Citations for
1PDGFRA
Dysregulated PDGFRα signaling alters coronal suture morphogenesis and leads to craniosynostosis through endochondral ossification.
He F, Soriano P.
Development 144(21):4026-4036. doi: 10.1242/dev.151068. Epub 2017 Sep 25. 2017
2PDGFRA
Stage specific requirement of platelet-derived growth factor receptor-α in embryonic development.
Qian C, Wong CWY, Wu Z, He Q, Xia H, Tam PKH, Wong KKY, Lui VCH.
PLoS One 12(9):e0184473. doi: 10.1371/journal.pone.0184473. eCollection 2017. 2017
3PDGFRA
PDGFRα controls the balance of stromal and adipogenic cells during adipose tissue organogenesis.
Sun C, Berry WL, Olson LE.
Development 144(1):83-94. doi: 10.1242/dev.135962. 2017
4PDGFA, PDGFRA
PDGF controls contact inhibition of locomotion by regulating N-cadherin during neural crest migration.
Bahm I, Barriga EH, Frolov A, Theveneau E, Frankel P, Mayor R.
Development 144(13):2456-2468. doi: 10.1242/dev.147926. Epub 2017 May 19. 2017
5HMGB2, HSD17B4, PDGFRA
PDGFRA, HSD17B4 and HMGB2 are potential therapeutic targets in polycystic ovarian syndrome and breast cancer.
Xu H, Han Y, Lou J, Zhang H, Zhao Y, Győrffy B, Li R.
Oncotarget 8(41):69520-69526. doi: 10.18632/oncotarget.17846. eCollection 2017 Sep 19. 2017
6PDGFRA
Structural and biochemical studies of the PDGFRA kinase domain.
Liang L, Yan XE, Yin Y, Yun CH.
Biochem Biophys Res Commun 477(4):667-672. doi: 10.1016/j.bbrc.2016.06.117. Epub 2016 Jun 24. 2016
7PDGFRA
Diversity of Interstitial Lung Fibroblasts Is Regulated by Platelet-Derived Growth Factor Receptor α Kinase Activity.
Green J, Endale M, Auer H, Perl AK.
Am J Respir Cell Mol Biol 54(4):532-45. doi: 10.1165/rcmb.2015-0095OC. 2016
8PDGFRA
PDGFRα plays a crucial role in connective tissue remodeling.
Horikawa S, Ishii Y, Hamashima T, Yamamoto S, Mori H, Fujimori T, Shen J, Inoue R, Nishizono H, Itoh H, Majima M, Abraham D, Miyawaki T, Sasahara M.
Sci Rep 5:17948. doi: 10.1038/srep17948. 2015
9PDGFRA
PDGFRα signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity.
Iwayama T, Steele C, Yao L, Dozmorov MG, Karamichos D, Wren JD, Olson LE.
Genes Dev 29(11):1106-19. doi: 10.1101/gad.260554.115. Epub 2015 May 27. 2015
10PDGFRA, PDGFRB
PDGF signalling in the dermis and in dermal condensates is dispensable for hair follicle induction and formation.
Rezza A, Sennett R, Tanguy M, Clavel C, Rendl M.
Exp Dermatol 24(6):468-70. doi: 10.1111/exd.12672. Epub 2015 Mar 25. 2015
11PDGFRA
Dysfunction of platelet-derived growth factor receptor α (PDGFRα) represses the production of oligodendrocytes from arylsulfatase A-deficient multipotential neural precursor cells.
Pituch KC, Moyano AL, Lopez-Rosas A, Marottoli FM, Li G, Hu C, van Breemen R, Månsson JE, Givogri MI.
J Biol Chem 290(11):7040-53. doi: 10.1074/jbc.M115.636498. Epub 2015 Jan 20. 2015
12NKX2-2, PDGFRA
Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS.
Zhu Q, Zhao X, Zheng K, Li H, Huang H, Zhang Z, Mastracci T, Wegner M, Chen Y, Sussel L, Qiu M.
Development 141(3):548-55. doi: 10.1242/dev.095323. 2014
13PDGFRA
Overexpression of platelet-derived growth factor receptor alpha promotes tumor progression and indicates poor prognosis in hepatocellular carcinoma.
Wei T, Zhang LN, Lv Y, Ma XY, Zhi L, Liu C, Ma F, Zhang XF.
Oncotarget 5(21):10307-17. 2014
14PDGFRA
A critical role for PDGFRα signaling in medial nasal process development.
He F, Soriano P.
