| 1 | KHSRP, PER2
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| KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression.
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| Chou CF, Zhu X, Lin YY, Gamble KL, Garvey WT, Chen CY.
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| J Lipid Res 56(2):227-40. doi: 10.1194/jlr.M050724. Epub 2014 Dec 16.
2015
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| 2 | PER2, PML
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| PML regulates PER2 nuclear localization and circadian function.
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| Miki T, Xu Z, Chen-Goodspeed M, Liu M, Van Oort-Jansen A, Rea MA, Zhao Z, Lee CC, Chang KS.
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| EMBO J 31(6):1427-39. doi: 10.1038/emboj.2012.1. Epub 2012 Jan 24.
2012
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| 3 | PER2, PRKCDBP
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| CAVIN-3 regulates circadian period length and PER:CRY protein abundance and interactions.
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| Schneider K, Köcher T, Andersin T, Kurzchalia T, Schibler U, Gatfield D.
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| EMBO Rep 13(12):1138-44. doi: 10.1038/embor.2012.158. Epub 2012 Oct 19.
2012
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| 4 | KDM5A, PER2
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| Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock.
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| DiTacchio L, Le HD, Vollmers C, Hatori M, Witcher M, Secombe J, Panda S.
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| Science 333(6051):1881-5. 2011
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| 5 | ARNTL, NPAS2, PER2
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| Sleep loss reduces the DNA-binding of BMAL1, CLOCK, and NPAS2 to specific clock genes in the mouse cerebral cortex.
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| Mongrain V, La Spada F, Curie T, Franken P.
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| PLoS One 6(10):e26622. doi: 10.1371/journal.pone.0026622.
2011
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| 6 | BHLHE40, PER2
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| Feeding-induced rapid resetting of the hepatic circadian clock is associated with acute induction of Per2 and Dec1 transcription in rats.
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| Wu T, Ni Y, Kato H, Fu Z.
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| Chronobiol Int 27(1):1-18.PMID: 20205554 2010
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| 7 | CRY2, PER2
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| The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation.
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| Maronde E, Schilling AF, Seitz S, Schinke T, Schmutz I, van der Horst G, Amling M, Albrecht U.
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| PLoS One 5(7):e11527. doi: 10.1371/journal.pone.0011527.
2010
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| 8 | ARNTL2, PER2
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| Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription.
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| Sasaki M, Yoshitane H, Du NH, Okano T, Fukada Y.
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| J Biol Chem 284(37):25149-59. Epub 2009 Jul 15.PMID: 19605937 2009
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| 9 | CRY1, PER2
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| Combined PER2 and CRY1 expression predicts outcome in chronic lymphocytic leukemia.
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| Eisele L, Prinz R, Klein-Hitpass L, Nückel H, Lowinski K, Thomale J, Moeller LC, Dührsen U, Dürig J.
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| Eur J Haematol 83(4):320-7. Epub 2009 Jun 2.PMID: 19500131 2009
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| 10 | PER2
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| A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock.
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| Maier B, Wendt S, Vanselow JT, Wallach T, Reischl S, Oehmke S, Schlosser A, Kramer A.
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| Genes Dev 23(6):708-18.PMID: 19299560 2009
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| 11 | NPAS2, PER2
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| NPAS2 and PER2 are linked to risk factors of the metabolic syndrome.
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| Englund A, Kovanen L, Saarikoski ST, Haukka J, Reunanen A, Aromaa A, Lönnqvist J, Partonen T.
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| J Circadian Rhythms 7:5. doi: 10.1186/1740-3391-7-5.
2009
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| 12 | PER2, SIRT1
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| SIRT1 regulates circadian clock gene expression through PER2 deacetylation.
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| Asher G, Gatfield D, Stratmann M, Reinke H, Dibner C, Kreppel F, Mostoslavsky R, Alt FW, Schibler U.
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| Cell 134(2):317-28.
2008
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| 13 | PER2, FASPS
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| Modeling of a human circadian mutation yields insights into clock regulation by PER2.
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| Xu Y, Toh KL, Jones CR, Shin JY, Fu YH, Ptacek LJ.
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| Cell 128(1):59-70. 2007
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| 14 | ARNTL,PER1,PER2
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| Circadian expression of clock genes in human peripheral leukocytes.
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| Fukuya H, Emoto N, Nonaka H, Yagita K, Okamura H, Yokoyama M.
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| Biochem Biophys Res Commun 354(4):924-8. Epub 2007 Jan 22. 2007
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| 15 | ARNTL,NPAS2,PER2
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| Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression.
