Citations for
1PBD2, PEX1, PEX26, PEX5, PEX6
Allelic Expression Imbalance Promoting a Mutant PEX6 Allele Causes Zellweger Spectrum Disorder.
Falkenberg KD, Braverman NE, Moser AB, Steinberg SJ, Klouwer FCC, Schlüter A, Ruiz M, Pujol A, Engvall M, Naess K, van Spronsen F, Körver-Keularts I, Rubio-Gozalbo ME, Ferdinandusse S, Wanders RJA, Waterham HR.
Am J Hum Genet 101(6):965-976. doi: 10.1016/j.ajhg.2017.11.007. 2017
2PEX5
PEX5 and Ubiquitin Dynamics on Mammalian Peroxisome Membranes.
Brown AI, Kim PK, Rutenberg AD.
PLoS Comput Biol 10(1):e1003426. doi: 10.1371/journal.pcbi.1003426. Epub 2014 Jan 16. 2014
3PEX14, PEX5
A Novel Pex14 Protein-interacting Site of Human Pex5 Is Critical for Matrix Protein Import into Peroxisomes.
Neuhaus A, Kooshapur H, Wolf J, Meyer NH, Madl T, Saidowsky J, Hambruch E, Lazam A, Jung M, Sattler M, Schliebs W, Erdmann R.
J Biol Chem 289(1):437-48. doi: 10.1074/jbc.M113.499707. Epub 2013 Nov 14. 2014
4PEX5
PEX5, the shuttling import receptor for peroxisomal matrix proteins, is a redox-sensitive protein.
Apanasets O, Grou CP, Van Veldhoven PP, Brees C, Wang B, Nordgren M, Dodt G, Azevedo JE, Fransen M.
Traffic 15(1):94-103. doi: 10.1111/tra.12129. Epub 2013 Oct 31. 2014
5PEX1, PEX14, PEX26, PEX5, PEX6
AAA peroxins and their recruiter Pex26p modulate the interactions of peroxins involved in peroxisomal protein import.
Tamura S, Matsumoto N, Takeba R, Fujiki Y.
J Biol Chem 289(35):24336-46. doi: 10.1074/jbc.M114.588038. Epub 2014 Jul 11. 2014
6PEX5
Redox-regulated cargo binding and release by the peroxisomal targeting signal receptor, Pex5.
Ma C, Hagstrom D, Polley SG, Subramani S.
J Biol Chem 288(38):27220-31. doi: 10.1074/jbc.M113.492694. Epub 2013 Jul 31. 2013
7PEX13, PEX5
Functional analysis of PEX13 mutation in a Zellweger syndrome spectrum patient reveals novel homooligomerization of PEX13 and its role in human peroxisome biogenesis.
Krause C, Rosewich H, Woehler A, Gärtner J.
Hum Mol Genet 22(19):3844-57. doi: 10.1093/hmg/ddt238. Epub 2013 May 27. 2013
8PEX5, PEX6, ZFAND6
AWP1/ZFAND6 functions in Pex5 export by interacting with cys-monoubiquitinated Pex5 and Pex6 AAA ATPase.
Miyata N, Okumoto K, Mukai S, Noguchi M, Fujiki Y.
Traffic 13(1):168-83. doi: 10.1111/j.1600-0854.2011.01298.x. Epub 2011 Nov 9. 2012
9PEX5, USP9X
Identification of ubiquitin-specific protease 9X (USP9X) as a deubiquitinase acting on ubiquitin-peroxin 5 (PEX5) thioester conjugate.
Grou CP, Francisco T, Rodrigues TA, Freitas MO, Pinto MP, Carvalho AF, Domingues P, Wood SA, Rodríguez-Borges JE, Sá-Miranda C, Fransen M, Azevedo JE.
J Biol Chem 287(16):12815-27. doi: 10.1074/jbc.M112.340158. Epub 2012 Feb 27. 2012
10PEX1, PEX26, PEX5, PEX6
New insights into dynamic and functional assembly of the AAA peroxins, Pex1p and Pex6p, and their membrane receptor Pex26p in shuttling of PTS1-receptor Pex5p during peroxisome biogenesis.
Fujiki Y, Nashiro C, Miyata N, Tamura S, Okumoto K.
Biochim Biophys Acta 1823(1):145-9. doi: 10.1016/j.bbamcr.2011.10.012. Epub 2011 Nov 4. Review. 2012
11PEX14, PEX5
PEX5 protein binds monomeric catalase blocking its tetramerization and releases it upon binding the N-terminal domain of PEX14.
Freitas MO, Francisco T, Rodrigues TA, Alencastre IS, Pinto MP, Grou CP, Carvalho AF, Fransen M, Sá-Miranda C, Azevedo JE.
J Biol Chem 286(47):40509-19. doi: 10.1074/jbc.M111.287201. Epub 2011 Oct 5. 2011
12PBD3, PEX5
Genotype-phenotype correlation in PEX5-deficient peroxisome biogenesis defective cell lines.
Ebberink MS, Mooyer PA, Koster J, Dekker CJ, Eyskens FJ, Dionisi-Vici C, Clayton PT, Barth PG, Wanders RJ, Waterham HR.
Hum Mutat 30(1):93-8. 2009
13PEX5
Mapping the cargo protein membrane translocation step into the PEX5 cycling pathway.
Alencastre IS, Rodrigues TA, Grou CP, Fransen M, Sá-Miranda C, Azevedo JE.
J Biol Chem 284(40):27243-51. Epub 2009 Jul 23. 2009
14PEX14, PEX5
Solution structure of human Pex5.Pex14.PTS1 protein complexes obtained by small angle X-ray scattering.
