Citations for
1CHTF18, CHTF8, PCNA, RFC1
Structural Basis for the Recruitment of Ctf18-RFC to the Replisome.
Grabarczyk DB, Silkenat S, Kisker C.
Structure 26(1):137-144.e3. doi: 10.1016/j.str.2017.11.004. Epub 2017 Dec 7. 2018
2FANCD2, FANCI, PCNA, USP1
Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1.
Arkinson C, Chaugule VK, Toth R, Walden H.
Life Sci Alliance 1(5):e201800162. doi: 10.26508/lsa.201800162. eCollection 2018 Oct. 2018
3NEO1, PCNA
The co-expression of Neogenin with SOX2 in hippocampal neurons.
Hong N, Kim MH, Min CK, Kim HJ, Lee JH.
Biochem Biophys Res Commun 490(2):453-459. doi: 10.1016/j.bbrc.2017.06.062. Epub 2017 Jun 13. 2017
4NEIL1, PCNA
Destabilization of the PCNA trimer mediated by its interaction with the NEIL1 DNA glycosylase.
Prakash A, Moharana K, Wallace SS, Doublié S.
Nucleic Acids Res. Mar 17;45(5):2897-2909. doi: 10.1093/nar/gkw1282. 2017
5PCNA, TRAIP
TRAIP regulates replication fork recovery and progression via PCNA.
Feng W, Guo Y, Huang J, Deng Y, Zang J, Huen MS.
Cell Discov 2:16016. doi: 10.1038/celldisc.2016.16. eCollection 2016. 2016
6PCNA, TRAIP
TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress.
Hoffmann S, Smedegaard S, Nakamura K, Mortuza GB, Räschle M, Ibañez de Opakua A, Oka Y, Feng Y, Blanco FJ, Mann M, Montoya G, Groth A, Bekker-Jensen S, Mailand N.
J Cell Biol 212(1):63-75. doi: 10.1083/jcb.201506071. Epub 2015 Dec 28. 2016
7PCNA, SDE2
PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress
Jo U, Cai W, Wang J, Kwon Y, D'Andrea AD, Kim H.
PLoS Genet. Dec 1;12(12):e1006465. doi: 10.1371/journal.pgen.1006465 2016
8PCNA, ZRANB3
Structure and specificity of the bacterial cysteine methyltransferase effector NleE suggests a novel substrate in human DNA repair pathway.
Yao Q, Zhang L, Wan X, Chen J, Hu L, Ding X, Li L, Karar J, Peng H, Chen S, Huang N, Rauscher FJ 3rd, Shao F.
PLoS Pathog 10(11):e1004522. doi: 10.1371/journal.ppat.1004522. eCollection 2014 Nov. 2014
9PCNA, RAD18, SIVA1
SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination.
Han J, Liu T, Huen MS, Hu L, Chen Z, Huang J.
J Cell Biol 205(6):811-27. doi: 10.1083/jcb.201311007. 2014
10DDB2, PCNA
DDB2 association with PCNA is required for its degradation after UV-induced DNA damage.
Cazzalini O, Perucca P, Mocchi R, Sommatis S, Prosperi E, Stivala LA.
Cell Cycle 13(2):240-8. doi: 10.4161/cc.26987. Epub 2013 Nov 4. 2014
11CCND1, PCNA, ROCK1, ROCK2
Rho-associated protein kinase isoforms stimulate proliferation of vascular smooth muscle cells through ERK and induction of cyclin D1 and PCNA.
Zhao Y, Lv M, Lin H, Cui Y, Wei X, Qin Y, Kohama K, Gao Y.
Biochem Biophys Res Commun 432(3):488-93. doi: 10.1016/j.bbrc.2013.02.009. Epub 2013 Feb 10. 2013
12PCNA, RTEL1
RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication.
Vannier JB, Sandhu S, Petalcorin MI, Wu X, Nabi Z, Ding H, Boulton SJ.
Science 342(6155):239-42. doi: 10.1126/science.1241779. 2013
13ATAD5, PCNA
Alternative replication factor C protein, Elg1, maintains chromosome stability by regulating PCNA levels on chromatin.
Shiomi Y, Nishitani H.
Genes Cells 18(11):946-59. doi: 10.1111/gtc.12087. Epub 2013 Aug 13. 2013
14PCNA, POLH, RAD18
A non-catalytic role of DNA polymerase η in recruiting Rad18 and promoting PCNA monoubiquitination at stalled replication forks.
Durando M, Tateishi S, Vaziri C.
