1 | ACDS, PDE4D
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| Mutations causing acrodysostosis-2 facilitate activation of phosphodiesterase 4D3.
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| Briet C, Pereda A, Le Stunff C, Motte E, de Dios Garcia-Diaz J, de Nanclares GP, Dumaz N, Silve C.
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| Hum Mol Genet 26(20):3883-3894. doi: 10.1093/hmg/ddx271.
2017
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2 | ACDS, PDE4D
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| Phenotypic Variability in a Family with Acrodysostosis Type 2 Caused by a Novel PDE4D Mutation Affecting the Serine Target of Protein Kinase-A Phosphorylation.
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| Hoppmann J, Gesing J, Silve C, Leroy C, Bertsche A, Hirsch FW, Kiess W, Pfäffle R, Schuster V.
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| J Clin Res Pediatr Endocrinol 9(4):360-365. doi: 10.4274/jcrpe.4488. Epub 2017 May 17.
2017
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3 | PDE4D
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| PDE4D promotes FAK-mediated cell invasion in BRAF-mutated melanoma.
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| Delyon J, Servy A, Laugier F, André J, Ortonne N, Battistella M, Mourah S, Bensussan A, Lebbé C, Dumaz N.
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| Oncogene 36(23):3252-3262. doi: 10.1038/onc.2016.469. Epub 2017 Jan 16.
2017
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4 | PDE1A, PDE4D, PDE8A, PDE8B
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| Role of Cyclic Nucleotide Phosphodiesterases During Meiotic Resumption From Diplotene Arrest in Mammalian Oocytes.
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| Gupta A, Tiwari M, Prasad S, Chaube SK.
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| J Cell Biochem 118(3):446-452. doi: 10.1002/jcb.25748. Epub 2016 Sep 30.
2017
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5 | PDE4D
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| Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling.
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| Yun S, Budatha M, Dahlman JE, Coon BG, Cameron RT, Langer R, Anderson DG, Baillie G, Schwartz MA.
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| Nat Cell Biol 18(10):1043-53. doi: 10.1038/ncb3405. Epub 2016 Sep 5.
2016
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6 | ACDS, ADOHR, PDE4D, PRKAR1A
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| Screening of PRKAR1A and PDE4D in a Large Italian Series of Patients Clinically Diagnosed With Albright Hereditary Osteodystrophy and/or Pseudohypoparathyroidism.
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| Elli FM, Bordogna P, de Sanctis L, Giachero F, Verrua E, Segni M, Mazzanti L, Boldrin V, Toromanovic A, Spada A, Mantovani G.
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| J Bone Miner Res 31(6):1215-24. doi: 10.1002/jbmr.2785. Epub 2016 Feb 9.
2016
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7 | PDE4D
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| Phosphodiesterase4D (PDE4D)--A risk factor for atrial fibrillation and stroke?
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| Jørgensen C, Yasmeen S, Iversen HK, Kruuse C.
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| J Neurol Sci 359(1-2):266-74. doi: 10.1016/j.jns.2015.11.010. Epub 2015 Nov 11. Review.
2015
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8 | PDE4D
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| Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma.
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| Ge X, Milenkovic L, Suyama K, Hartl T, Purzner T, Winans A, Meyer T, Scott MP.
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| Elife 4. doi: 10.7554/eLife.07068.
2015
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9 | ADRB1, DLG1, PDE4D
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| A long lasting β1 adrenergic receptor stimulation of cAMP/protein kinase A (PKA) signal in cardiac myocytes.
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| Fu Q, Kim S, Soto D, De Arcangelis V, DiPilato L, Liu S, Xu B, Shi Q, Zhang J, Xiang YK.
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| J Biol Chem 289(21):14771-81. doi: 10.1074/jbc.M113.542589. Epub 2014 Apr 8.
2014
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10 | PDE4D
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| Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression.
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| Sheppard CL, Lee LC, Hill EV, Henderson DJ, Anthony DF, Houslay DM, Yalla KC, Cairns LS, Dunlop AJ, Baillie GS, Huston E, Houslay MD.
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| Cell Signal 26(9):1958-74. doi: 10.1016/j.cellsig.2014.04.023. Epub 2014 May 9.
2014
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11 | PDE4D
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| Association between phosphodiesterase 4D polymorphism SNP83 and ischemic stroke.
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| Yan Y, Luo X, Zhang J, Su L, Liang W, Huang G, Wu G, Huang G, Gu L.
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| J Neurol Sci 338(1-2):3-11. doi: 10.1016/j.jns.2013.12.012. Epub 2013 Dec 12. Review.
2014
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12 | ACDS, PDE4D
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| Identification of novel mutations confirms PDE4D as a major gene causing acrodysostosis.
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| Lynch DC, Dyment DA, Huang L, Nikkel SM, Lacombe D, Campeau PM, Lee B, Bacino CA, Michaud JL, Bernier FP; FORGE Canada Consortium, Parboosingh JS, Innes AM.
