| 1 | COCH, PDE2A
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| A homozygous loss-of-function mutation in PDE2A associated to early-onset hereditary chorea.
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| Salpietro V, Perez-Dueñas B, Nakashima K, San Antonio-Arce V, Manole A, Efthymiou S, Vandrovcova J, Bettencourt C, Mencacci NE, Klein C, Kelly MP, Davies CH, Kimura H, Macaya A, Houlden H.
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| Mov Disord ov Disord. 2018 Feb 2. doi: 10.1002/mds.27286. [Epub ahead of print]
2018
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| 2 | AIP, PDE2A, PDE4A
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| Role of Phosphodiesterases on the Function of Aryl Hydrocarbon Receptor-Interacting Protein (AIP) in the Pituitary Gland and on the Evaluation of AIP Gene Variants.
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| Hernández-Ramírez LC, Trivellin G, Stratakis CA.
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| Horm Metab Res 49(4):286-295. doi: 10.1055/s-0043-104700. Epub 2017 Apr 20. Review.
2017
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| 3 | PDE2A
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| PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling.
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| Monterisi S, Lobo MJ, Livie C, Castle JC, Weinberger M, Baillie G, Surdo NC, Musheshe N, Stangherlin A, Gottlieb E, Maizels R, Bortolozzi M, Micaroni M, Zaccolo M.
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| Elife 6. pii: e21374. doi: 10.7554/eLife.21374.
2017
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| 4 | PDE2A
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| Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2.
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| Zoccarato A, Surdo NC, Aronsen JM, Fields LA, Mancuso L, Dodoni G, Stangherlin A, Livie C, Jiang H, Sin YY, Gesellchen F, Terrin A, Baillie GS, Nicklin SA, Graham D, Szabo-Fresnais N, Krall J, Vandeput F, Movsesian M, Furlan L, Corsetti V, Hamilton G, Lefkimmiatis K, Sjaastad I, Zaccolo M.
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| Circ Res 117(8):707-19. doi: 10.1161/CIRCRESAHA.114.305892. Epub 2015 Aug 4.
2015
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| 5 | PDE2A
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| Efficacy of B-Type Natriuretic Peptide Is Coupled to Phosphodiesterase 2A in Cardiac Sympathetic Neurons.
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| Li D, Lu CJ, Hao G, Wright H, Woodward L, Liu K, Vergari E, Surdo NC, Herring N, Zaccolo M, Paterson DJ.
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| Hypertension 66(1):190-8. doi: 10.1161/HYPERTENSIONAHA.114.05054. Epub 2015 Apr 27.
2015
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| 6 | PDE2A
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| Inhibition of phosphodiesterase 2 reverses impaired cognition and neuronal remodeling caused by chronic stress.
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| Xu Y, Pan J, Sun J, Ding L, Ruan L, Reed M, Yu X, Klabnik J, Lin D, Li J, Chen L, Zhang C, Zhang H, O'Donnell JM.
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| Neurobiol Aging 36(2):955-70. doi: 10.1016/j.neurobiolaging.2014.08.028. Epub 2014 Aug 30.
2015
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| 7 | PDE2A
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| Role of phosphodiesterase 2 in growth and invasion of human malignant melanoma cells.
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| Hiramoto K, Murata T, Shimizu K, Morita H, Inui M, Manganiello VC, Tagawa T, Arai N.
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| Cell Signal 26(9):1807-17. doi: 10.1016/j.cellsig.2014.03.031. Epub 2014 Apr 3.
2014
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| 8 | PDE2A
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| Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes.
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| Mehel H, Emons J, Vettel C, Wittköpper K, Seppelt D, Dewenter M, Lutz S, Sossalla S, Maier LS, Lechêne P, Leroy J, Lefebvre F, Varin A, Eschenhagen T, Nattel S, Dobrev D, Zimmermann WH, Nikolaev VO, Vandecasteele G, Fischmeister R, El-Armouche A.
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| J Am Coll Cardiol 62(17):1596-606. doi: 10.1016/j.jacc.2013.05.057. Epub 2013 Jun 26.
2013
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| 9 | PDE2A
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| The distribution of phosphodiesterase 2A in the rat brain.
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| Stephenson DT, Coskran TM, Kelly MP, Kleiman RJ, Morton D, O'Neill SM, Schmidt CJ, Weinberg RJ, Menniti FS.
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| Neuroscience 226:145-55. doi: 10.1016/j.neuroscience.2012.09.011. Epub 2012 Sep 19.
2012
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| 10 | NPPA, NPR1, PDE2A
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| Natriuretic peptides block synaptic transmission by activating phosphodiesterase 2A and reducing presynaptic PKA activity.
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| Hu F, Ren J, Zhang JE, Zhong W, Luo M.
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| Proc Natl Acad Sci U S A 109(43):17681-6. doi: 10.1073/pnas.1209185109. Epub 2012 Oct 8.