Nucleic Acids Res 41(5):3079-93. doi: 10.1093/nar/gkt016. Epub 2013 Jan 23. 2013
15BAX, ING1, PCNA
ING1 induces apoptosis through direct effects at the mitochondria.
Bose P, Thakur S, Thalappilly S, Ahn BY, Satpathy S, Feng X, Suzuki K, Kim SW, Riabowol K.
Cell Death Dis 4:e788. doi: 10.1038/cddis.2013.321. Erratum in: Cell Death Dis. 2013;4:e837. 2013
16FANCD2, PCNA, USP1, WDR48
Inactivation of Uaf1 causes defective homologous recombination and early embryonic lethality in mice.
Park E, Kim JM, Primack B, Weinstock DM, Moreau LA, Parmar K, D'Andrea AD.
Mol Cell Biol 33(22):4360-70. doi: 10.1128/MCB.00870-13. Epub 2013 Sep 3. 2013
17PCNA, SUMO1
Role of SUMO modification of human PCNA at stalled replication fork.
Gali H, Juhasz S, Morocz M, Hajdu I, Fatyol K, Szukacsov V, Burkovics P, Haracska L.
Nucleic Acids Res 40(13):6049-59. Epub 2012 Mar 28. 2012
18PCNA, SETD8
Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression.
Takawa M, Cho HS, Hayami S, Toyokawa G, Kogure M, Yamane Y, Iwai Y, Maejima K, Ueda K, Masuda A, Dohmae N, Field HI, Tsunoda T, Kobayashi T, Akasu T, Sugiyama M, Ohnuma S, Atomi Y, Ponder BA, Nakamura Y, Hamamoto R.
Cancer Res 72(13):3217-27. doi: 10.1158/0008-5472.CAN-11-3701. Epub 2012 May 3. 2012
19PCNA, UNG
The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.
Torseth K, Doseth B, Hagen L, Olaisen C, Liabakk NB, Græsmann H, Durandy A, Otterlei M, Krokan HE, Kavli B, Slupphaug G.
DNA Repair (Amst) 11(6):559-69. doi: 10.1016/j.dnarep.2012.03.006. Epub 2012 Apr 20. 2012
20PCNA, SPRTN
Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis.
Ghosal G, Leung JW, Nair BC, Fong KW, Chen J.
J Biol Chem 287(41):34225-33. doi: 10.1074/jbc.M112.400135. Epub 2012 Aug 17. 2012
21PCNA, SPRTN
Spartan/C1orf124 is important to prevent UV-induced mutagenesis.
Machida Y, Kim MS, Machida YJ.
Cell Cycle 11(18):3395-402. doi: 10.4161/cc.21694. Epub 2012 Aug 16. 2012
22ATM, PCNA
ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis.
Gamper AM, Choi S, Matsumoto Y, Banerjee D, Tomkinson AE, Bakkenist CJ.
J Biol Chem 287(15):12445-54. doi: 10.1074/jbc.M112.352310. Epub 2012 Feb 23. 2012
23KCTD13, MYBL2, PCNA
B-Myb promotes S-phase independently of its sequence-specific DNA binding activity and interacts with polymerase delta-interacting protein 1 (Pdip1).
Werwein E, Schmedt T, Hoffmann H, Usadel C, Obermann N, Singer JD, Klempnauer KH.
Cell Cycle 11(21):4047-58. doi: 10.4161/cc.22386. Epub 2012 Oct 3. 2012
24PCNA, ZRANB3
Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.
Ciccia A, Nimonkar AV, Hu Y, Hajdu I, Achar YJ, Izhar L, Petit SA, Adamson B, Yoon JC, Kowalczykowski SC, Livingston DM, Haracska L, Elledge SJ.
Mol Cell 47(3):396-409. doi: 10.1016/j.molcel.2012.05.024. Epub 2012 Jun 14. 2012
25PCNA, ZRANB3
Finally, polyubiquitinated PCNA gets recognized.
Zeman MK, Cimprich KA.
Mol Cell 47(3):333-4. doi: 10.1016/j.molcel.2012.07.024. 2012
26HMGN1, PCNA
The nucleosome binding protein HMGN1 interacts with PCNA and facilitates its binding to chromatin.
Postnikov YV, Kurahashi T, Zhou M, Bustin M.
Mol Cell Biol 32(10):1844-54. doi: 10.1128/MCB.06429-11. Epub 2012 Mar 5. 2012
27PCNA, SPRTN
Spartan/C1orf124, a reader of PCNA ubiquitylation and a regulator of UV-induced DNA damage response.