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| Hum Mutat 34(1):97-102. doi: 10.1002/humu.22222. Epub 2012 Nov 9. Erratum in: Hum Mutat. 2013 Apr;34(4):667.
2013
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13 | CC2D1A, PDE4D
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| Phosphodiesterase activity is regulated by CC2D1A that is implicated in non-syndromic intellectual disability.
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| Al-Tawashi A, Gehring C.
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| Cell Commun Signal 11(1):47. doi: 10.1186/1478-811X-11-47. 2013
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14 | ARRB2, PDE4D, TRPV1
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| Phosphorylation regulates TRPV1 association with β-arrestin-2.
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| Por ED, Gomez R, Akopian AN, Jeske NA.
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| Biochem J 451(1):101-9. doi: 10.1042/BJ20121637.
2013
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15 | PDE4A, PDE4B, PDE4C, PDE4D
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| Disease progression in MRL/lpr lupus-prone mice is reduced by NCS 613, a specific cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitor.
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| Keravis T, Monneaux F, Yougbaré I, Gazi L, Bourguignon JJ, Muller S, Lugnier C.
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| PLoS One 7(1):e28899. Epub 2012 Jan 11.
2012
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16 | ACDS, PDE4D
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| Exome Sequencing Identifies PDE4D Mutations as Another Cause of Acrodysostosis.
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| Michot C, Le Goff C, Goldenberg A, Abhyankar A, Klein C, Kinning E, Guerrot AM, Flahaut P, Duncombe A, Baujat G, Lyonnet S, Thalassinos C, Nitschke P, Casanova JL, Le Merrer M, Munnich A, Cormier-Daire V.
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| Am J Hum Genet 90(4):740-5. Epub 2012 Mar 29.
2012
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17 | ACDS, PDE4D
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| Exome Sequencing Identifies PDE4D Mutations in Acrodysostosis.
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| Lee H, Graham JM Jr, Rimoin DL, Lachman RS, Krejci P, Tompson SW, Nelson SF, Krakow D, Cohn DH.
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| Am J Hum Genet 90(4):746-51. Epub 2012 Mar 29.
2012
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18 | NOX4, PDE4A, PDE4B, PDE4D
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| NADPH oxidase 4 mediates upregulation of type 4 phosphodiesterases in human endothelial cells.
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| Muzaffar S, Jeremy JY, Angelini GD, Shukla N.
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| J Cell Physiol 227(5):1941-50. doi: 10.1002/jcp.22922.
2012
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19 | AKAP9, PDE4D, PRKACA
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| PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome.
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| Terrin A, Monterisi S, Stangherlin A, Zoccarato A, Koschinski A, Surdo NC, Mongillo M, Sawa A, Jordanides NE, Mountford JC, Zaccolo M.
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| J Cell Biol 198(4):607-21. doi: 10.1083/jcb.201201059.
2012
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20 | PDE4A, PDE4B, PDE4C, PDE4D
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| The differential impact of PDE4 subtypes in human lung fibroblasts on cytokine-induced proliferation and myofibroblast conversion.
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| Selige J, Hatzelmann A, Dunkern T.
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| J Cell Physiol 226(8):1970-80. doi: 10.1002/jcp.22529.
2011
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21 | PDE4D
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| Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current.
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| Beca S, Helli PB, Simpson JA, Zhao D, Farman GP, Jones PP, Tian X, Wilson LS, Ahmad F, Chen SR, Movsesian MA, Manganiello V, Maurice DH, Conti M, Backx PH.
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| Circ Res 109(9):1024-30. Epub 2011 Sep 8.
2011
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22 | PDE4B, PDE4D
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| PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts.
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| Blackman BE, Horner K, Heidmann J, Wang D, Richter W, Rich TC, Conti M.
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| J Biol Chem 286(14):12590-601. doi: 10.1074/jbc.M110.203604. Epub 2011 Feb 1.
2011
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23 | PDE4A, PDE4D
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| Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK.
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| Li X, Vadrevu S, Dunlop A, Day J, Advant N, Troeger J, Klussmann E, Jaffrey E, Hay RT, Adams DR, Houslay MD, Baillie GS.
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| Biochem J 428(1):55-65.PMID: 20196770 2010
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24 | PDE4A, PDE4B, PDE4C, PDE4D
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| An evolutionary analysis of cAMP-specific Phosphodiesterase 4 alternative splicing.
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| Johnson KR, Nicodemus-Johnson J, Danziger RS.
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| BMC Evol Biol 10:247.
2010
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25 | PDE4D
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| Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.
