| 1 | LDHA, PCK1
|
| PCK1 Regulates Glycolysis and Tumor Progression in Clear Cell Renal Cell Carcinoma Through LDHA.
|
| Shi L, An S, Liu Y, Liu J, Wang F.
|
| Onco Targets Ther 13:2613-2627. doi: 10.2147/OTT.S241717. eCollection 2020.
2020
|
| 2 | INSIG1, INSIG2, PCK1
|
| The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.
|
| Xu D, Wang Z, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee JH, Du L, Zheng Y, Lv G, Leu JS, Wang H, Xing D, Liang T, Hung MC, Lu Z.
|
| Nature Apr;580(7804):530-535. doi: 10.1038/s41586-020-2183-2. Epub 2020 Apr 8 2020
|
| 3 | DHODH, PCK1
|
| PCK1 and DHODH drive colorectal cancer liver metastatic colonization and hypoxic growth by promoting nucleotide synthesis.
|
| Yamaguchi N, Weinberg EM, Nguyen A, Liberti MV, Goodarzi H, Janjigian YY, Paty PB, Saltz LB, Kingham TP, Loo JM, de Stanchina E, Tavazoie SF.
|
| Elife Dec 16;8:e52135. doi: 10.7554/eLife.52135 2019
|
| 4 | PCK1
|
| Macrophages with a deletion of the phosphoenolpyruvate carboxykinase 1 (Pck1) gene have a more proinflammatory phenotype.
|
| Ko CW, Counihan D, Wu J, Hatzoglou M, Puchowicz MA, Croniger CM.
|
| J Biol Chem. Mar 2;293(9):3399-3409. doi: 10.1074/jbc.M117.819136. Epub 2018 Jan 9 2018
|
| 5 | PCK1, PCKDC
|
| Novel homozygous PCK1 mutation causing cytosolic phosphoenolpyruvate carboxykinase deficiency presenting as childhood hypoglycemia, an abnormal pattern of urine metabolites and liver dysfunction.
|
| Vieira P, Cameron J, Rahikkala E, Keski-Filppula R, Zhang LH, Santra S, Matthews A, Myllynen P, Nuutinen M, Moilanen JS, Rodenburg RJ, Rolfs A, Uusimaa J, van Karnebeek CDM.
|
| Mol Genet Metab. Apr;120(4):337-341. doi: 10.1016/j.ymgme.2017.02.003. Epub 2017 Feb 6 2017
|
| 6 | CREB3L3, G6PC, PCK1, PYGL
|
| CREBH Maintains Circadian Glucose Homeostasis by Regulating Hepatic Glycogenolysis and Gluconeogenesis.
|
| Kim H, Zheng Z, Walker PD, Kapatos G, Zhang K.
|
| Mol Cell Biol. Jun 29;37(14):e00048-17. doi: 10.1128/MCB.00048-17. Print 2017 Jul 15 2017
|
| 7 | FOXO1, LAMTOR5, PCK1
|
| The oncoprotein HBXIP suppresses gluconeogenesis through modulating PCK1 to enhance the growth of hepatoma cells.
|
| Shi H, Fang R, Li Y, Li L, Zhang W, Wang H, Chen F, Zhang S, Zhang X, Ye L.
|
| Cancer Lett. Nov 28;382(2):147-156. doi: 10.1016/j.canlet.2016.08.025. Epub 2016 Sep 5 2016
|
| 8 | PCK1, PCK2
|
| Kinetic and functional properties of human mitochondrial phosphoenolpyruvate carboxykinase.
|
| Escós M, Latorre P, Hidalgo J, Hurtado-Guerrero R, Carrodeguas JA, López-Buesa P.
|
| Biochem Biophys Rep. Jun 8;7:124-129. doi: 10.1016/j.bbrep.2016.06.007. eCollection 2016 Sep. 2016
|
| 9 | PCK1
|
| Induction of Phosphoenolpyruvate Carboxykinase (PEPCK) during Acute Acidosis and Its Role in Acid Secretion by V-ATPase-Expressing Ionocytes.
|
| Furukawa F, Tseng YC, Liu ST, Chou YL, Lin CC, Sung PH, Uchida K, Lin LY, Hwang PP.
|
| Int J Biol Sci. May 1;11(6):712-25. doi: 10.7150/ijbs.11827. eCollection 2015 2015
|
| 10 | G6PC, PCK1, THRA, THRB
|
| FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes.
|
| Singh BK, Sinha RA, Zhou J, Xie SY, You SH, Gauthier K, Yen PM.
|
| J Biol Chem 18;288(42):30365-72. doi: 10.1074/jbc.M113.504845. Epub 2013 Aug 30 2013
|
| 11 | ESRRG, G6PC, PCK1
|
| Orphan nuclear receptor estrogen-related receptor γ (ERRγ) is key regulator of hepatic gluconeogenesis.
|
| Kim DK, Ryu D, Koh M, Lee MW, Lim D, Kim MJ, Kim YH, Cho WJ, Lee CH, Park SB, Koo SH, Choi HS.
|
| J Biol Chem. Jun 22;287(26):21628-39. doi: 10.1074/jbc.M111.315168. Epub 2012 May 1 2012
|
| 12 | EP300, PCK1, UBR5
|
| Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase.