Centore RC, Yazinski SA, Tse A, Zou L.
Mol Cell 46(5):625-35. doi: 10.1016/j.molcel.2012.05.020. 2012
28CCNA2, E2F1, PCNA, RSL1D1
The retinoblastoma protein selectively represses E2F1 targets via a TAAC DNA element during cellular senescence.
Chen T, Xue L, Niu J, Ma L, Li N, Cao X, Li Q, Wang M, Zhao W, Li G, Wang J, Tong T.
J Biol Chem 287(44):37540-51. doi: 10.1074/jbc.M111.260679. Epub 2012 Sep 6. 2012
29NCR2, PCNA
Proliferating cell nuclear antigen is a novel inhibitory ligand for the natural cytotoxicity receptor NKp44.
Rosental B, Brusilovsky M, Hadad U, Oz D, Appel MY, Afergan F, Yossef R, Rosenberg LA, Aharoni A, Cerwenka A, Campbell KS, Braiman A, Porgador A.
J Immunol 187(11):5693-702. Epub 2011 Oct 21. 2011
30PARG, PCNA
PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms.
Mortusewicz O, Fouquerel E, Amé JC, Leonhardt H, Schreiber V.
Nucleic Acids Res 39(12):5045-56. Epub 2011 Mar 11. 2011
31ATR, FAN1, FANCD2, FANCI, FANCL, FANCM, PCNA, SLX4
Ubiquitylation and the Fanconi anemia pathway.
Garner E, Smogorzewska A.
FEBS Lett 585(18):2853-60. Epub 2011 May 19. Review. 2011
32KDM5C, PCNA
Proliferating cell nuclear antigen is required for loading of the SMCX/KMD5C histone demethylase onto chromatin.
Liang Z, Diamond M, Smith JA, Schnell M, Daniel R.
Epigenetics Chromatin 4(1):18. doi: 10.1186/1756-8935-4-18. 2011
33CDT1, DTL, PCNA
A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction.
Raman M, Havens CG, Walter JC, Harper JW.
Mol Cell 44(1):72-84. doi: 10.1016/j.molcel.2011.06.036. 2011
34HLTF, PCNA, USP7
USP7 regulates the stability and function of HLTF through deubiquitination.
Qing P, Han L, Bin L, Yan L, Ping WX.
J Cell Biochem 112(12):3856-62. doi: 10.1002/jcb.23317. 2011
35ATAD5, PCNA, USP1, WDR48
Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1.
Lee KY, Yang K, Cohn MA, Sikdar N, D'Andrea AD, Myung K.
J Biol Chem 285(14):10362-9. Epub 2010 Feb 9. 2010
36DCLRE1A, PCNA, RAD18
RAD18-dependent recruitment of SNM1A to DNA repair complexes by a ubiquitin-binding zinc finger.
Yang K, Moldovan GL, D'Andrea AD.
J Biol Chem 285(25):19085-91. Epub 2010 Apr 12.PMID: 20385554 2010
37DTL, PCNA, SETD8
Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage.
Oda H, Hübner MR, Beck DB, Vermeulen M, Hurwitz J, Spector DL, Reinberg D.
Mol Cell 40(3):364-76. doi: 10.1016/j.molcel.2010.10.011. Epub 2010 Oct 28. 2010
38PCNA, RBBP8
Expression of PCNA-binding domain of CtIP, a motif required for CtIP localization at DNA replication foci, causes DNA damage and activation of DNA damage checkpoint.
Gu B, Chen PL.
Cell Cycle 8(9):1409-20. Epub 2009 May 2. 2009
39PCNA
Ubiquitination and deubiquitination of PCNA in response to stalling of the replication fork.
Brown S, Niimi A, Lehmann AR.
Cell Cycle 8(5):689-92. Epub 2009 Mar 25. 2009
40PCNA
Structural basis for novel interactions between human translesion synthesis polymerases and proliferating cell nuclear antigen.
Hishiki A, Hashimoto H, Hanafusa T, Kamei K, Ohashi E, Shimizu T, Ohmori H, Sato M.
J Biol Chem 284(16):10552-60. Epub 2009 Feb 10. 2009
41CDT1, DTL, PCNA
Docking of a specialized PIP Box onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt2.
Havens CG, Walter JC.
Mol Cell 35(1):93-104. doi: 10.1016/j.molcel.2009.05.012. 2009
42NUDT15, PCNA
Proliferating cell nuclear antigen is protected from degradation by forming a complex with MutT Homolog2.
