Citations for
1ACDS, PDE4D
Mutations causing acrodysostosis-2 facilitate activation of phosphodiesterase 4D3.
Briet C, Pereda A, Le Stunff C, Motte E, de Dios Garcia-Diaz J, de Nanclares GP, Dumaz N, Silve C.
Hum Mol Genet 26(20):3883-3894. doi: 10.1093/hmg/ddx271. 2017
2ACDS, PDE4D
Phenotypic Variability in a Family with Acrodysostosis Type 2 Caused by a Novel PDE4D Mutation Affecting the Serine Target of Protein Kinase-A Phosphorylation.
Hoppmann J, Gesing J, Silve C, Leroy C, Bertsche A, Hirsch FW, Kiess W, Pfäffle R, Schuster V.
J Clin Res Pediatr Endocrinol 9(4):360-365. doi: 10.4274/jcrpe.4488. Epub 2017 May 17. 2017
3PDE4D
PDE4D promotes FAK-mediated cell invasion in BRAF-mutated melanoma.
Delyon J, Servy A, Laugier F, André J, Ortonne N, Battistella M, Mourah S, Bensussan A, Lebbé C, Dumaz N.
Oncogene 36(23):3252-3262. doi: 10.1038/onc.2016.469. Epub 2017 Jan 16. 2017
4PDE1A, PDE4D, PDE8A, PDE8B
Role of Cyclic Nucleotide Phosphodiesterases During Meiotic Resumption From Diplotene Arrest in Mammalian Oocytes.
Gupta A, Tiwari M, Prasad S, Chaube SK.
J Cell Biochem 118(3):446-452. doi: 10.1002/jcb.25748. Epub 2016 Sep 30. 2017
5PDE4D
Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling.
Yun S, Budatha M, Dahlman JE, Coon BG, Cameron RT, Langer R, Anderson DG, Baillie G, Schwartz MA.
Nat Cell Biol 18(10):1043-53. doi: 10.1038/ncb3405. Epub 2016 Sep 5. 2016
6ACDS, ADOHR, PDE4D, PRKAR1A
Screening of PRKAR1A and PDE4D in a Large Italian Series of Patients Clinically Diagnosed With Albright Hereditary Osteodystrophy and/or Pseudohypoparathyroidism.
Elli FM, Bordogna P, de Sanctis L, Giachero F, Verrua E, Segni M, Mazzanti L, Boldrin V, Toromanovic A, Spada A, Mantovani G.
J Bone Miner Res 31(6):1215-24. doi: 10.1002/jbmr.2785. Epub 2016 Feb 9. 2016
7PDE4D
Phosphodiesterase4D (PDE4D)--A risk factor for atrial fibrillation and stroke?
Jørgensen C, Yasmeen S, Iversen HK, Kruuse C.
J Neurol Sci 359(1-2):266-74. doi: 10.1016/j.jns.2015.11.010. Epub 2015 Nov 11. Review. 2015
8PDE4D
Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma.
Ge X, Milenkovic L, Suyama K, Hartl T, Purzner T, Winans A, Meyer T, Scott MP.
Elife 4. doi: 10.7554/eLife.07068. 2015
9ADRB1, DLG1, PDE4D
A long lasting β1 adrenergic receptor stimulation of cAMP/protein kinase A (PKA) signal in cardiac myocytes.
Fu Q, Kim S, Soto D, De Arcangelis V, DiPilato L, Liu S, Xu B, Shi Q, Zhang J, Xiang YK.
J Biol Chem 289(21):14771-81. doi: 10.1074/jbc.M113.542589. Epub 2014 Apr 8. 2014
10PDE4D
Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression.
Sheppard CL, Lee LC, Hill EV, Henderson DJ, Anthony DF, Houslay DM, Yalla KC, Cairns LS, Dunlop AJ, Baillie GS, Huston E, Houslay MD.
Cell Signal 26(9):1958-74. doi: 10.1016/j.cellsig.2014.04.023. Epub 2014 May 9. 2014
11PDE4D
Association between phosphodiesterase 4D polymorphism SNP83 and ischemic stroke.
Yan Y, Luo X, Zhang J, Su L, Liang W, Huang G, Wu G, Huang G, Gu L.
J Neurol Sci 338(1-2):3-11. doi: 10.1016/j.jns.2013.12.012. Epub 2013 Dec 12. Review. 2014
12ACDS, PDE4D
Identification of novel mutations confirms PDE4D as a major gene causing acrodysostosis.
Lynch DC, Dyment DA, Huang L, Nikkel SM, Lacombe D, Campeau PM, Lee B, Bacino CA, Michaud JL, Bernier FP; FORGE Canada Consortium, Parboosingh JS, Innes AM.