PLoS Genet 9(9):e1003851. doi: 10.1371/journal.pgen.1003851. Epub 2013 Sep 26. 2013
15PDGFC, PDGFRA
Regulation of PDGFC signalling and extracellular matrix composition by FREM1 in mice.
Wiradjaja F, Cottle DL, Jones L, Smyth I.
Dis Model Mech 6(6):1426-33. doi: 10.1242/dmm.013748. Epub 2013 Aug 15. 2013
16PDGFRA
PDGFRa mutations in humans with isolated cleft palate.
Rattanasopha S, Tongkobpetch S, Srichomthong C, Siriwan P, Suphapeetiporn K, Shotelersuk V.
Eur J Hum Genet 20(10):1058-62. doi: 10.1038/ejhg.2012.55. Epub 2012 Apr 4. 2012
17BCL2, BMP7, FGFR2, HOXC6, PDGFRA
HOXC6 is deregulated in human head and neck squamous cell carcinoma and modulates Bcl-2 expression.
Moon SM, Kim SA, Yoon JH, Ahn SG.
J Biol Chem 287(42):35678-88. doi: 10.1074/jbc.M112.361675. Epub 2012 Aug 15. 2012
18PDGFRA
KIT and PDGFRA mutations and PDGFRA immunostaining in gastrointestinal stromal tumors.
Barreca A, Fornari A, Bonello L, Tondat F, Chiusa L, Lista P, Pich A.
Mol Med Report 4(1):3-8. doi: 10.3892/mmr.2010.399. Epub 2010 Nov 30. 2011
19HES1, PDGFRA
Durable remission after treatment with very low doses of imatinib for FIP1L1-PDGFRα-positive chronic eosinophilic leukaemia.
Helbig G, Moskwa A, Hus M, Piszcz J, Swiderska A, Urbanowicz A, Całbecka M, Seferyńska I, Raźny M, Rodzaj M, Żuk E, Kyrcz-Krzemień S.
Cancer Chemother Pharmacol 67(4):967-9. Epub 2011 Feb 17. No abstract available. 2011
20MTOR, PDGFRA
Association of variants in FRAP1 and PDGFRA with corneal curvature in Asian populations from Singapore.
Han S, Chen P, Fan Q, Khor CC, Sim X, Tay WT, Ong RT, Suo C, Goh LK, Lavanya R, Zheng Y, Wu R, Seielstad M, Vithana E, Liu J, Chia KS, Lee JJ, Tai ES, Wong TY, Aung T, Teo YY, Saw SM.
Hum Mol Genet 20(18):3693-8. doi: 10.1093/hmg/ddr269. Epub 2011 Jun 10. 2011
21CDKN2A, EZH2, PDGFA, PDGFRA, PDGFRB
PDGF signalling controls age-dependent proliferation in pancreatic β-cells.
Chen H, Gu X, Liu Y, Wang J, Wirt SE, Bottino R, Schorle H, Sage J, Kim SK.
Nature 478(7369):349-55. doi: 10.1038/nature10502. 2011
22NRP1, PDGFRA, PDGFRB
Neuropilin-1 regulates platelet-derived growth factor receptor signalling in mesenchymal stem cells.
Ball SG, Bayley C, Shuttleworth CA, Kielty CM.
Biochem J 427(1):29-40. 2010
23PDGFRA, TAPVR1
Dysregulation of the PDGFRA gene causes inflow tract anomalies including TAPVR: integrating evidence from human genetics and model organisms.
Bleyl SB, Saijoh Y, Bax NA, Gittenberger-de Groot AC, Wisse LJ, Chapman SC, Hunter J, Shiratori H, Hamada H, Yamada S, Shiota K, Klewer SE, Leppert MF, Schoenwolf GC.
Hum Mol Genet 19(7):1286-301. Epub 2010 Jan 13. 2010
24PDGFRA
Co-activated PDGFRA and EGFR are potential therapeutic targets in intimal sarcoma.
Dewaele BM, Floris G, Finalet-Ferreiro J, Fletcher C, Coindre JM, Guillou L, Hogendoorn PC, Wozniak A, Vanspauwen V, Schoffski P, Marynen P, Vandenberghe P, Sciot R, Debiec-Rychter M.
Cancer Res ancer Res. 2010 Aug 4. [Epub ahead of print]PMID: 20685895 2010
25KDR, KIT, PDGFRA
Amplification and overexpression of KIT, PDGFRA, and VEGFR2 in medulloblastomas and primitive neuroectodermal tumors.
