1 | FFAR1, PCSK2
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| Regulation of prohormone convertase 2 protein expression via GPR40/FFA1 in the hypothalamus.
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| Nakamoto K, Aizawa F, Nishinaka T, Tokuyama S.
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| Eur J Pharmacol 762:459-63. doi: 10.1016/j.ejphar.2015.06.013. Epub 2015 Jun 11.
2015
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2 | FURIN, PAX6, PCSK1, PCSK2
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| Mutant PAX6 downregulates prohormone convertase 2 expression in mouse islets.
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| Chen Y, Cao W, Zhou S, Shen L, Wen J.
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| Exp Biol Med (Maywood) 238(11):1259-64. doi: 10.1177/1535370213502627. Epub 2013 Sep 18.
2013
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3 | FURIN, PCSK1, PCSK2
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| Decreased hypothalamic prohormone convertase expression in huntington disease patients.
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| van Wamelen DJ, Aziz NA, Zhao J, Balesar R, Unmehopa U, Roos RA, Swaab DF.
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| J Neuropathol Exp Neurol 72(12):1126-34. doi: 10.1097/NEN.0000000000000010.
2013
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4 | PCSK2
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| Effect of a common variant of the PCSK2 gene on reduced insulin secretion.
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| Jonsson A, Isomaa B, Tuomi T, Eriksson JG, Groop L, Lyssenko V.
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| Diabetologia 55(12):3245-51. doi: 10.1007/s00125-012-2728-5. Epub 2012 Sep 26.
2012
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5 | PCSK2, SCG5
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| Dynamic modulation of prohormone convertase 2 (PC2)-mediated precursor processing by 7B2 protein: preferential effect on glucagon synthesis.
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| Helwig M, Lee SN, Hwang JR, Ozawa A, Medrano JF, Lindberg I.
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| J Biol Chem 286(49):42504-13. doi: 10.1074/jbc.M111.281980. Epub 2011 Oct 19.
2011
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6 | PCSK2, SCG5
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| PCSK2-null mice exhibit delayed intestinal motility, reduced refeeding response and altered plasma levels of several regulatory peptides.
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| Gagnon J, Mayne J, Chen A, Raymond A, Woulfe J, Mbikay M, Chrétien M.
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| Life Sci 88(5-6):212-7. doi: 10.1016/j.lfs.2010.11.010. Epub 2010 Nov 16.
2011
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7 | PCSK1, PCSK2, PCSK5, PCSK6
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| Subtilisin-like proprotein convertase expression, localization, and activity in the human retina and optic nerve head.
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| Fuller JA, Brun-Zinkernagel AM, Clark AF, Wordinger RJ.
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| Invest Ophthalmol Vis Sci 50(12):5759-68. Epub 2009 Apr 1. 2009
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8 | PCSK1, PCSK2
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| Molecular cloning, ontogeny and tissue distribution of zebrafish (Danio rerio) prohormone convertases: pcsk1 and pcsk2.
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| Morash MG, MacDonald AB, Croll RP, Anini Y.
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| Gen Comp Endocrinol 162(2):179-87. doi: 10.1016/j.ygcen.2009.03.013. Epub 2009 Mar 28.
2009
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9 | PCSK2, SCG5
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| 7B2 prevents unfolding and aggregation of prohormone convertase 2.
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| Lee SN, Lindberg I.
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| Endocrinology 149(8):4116-27. doi: 10.1210/en.2008-0064. Epub 2008 May 8.
2008
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10 | FURIN, PCSK1, PCSK2, PCSK5, PCSK6
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| PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism.
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| Dikeakos JD, Mercure C, Lacombe MJ, Seidah NG, Reudelhuber TL.
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| FEBS J 274(16):4094-102. Epub 2007 Jul 20.
2007
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11 | PCSK2, PCSK5
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| Inhibition of PC5 expression decreases CCK secretion and increases PC2 expression.
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| Reynolds NA, Blum A, Kitagawa K, Beinfeld MC.
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| Peptides 27(4):901-4. Epub 2005 Nov 2.
2006
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12 | FURIN, PCSK1, PCSK2
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| Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide.
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| Marzban L, Trigo-Gonzalez G, Zhu X, Rhodes CJ, Halban PA, Steiner DF, Verchere CB.
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| Diabetes 53(1):141-8.
2004
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13 | PCSK2
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| Human proprotein convertase 2 homologue from a plant nematode: cloning, characterization, and comparison with other species.
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| Kovaleva ES, Yakovlev AG, Masler EP, Chitwood DJ.
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| FASEB J 16(9):1099-101. Epub 2002 May 08. 2002
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14 | FURIN, PCSK6, PCSK1, PCSK2, PCSK4, PCSK5, PCSK7
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| A model for the structure of the P domains in the subtilisin-like prohormone convertases.
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| Lipkind GM, et al.
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| Proc Natl Acad Sci U S A 95(13):7310-5. 1998
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15 | PCSK2, THBD, SNAP25
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| Radiation hybrid mapping of SNAP, PCSK2, and THBD (human chromosome 20p).
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| Maglott DR, et al.
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| Mamm Genome 7 : 400-401. 1996
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16 | FURIN, PCSK6, PCSK1, PCSK2, PCSK4, PCSK5, PCSK7
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| The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.
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| Seidah NG, et al.
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| Biochimie 76(3-4):197-209. Review. 1994
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17 | PCSK2
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| Dinucleotide repeat polymorphism in the NEC2 gene.
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| Seo TS, et al.
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| Hum Mol Genet 2 : 1983. 1993
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18 | FURIN, PCSK6, PCSK1, PCSK2, PCSK4, PCSK5, PCSK7
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| Structure and function of eukaryotic proprotein processing enzymes of the subtilisin family of serine proteases.
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| Van de Ven WJ, et al.
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| Crit Rev Oncog 4(2):115-36. Review. 1993
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19 | THBD, SSTR4, PCSK2, PYGB
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| Human somatostatin receptor genes: localization of SSTR5 to human chromosome 20p11.2.
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| Yasuda K, Espinosa R 3rd, Davis EM, Le Beau MM, Bell GI.
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| Genomics 17(3):785-6. 1993
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20 | PCSK2
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| Identification and analysis of the gene encoding human PC2, a prohormone convertase expressed in neuroendocrine tissues.
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| Ohagi S, et al.
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| Proc Natl Acad Sci U S A 89 : 4977-4981. 1992
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21 | PCSK1, PCSK2
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| Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and furin (mouse 7(D1-E2) region).
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| Seidah NG, et al.
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| Genomics 11 : 103-107. 1991
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22 | PCSK1, PCSK2
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| PC1 and PC2 are pro-protein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.
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| Benjannet S, et al.
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| Proc Natl Acad Sci U S A 88 : 3564-3568. 1991
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23 | PCSK1, PCSK2, FURIN, PCSK4, PCSK5, PCSK6
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| Mammalian subtilisins : the long-sought dibasic processing endoproteases.
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| Barr PJ.
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| Cell 66 : 1-3. 1991
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