| 1 | PBD2, PEX1, PEX26, PEX5, PEX6
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| Allelic Expression Imbalance Promoting a Mutant PEX6 Allele Causes Zellweger Spectrum Disorder.
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| Falkenberg KD, Braverman NE, Moser AB, Steinberg SJ, Klouwer FCC, Schlüter A, Ruiz M, Pujol A, Engvall M, Naess K, van Spronsen F, Körver-Keularts I, Rubio-Gozalbo ME, Ferdinandusse S, Wanders RJA, Waterham HR.
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| Am J Hum Genet 101(6):965-976. doi: 10.1016/j.ajhg.2017.11.007.
2017
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| 2 | PEX5
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| PEX5 and Ubiquitin Dynamics on Mammalian Peroxisome Membranes.
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| Brown AI, Kim PK, Rutenberg AD.
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| PLoS Comput Biol 10(1):e1003426. doi: 10.1371/journal.pcbi.1003426. Epub 2014 Jan 16.
2014
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| 3 | PEX14, PEX5
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| A Novel Pex14 Protein-interacting Site of Human Pex5 Is Critical for Matrix Protein Import into Peroxisomes.
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| Neuhaus A, Kooshapur H, Wolf J, Meyer NH, Madl T, Saidowsky J, Hambruch E, Lazam A, Jung M, Sattler M, Schliebs W, Erdmann R.
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| J Biol Chem 289(1):437-48. doi: 10.1074/jbc.M113.499707. Epub 2013 Nov 14.
2014
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| 4 | PEX5
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| PEX5, the shuttling import receptor for peroxisomal matrix proteins, is a redox-sensitive protein.
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| Apanasets O, Grou CP, Van Veldhoven PP, Brees C, Wang B, Nordgren M, Dodt G, Azevedo JE, Fransen M.
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| Traffic 15(1):94-103. doi: 10.1111/tra.12129. Epub 2013 Oct 31.
2014
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| 5 | PEX1, PEX14, PEX26, PEX5, PEX6
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| AAA peroxins and their recruiter Pex26p modulate the interactions of peroxins involved in peroxisomal protein import.
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| Tamura S, Matsumoto N, Takeba R, Fujiki Y.
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| J Biol Chem 289(35):24336-46. doi: 10.1074/jbc.M114.588038. Epub 2014 Jul 11. 2014
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| 6 | PEX5
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| Redox-regulated cargo binding and release by the peroxisomal targeting signal receptor, Pex5.
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| Ma C, Hagstrom D, Polley SG, Subramani S.
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| J Biol Chem 288(38):27220-31. doi: 10.1074/jbc.M113.492694. Epub 2013 Jul 31.
2013
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| 7 | PEX13, PEX5
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| Functional analysis of PEX13 mutation in a Zellweger syndrome spectrum patient reveals novel homooligomerization of PEX13 and its role in human peroxisome biogenesis.
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| Krause C, Rosewich H, Woehler A, Gärtner J.
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| Hum Mol Genet 22(19):3844-57. doi: 10.1093/hmg/ddt238. Epub 2013 May 27. 2013
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| 8 | PEX5, PEX6, ZFAND6
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| AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase.
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| Miyata N, Okumoto K, Mukai S, Noguchi M, Fujiki Y.
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| Traffic 13(1):168-83. doi: 10.1111/j.1600-0854.2011.01298.x. Epub 2011 Nov 9.
2012
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| 9 | PEX5, USP9X
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| Identification of ubiquitin-specific protease 9X (USP9X) as a deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester conjugate.
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| Grou CP, Francisco T, Rodrigues TA, Freitas MO, Pinto MP, Carvalho AF, Domingues P, Wood SA, Rodríguez-Borges JE, Sá-Miranda C, Fransen M, Azevedo JE.
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| J Biol Chem 287(16):12815-27. doi: 10.1074/jbc.M112.340158. Epub 2012 Feb 27.