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| Partonen T, Treutlein J, Alpman A, Frank J, Johansson C, Depner M, Aron L, Rietschel M, Wellek S, Soronen P, Paunio T, Koch A, Chen P, Lathrop M, Adolfsson R, Persson ML, Kasper S, Schalling M, Peltonen L, Schumann G.
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| Ann Med 39(3):229-38. 2007
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| 16 | PER2
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| PER2 controls circadian periods through nuclear localization in the suprachiasmatic nucleus.
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| Miyazaki K, Wakabayashi M, Chikahisa S, Sei H, Ishida N.
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| Genes Cells 12(11):1225-34.PMID: 17986006 2007
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| 17 | FASPS, PER2
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| Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS).
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| Vanselow K, Vanselow JT, Westermark PO, Reischl S, Maier B, Korte T, Herrmann A, Herzel H, Schlosser A, Kramer A.
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| Genes Dev 20(19):2660-72. Epub 2006 Sep 18. 2006
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| 18 | PER2, PPP1CA
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| Protein phosphatase 1 regulates the stability of the circadian protein PER2.
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| Gallego M, Kang H, Virshup DM.
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| Biochem J 399(1):169-75. 2006
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| 19 | PER2
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| The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption.
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| Spanagel R, Pendyala G, Abarca C, Zghoul T, Sanchis-Segura C, Magnone MC, Lascorz J, Depner M, Holzberg D, Soyka M, Schreiber S, Matsuda F, Lathrop M, Schumann G, Albrecht U.
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| Nat Med 11(1):35-42. Epub 2004 Dec 19. Erratum in: Nat Med. 2005 Feb;11(2):233. 2005
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| 20 | FASPS, PER2
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| An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome.
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| Toh KL, Jones CR, He Y, Eide EJ, Hinz WA, Virshup DM, Ptacek LJ, Fu YH.
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| Science 291(5506):1040-3. 2001
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| 21 | PER1, PER2
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| Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock.
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| Zheng B, Albrecht U, Kaasik K, Sage M, Lu W, Vaishnav S, Li Q, Sun ZS, Eichele G, Bradley A, Lee CC.
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| Cell 105(5):683-94. 2001
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| 22 | ARNTL, PER2
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| Interacting molecular loops in the mammalian circadian clock.
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| Shearman LP, Sriram S, Weaver DR, Maywood ES, Chaves I, Zheng B, Kume K, Lee CC, van der Horst GT, Hastings MH, Reppert SM.
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| Science 288(5468):1013-9. 2000
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| 23 | PER1, PER2, PER3
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| Three period homologs in mammals: differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain.
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| Zylka MJ, Shearman LP, Weaver DR, Reppert SM.
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| Neuron 20(6):1103-10. 1998
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| 24 | ADAMTS3, AKAP6, ALMS1, ANKRD28, AREL1, ARHGEF10, ARHGEF11, ARHGEF17, ARNT2, BAZ2A, CABIN1, CAST, CHD9, CIC, CLEC16A, CLOCK, CTNND1, DCLK1, DDX46, DIDO1, DNAH9, DNM3, DOCK3, DYNC1H1, ECM29, ENTPD4, EPB41L1, EZH1, FRMPD4, GCC2, HECW1, HERC2, HISPPD1, HUWE1, IGSF1, KAT6B, KHNYN, KIAA0319, KIAA0355, KIAA0379, KIF3B, KMT2B, LBA1, MADD, MAST4, MCF2L, MDN1, MTMR3, MYO6, N4BP3, NACAD, NRCAM, PCDH9, PCDHGA8, PCDHGC3, PDZD2, PER2, PFAS, PLEKHM1, PLXNB2, PRORP, PRUNE2, PTPRN2, RAPGEF2, RIMBP2, RIMS1, RIPOR2, RUSC2, SALL2, SEC16A, SEMA3C, SEMA3E, SETD1A, SFRS14, SNPH, SPECC1L, SPTBN2, SR140, SRCAP, SRRM2, SYNJ2, TECPR2, TLN2, TRIM66, TTC37, UBR2, WNK1, XPO6, ZBTB39, ZBTB5, ZFYVE16, ZFYVE26, ZMYM3, ZNF518A, ZNF609, ZNF629, ZNF646
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| Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
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| Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A,Kotani H, Nomura N, Ohara O.
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| DNA Res 4(2):141-50. 1997
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| 25 | PER1, PER2
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| Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei.
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| Shearman LP, Zylka MJ, Weaver DR, Kolakowski LF Jr, Reppert SM.
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| Neuron 19(6):1261-9.PMID: 9427249 1997
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