2012
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| 11 | PDE2A
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| A phosphodiesterase 2A isoform localized to mitochondria regulates respiration.
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| Acin-Perez R, Russwurm M, Günnewig K, Gertz M, Zoidl G, Ramos L, Buck J, Levin LR, Rassow J, Manfredi G, Steegborn C.
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| J Biol Chem 286(35):30423-32. Epub 2011 Jul 1.
2011
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| 12 | PDE2A
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| Nitric oxide signaling via cGMP-stimulated phosphodiesterase in striatal neurons.
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| Lin DT, Fretier P, Jiang C, Vincent SR.
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| Synapse 64(6):460-6.PMID: 20175220 2010
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| 13 | GUCA1A, GUCY2D, PDE2A
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| Ca(2+) sensor GCAP1: A constitutive element of the ONE-GC-modulated odorant signal transduction pathway.
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| Pertzev A, Duda T, Sharma RK.
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| Biochemistry 49(34):7303-13.PMID: 20684533 2010
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| 14 | PDE2A
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| Dual acylation of PDE2A splice variant 3: targeting to synaptic membranes.
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| Russwurm C, Zoidl G, Koesling D, Russwurm M.
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| J Biol Chem 284(38):25782-90. Epub 2009 Jul 24.PMID: 19632989 2009
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| 15 | PDE2A
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| Immunohistochemical localization of phosphodiesterase 2A in multiple mammalian species.
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| Stephenson DT, Coskran TM, Wilhelms MB, Adamowicz WO, O'Donnell MM, Muravnick KB, Menniti FS, Kleiman RJ, Morton D.
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| J Histochem Cytochem 57(10):933-49. Epub 2009 Jun 8.PMID: 19506089 2009
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| 16 | PDE2A
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| Phosphodiesterase 2 mediates redox-sensitive endothelial cell proliferation and angiogenesis by thrombin via Rac1 and NADPH oxidase 2.
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| Diebold I, Djordjevic T, Petry A, Hatzelmann A, Tenor H, Hess J, Görlach A.
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| Circ Res 104(10):1169-77. Epub 2009 Apr 23.PMID: 19390057 2009
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| 17 | PDE2A
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| Phosphodiesterase type 2 and the homeostasis of cyclic GMP in living thalamic neurons.
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| Hepp R, Tricoire L, Hu E, Gervasi N, Paupardin-Tritsch D, Lambolez B, Vincent P.
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| J Neurochem 102(6):1875-86. Epub 2007 Jun 11.PMID: 17561940 2007
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| 18 | PDE2A, PDE9A
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| Expression of the cGMP-specific phosphodiesterases 2 and 9 in normal and Alzheimer's disease human brains.
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| Reyes-Irisarri E, Markerink-Van Ittersum M, Mengod G, de Vente J.
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| Eur J Neurosci 25(11):3332-8.PMID: 17553001 2007
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| 19 | PDE2A
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| Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability.
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| Seybold J, Thomas D, Witzenrath M, Boral S, Hocke AC, Bürger A, Hatzelmann A, Tenor H, Schudt C, Krüll M, Schütte H, Hippenstiel S, Suttorp N.
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| Blood 105(9):3569-76. Epub 2005 Jan 13.PMID: 15650061 2005
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| 20 | ARAP1, ARHGEF17, P2RY2, P2RY6, PDE2A, RELT
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| Refined genetic mapping of autosomal recessive chronic distal spinal muscular atrophy to chromosome 11q13.3 and evidence of linkage disequilibrium in European families.
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| Viollet L, Zarhrate M, Maystadt I, Estournet-Mathiaut B, Barois A, Desguerre I, Mayer M, Chabrol B, LeHeup B, Cusin V, Billette De Villemeur T, Bonneau D, Saugier-Veber P, Touzery-De Villepin A, Delaubier A, Kaplan J, Jeanpierre M, Feingold J, Munnich A.
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| Eur J Hum Genet 12(6):483-8. 2004
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| 21 | PDE2A
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| Differential regulation of human platelet responses by cGMP inhibited and stimulated cAMP phosphodiesterases.
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| Manns JM, Brenna KJ, Colman RW, Sheth SB.
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| Thromb Haemost 87(5):873-9. 2002
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| 22 | PDE2A
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| Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases.
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| Loughney K, Martins TJ, Harris EA, Sadhu K, Hicks JB, Sonnenburg WK, Beavo JA, Ferguson K.
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| J Biol Chem 271(2):796-806.PMID: 8557689 1996
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| 23 | APLP2, CAMK2B, CPB1, ENO1, VWF, GLS, ITPKC, LONP1, MTFN, PDE2A, PPP2R2A, MAP2K1L, RAB5B, SCN2A, TST
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| Toward a cDNA map of the human genome.
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| Korenberg JR, et al.
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| Genomics 29 : 364-370. 1995
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