| 1 | CASP9, PDCD6, PDCD6IP, SHISA5
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| Alix is involved in caspase 9 activation during calcium-induced apoptosis.
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| Strappazzon F, Torch S, Chatellard-Causse C, Petiot A, Thibert C, Blot B, Verna JM, Sadoul R.
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| Biochem Biophys Res Commun 397(1):64-9. Epub 2010 May 21.PMID: 20471954 2010
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| 2 | CEP55, CHMP4A, CHMP4A, CHMP4B, CHMP5, PDCD6IP, VPS24, VPS4A, VPS4B
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| Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance.
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| Morita E, Colf LA, Karren MA, Sandrin V, Rodesch CK, Sundquist WI.
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| Proc Natl Acad Sci U S A 107(29):12889-94. Epub 2010 Jun 29.PMID: 20616062 2010
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| 3 | HCK, PDCD6IP
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| Identification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X.
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| Shi X, Opi S, Lugari A, Restouin A, Coursindel T, Parrot I, Perez J, Madore E, Zimmermann P, Corbeil J, Huang M, Arold ST, Collette Y, Morelli X.
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| Biochem J 431(1):93-102.
2010
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| 4 | ALG2, PDCD6, PDCD6IP, TSG101
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| Penta-EF-hand protein ALG-2 functions as a Ca2+-dependent adaptor that bridges Alix and TSG101.
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| Okumura M, Ichioka F, Kobayashi R, Suzuki H, Yoshida H, Shibata H, Maki M.
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| Biochem Biophys Res Commun 386(1):237-41. Epub 2009 Jun 9. 2009
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| 5 | CHMP4B, PDCD6IP
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| The CHMP4b- and Src-docking sites in the Bro1 domain are autoinhibited in the native state of Alix.
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| Zhou X, Pan S, Sun L, Corvera J, Lee YC, Lin SH, Kuang J.
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| Biochem J 418(2):277-84.PMID: 19016654 2009
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| 6 | PDCD6IP, CHMP4A, CHMP4B, CHMP4C
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| ALIX-CHMP4 interactions in the human ESCRT pathway.
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| McCullough J, Fisher RD, Whitby FG, Sundquist WI, Hill CP.
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| Proc Natl Acad Sci U S A 105(22):7687-91. Epub 2008 May 29. 2008
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| 7 | ALG2, PDCD6, PDCD6IP
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| Alix and ALG-2 are involved in tumor necrosis factor receptor 1-induced cell death.
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| Mahul-Mellier AL, Strappazzon F, Petiot A, Chatellard-Causse C, Torch S, Blot B, Freeman K, Kuhn L, Garin J, Verna JM, Fraboulet S, Sadoul R.
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| J Biol Chem 283(50):34954-65. Epub 2008 Oct 20. 2008
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| 8 | PDCD6IP
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| ALG-2 interacting protein AIP1: a novel link between D1 and D3 signalling.
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| Zhan L, Liu B, Jose-Lafuente M, Chibalina MV, Grierson A, Maclean A, Nasir J.
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| Eur J Neurosci 27(7):1626-33.PMID: 18380665 2008
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| 9 | PDCD6, PDCD6IP
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| Structural basis for Ca2+ -dependent formation of ALG-2/Alix peptide complex: Ca2+/EF3-driven arginine switch mechanism.
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| Suzuki H, Kawasaki M, Inuzuka T, Okumura M, Kakiuchi T, Shibata H, Wakatsuki S, Maki M.
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| Structure 16(10):1562-73.PMID: 18940611 2008
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| 10 | SEC31A, PDCD6, PDCD6IP
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| ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+-dependent manner.
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| Shibata H, Suzuki H, Yoshida H, Maki M.
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| Biochem Biophys Res Commun 353(3):756-63. Epub 2006 Dec 22. 2007
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| 11 | PDCD6IP, CEP55, TSG101, ROCK1, IQGAP1, CD2AP
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| Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.
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| Morita E, Sandrin V, Chung HY, Morham SG, Gygi SP, Rodesch CK, Sundquist WI.
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| EMBO J 26(19):4215-27. Epub 2007 Sep 13. 2007
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| 12 | PDCD6, PDCD6IP
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| Alix, a protein regulating endosomal trafficking, is involved in neuronal death.
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| Trioulier Y, Torch S, Blot B, Cristina N, Chatellard-Causse C, Verna JM, Sadoul R.
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| J Biol Chem 279(3):2046-52. Epub 2003 Oct 29. 2004
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| 13 | CHMP4A, CHMP4B, CHMP4C, PDCD6IP
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| The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting.
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| Katoh K, Shibata H, Suzuki H, Nara A, Ishidoh K, Kominami E, Yoshimori T, Maki M.
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| J Biol Chem 278(40):39104-13. Epub 2003 Jul 14. 2003
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| 14 | PDCD6IP
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| Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization.
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| Chatellard-Causse C, Blot B, Cristina N, Torch S, Missotten M, Sadoul R.
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| J Biol Chem 277(32):29108-15. Epub 2002 May 28. 2002
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| 15 | ALPK3, ARHGAP21, ARHGAP28, ASH1L, BOD1L, CASKIN1, CDH6, CGN, CHD7, COG1, CPSF2, CRAMP1L, DNAH1, EBF4, EIF2AK1, EIF2AK4, FAM135A, FAM63A, FBXO41, FBXO42, FGD6, FRMD4A, G2E3, HACE1, HEATR5B, HOMEZ, IBTK, IFT80, IGSF9, JMJD1C, KCNT1, KIAA1109, KIAA1328, KIAA1377, KIAA1383, KIAA1407, KIAA1430, KIAA1432, KIF17, KLF17, KLHDC5, KLHL11, KLHL12, KLHL13, KLHL14, KLHL15, KLHL8, KLHL9, LRP2BP, LRRC7, MARCH4, MIB1, MKL1, N4BP2, NFIA, NUFIP2, PCDH10, PDCD6IP, PDP2, PTCHD2, RBM27, RCOR3, RGAG1, ROBO2, RPAP1, SEMA6A, SH3PXD2B, SIPA1L2, STAMBPL1, STARD9, TSR1, TULP4, TXNDC16, UPF2, WDFY1, WDR11, WDR35, ZMYM6, ZNF391, ZNF395, ZNF398, ZNF471, ZNF687, ZNFX1
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| Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.
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| Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O.
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| DNA Res 7(1):65-73. 2000
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| 16 | ABI2, PDCD6IP
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| Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction.
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| Vito P, Pellegrini L, Guiet C, D'Adamio L.
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| J Biol Chem 274(3):1533-40. 1999
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| 17 | PDCD6IP
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| Alix, a novel mouse protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein.
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| Missotten M, Nichols A, Rieger K, Sadoul R.
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| Cell Death Differ 6(2):124-9. 1999
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