|
| Jiang W, Wang S, Xiao M, Lin Y, Zhou L, Lei Q, Xiong Y, Guan KL, Zhao S.
|
| Mol Cell. Jul 8;43(1):33-44. doi: 10.1016/j.molcel.2011.04.028 2011
|
| 13 | PCK1
|
| Function of phosphoenolpyruvate carboxykinase in mammary gland epithelial cells.
|
| Hsieh CW, Huang C, Bederman I, Yang J, Beidelschies M, Hatzoglou M, Puchowicz M, Croniger CM.
|
| J Lipid Res. Jul;52(7):1352-62. doi: 10.1194/jlr.M012666. Epub 2011 Apr 19 2011
|
| 14 | PCK1, GALP, TRAK2, TNK1
|
| Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants.
|
| Grupe A, Abraham R, Li Y, Rowland C, Hollingworth P, Morgan A, Jehu L, Segurado R, Stone D, Schadt E, Karnoub M, Nowotny P, Tacey K, Catanese J, Sninsky J, Brayne C, Rubinsztein D, Gill M, Lawlor B, Lovestone S, Holmans P, O'donovan M, Morris JC, Thal L, Goate A, Owen MJ, Williams J.
|
| Hum Mol Genet 16(8):865-73. Epub 2007 Feb 22. 2007
|
| 15 | PCK1, PCK2
|
| PCK1 and PCK2 as candidate diabetes and obesity genes.
|
| Beale EG, Harvey BJ, Forest C.
|
| Cell Biochem Biophys 48(2-3):89-95. Review.
2007
|
| 16 | PCK1
|
| Promoter polymorphism in PCK1 (phosphoenolpyruvate carboxykinase gene) associated with type 2 diabetes mellitus.
|
| Cao H, van der Veer E, Ban MR, Hanley AJ, Zinman B, Harris SB, Young TK, Pickering JG, Hegele RA.
|
| J Clin Endocrinol Metab 89(2):898-903. 2004
|
| 17 | PCK1, PCK2
|
| Parallel acceleration of phosphoenolpyruvate carboxykinase mRNA degradation and increase in ribonuclease activity induced by insulin in cultured rat hepatocytes.
|
| Heise T, Krones A, Nath A, Jungermann K, Christ B.
|
| Biol Chem 379(7):875-83. 1998
|
| 18 | PCK1, PCK2
|
| Involvement of a local fenton reaction in the reciprocal modulation by O2 of the glucagon-dependent activation of the phosphoenolpyruvate carboxykinase gene and the insulin-dependent activation of the glucokinase gene in rat hepatocytes.
|
| Kietzmann T, Porwol T, Zierold K, Jungermann K, Acker H.
|
| Biochem J 335 ( Pt 2):425-32. 1998
|
| 19 | NIDDM7, PCK1
|
| Indication for genetic linkage of the phosphoenolpyruvate carboxykinase (PCK1) gene region on chromosome 20q to non-insulin-dependent diabetes mellitus.
|
| Hani EH, et al.
|
| Diabetes Metab 22 : 451-454. 1996
|
| 20 | PCK1
|
| Phosphoenolpyruvate carboxykinase (GTP) : characterization of the human PCK1 gene localization distal to MODY on chromosome 21.
|
| Ting CN, et al.
|
| Genomics 16 : 698-706. 1993
|
| 21 | PCK1
|
| Human PCK1 encoding phosphoenolpyruvate carboxykinase is located on chromosome 20q13.2.
|
| Yu H, et al.
|
| Genomics 15 : 219-221. 1993
|
| 22 | PCK1
|
| cDNA sequence and localization of polymorphic human cytosolic phosphoenolpyruvate carboxykinase gene (PCK1) to chromosome 20, band q13.31: PCK1 is not tightly linked to maturity-onset diabetes of the young.
|
| Stoffel M, Xiang KS, Espinosa R 3rd, Cox NJ, Le Beau MM, Bell GI.
|
| Hum Mol Genet 2(1):1-4. 1993
|
| 23 | PCK1, CHRNA4
|
| The genes coding for phosphoenolpyruvate carboxykinase-1 (PCK1) and neuronal nicotinic acetylcholine receptor alpha4 subunit (CHRNA4) map to human chromosome 20, extending the known region of homology with mouse chromosome 2.
|
| Pilz AJ, et al.
|
| Ann Hum Genet 56 : 289-293. 1992
|
| 24 | PCK1
|
| Identification of a thyroid hormone response element in the phosphoenolpyruvate carboxykinase (GTP) gene. Evidence for synergistic interaction between thyroid hormone and cAMP cis-regulatory elements.
|
| Giralt M, Park EA, Gurney AL, Liu JS, Hakimi P, Hanson RW.
|
| J Biol Chem 266(32):21991-6. 1991
|
| 25 | PCK1, PCK1D
|
| Gluconeogenesis in infancy and childhood. III. Deficiency of the extramitochondrial form of hepatic phosphoenolpyruvate carboxykinase in a case of persistent neonatal hypoglycaemia.
|
| Vidnes J, Sovik O.
|
| Acta Paediatr Scand 65(3):307-12. 1976
|