Hum Mutat 34(1):97-102. doi: 10.1002/humu.22222. Epub 2012 Nov 9. Erratum in: Hum Mutat. 2013 Apr;34(4):667. 2013
13CC2D1A, PDE4D
Phosphodiesterase activity is regulated by CC2D1A that is implicated in non-syndromic intellectual disability.
Al-Tawashi A, Gehring C.
Cell Commun Signal 11(1):47. doi: 10.1186/1478-811X-11-47. 2013
14ARRB2, PDE4D, TRPV1
Phosphorylation regulates TRPV1 association with β-arrestin-2.
Por ED, Gomez R, Akopian AN, Jeske NA.
Biochem J 451(1):101-9. doi: 10.1042/BJ20121637. 2013
15PDE4A, PDE4B, PDE4C, PDE4D
Disease progression in MRL/lpr lupus-prone mice is reduced by NCS 613, a specific cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitor.
Keravis T, Monneaux F, Yougbaré I, Gazi L, Bourguignon JJ, Muller S, Lugnier C.
PLoS One 7(1):e28899. Epub 2012 Jan 11. 2012
16ACDS, PDE4D
Exome Sequencing Identifies PDE4D Mutations as Another Cause of Acrodysostosis.
Michot C, Le Goff C, Goldenberg A, Abhyankar A, Klein C, Kinning E, Guerrot AM, Flahaut P, Duncombe A, Baujat G, Lyonnet S, Thalassinos C, Nitschke P, Casanova JL, Le Merrer M, Munnich A, Cormier-Daire V.
Am J Hum Genet 90(4):740-5. Epub 2012 Mar 29. 2012
17ACDS, PDE4D
Exome Sequencing Identifies PDE4D Mutations in Acrodysostosis.
Lee H, Graham JM Jr, Rimoin DL, Lachman RS, Krejci P, Tompson SW, Nelson SF, Krakow D, Cohn DH.
Am J Hum Genet 90(4):746-51. Epub 2012 Mar 29. 2012
18NOX4, PDE4A, PDE4B, PDE4D
NADPH oxidase 4 mediates upregulation of type 4 phosphodiesterases in human endothelial cells.
Muzaffar S, Jeremy JY, Angelini GD, Shukla N.
J Cell Physiol 227(5):1941-50. doi: 10.1002/jcp.22922. 2012
19AKAP9, PDE4D, PRKACA
PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome.
Terrin A, Monterisi S, Stangherlin A, Zoccarato A, Koschinski A, Surdo NC, Mongillo M, Sawa A, Jordanides NE, Mountford JC, Zaccolo M.
J Cell Biol 198(4):607-21. doi: 10.1083/jcb.201201059. 2012
20PDE4A, PDE4B, PDE4C, PDE4D
The differential impact of PDE4 subtypes in human lung fibroblasts on cytokine-induced proliferation and myofibroblast conversion.
Selige J, Hatzelmann A, Dunkern T.
J Cell Physiol 226(8):1970-80. doi: 10.1002/jcp.22529. 2011
21PDE4D
Phosphodiesterase 4D regulates baseline sarcoplasmic reticulum Ca2+ release and cardiac contractility, independently of L-type Ca2+ current.
Beca S, Helli PB, Simpson JA, Zhao D, Farman GP, Jones PP, Tian X, Wilson LS, Ahmad F, Chen SR, Movsesian MA, Manganiello V, Maurice DH, Conti M, Backx PH.
Circ Res 109(9):1024-30. Epub 2011 Sep 8. 2011
22PDE4B, PDE4D
PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts.
Blackman BE, Horner K, Heidmann J, Wang D, Richter W, Rich TC, Conti M.
J Biol Chem 286(14):12590-601. doi: 10.1074/jbc.M110.203604. Epub 2011 Feb 1. 2011
23PDE4A, PDE4D
Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK.
Li X, Vadrevu S, Dunlop A, Day J, Advant N, Troeger J, Klussmann E, Jaffrey E, Hay RT, Adams DR, Houslay MD, Baillie GS.
Biochem J 428(1):55-65.PMID: 20196770 2010
24PDE4A, PDE4B, PDE4C, PDE4D
An evolutionary analysis of cAMP-specific Phosphodiesterase 4 alternative splicing.
Johnson KR, Nicodemus-Johnson J, Danziger RS.
BMC Evol Biol 10:247. 2010
25PDE4D
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.
