Citations for
1PDCD6IP
The yeast Alix homolog Bro1 functions as a ubiquitin receptor for protein sorting into multivesicular endosomes.
Pashkova N, Gakhar L, Winistorfer SC, Sunshine AB, Rich M, Dunham MJ, Yu L, Piper RC.
Dev Cell 25(5):520-33. doi: 10.1016/j.devcel.2013.04.007. Epub 2013 May 30. 2013
2NEURL2, PDCD6IP
Alix protein is substrate of Ozz-E3 ligase and modulates actin remodeling in skeletal muscle.
Bongiovanni A, Romancino DP, Campos Y, Paterniti G, Qiu X, Moshiach S, Di Felice V, Vergani N, Ustek D, d'Azzo A.
J Biol Chem 287(15):12159-71. doi: 10.1074/jbc.M111.297036. Epub 2012 Feb 13. 2012
3PDCD6IP, SDCBP
Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.
Baietti MF, Zhang Z, Mortier E, Melchior A, Degeest G, Geeraerts A, Ivarsson Y, Depoortere F, Coomans C, Vermeiren E, Zimmermann P, David G.
Nat Cell Biol 14(7):677-85. doi: 10.1038/ncb2502. 2012
4PDCD6IP
ALIX is a Lys63-specific polyubiquitin binding protein that functions in retrovirus budding.
Dowlatshahi DP, Sandrin V, Vivona S, Shaler TA, Kaiser SE, Melandri F, Sundquist WI, Kopito RR.
Dev Cell 23(6):1247-54. doi: 10.1016/j.devcel.2012.10.023. Epub 2012 Nov 29. 2012
5PDCD6IP
The Phe105 loop of Alix Bro1 domain plays a key role in HIV-1 release.
Sette P, Mu R, Dussupt V, Jiang J, Snyder G, Smith P, Xiao TS, Bouamr F.
Structure 19(10):1485-95. doi: 10.1016/j.str.2011.07.016. Epub 2011 Sep 1. 2011
6PDCD6IP
Activation of the retroviral budding factor ALIX.
Zhai Q, Landesman MB, Chung HY, Dierkers A, Jeffries CM, Trewhella J, Hill CP, Sundquist WI.
J Virol 85(17):9222-6. doi: 10.1128/JVI.02653-10. Epub 2011 Jun 29. 2011
7CASP9, PDCD6, PDCD6IP, SHISA5
Alix is involved in caspase 9 activation during calcium-induced apoptosis.
Strappazzon F, Torch S, Chatellard-Causse C, Petiot A, Thibert C, Blot B, Verna JM, Sadoul R.
Biochem Biophys Res Commun 397(1):64-9. Epub 2010 May 21.PMID: 20471954 2010
8CEP55, CHMP4A, CHMP4A, CHMP4B, CHMP5, PDCD6IP, VPS24, VPS4A, VPS4B
Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance.
Morita E, Colf LA, Karren MA, Sandrin V, Rodesch CK, Sundquist WI.
Proc Natl Acad Sci U S A 107(29):12889-94. Epub 2010 Jun 29.PMID: 20616062 2010
9HCK, PDCD6IP
Identification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X.
Shi X, Opi S, Lugari A, Restouin A, Coursindel T, Parrot I, Perez J, Madore E, Zimmermann P, Corbeil J, Huang M, Arold ST, Collette Y, Morelli X.
Biochem J 431(1):93-102. 2010
10ALG2, PDCD6, PDCD6IP, TSG101
Penta-EF-hand protein ALG-2 functions as a Ca2+-dependent adaptor that bridges Alix and TSG101.
Okumura M, Ichioka F, Kobayashi R, Suzuki H, Yoshida H, Shibata H, Maki M.
Biochem Biophys Res Commun 386(1):237-41. Epub 2009 Jun 9. 2009
11CHMP4B, PDCD6IP
The CHMP4b- and Src-docking sites in the Bro1 domain are autoinhibited in the native state of Alix.
Zhou X, Pan S, Sun L, Corvera J, Lee YC, Lin SH, Kuang J.
Biochem J 418(2):277-84.PMID: 19016654 2009
12PDCD6IP, CHMP4A, CHMP4B, CHMP4C
ALIX-CHMP4 interactions in the human ESCRT pathway.
McCullough J, Fisher RD, Whitby FG, Sundquist WI, Hill CP.