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| Himes BE, Hunninghake GM, Baurley JW, Rafaels NM, Sleiman P, Strachan DP, Wilk JB, Willis-Owen SA, Klanderman B, Lasky-Su J, Lazarus R, Murphy AJ, Soto-Quiros ME, Avila L, Beaty T, Mathias RA, Ruczinski I, Barnes KC, Celedón JC, Cookson WO, Gauderman WJ, Gilliland FD, Hakonarson H, Lange C, Moffatt MF, O'Connor GT, Raby BA, Silverman EK, Weiss ST.
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| Am J Hum Genet 84(5):581-93. Epub 2009 May 7.
2009
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26 | PDE4A, PDE4B, PDE4D
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| The novel distribution of phosphodiesterase-4 subtypes within the rat retina.
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| Whitaker CM, Cooper NG.
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| Neuroscience 163(4):1277-91. Epub 2009 Jul 26.
2009
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27 | ALOX5AP, PDE4D
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| Ischaemic stroke in hypertensive patients is associated with variations in the PDE4D genome region.
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| Lövkvist H, Smith JG, Luthman H, Höglund P, Norrving B, Kristoffersson U, Jönsson AC, Lindgren AG.
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| Eur J Hum Genet 16(9):1117-25. Epub 2008 Apr 9.
2008
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28 | ARRB2, PDE4D
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| Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays.
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| Baillie GS, Adams DR, Bhari N, Houslay TM, Vadrevu S, Meng D, Li X, Dunlop A, Milligan G, Bolger GB, Klussmann E, Houslay MD.
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| Biochem J 404(1):71-80.
2007
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29 | PDE4D
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| Phosphodiesterase 4D polymorphisms and the risk of cerebral infarction in a biracial population: the Stroke Prevention in Young Women Study.
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| Song Q, Cole JW, O'Connell JR, Stine OC, Gallagher M, Giles WH, Mitchell BD, Wozniak MA, Stern BJ, Sorkin JD, McArdle PF, Naj AC, Xu Q, Gibbons GH, Kittner SJ.
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| Hum Mol Genet 15(16):2468-78. Epub 2006 Jul 11. 2006
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30 | PDE4D
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| Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias.
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| Lehnart SE, Wehrens XH, Reiken S, Warrier S, Belevych AE, Harvey RD, Richter W, Jin SL, Conti M, Marks AR.
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| Cell 123(1):25-35. 2005
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31 | PART1, PDE4D, STRK1
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| Cloning and characterization of novel PDE4D isoforms PDE4D6 and PDE4D7.
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| Wang D, Deng C, Bugaj-Gaweda B, Kwan M, Gunwaldsen C, Leonard C, Xin X, Hu Y, Unterbeck A, De Vivo M.
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| Cell Signal 15(9):883-91. 2003
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32 | PART1, PDE4D, STRK1
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| The gene encoding phosphodiesterase 4D confers risk of ischemic stroke.
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| Gretarsdottir S, Thorleifsson G, Reynisdottir ST, Manolescu A, Jonsdottir S, Jonsdottir T, Gudmundsdottir T, Bjarnadottir SM, Einarsson OB, Gudjonsdottir HM, Hawkins M, Gudmundsson G, Gudmundsdottir H, Andrason H, Gudmundsdottir AS, Sigurdardottir M, Chou TT, Nahmias J, Goss S, Sveinbjornsdottir S, Valdimarsson EM, Jakobsson F, Agnarsson U, Gudnason V, Thorgeirsson G, Fingerle J, Gurney M, Gudbjartsson D, Frigge ML, Kong A, Stefansson K, Gulcher JR.
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| Nat Genet 35(2):131-8. Epub 2003 Sep 21. 2003
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33 | PDE4D
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| PDE4D plays a critical role in the control of airway smooth muscle contraction.
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| Mehats C, Jin SL, Wahlstrom J, Law E, Umetsu DT, Conti M.
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| FASEB J 17(13):1831-41. 2003
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34 | PDE4D
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| Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification and characterization of a novel PDE4D5 promoter.
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| Le Jeune IR, Shepherd M, Van Heeke G, Houslay MD, Hall IP.
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| J Biol Chem 277(39):35980-9. Epub 2002 Jul 16. 2002
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35 | PDE4D
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| Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation.
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| Sette C, Conti M.
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| J Biol Chem 271(28):16526-34.
1996
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36 | PDE4B, PDE4D
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| Chromosomal localization of the human and rat genes (PDE4D and PDE4B) encoding the cAMP-specific phosphodiesterases 3 and 4.
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| Szpirer C, et al.
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| Cytogenet Cell Genet 69 : 11-14. 1995
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37 | PDE4A, PDE4B, PDE4C, PDE4D, PDE7A
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| Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse.
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| Milatovich A, et al.
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| Somat Cell Mol Genet 20 : 75-86. 1994
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38 | PDE4A, PDE4B, PDE4C, PDE4D
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| A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.
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| Bolger G, et al.
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| Mol Cell Biol 13 : 6558-6571. 1993
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