Yu Y, Cai JP, Tu B, Wu L, Zhao Y, Liu X, Li L, McNutt MA, Feng J, He Q, Yang Y, Wang H, Sekiguchi M, Zhu WG.
J Biol Chem 284(29):19310-20. doi: 10.1074/jbc.M109.015289. Epub 2009 May 6. 2009
43CHEK1, PCNA
Chk1 and Claspin potentiate PCNA ubiquitination.
Yang XH, Shiotani B, Classon M, Zou L.
Genes Dev 22(9):1147-52. 2008
44PCNA
Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells.
Niimi A, Brown S, Sabbioneda S, Kannouche PL, Scott A, Yasui A, Green CM, Lehmann AR.
Proc Natl Acad Sci U S A 105(42):16125-30. Epub 2008 Oct 9. 2008
45PCNA, POLD3
Phosphorylation of the C subunit (p66) of human DNA polymerase delta.
Lemmens L, Urbach S, Prudent R, Cochet C, Baldacci G, Hughes P.
Biochem Biophys Res Commun 367(2):264-70. Epub 2007 Dec 26. 2008
46NEIL1, NEIL2, PCNA
Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen. The potential for replication-associated repair of oxidized bases in mammalian genomes.
Dou H, Theriot CA, Das A, Hegde ML, Matsumoto Y, Boldogh I, Hazra TK, Bhakat KK, Mitra S.
J Biol Chem 283(6):3130-40. Epub 2007 Nov 21.PMID: 18032376 2008
47DTL, PCNA
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex.
Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A.
Genes Dev 22(18):2496-506. doi: 10.1101/gad.1676108. 2008
48PCNA, POLD3
Dynamics of human replication factors in the elongation phase of DNA replication.
Masuda Y, Suzuki M, Piao J, Gu Y, Tsurimoto T, Kamiya K.
Nucleic Acids Res 35(20):6904-16. Epub 2007 Oct 11. 2007
49OEATC1, PCNA, ING1
The PCNA-associated factor KIAA0101/p15(PAF) binds the potential tumor suppressor product p33ING1b.
Simpson F, Lammerts van Bueren K, Butterfield N, Bennetts JS, Bowles J, Adolphe C, Simms LA, Young J, Walsh MD, Leggett B, Fowles LF, Wicking C.
Exp Cell Res 312(1):73-85. Epub 2005 Nov 8. 2006
50REV1, PCNA
REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo.
Guo C, Sonoda E, Tang TS, Parker JL, Bielen AB, Takeda S, Ulrich HD, Friedberg EC.
Mol Cell 23(2):265-71. 2006
51PCNA
PCNA controls establishment of sister chromatid cohesion during S phase.
Moldovan GL, Pfander B, Jentsch S.
Mol Cell 23(5):723-32. Epub 2006 Aug 24. 2006
52CDT1, PCNA
PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination.
Senga T, Sivaprasad U, Zhu W, Park JH, Arias EE, Walter JC, Dutta A.
J Biol Chem 281(10):6246-52. Epub 2006 Jan 9. 2006
53PCNA, POLD3
An in vivo analysis of the localisation and interactions of human p66 DNA polymerase delta subunit.
Pohler JR, Otterlei M, Warbrick E.
BMC Mol Biol 6:17. 2005
54FEN1, PCNA
Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair.
Chapados BR, Hosfield DJ, Han S, Qiu J, Yelent B, Shen B, Tainer JA.
Cell 116(1):39-50. 2004
55BAZ1B, PCNA, SMARCA5
The Williams syndrome transcription factor interacts with PCNA to target chromatin remodelling by ISWI to replication foci.
Poot RA, Bozhenok L, van den Berg DL, Steffensen S, Ferreira F, Grimaldi M, Gilbert N, Ferreira J, Varga-Weisz PD.
Nat Cell Biol 6(12):1236-44. Epub 2004 Nov 14. 2004
56CYP11A1, CYP11B1, CYP11B2, CYP17A1D, CYP19A1, GATA4, NR0B1, NR2F1, NR2F2, NR5A1, PCNA, COPS2
DAX1 and its network partners: exploring complexity in development.
Clipsham R, McCabe ER.
Mol Genet Metab 80(1-2):81-120. 2003
57PCNA, CHAF1A, TSC1, TSC2
Regulation of PCNA and CAF-1 expression by the two tuberous sclerosis gene products.
Hengstschlager M, Rosner M, Fountoulakis M, Lubec G.
Biochem Biophys Res Commun 307(3):737-42. 2003
58TAF5L, PCNA
The human proliferating Cell nuclear antigen regulates transcriptional coactivator p300 activity and promotes transcriptional repression.