Proc Natl Acad Sci U S A 105(22):7687-91. Epub 2008 May 29. 2008
13ALG2, PDCD6, PDCD6IP
Alix and ALG-2 are involved in tumor necrosis factor receptor 1-induced cell death.
Mahul-Mellier AL, Strappazzon F, Petiot A, Chatellard-Causse C, Torch S, Blot B, Freeman K, Kuhn L, Garin J, Verna JM, Fraboulet S, Sadoul R.
J Biol Chem 283(50):34954-65. Epub 2008 Oct 20. 2008
14PDCD6IP
ALG-2 interacting protein AIP1: a novel link between D1 and D3 signalling.
Zhan L, Liu B, Jose-Lafuente M, Chibalina MV, Grierson A, Maclean A, Nasir J.
Eur J Neurosci 27(7):1626-33.PMID: 18380665 2008
15PDCD6, PDCD6IP
Structural basis for Ca2+ -dependent formation of ALG-2/Alix peptide complex: Ca2+/EF3-driven arginine switch mechanism.
Suzuki H, Kawasaki M, Inuzuka T, Okumura M, Kakiuchi T, Shibata H, Wakatsuki S, Maki M.
Structure 16(10):1562-73.PMID: 18940611 2008
16SEC31A, PDCD6, PDCD6IP
ALG-2 directly binds Sec31A and localizes at endoplasmic reticulum exit sites in a Ca2+-dependent manner.
Shibata H, Suzuki H, Yoshida H, Maki M.
Biochem Biophys Res Commun 353(3):756-63. Epub 2006 Dec 22. 2007
17PDCD6IP, CEP55, TSG101, ROCK1, IQGAP1, CD2AP
Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.
Morita E, Sandrin V, Chung HY, Morham SG, Gygi SP, Rodesch CK, Sundquist WI.
EMBO J 26(19):4215-27. Epub 2007 Sep 13. 2007
18PDCD6, PDCD6IP
Alix, a protein regulating endosomal trafficking, is involved in neuronal death.
Trioulier Y, Torch S, Blot B, Cristina N, Chatellard-Causse C, Verna JM, Sadoul R.
J Biol Chem 279(3):2046-52. Epub 2003 Oct 29. 2004
19CHMP4A, CHMP4B, CHMP4C, PDCD6IP
The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting.
Katoh K, Shibata H, Suzuki H, Nara A, Ishidoh K, Kominami E, Yoshimori T, Maki M.
J Biol Chem 278(40):39104-13. Epub 2003 Jul 14. 2003
20PDCD6IP
Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization.
Chatellard-Causse C, Blot B, Cristina N, Torch S, Missotten M, Sadoul R.
J Biol Chem 277(32):29108-15. Epub 2002 May 28. 2002
21ALPK3, ARHGAP21, ARHGAP28, ASH1L, BOD1L, CASKIN1, CDH6, CGN, CHD7, COG1, CPSF2, CRAMP1L, DNAH1, EBF4, EIF2AK1, EIF2AK4, FAM135A, FAM63A, FBXO41, FBXO42, FGD6, FRMD4A, G2E3, HACE1, HEATR5B, HOMEZ, IBTK, IFT80, IGSF9, JMJD1C, KCNT1, KIAA1109, KIAA1328, KIAA1377, KIAA1383, KIAA1407, KIAA1430, KIAA1432, KIF17, KLF17, KLHDC5, KLHL11, KLHL12, KLHL13, KLHL14, KLHL15, KLHL8, KLHL9, LRP2BP, LRRC7, MARCH4, MIB1, MKL1, N4BP2, NFIA, NUFIP2, PCDH10, PDCD6IP, PDP2, PTCHD2, RBM27, RCOR3, RGAG1, ROBO2, RPAP1, SEMA6A, SH3PXD2B, SIPA1L2, STAMBPL1, STARD9, TSR1, TULP4, TXNDC16, UPF2, WDFY1, WDR11, WDR35, ZMYM6, ZNF391, ZNF395, ZNF398, ZNF471, ZNF687, ZNFX1
Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.
Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O.
DNA Res 7(1):65-73. 2000
22ABI2, PDCD6IP
Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction.
Vito P, Pellegrini L, Guiet C, D'Adamio L.
J Biol Chem 274(3):1533-40. 1999
23PDCD6IP
Alix, a novel mouse protein undergoing calcium-dependent interaction with the apoptosis-linked-gene 2 (ALG-2) protein.
Missotten M, Nichols A, Rieger K, Sadoul R.
Cell Death Differ 6(2):124-9. 1999