Himes BE, Hunninghake GM, Baurley JW, Rafaels NM, Sleiman P, Strachan DP, Wilk JB, Willis-Owen SA, Klanderman B, Lasky-Su J, Lazarus R, Murphy AJ, Soto-Quiros ME, Avila L, Beaty T, Mathias RA, Ruczinski I, Barnes KC, Celedón JC, Cookson WO, Gauderman WJ, Gilliland FD, Hakonarson H, Lange C, Moffatt MF, O'Connor GT, Raby BA, Silverman EK, Weiss ST.
Am J Hum Genet 84(5):581-93. Epub 2009 May 7. 2009
26PDE4A, PDE4B, PDE4D
The novel distribution of phosphodiesterase-4 subtypes within the rat retina.
Whitaker CM, Cooper NG.
Neuroscience 163(4):1277-91. Epub 2009 Jul 26. 2009
27ALOX5AP, PDE4D
Ischaemic stroke in hypertensive patients is associated with variations in the PDE4D genome region.
Lövkvist H, Smith JG, Luthman H, Höglund P, Norrving B, Kristoffersson U, Jönsson AC, Lindgren AG.
Eur J Hum Genet 16(9):1117-25. Epub 2008 Apr 9. 2008
28ARRB2, PDE4D
Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays.
Baillie GS, Adams DR, Bhari N, Houslay TM, Vadrevu S, Meng D, Li X, Dunlop A, Milligan G, Bolger GB, Klussmann E, Houslay MD.
Biochem J 404(1):71-80. 2007
29PDE4D
Phosphodiesterase 4D polymorphisms and the risk of cerebral infarction in a biracial population: the Stroke Prevention in Young Women Study.
Song Q, Cole JW, O'Connell JR, Stine OC, Gallagher M, Giles WH, Mitchell BD, Wozniak MA, Stern BJ, Sorkin JD, McArdle PF, Naj AC, Xu Q, Gibbons GH, Kittner SJ.
Hum Mol Genet 15(16):2468-78. Epub 2006 Jul 11. 2006
30PDE4D
Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias.
Lehnart SE, Wehrens XH, Reiken S, Warrier S, Belevych AE, Harvey RD, Richter W, Jin SL, Conti M, Marks AR.
Cell 123(1):25-35. 2005
31PART1, PDE4D, STRK1
Cloning and characterization of novel PDE4D isoforms PDE4D6 and PDE4D7.
Wang D, Deng C, Bugaj-Gaweda B, Kwan M, Gunwaldsen C, Leonard C, Xin X, Hu Y, Unterbeck A, De Vivo M.
Cell Signal 15(9):883-91. 2003
32PART1, PDE4D, STRK1
The gene encoding phosphodiesterase 4D confers risk of ischemic stroke.
Gretarsdottir S, Thorleifsson G, Reynisdottir ST, Manolescu A, Jonsdottir S, Jonsdottir T, Gudmundsdottir T, Bjarnadottir SM, Einarsson OB, Gudjonsdottir HM, Hawkins M, Gudmundsson G, Gudmundsdottir H, Andrason H, Gudmundsdottir AS, Sigurdardottir M, Chou TT, Nahmias J, Goss S, Sveinbjornsdottir S, Valdimarsson EM, Jakobsson F, Agnarsson U, Gudnason V, Thorgeirsson G, Fingerle J, Gurney M, Gudbjartsson D, Frigge ML, Kong A, Stefansson K, Gulcher JR.
Nat Genet 35(2):131-8. Epub 2003 Sep 21. 2003
33PDE4D
PDE4D plays a critical role in the control of airway smooth muscle contraction.
Mehats C, Jin SL, Wahlstrom J, Law E, Umetsu DT, Conti M.
FASEB J 17(13):1831-41. 2003
34PDE4D
Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification and characterization of a novel PDE4D5 promoter.
Le Jeune IR, Shepherd M, Van Heeke G, Houslay MD, Hall IP.
J Biol Chem 277(39):35980-9. Epub 2002 Jul 16. 2002
35PDE4D
Phosphorylation and activation of a cAMP-specific phosphodiesterase by the cAMP-dependent protein kinase. Involvement of serine 54 in the enzyme activation.
Sette C, Conti M.
J Biol Chem 271(28):16526-34. 1996
36PDE4B, PDE4D
Chromosomal localization of the human and rat genes (PDE4D and PDE4B) encoding the cAMP-specific phosphodiesterases 3 and 4.
Szpirer C, et al.
Cytogenet Cell Genet 69 : 11-14. 1995
37PDE4A, PDE4B, PDE4C, PDE4D, PDE7A
Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse.
Milatovich A, et al.
Somat Cell Mol Genet 20 : 75-86. 1994
38PDE4A, PDE4B, PDE4C, PDE4D
A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.
Bolger G, et al.
Mol Cell Biol 13 : 6558-6571. 1993