2012
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| 10 | PEX1, PEX26, PEX5, PEX6
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| New insights into dynamic and functional assembly of the AAA peroxins, Pex1p and Pex6p, and their membrane receptor Pex26p in shuttling of PTS1-receptor Pex5p during peroxisome biogenesis.
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| Fujiki Y, Nashiro C, Miyata N, Tamura S, Okumoto K.
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| Biochim Biophys Acta 1823(1):145-9. doi: 10.1016/j.bbamcr.2011.10.012. Epub 2011 Nov 4. Review.
2012
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| 11 | PEX14, PEX5
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| PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14.
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| Freitas MO, Francisco T, Rodrigues TA, Alencastre IS, Pinto MP, Grou CP, Carvalho AF, Fransen M, Sá-Miranda C, Azevedo JE.
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| J Biol Chem 286(47):40509-19. doi: 10.1074/jbc.M111.287201. Epub 2011 Oct 5.
2011
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| 12 | PBD3, PEX5
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| Genotype-phenotype correlation in PEX5-deficient peroxisome biogenesis defective cell lines.
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| Ebberink MS, Mooyer PA, Koster J, Dekker CJ, Eyskens FJ, Dionisi-Vici C, Clayton PT, Barth PG, Wanders RJ, Waterham HR.
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| Hum Mutat 30(1):93-8.
2009
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| 13 | PEX5
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| Mapping the cargo protein membrane translocation step into the PEX5 cycling pathway.
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| Alencastre IS, Rodrigues TA, Grou CP, Fransen M, Sá-Miranda C, Azevedo JE.
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| J Biol Chem 284(40):27243-51. Epub 2009 Jul 23.
2009
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| 14 | PEX14, PEX5
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| Solution structure of human Pex5.Pex14.PTS1 protein complexes obtained by small angle X-ray scattering.
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| Shiozawa K, Konarev PV, Neufeld C, Wilmanns M, Svergun DI.
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| J Biol Chem 284(37):25334-42. Epub 2009 Jul 6.
2009
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| 15 | PEX14, PEX19, PEX5
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| Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.
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| Neufeld C, Filipp FV, Simon B, Neuhaus A, Schüller N, David C, Kooshapur H, Madl T, Erdmann R, Schliebs W, Wilmanns M, Sattler M.
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| EMBO J 28(6):745-54. Epub 2009 Feb 5.
2009
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| 16 | PEX10, PEX5
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| Pex10p functions as an E3 ligase for the Ubc4p-dependent ubiquitination of Pex5p.
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| Williams C, van den Berg M, Geers E, Distel B.
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| Biochem Biophys Res Commun 374(4):620-4. Epub 2008 Jul 21.
2008
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| 17 | PEX5, MYOC, GLC1A
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| Glaucoma-causing myocilin mutants require the Peroxisomal targeting signal-1 receptor (PTS1R) to elevate intraocular pressure.
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| Shepard AR, Jacobson N, Millar JC, Pang IH, Steely HT, Searby CC, Sheffield VC, Stone EM, Clark AF.
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| Hum Mol Genet 16(6):609-17. Epub 2007 Feb 22. 2007
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| 18 | PEX5
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| Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes.
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| Kassmann CM, Lappe-Siefke C, Baes M, Brugger B, Mildner A, Werner HB, Natt O, Michaelis T, Prinz M, Frahm J, Nave KA.
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| Nat Genet 39(8):969-76. Epub 2007 Jul 22. 2007
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| 19 | PEX5
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| Pex5p, the peroxisomal cycling receptor, is a monomeric non-globular protein.
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| Costa-Rodrigues J, Carvalho AF, Fransen M, Hambruch E, Schliebs W, Sa-Miranda C, Azevedo JE.
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| J Biol Chem 280(26):24404-11. Epub 2005 May 2. 2005
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| 20 | PEX5
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| The N terminus of the peroxisomal cycling receptor, Pex5p, is required for redirecting the peroxisome-associated peroxin back to the cytosol.
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| Costa-Rodrigues J, Carvalho AF, Gouveia AM, Fransen M, Sa-Miranda C, Azevedo JE.
