Citations for
1FFAR1, PCSK2
Regulation of prohormone convertase 2 protein expression via GPR40/FFA1 in the hypothalamus.
Nakamoto K, Aizawa F, Nishinaka T, Tokuyama S.
Eur J Pharmacol 762:459-63. doi: 10.1016/j.ejphar.2015.06.013. Epub 2015 Jun 11. 2015
2FURIN, PAX6, PCSK1, PCSK2
Mutant PAX6 downregulates prohormone convertase 2 expression in mouse islets.
Chen Y, Cao W, Zhou S, Shen L, Wen J.
Exp Biol Med (Maywood) 238(11):1259-64. doi: 10.1177/1535370213502627. Epub 2013 Sep 18. 2013
3FURIN, PCSK1, PCSK2
Decreased hypothalamic prohormone convertase expression in huntington disease patients.
van Wamelen DJ, Aziz NA, Zhao J, Balesar R, Unmehopa U, Roos RA, Swaab DF.
J Neuropathol Exp Neurol 72(12):1126-34. doi: 10.1097/NEN.0000000000000010. 2013
4PCSK2
Effect of a common variant of the PCSK2 gene on reduced insulin secretion.
Jonsson A, Isomaa B, Tuomi T, Eriksson JG, Groop L, Lyssenko V.
Diabetologia 55(12):3245-51. doi: 10.1007/s00125-012-2728-5. Epub 2012 Sep 26. 2012
5PCSK2, SCG5
Dynamic modulation of prohormone convertase 2 (PC2)-mediated precursor processing by 7B2 protein: preferential effect on glucagon synthesis.
Helwig M, Lee SN, Hwang JR, Ozawa A, Medrano JF, Lindberg I.
J Biol Chem 286(49):42504-13. doi: 10.1074/jbc.M111.281980. Epub 2011 Oct 19. 2011
6PCSK2, SCG5
PCSK2-null mice exhibit delayed intestinal motility, reduced refeeding response and altered plasma levels of several regulatory peptides.
Gagnon J, Mayne J, Chen A, Raymond A, Woulfe J, Mbikay M, Chrétien M.
Life Sci 88(5-6):212-7. doi: 10.1016/j.lfs.2010.11.010. Epub 2010 Nov 16. 2011
7PCSK1, PCSK2, PCSK5, PCSK6
Subtilisin-like proprotein convertase expression, localization, and activity in the human retina and optic nerve head.
Fuller JA, Brun-Zinkernagel AM, Clark AF, Wordinger RJ.
Invest Ophthalmol Vis Sci 50(12):5759-68. Epub 2009 Apr 1. 2009
8PCSK1, PCSK2
Molecular cloning, ontogeny and tissue distribution of zebrafish (Danio rerio) prohormone convertases: pcsk1 and pcsk2.
Morash MG, MacDonald AB, Croll RP, Anini Y.
Gen Comp Endocrinol 162(2):179-87. doi: 10.1016/j.ygcen.2009.03.013. Epub 2009 Mar 28. 2009
9PCSK2, SCG5
7B2 prevents unfolding and aggregation of prohormone convertase 2.
Lee SN, Lindberg I.
Endocrinology 149(8):4116-27. doi: 10.1210/en.2008-0064. Epub 2008 May 8. 2008
10FURIN, PCSK1, PCSK2, PCSK5, PCSK6
PC1/3, PC2 and PC5/6A are targeted to dense core secretory granules by a common mechanism.
Dikeakos JD, Mercure C, Lacombe MJ, Seidah NG, Reudelhuber TL.
FEBS J 274(16):4094-102. Epub 2007 Jul 20. 2007
11PCSK2, PCSK5
Inhibition of PC5 expression decreases CCK secretion and increases PC2 expression.
Reynolds NA, Blum A, Kitagawa K, Beinfeld MC.
Peptides 27(4):901-4. Epub 2005 Nov 2. 2006
12FURIN, PCSK1, PCSK2
Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide.
Marzban L, Trigo-Gonzalez G, Zhu X, Rhodes CJ, Halban PA, Steiner DF, Verchere CB.
Diabetes 53(1):141-8. 2004
13PCSK2
Human proprotein convertase 2 homologue from a plant nematode: cloning, characterization, and comparison with other species.
Kovaleva ES, Yakovlev AG, Masler EP, Chitwood DJ.
FASEB J 16(9):1099-101. Epub 2002 May 08. 2002
14FURIN, PCSK6, PCSK1, PCSK2, PCSK4, PCSK5, PCSK7
A model for the structure of the P domains in the subtilisin-like prohormone convertases.
Lipkind GM, et al.
Proc Natl Acad Sci U S A 95(13):7310-5. 1998
15PCSK2, THBD, SNAP25
Radiation hybrid mapping of SNAP, PCSK2, and THBD (human chromosome 20p).
Maglott DR, et al.
Mamm Genome 7 : 400-401. 1996
16FURIN, PCSK6, PCSK1, PCSK2, PCSK4, PCSK5, PCSK7
The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.
Seidah NG, et al.
Biochimie 76(3-4):197-209. Review. 1994
17PCSK2
Dinucleotide repeat polymorphism in the NEC2 gene.
Seo TS, et al.
Hum Mol Genet 2 : 1983. 1993
18FURIN, PCSK6, PCSK1, PCSK2, PCSK4, PCSK5, PCSK7
Structure and function of eukaryotic proprotein processing enzymes of the subtilisin family of serine proteases.
Van de Ven WJ, et al.
Crit Rev Oncog 4(2):115-36. Review. 1993
19THBD, SSTR4, PCSK2, PYGB
Human somatostatin receptor genes: localization of SSTR5 to human chromosome 20p11.2.
Yasuda K, Espinosa R 3rd, Davis EM, Le Beau MM, Bell GI.
Genomics 17(3):785-6. 1993
20PCSK2
Identification and analysis of the gene encoding human PC2, a prohormone convertase expressed in neuroendocrine tissues.
Ohagi S, et al.
Proc Natl Acad Sci U S A 89 : 4977-4981. 1992
21PCSK1, PCSK2
Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and furin (mouse 7(D1-E2) region).
Seidah NG, et al.
Genomics 11 : 103-107. 1991
22PCSK1, PCSK2
PC1 and PC2 are pro-protein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues.
Benjannet S, et al.
Proc Natl Acad Sci U S A 88 : 3564-3568. 1991
23PCSK1, PCSK2, FURIN, PCSK4, PCSK5, PCSK6
Mammalian subtilisins : the long-sought dibasic processing endoproteases.
Barr PJ.
Cell 66 : 1-3. 1991