Hong R, Chakravarti D.
J Biol Chem 278(45):44505-13. Epub 2003 Aug 23. 2003
59PCNA, POLD1, POLD2
Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta.
Lu X, Tan CK, Zhou JQ, You M, Carastro LM, Downey KM, So AG.
J Biol Chem 277(27):24340-5. 2002
60HDAC1, PCNA
Proliferating cell nuclear antigen associates with histone deacetylase activity, integrating DNA replication and chromatin modification.
Milutinovic S, Zhuang Q, Szyf M.
J Biol Chem 277(23):20974-8. 2002
61PCNA, POLE
Human DNA polymerase epsilon colocalizes with proliferating cell nuclear antigen and DNA replication late, but not early, in S phase.
Fuss J, Linn S.
J Biol Chem 277(10):8658-66. 2002
62PCNA, SUMO1
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.
Hoege C, Pfander B, Moldovan GL, Pyrowolakis G, Jentsch S.
Nature 419(6903):135-41. 2002
63EP300, PCNA
Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis.
Hasan S, Hassa PO, Imhof R, Hottiger MO.
Nature 410(6826):387-91. 2001
64PCNA
Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair.
Dianova II, Bohr VA, Dianov GL.
Biochemistry 40(42):12639-44. 2001
65FEN1, PCNA
Mechanism whereby proliferating cell nuclear antigen stimulates flap endonuclease 1.
Tom S, Henricksen LA, Bambara RA.
J Biol Chem 275(14):10498-505. 2000
66PCNA
ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair.
Gu L, Hong Y, McCulloch S, Watanabe H, Li GM.
Nucleic Acids Res 26(5):1173-8. 1998
67PCNA, LIG1
Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen.
Jonsson ZO, et al.
EMBO J 17(8):2412-25. 1998
68PCNA
Proliferating cell nuclear antigen promotes DNA synthesis past template lesions by mammalian DNA polymerase delta.
Mozzherin DJ, Shibutani S, Tan CK, Downey KM, Fisher PA.
Proc Natl Acad Sci U S A 94(12):6126-31. 1997
69PCNA
Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21 WAF1.
Chuang LS, Ian HI, Koh TW, Ng HH, Xu G, Li BF.
Science 277(5334):1996-2000. 1997
70GADD45A, FEN1, PCNA, POLD1, POLE, RFC1
Proliferating cell nuclear antigen : more than a clamp for DNA polymerases.
Jonsson ZO, Hubscher U.
BioEssays 19(11):967-75. 1997
71PCNA
Multiple roles of the proliferating cell nuclear antigen: DNA replication, repair and cell cycle control.
Prosperi E.
Prog Cell Cycle Res 3:193-210. Review. 1997
72CDKN1A, PCNA
Structure of the C-terminal region of p21WAF1/CIP1 complexed with human PCNA.
Gulbis JM, et al.
Cell 87 : 297-306. 1996
73CDKN1A, GADD45B, PCNA
The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1.
Vairapandi M, Balliet AG, Fornace AJ Jr, Hoffman B, Liebermann DA.
Oncogene 12(12):2579-94. 1996
74PCNA
Purification of PCNA as a nucleotide excision repair protein.
Nichols AF, et al.
Nucleic Acids Res 20 : 2441-2446. 1992
75PCNA
Chromosomal localization of the human proliferating cell nuclear antigen (PCNA) gene to or close to 20p12 by in situ hybridization.
Rao VVNG, et al.
Cytogenet Cell Genet 56 : 169-170. 1991
76PCNA
Localization of the gene for human proliferating nuclear antigen/cyclin by in situ hybridization.
Webb G, et al.
Hum Genet 86 : 84-86. 1990
77PCNA, PCNAL, PCNAP
Human gene for proliferating cell nuclear antigen Has pseudogenes and localizes to chromosome 20.
Ku DH, Travali S, Calabretta B, Huebner K, Baserga R.
Somat Cell Mol Genet 15 : 297-307. 1989
78PCNA
Structure of the human gene for the proliferating cell nuclear antigen.
Travali S, Ku DH, Rizzo MG, Ottavio L, Baserga R, Calabretta B.
J Biol Chem 264(13):7466-72. 1989
79PCNA
Cloning and sequence of the human nuclear protein cyclin: homology with DNA-binding proteins.
Almendral JM, Huebsch D, Blundell PA, Macdonald-Bravo H, Bravo R.
Proc Natl Acad Sci U S A 84(6):1575-9. 1987