacobucci S, Badosa C, Lois S, Balada M, Bosch-Presegué L, Vaquero A, Gutiérrez S, Caelles C, Gallego C, de la Cruz X, Martínez-Balbás MA.
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| Nucleic Acids Res 45(7):3800-3811. doi: 10.1093/nar/gkw1346.
2017
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| 5 | PHF8
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| Histone demethylase PHF8 promotes epithelial to mesenchymal transition and breast tumorigenesis.
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| Shao P, Liu Q, Maina PK, Cui J, Bair TB, Li T, Umesalma S, Zhang W, Qi HH.
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| Nucleic Acids Res 45(4):1687-1702. doi: 10.1093/nar/gkw1093.
2017
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| 6 | PHF8
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| Plant Homeo Domain Finger Protein 8 Regulates Mesodermal and Cardiac Differentiation of Embryonic Stem Cells Through Mediating the Histone Demethylation of pmaip1.
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| Tang Y, Hong YZ, Bai HJ, Wu Q, Chen CD, Lang JY, Boheler KR, Yang HT.
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| Stem Cells 34(6):1527-40. doi: 10.1002/stem.2333. Epub 2016 Apr 18.
2016
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| 7 | E2F4, PHF8
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| The Histone Demethylase PHF8 Is Essential for Endothelial Cell Migration.
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| Gu L, Hitzel J, Moll F, Kruse C, Malik RA, Preussner J, Looso M, Leisegang MS, Steinhilber D, Brandes RP, Fork C.
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| PLoS One 11(1):e0146645. doi: 10.1371/journal.pone.0146645. eCollection 2016.
2016
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| 8 | PHF8
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| The histone demethylase PHF8 represses cardiac hypertrophy upon pressure overload.
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| Liu X, Wang X, Bi Y, Bu P, Zhang M.
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| Exp Cell Res 335(1):123-34. doi: 10.1016/j.yexcr.2015.04.012. Epub 2015 Apr 25.
2015
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| 9 | PHF2, PHF8
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| PHD finger protein 2 (PHF2) represses ribosomal RNA gene transcription by antagonizing PHF finger protein 8 (PHF8) and recruiting methyltransferase SUV39H1.
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| Shi G, Wu M, Fang L, Yu F, Cheng S, Li J, Du JX, Wong J.
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| J Biol Chem 289(43):29691-700. doi: 10.1074/jbc.M114.571653. Epub 2014 Sep 9.
2014
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| 10 | PHF8
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| The histone demethylase PHF8 is an oncogenic protein in human non-small cell lung cancer.
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| Shen Y, Pan X, Zhao H.
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| Biochem Biophys Res Commun 451(1):119-25. doi: 10.1016/j.bbrc.2014.07.076. Epub 2014 Jul 24.
2014
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| 11 | PHF8
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| PHF8 and REST/NRSF co-occupy gene promoters to regulate proximal gene expression.
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| Wang J, Lin X, Wang S, Wang C, Wang Q, Duan X, Lu P, Wang Q, Wang C, Liu XS, Huang J.
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| Sci Rep 4:5008. doi: 10.1038/srep05008.
2014
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| 12 | CDC20, PHF8
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| The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20.
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| Lim HJ, Dimova NV, Tan MK, Sigoillot FD, King RW, Shi Y.
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| Mol Cell Biol 33(21):4166-80. doi: 10.1128/MCB.00689-13. Epub 2013 Aug 26.
2013
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| 13 | MRXSSD, PHF8
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| The histone demethylase PHF8 is essential for cytoskeleton dynamics.
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| Asensio-Juan E, Gallego C, Martínez-Balbás MA.
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| Nucleic Acids Res 40(19):9429-40. doi: 10.1093/nar/gks716. Epub 2012 Jul 31.
2012
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| 14 | KDM7A, PHF2, PHF8
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| Plant homeodomain fingers form a helping hand for transcription.
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| Fortschegger K, Shiekhattar R.
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| Epigenetics 6(1). [Epub ahead of print]PMID: 20818169 2011
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| 15 | MRXSSD, PHF8
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| PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase.
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| Loenarz C, Ge W, Coleman ML, Rose NR, Cooper CD, Klose RJ, Ratcliffe PJ, Schofield CJ.