Blom T, Roselli A, Häyry V, Tynninen O, Wartiovaara K, Korja M, Nordfors K, Haapasalo H, Nupponen NN.
J Neurooncol 97(2):217-24. Epub 2009 Sep 25.PMID: 19779861 2010
26PDGFRA
PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas.
Ozawa T, Brennan CW, Wang L, Squatrito M, Sasayama T, Nakada M, Huse JT, Pedraza A, Utsuki S, Yasui Y, Tandon A, Fomchenko EI, Oka H, Levine RL, Fujii K, Ladanyi M, Holland EC.
Genes Dev 24(19):2205-18. 2010
27PDGFRA
Pathological characteristics of gastrointestinal stromal tumours with PDGFRA mutations.
Kwon JE, Kang HJ, Kim SH, Lee YC, Hyung WJ, Noh SH, Kim NK, Kim H.
Pathology 41(6):544-54. 2009
28PDGFRA
Expression and mutational status of PDGFR in thymic tumours.
Meister M, Kahl P, Muley T, Morresi-Hauf A, Sebening C, Kern MA, Breinig M, Schnabel P, Dienemann H, Schirmacher P, Rieker RJ.
Anticancer Res 29(10):4057-61. 2009
29PDGFA, PDGFRA
Expression, mutation and copy number analysis of platelet-derived growth factor receptor A (PDGFRA) and its ligand PDGFA in gliomas.
Martinho O, Longatto-Filho A, Lambros MB, Martins A, Pinheiro C, Silva A, Pardal F, Amorim J, Mackay A, Milanezi F, Tamber N, Fenwick K, Ashworth A, Reis-Filho JS, Lopes JM, Reis RM.
Br J Cancer 101(6):973-82. Epub 2009 Aug 25. 2009
30PDGFRA
PDGFRalpha: a new therapeutic target in the treatment of hepatocellular carcinoma?
Oseini AM, Roberts LR.
Expert Opin Ther Targets 13(4):443-54. Review. 2009
31PDGFA, PDGFB, PDGFRA, PDGFRB
Platelet-derived growth factors (PDGF-A and -B) and their receptors in human fetal and adult ovaries.
Pinkas H, Fisch B, Rozansky G, Felz C, Kessler-Icekson G, Krissi H, Nitke S, Ao A, Abir R.
Mol Hum Reprod 14(4):199-206. Epub 2008 Mar 7.PMID: 18326546 2008
32PDGFRA, ZFPM2
Candidate genes for congenital diaphragmatic hernia from animal models: sequencing of FOG2 and PDGFRalpha reveals rare variants in diaphragmatic hernia patients.
Bleyl SB, Moshrefi A, Shaw GM, Saijoh Y, Schoenwolf GC, Pennacchio LA, Slavotinek AM.
Eur J Hum Genet 15(9):950-8. Epub 2007 Jun 13. 2007
33E2F1, PDGFRA
Transcriptional regulation of a new variant of human platelet-derived growth factor receptor alpha transcript by E2F-1.
Minato Y, Tashiro E, Kanai M, Nihei Y, Kodama Y, Imoto M.
Gene 403(1-2):89-97. Epub 2007 Aug 25. 2007
34PDGFRA, ZNF148
A PDGFRA promoter polymorphism, which disrupts the binding of ZNF148, is associated with primitive neuroectodermal tumours and ependymomas.
De Bustos C, Smits A, Stromberg B, Collins VP, Nister M, Afink G.
J Med Genet 42(1):31-7. 2005
35KIT, PDGFRA
Mutational analysis of the c-KIT AND PDGFRalpha in a series of molecularly well-characterized synovial sarcomas.
Lopez-Guerrero JA, Navarro S, Noguera R, Carda C, Farinas SC, Pellin A, Llombart-Bosch A.
Diagn Mol Pathol 14(3):134-9. 2005
36PDGFRA
Promoter haplotype combinations for the human PDGFRA gene are associated with risk of neural tube defects.
Zhu H, Wicker NJ, Volcik K, Zhang J, Shaw GM, Lammer EJ, Suarez L, Canfield M, Finnell RH.
Mol Genet Metab 81(2):127-32. 2004
37PDGFRA
DGFRA activating mutations in gastrointestinal stromal tumors.
Heinrich MC, Corless CL, Duensing A, McGreevey L, Chen CJ, Joseph N, Singer S, Griffith DJ, Haley A, Town A, Demetri GD, Fletcher CD, Fletcher JA.
