| 1 | CFH, CTRB1, PELI3
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| Protective coding variants in CFH and PELI3 and a variant near CTRB1 are associated with age-related macular degeneration†
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| Yu Y, Wagner EK, Souied EH, Seitsonen S, Immonen IJ, Häppölä P, Raychaudhuri S, Daly MJ, Seddon JM.
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| Hum Mol Genet. Dec 1;25(23):5276-5285. doi: 10.1093/hmg/ddw336. 2016
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| 2 | PELI1, PELI2, PELI3
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| E3 ubiquitin ligases Pellinos as regulators of pattern recognition receptor signaling and immune responses.
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| Medvedev AE, Murphy M, Zhou H, Li X.
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| Immunol Rev 266(1):109-22. doi: 10.1111/imr.12298. Review.
2015
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| 3 | PELI1, PELI2, PELI3
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| The pellino e3 ubiquitin ligases recognize specific phosphothreonine motifs and have distinct substrate specificities.
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| Huoh YS, Ferguson KM.
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| Biochemistry 53(30):4946-55. doi: 10.1021/bi5005156. Epub 2014 Jul 16.
2014
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| 4 | PELI1, PELI2, PELI3
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| The roles of Pellino E3 ubiquitin ligases in immunity.
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| Moynagh PN.
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| Nat Rev Immunol 14(2):122-31. doi: 10.1038/nri3599. Epub 2014 Jan 21. Review.
2014
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| 5 | PELI3
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| Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-α.
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| Yang S, Wang B, Tang LS, Siednienko J, Callanan JJ, Moynagh PN.
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| Nat Commun 4:2583. doi: 10.1038/ncomms3583.
2013
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| 6 | NOD2, PELI3, RIPK2
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| Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis.
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| Yang S, Wang B, Humphries F, Jackson R, Healy ME, Bergin R, Aviello G, Hall B, McNamara D, Darby T, Quinlan A, Shanahan F, Melgar S, Fallon PG, Moynagh PN.
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| Nat Immunol 14(9):927-36. doi: 10.1038/ni.2669. Epub 2013 Jul 28.
2013
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| 7 | PELI3, RIPK1
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| Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-α.
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| Yang S, Wang B, Tang LS, Siednienko J, Callanan JJ, Moynagh PN.
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| Nat Commun 4:2583. doi: 10.1038/ncomms3583.
2013
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| 8 | PELI1, PELI2, PELI3
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| Pellino 2 is critical for Toll-like receptor/interleukin-1 receptor (TLR/IL-1R)-mediated post-transcriptional control.
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| Kim TW, Yu M, Zhou H, Cui W, Wang J, DiCorleto P, Fox P, Xiao H, Li X.
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| J Biol Chem 287(30):25686-95. doi: 10.1074/jbc.M112.352625. Epub 2012 Jun 5.
2012
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| 9 | PELI3, TICAM1
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| OxLDL inhibits LPS-induced IFNβ expression by Pellino3- and IRAK1/4-dependent modification of TANK.
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| Tzieply N, Kuhn AM, Morbitzer D, Namgaladze D, Heeg A, Schaefer L, von Knethen A, Jensen LE, Brüne B.
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| Cell Signal 24(6):1141-9. doi: 10.1016/j.cellsig.2012.01.021. Epub 2012 Feb 10.
2012
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| 10 | IRF7, PELI3
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| Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons.
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| Siednienko J, Jackson R, Mellett M, Delagic N, Yang S, Wang B, Tang LS, Callanan JJ, Mahon BP, Moynagh PN.
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| Nat Immunol 13(11):1055-62. doi: 10.1038/ni.2429. Epub 2012 Oct 7.
2012
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| 11 | IRAK1, IRAK4, PELI1, PELI2, PELI3
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| Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4.
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| Smith H, Peggie M, Campbell DG, Vandermoere F, Carrick E, Cohen P.
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| Proc Natl Acad Sci U S A 106(12):4584-90. Epub 2009 Mar 5.
2009
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| 12 | PELI3
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| Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation.
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| Xiao H, Qian W, Staschke K, Qian Y, Cui G, Deng L, Ehsani M, Wang X, Qian YW, Chen ZJ, Gilmour R, Jiang Z, Li X.
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| J Biol Chem 283(21):14654-64. Epub 2008 Mar 7. 2008
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| 13 | PELI1, PELI2, PELI3
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| Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1.
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| Lin CC, Huoh YS, Schmitz KR, Jensen LE, Ferguson KM.
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| Structure 16(12):1806-16. doi: 10.1016/j.str.2008.09.011.
2008
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| 14 | PELI3
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| Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation.
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| Xiao H, Qian W, Staschke K, Qian Y, Cui G, Deng L, Ehsani M, Wang X, Qian YW, Chen ZJ, Gilmour R, Jiang Z, Li X.
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| J Biol Chem 283(21):14654-64. doi: 10.1074/jbc.M706931200. Epub 2008 Mar 7.
2008
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| 15 | PELI1, PELI2, PELI3, IRAK1, IRAK4
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| Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases.
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| Butler MP, Hanly JA, Moynagh PN.
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| J Biol Chem 282(41):29729-37. Epub 2007 Aug 3. 2007
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| 16 | IRAK1, IRAK2, IRAK4, PELI1, PELI2, PELI3
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| Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases.
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| Butler MP, Hanly JA, Moynagh PN.
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| J Biol Chem 282(41):29729-37. Epub 2007 Aug 3.
2007
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| 17 | PELI1, PELI2, PELI3, IRAK1
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| Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases.
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| Schauvliege R, Janssens S, Beyaert R.
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| FEBS Lett 580(19):4697-702. Epub 2006 Jul 24. 2006
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| 18 | PELI3, MAPK14
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| Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner.
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| Butler MP, Hanly JA, Moynagh PN.
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| J Biol Chem 280(30):27759-68. Epub 2005 May 25. 2005
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| 19 | PELI3
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| Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein.
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| Jensen LE, Whitehead AS.
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| J Immunol 171(3):1500-6. 2003
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