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| Hum Mol Genet 19(2):217-22. Epub 2009 Oct 19.PMID: 19843542 2010
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| 16 | PHF8
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| PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression.
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| Liu W, Tanasa B, Tyurina OV, Zhou TY, Gassmann R, Liu WT, Ohgi KA, Benner C, Garcia-Bassets I, Aggarwal AK, Desai A, Dorrestein PC, Glass CK, Rosenfeld MG.
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| Nature 466(7305):508-12. Epub 2010 Jul 11.PMID: 20622854 2010
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| 17 | MRXSSD, PHF8
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| PHF8 targets histone methylation and RNA polymerase II to activate transcription.
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| Fortschegger K, de Graaf P, Outchkourov NS, van Schaik FM, Timmers HT, Shiekhattar R.
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| Mol Cell Biol 30(13):3286-98. Epub 2010 Apr 26.PMID: 20421419 2010
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| 18 | PHF8
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| Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development.
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| Qi HH, Sarkissian M, Hu GQ, Wang Z, Bhattacharjee A, Gordon DB, Gonzales M, Lan F, Ongusaha PP, Huarte M, Yaghi NK, Lim H, Garcia BA, Brizuela L, Zhao K, Roberts TM, Shi Y.
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| Nature 466(7305):503-7. Epub 2010 Jul 11.PMID: 20622853 2010
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| 19 | PHF8
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| The X-linked mental retardation gene PHF8 is a histone demethylase involved in neuronal differentiation.
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| Qiu J, Shi G, Jia Y, Li J, Wu M, Li J, Dong S, Wong J.
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| Cell Res 20(8):908-18. Epub 2010 Jun 15.PMID: 20548336 2010
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| 20 | PHF8
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| PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis.
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| Zhu Z, Wang Y, Li X, Wang Y, Xu L, Wang X, Sun T, Dong X, Chen L, Mao H, Yu Y, Li J, Chen PA, Chen CD.
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| Cell Res 20(7):794-801. Epub 2010 Jun 8. Erratum in: Cell Res. 2010 Aug;20(8):970. Li, Jingsong [corrected to Li, Jinsong]. PMID: 2053137 2010
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| 21 | PHF8, ZNF711
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| A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation.
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| Kleine-Kohlbrecher D, Christensen J, Vandamme J, Abarrategui I, Bak M, Tommerup N, Shi X, Gozani O, Rappsilber J, Salcini AE, Helin K.
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| Mol Cell 38(2):165-78. doi: 10.1016/j.molcel.2010.03.002. Epub 2010 Mar 25.
2010
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| 22 | PHF8, POLR2A
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| PHF8 targets histone methylation and RNA polymerase II to activate transcription.
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| Fortschegger K, de Graaf P, Outchkourov NS, van Schaik FM, Timmers HT, Shiekhattar R.
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| Mol Cell Biol 30(13):3286-98. doi: 10.1128/MCB.01520-09. Epub 2010 Apr 26.
2010
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| 23 | PHF8, DELXP11
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| Autism-associated familial microdeletion of Xp11.22.
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| Qiao Y, Liu X, Harvard C, Hildebrand MJ, Rajcan-Separovic E, Holden JJ, Lewis ME.
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| Clin Genet lin Genet. 2008 May 21. [Epub ahead of print] 2008
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| 24 | MRXSSD,PHF8
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| A novel mutation in the PHF8 gene is associated with X-linked mental retardation with cleft lip/cleft palate.
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| Abidi FE, Miano MG, Murray JC, Schwartz CE.
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| Clin Genet 72(1):19-22. 2007
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| 25 | PHF8, MRXSSD
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| Screening of mutations in the PHF8 gene and identification of a novel mutation in a Finnish family with XLMR and cleft lip/cleft palate.
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| Koivisto AM, Ala-Mello S, Lemmela S, Komu HA, Rautio J, Jarvela I.
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| Clin Genet 72(2):145-9. 2007
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| 26 | PHF8, MRXSSD
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| Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate.
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| Laumonnier F, Holbert S, Ronce N, Faravelli F, Lenzner S, Schwartz CE, Lespinasse J, Van Esch H, Lacombe D, Goizet C, Phan-Dinh Tuy F, van Bokhoven H, Fryns JP, Chelly J, Ropers HH, Moraine C, Hamel BC, Briault S.
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| J Med Genet 42(10):780-6. 2005
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