Science 299(5607):708-10. 2003
38NOV, MMP2, PDGFRA
NOVH increases MMP3 expression and cell migration in glioblastoma cells via a PDGFR-alpha-dependent mechanism.
Laurent M, Martinerie C, Thibout H, Hoffman MP, Verrecchia F, Le Bouc Y, Mauviel A, Kleinman HK.
FASEB J 17(13):1919-21. Epub 2003 Aug 15. 2003
39HES1, PDGFRA
Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome.
Griffin JH, Leung J, Bruner RJ, Caligiuri MA, Briesewitz R.
Proc Natl Acad Sci U S A 100(13):7830-5. Epub 2003 Jun 13. 2003
40BCR, PDGFRA
The t(4;22)(q12;q11) in atypical chronic myeloid leukaemia fuses BCR to PDGFRA.
Baxter EJ, Hochhaus A, Bolufer P, Reiter A, Fernandez JM, Senent L, Cervera J, Moscardo F, Sanz MA, Cross NC.
Hum Mol Genet 11(12):1391-7. 2002
41PDGFRA
A regulating element essential for PDGFRA transcription is recognized by neural tube defect-associated PRX homeobox transcription factors.
Joosten PH, Toepoel M, van Oosterhout D, Afink GB, van Zoelen EJ.
Biochim Biophys Acta 1588(3):254-60. 2002
42GLI1, PDGFRA
A role of PDGFRalpha in basal cell carcinoma proliferation.
Xie J, Aszterbaum M, Zhang X, Bonifas JM, Zachary C, Epstein E, McCormick F.
Proc Natl Acad Sci U S A 98(16):9255-9. 2001
43ADRA2A, ADRB1, AGTR1, CAFG, CD36, CETP, CSF1, CSF2, CYP11B2, ECE1, EDN1, EDNRA, EDNRB, EGR1, F2R, FGA, FGB, FHBL1, HGF, ICAM1, IGF1, IL1A, IL6, LPA, MGP, MSR1, MTTP, NOS2, NOS3, PDGFA, PDGFRA, SELP, TGFB1, TNF, VCAM1, VDR
Sequence diversity in 36 candidate genes for cardiovascular disorders.
Cambien F, Poirier O, Nicaud V, Herrmann SM, Mallet C, Ricard S, Behague I, Hallet V, Blanc H, Loukaci V, Thillet J, Evans A, Ruidavets JB, Arveiler D, Luc G, Tiret L.
Am J Hum Genet 65(1):183-91. 1999
44PDGFRA, PDGFRB
Chimaeric analysis reveals role of Pdgf receptors in all muscle lineages.
Crosby JR, Seifert RA, Soriano P, Bowen-Pope DF.
Nat Genet 18(4):385-8. 1998
45PDGFRA
The platelet-derived growth factor alpha-receptor is encoded by a growth-arrest-specific (gas) gene.
Lih CJ, et al.
Proc Natl Acad Sci U S A 93 : 4617-4622. 1996
46PDGFRA
Structure, organization and transcription units of the human alpha-platelet-derived growth factor receptor gene, PDGFRA.
Kawagishi J, et al.
Genomics 30 : 224-232. 1995
47PDGFRA
Molecular cloning and functional characterization of the human platelet-derived growth factor alpha receptor gene promoter.
Afink GB, et al.
Oncogene 10 : 1667-1672. 1995
48PDGFRA, KDR, KIT, EPHA5
A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12.
Spritz RA, et al.
Genomics 22 : 431-436. 1994
49PDGFRA
Chromosomal localization of the gene for AA-type platelet-derived growth factor receptor (PDGFRA) in humans and mice.
Hsieh CL, et al.
Cytogenet Cell Genet 56 : 160-163. 1991
50PDGFRA
The human PDGF receptor alpha-subunit gene maps to chromosome 4 in close proximity to c-kit.
Gronwald RGK, et al.
Hum Genet 85 : 383-385. 1990
51PDGFRA, PDGFRB
Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes.
Matsui T, Heidaran M, Miki T, Popescu N, La Rochelle W, Kraus M, Pierce J, Aaronson S.
Science 243(4892):800-4. 1989
52PDGFRA, AREG
Mapping of the amphiregulin and platelet-growth factor receptor a genes to the proximal long arm of chromosome 4.
Disteche CM, et al.
(HGM10) Cytogenet Cell Genet 51 : 990. 1989
53PDGFRA
Human PDGFA receptor gene maps to the same region on chromosome 4 as the KIT oncogene.
Stenman G, et al.
Genes Chromosomes Cancer 1 : 155-158. 1989