Shiozawa K, Konarev PV, Neufeld C, Wilmanns M, Svergun DI.
J Biol Chem 284(37):25334-42. Epub 2009 Jul 6. 2009
15PEX14, PEX19, PEX5
Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.
Neufeld C, Filipp FV, Simon B, Neuhaus A, Schüller N, David C, Kooshapur H, Madl T, Erdmann R, Schliebs W, Wilmanns M, Sattler M.
EMBO J 28(6):745-54. Epub 2009 Feb 5. 2009
16PEX10, PEX5
Pex10p functions as an E3 ligase for the Ubc4p-dependent ubiquitination of Pex5p.
Williams C, van den Berg M, Geers E, Distel B.
Biochem Biophys Res Commun 374(4):620-4. Epub 2008 Jul 21. 2008
17PEX5, MYOC, GLC1A
Glaucoma-causing myocilin mutants require the Peroxisomal targeting signal-1 receptor (PTS1R) to elevate intraocular pressure.
Shepard AR, Jacobson N, Millar JC, Pang IH, Steely HT, Searby CC, Sheffield VC, Stone EM, Clark AF.
Hum Mol Genet 16(6):609-17. Epub 2007 Feb 22. 2007
18PEX5
Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes.
Kassmann CM, Lappe-Siefke C, Baes M, Brugger B, Mildner A, Werner HB, Natt O, Michaelis T, Prinz M, Frahm J, Nave KA.
Nat Genet 39(8):969-76. Epub 2007 Jul 22. 2007
19PEX5
Pex5p, the peroxisomal cycling receptor, is a monomeric non-globular protein.
Costa-Rodrigues J, Carvalho AF, Fransen M, Hambruch E, Schliebs W, Sa-Miranda C, Azevedo JE.
J Biol Chem 280(26):24404-11. Epub 2005 May 2. 2005
20PEX5
The N terminus of the peroxisomal cycling receptor, Pex5p, is required for redirecting the peroxisome-associated peroxin back to the cytosol.
Costa-Rodrigues J, Carvalho AF, Gouveia AM, Fransen M, Sa-Miranda C, Azevedo JE.
J Biol Chem 279(45):46573-9. Epub 2004 Aug 24. 2004
21PEX5
Characterization of the peroxisomal cycling receptor, Pex5p, using a cell-free in vitro import system.
Gouveia AM, Guimaraes CP, Oliveira ME, Reguenga C, Sa-Miranda C, Azevedo JE.
J Biol Chem 278(1):226-32. Epub 2002 Oct 30. 2003
22PEX5
The human peroxisomal targeting signal receptor, Pex5p, is translocated into the peroxisomal matrix and recycled to the cytosol.
Dammai V, Subramani S.
Cell 105(2):187-96. 2001
23ABCD4, PBD1, PBD2, PBD3, PBD4, PBD5, PEX1, PEX13, PEX6, PEX7, PEX19, PXMP3, PEX5, RCDP1, ZWS1, ZWS2, ZWS3, IRD7, IRD8, PBD12
Genotype-Phenotype Correlations in Disorders of Peroxisome Biogenesis.
Moser HW.
Mol Genet Metab 68(2):316-327 1999
24PBD1, PEX5
Functional heterogeneity of C-terminal peroxisome targeting signal 1 in PEX5-defective patients.
Shimozawa N, Zhang Z, Suzuki Y, Imamura A, Tsukamoto T, Osumi T, Fujiki Y, Orii T, Barth PG, Wanders RJ, Kondo N.
Biochem Biophys Res Commun 262(2):504-8 1999
25PEX10, PEX12, PEX5
PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import.
Chang CC, Warren DS, Sacksteder KA, Gould SJ.
J Cell Biol 147(4):761-74. 1999
26PBD1, PEX5
An isoform of Pex5p, the human PTS1 receptor, is required for the import of PTS2 proteins into peroxisomes.
Braverman N, et al.
Hum Mol Genet 7 : 1195-1205. 1998
27PEX5
The gene for the peroxisomal targeting signal import receptor (PXR1) is located on human chromosome 12p13, flanked by TPI1 and D12S1089.
Marynen P, et al.
Genomics 30 : 366-368. 1995
28PEX5, PBD1
Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders.
Dodt G, et al.
Nat Genet 9 : 115-124. 1995
29PEX5
Identification and characterization of the putative human peroxisomal C-terminal targeting signal import receptor.
Fransen M, et al.
J Biol Chem 270 : 7731-7736. 1995
30PBD1, PEX5
Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders.
Wiemer EAC, et al.
J Cell Biol 130 : 51-65. 1995
31ABCD3, PXMP3, PEX5, PBD12
Standardization of complementation grouping of peroxisome-deficient disorders and the second Zellweger patient with peroxisomal assembly factor-1 (PAF-1) defect.
Shimozawa N, et al.
Am J Hum Genet 52 : 843-844. 1993
32NALD1, NALD2, PEX1, PEX5
Peroxisomal beta-oxidation enzyme proteins in adrenoleukodystrophy: distinction between X-linked adrenoleukodystrophy and neonatal adrenoleukodystrophy.
Chen WW, Watkins PA, Osumi T, Hashimoto T, Moser HW.
Proc Natl Acad Sci U S A 84(5):1425-8. 1987
33NALD1, NALD2, PEX1, PEX5
X-linked adrenoleukodystrophy: defective peroxisomal oxidation of very long chain fatty acids but not of very long chain fatty acyl-CoA esters.
Wanders RJ, van Roermund CW, van Wijland MJ, Nijenhuis AA, Tromp A, Schutgens RB, Brouwer-Kelder EM, Schram AW, Tager JM, van den Bosch H, et al.
Clin Chim Acta 165(2-3):321-9. 1987