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| J Biol Chem 279(45):46573-9. Epub 2004 Aug 24. 2004
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| 21 | PEX5
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| Characterization of the peroxisomal cycling receptor, Pex5p, using a cell-free in vitro import system.
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| Gouveia AM, Guimaraes CP, Oliveira ME, Reguenga C, Sa-Miranda C, Azevedo JE.
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| J Biol Chem 278(1):226-32. Epub 2002 Oct 30. 2003
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| 22 | PEX5
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| The human peroxisomal targeting signal receptor, Pex5p, is translocated into the peroxisomal matrix and recycled to the cytosol.
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| Dammai V, Subramani S.
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| Cell 105(2):187-96. 2001
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| 23 | ABCD4, PBD1, PBD2, PBD3, PBD4, PBD5, PEX1, PEX13, PEX6, PEX7, PEX19, PXMP3, PEX5, RCDP1, ZWS1, ZWS2, ZWS3, IRD7, IRD8, PBD12
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| Genotype-Phenotype Correlations in Disorders of Peroxisome Biogenesis.
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| Moser HW.
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| Mol Genet Metab 68(2):316-327 1999
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| 24 | PBD1, PEX5
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| Functional heterogeneity of C-terminal peroxisome targeting signal 1 in PEX5-defective patients.
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| Shimozawa N, Zhang Z, Suzuki Y, Imamura A, Tsukamoto T, Osumi T, Fujiki Y, Orii T, Barth PG, Wanders RJ, Kondo N.
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| Biochem Biophys Res Commun 262(2):504-8 1999
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| 25 | PEX10, PEX12, PEX5
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| PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import.
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| Chang CC, Warren DS, Sacksteder KA, Gould SJ.
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| J Cell Biol 147(4):761-74. 1999
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| 26 | PBD1, PEX5
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| An isoform of Pex5p, the human PTS1 receptor, is required for the import of PTS2 proteins into peroxisomes.
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| Braverman N, et al.
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| Hum Mol Genet 7 : 1195-1205. 1998
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| 27 | PEX5
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| The gene for the peroxisomal targeting signal import receptor (PXR1) is located on human chromosome 12p13, flanked by TPI1 and D12S1089.
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| Marynen P, et al.
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| Genomics 30 : 366-368. 1995
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| 28 | PEX5, PBD1
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| Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders.
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| Dodt G, et al.
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| Nat Genet 9 : 115-124. 1995
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| 29 | PEX5
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| Identification and characterization of the putative human peroxisomal C-terminal targeting signal import receptor.
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| Fransen M, et al.
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| J Biol Chem 270 : 7731-7736. 1995
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| 30 | PBD1, PEX5
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| Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders.
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| Wiemer EAC, et al.
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| J Cell Biol 130 : 51-65. 1995
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| 31 | ABCD3, PXMP3, PEX5, PBD12
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| Standardization of complementation grouping of peroxisome-deficient disorders and the second Zellweger patient with peroxisomal assembly factor-1 (PAF-1) defect.
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| Shimozawa N, et al.
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| Am J Hum Genet 52 : 843-844. 1993
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| 32 | NALD1, NALD2, PEX1, PEX5
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| Peroxisomal beta-oxidation enzyme proteins in adrenoleukodystrophy: distinction between X-linked adrenoleukodystrophy and neonatal adrenoleukodystrophy.
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| Chen WW, Watkins PA, Osumi T, Hashimoto T, Moser HW.
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| Proc Natl Acad Sci U S A 84(5):1425-8. 1987
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| 33 | NALD1, NALD2, PEX1, PEX5
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| X-linked adrenoleukodystrophy: defective peroxisomal oxidation of very long chain fatty acids but not of very long chain fatty acyl-CoA esters.
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| Wanders RJ, van Roermund CW, van Wijland MJ, Nijenhuis AA, Tromp A, Schutgens RB, Brouwer-Kelder EM, Schram AW, Tager JM, van den Bosch H, et al.
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| Clin Chim Acta 165(2-3):321-9. 1987
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